Correction to: Angiotensin II and angiotensin 1 –7: which is their role in atrial fibrillation?
There was a mistake in Prof. Giuseppe Massimo Claudio Rosano ’s affiliation. (Source: Heart Failure Reviews)
Source: Heart Failure Reviews - July 9, 2020 Category: Cardiology Source Type: research

Targeting the forkhead box protein P1 pathway as a novel therapeutic approach for cardiovascular diseases
AbstractCardiovascular disease (CVD) is the leading cause of death worldwide and encompasses diverse diseases of the vasculature, myocardium, cardiac electrical circuit, and cardiac development. Forkhead box protein P1 (Foxp1) is a large multi-domain transcriptional regulator belonging to the Fox family with winged helix DNA-binding protein, which plays critical roles in cardiovascular homeostasis and disorders. The broad distribution of Foxp1 and alternative splicing isoforms implicate its distinct functions in diverse cardiac and vascular cells and tissue types. Foxp1 is essential for diverse biological processes and has...
Source: Heart Failure Reviews - July 9, 2020 Category: Cardiology Source Type: research

Therapeutic angiogenesis with exosomal microRNAs: an effectual approach for the treatment of myocardial ischemia
AbstractTherapeutic angiogenesis presents a potential approach for treating ischemic heart diseases especially in patients who are not appropriate candidates for traditional approaches of revascularization. This approach acts through inducing the neovascularization or maturation of pre-existing collateral vessels into functional arteries to bypass the blocked arteries and restore perfusion to ischemic myocardium. Successful stimulation of local angiogenesis can be established by the cross talk between stem cells, endothelial cells, and cardiomyocytes, which is mainly mediated by paracrine communication accompanied by secre...
Source: Heart Failure Reviews - July 6, 2020 Category: Cardiology Source Type: research

The roles of epicardial adipose tissue in heart failure
AbstractHeart failure is a growing health problem resulting in the decreased life expectancy of patients and severely increased the healthcare burden. Penetrating research on the pathogenesis and regulation mechanism of heart failure is important for treatment of heart failure. Epicardial adipose tissue (EAT) has been demonstrated as not only a dynamic organ with biological functions but also an inert lipid store with regulating systemic metabolism. EAT mediates physiological and pathophysiological processes of heart failure by regulating adipogenesis, cardiac remodeling, insulin resistance, cardiac output, and renin angio...
Source: Heart Failure Reviews - June 29, 2020 Category: Cardiology Source Type: research

Letter regarding the article “Immunomodulatory treatment for lymphocytic myocarditis—a systematic review and meta-analysis”
(Source: Heart Failure Reviews)
Source: Heart Failure Reviews - June 25, 2020 Category: Cardiology Source Type: research

Beyond the myocardium? SGLT2 inhibitors target peripheral components of reduced oxygen flux in the diabetic patient with heart failure with preserved ejection fraction
AbstractRecent cardiovascular outcome trials have highlighted the propensity of the antidiabetic agents, SGLT2 inhibitors (SGLT2is or -flozin drugs), to exert positive clinical outcomes in patients with cardiovascular disease at risk for major adverse cardiovascular events (MACEs). Of interest in cardiac diabetology is the physiological status of the patient with T2DM and heart failure with preserved ejection fraction (HFpEF), a well-examined association. Underlying this pathologic tandem are the effects that long-standing hyperglycemia has on the ability of the HFpEF heart to adequately deliver oxygen. It is believed that...
Source: Heart Failure Reviews - June 24, 2020 Category: Cardiology Source Type: research

Direct oral anticoagulants across the heart failure spectrum: the precision medicine era
AbstractHeart failure (HF) is characterized by a pro-thrombotic state, which might aggravate its morbidity and, consequently, mortality. Several and commonly observed comorbidities, such as coronary artery disease, atrial fibrillation (AF), renal dysfunction, and diabetes often complicate HF, increasing the thromboembolic risk. In the past decade, direct oral anticoagulants (DOACs) have been approved for the treatment and prevention of stroke and embolic events in patients with nonvalvular AF. Due to their lower bleeding risk, these drugs are frequently used instead of warfarin; however, some controversies exist on their u...
Source: Heart Failure Reviews - June 24, 2020 Category: Cardiology Source Type: research

Cardiac xenotransplantation: a promising way to treat advanced heart failure
AbstractCardiac xenotransplantation (CXTx) might be a promising approach to bridge the gap between the supply and demand of a donor heart. The survival of cardiac xenograft has been significantly extended in pig-to-nonhuman primate (NHP) CXTx, with records of 195  days and 945 days for orthotropic and heterotopic CXTx, respectively. To present the history of CXTx, we list the reported clinical CXTx, compare pigs and NHPs as sources of hearts, and compare three different kinds of preclinical CXTx models. The application of genetically modified pigs and nove l immunosuppressive drugs accelerates the development of ...
Source: Heart Failure Reviews - June 23, 2020 Category: Cardiology Source Type: research

Cardiovascular magnetic resonance for the diagnosis and management of heart failure with preserved ejection fraction
AbstractHeart failure with preserved ejection fraction (HFpEF) is characterized by an impaired ventricular filling resulting in the development of dyspnea and other HF symptoms. Even though echocardiography is the cornerstone to demonstrate structural and/or functional alterations of the heart as the underlying cause for the clinical presentation, cardiovascular magnetic resonance (CMR) represents the noninvasive gold standard to assess cardiac morphology, function, and tissue changes. Indeed, CMR allows quantification of biventricular volumes, mass, wall thickness, systolic function, and intra- and extracardiac flows; dia...
Source: Heart Failure Reviews - June 22, 2020 Category: Cardiology Source Type: research

Association of loop diuretics use and dose with outcomes in outpatients with heart failure: a systematic review and meta-analysis of observational studies involving 96,959 patients
AbstractThere is ongoing controversy regarding the association between loop diuretics (LD), especially in high doses, and adverse clinical outcomes in outpatients with heart failure (HF). We performed a systematic review of the evidence for LD in outpatients with HF. We searched MEDLINE, EMBASE, and Cochrane Clinical Trial Collection to identify controlled studies, evaluating the association between LD and morbidity and mortality in patients with HF. The primary endpoint was all-cause mortality and secondary endpoint  HF hospitalizations. Quantitative analysis was performed by generating forest plots and pooling adjus...
Source: Heart Failure Reviews - June 21, 2020 Category: Cardiology Source Type: research

Arrhythmic risk stratification by cardiac magnetic resonance tissue characterization: disclosing the arrhythmic substrate within the heart muscle
AbstractSudden cardiac death (SCD) is a pivotal health problem worldwide. The identification of subjects at increased risk of SCD is crucial for the accurate selection of candidates for implantable cardioverter defibrillator (ICD) therapy. Current strategies for arrhythmic stratification largely rely on left ventricular (LV) ejection fraction (EF), mostly measured by echocardiography, and New York Heart Association functional status for heart failure with reduced EF. For specific diseases, such as hypertrophic and arrhythmogenic cardiomyopathy, some risk scores have been proposed; however, these scores take into account so...
Source: Heart Failure Reviews - June 20, 2020 Category: Cardiology Source Type: research

Cardiogenic shock in autoimmune rheumatologic diseases: an insight on etiologies, management, and treatment outcomes
AbstractAutoimmune rheumatological disorders are known to have an increased risk for cardiovascular diseases including coronary artery disease (CAD), myocarditis, pericarditis, valvulopathy, and in consequence cardiogenic shock. Data on cardiogenic shock in rheumatological diseases are scarce; however, several reports have highlighted this specific entity. We sought to review the available literature and highlight major outcomes and the management approaches in each disease. Systematic literature search, including PubMed, Ovid/Medline, Cochrane Library, and Web of Science, was conducted between January 2000 and December 20...
Source: Heart Failure Reviews - June 20, 2020 Category: Cardiology Source Type: research

Effect of renin-angiotensin system inhibition on cardiac structure and function and exercise capacity in heart failure with preserved ejection fraction: a meta-analysis of randomized controlled trials
AbstractTargeting the renin-angiotensin system (RAS) pathways has been considered a logical intervention for patients with heart failure with preserved ejection fraction (HFpEF), due to its hypothesized link to left ventricular (LV) remodeling. Although the effects of RAS inhibitors including angiotensin-converting enzyme inhibitors (ACE-Is), angiotensin receptor blockers (ARBs), and direct renin inhibitors (DRIs) on LV structure and function and exercise capacity in HFpEF patients have been examined in multiple randomized controlled trials (RCTs), results are inconsistent due partly to limited power. We conducted a meta-a...
Source: Heart Failure Reviews - June 19, 2020 Category: Cardiology Source Type: research

Right ventricular phenotype, function, and failure: a journey from evolution to clinics
AbstractThe right ventricle has long been perceived as the “low pressure bystander” of the left ventricle. Although the structure consists of, at first glance, the same cardiomyocytes as the left ventricle, it is in fact derived from a different set of precursor cells and has a complex three-dimensional anatomy and a very distinct contraction pattern. M echanisms of right ventricular failure, its detection and follow-up, and more specific different responses to pressure versus volume overload are still incompletely understood. In order to fully comprehend right ventricular form and function, evolutionary biolog...
Source: Heart Failure Reviews - June 17, 2020 Category: Cardiology Source Type: research

Ventricular arrhythmias and ARNI: is it time to reappraise their management in the light of new evidence?
AbstractThe remarkable scientific progress in the treatment of patients with heart failure (HF) and reduced ejection fraction (HFrEF) has more than halved the risk of sudden cardiac death (SCD) in this setting. However, SCD remains one of the major causes of death in this patient population. Beyond the acknowledged role of beta blockers and inhibitors of the renin-angiotensin-aldosterone system (RAAS), a new class of drugs, the angiotensin receptor neprilysin inhibitors (ARNI), proved to reduce the overall cardiovascular mortality and, more specifically, the risk of SCD in HFrEF patients. The mechanism by which ARNI may re...
Source: Heart Failure Reviews - June 17, 2020 Category: Cardiology Source Type: research

A systematic review on focal takotsubo syndrome: a not-so-small matter
AbstractA focal contraction pattern in takotsubo syndrome (TTS) is considered rare. Due to its peculiar presentation, which includes segmental left ventricular (LV) regional wall motion abnormalities (RWMA), the focal TTS pattern may be hardly differentiable from other entities, such as myocarditis or myocardial infarction. We performed a comprehensive systematic literature review researching for works in English published in Journals indexed in Embase, available online for consultation, using the following keywords (in Title and/or Abstract): ( “takotsubo” OR “broken heart” OR “apical balloon...
Source: Heart Failure Reviews - June 13, 2020 Category: Cardiology Source Type: research

Pathogenesis of chronic heart failure: cardiovascular aging, risk factors, comorbidities, and disease modifiers
AbstractChronic heart failure (HF) is rare in the young and common in the elderly in the Western world. HF in the young is usually due to specific causes, predominantly or exclusively affecting the heart (adult congenital heart disease, different types of cardiomyopathies, myocarditis, or cardiotoxicity). In contrast, the mechanisms underlying HF development in the elderly have not been completely delineated. We propose that in most elderly patients, HF, regardless of the left ventricular ejection fraction (LVEF), is the consequence of the acceleration of cardiovascular aging by specific risk factors (usually hypertension,...
Source: Heart Failure Reviews - June 10, 2020 Category: Cardiology Source Type: research

Hormonal prostate cancer therapies and cardiovascular disease: a systematic review
AbstractTherapeutic intervention for prostate cancer mostly relies on eliminating circulating androgen or antagonizing its effect at the cellular level. As the use of endocrine therapies grows, an under-reported incidence of cardiovascular toxicities occurs in prostate cancer patients. In this review, we summarize data of clinical studies, investigating the cardiovascular and metabolic alterations associated with the use of old and new endocrine drugs (gonadotropin-releasing hormone [GnRH] agonists and antagonists, androgen receptor inhibitors, 17 α-hydroxylase/c-17,20-lyase [CYP17] inhibitor) in prostate cancer. To ...
Source: Heart Failure Reviews - June 4, 2020 Category: Cardiology Source Type: research

The effect of nutraceuticals on multiple signaling pathways in cardiac fibrosis injury and repair
AbstractCardiac fibrosis is one of the most common pathological conditions caused by different heart diseases, including myocardial infarction and diabetic cardiomyopathy. Cardiovascular disease is one of the major causes of mortality worldwide. Cardiac fibrosis is caused by different processes, including inflammatory reactions and oxidative stress. The process of fibrosis begins by changing the balance between production and destruction of extracellular matrix components and stimulating the proliferation and differentiation of cardiac fibroblasts. Many studies have focused on finding drugs with less adverse effects for th...
Source: Heart Failure Reviews - June 3, 2020 Category: Cardiology Source Type: research

Cardiac magnetic resonance in cocaine-induced myocardial damage: cocaine, heart, and magnetic resonance
AbstractThe use of cocaine constitutes a major health problem. Cocaine use is associated with acute and chronic complications that might involve any system, the most common being the cardiovascular system. The precise incidence of cocaine-induced cardiomyopathy remains mysterious and probably underreported. Cocaine use should be considered in young patients presenting with chest pain or heart failure without other underlying risk factors. Cocaine-related cardiovascular complications can be acute or chronic and include ischemic and non-ischemic events. Frequent cocaine users have a seven-fold higher risk of myocardial infar...
Source: Heart Failure Reviews - June 2, 2020 Category: Cardiology Source Type: research

Diagnostic value of echocardiographic markers for diastolic dysfunction and heart failure with preserved ejection fraction
This study aimed to evaluate the diagnostic performance of echocardiographic markers of heart failure with preserved ejection fraction (HFpEF) and left ventricular diastolic dysfunction (LVDD) in comparison with the gold standard of cardiac catheterization. Diagnosing HFpEF is challenging, as symptoms are non-specific and often absent at rest. A clear need exists for sensitive echocardiographic markers to diagnose HFpEF. We systematically searched for studies testing the diagnostic value of novel echocardiographic markers for HFpEF and LVDD. Two investigators independently reviewed the studies and assessed the risk of bias...
Source: Heart Failure Reviews - June 2, 2020 Category: Cardiology Source Type: research

Clinical inertia in the treatment of heart failure: a major issue to tackle
AbstractDespite an enormous improvement in heart failure management during the last decades, the hospitalization and mortality rate of heart failure patients still remain very high. Clinical inertia, defined as the lack of treatment intensification in a patient not at evidence-based goals for care, is an important underlying cause. Clinical inertia is extensively described in hypertension and type 2 diabetes mellitus, but increasingly recognized in heart failure as well. Given the well-established guidelines for the management of heart failure, these are still not being reflected in clinical practice. While the absolute ma...
Source: Heart Failure Reviews - May 30, 2020 Category: Cardiology Source Type: research

Anthracycline-induced cardiotoxicity and renin-angiotensin-aldosterone system —from molecular mechanisms to therapeutic applications
AbstractFew millions of new cancer cases are diagnosed worldwide every year. Due to significant progress in understanding cancer biology and developing new therapies, the mortality rates are decreasing with many of patients that can be completely cured. However, vast majority of them require chemotherapy which comes with high medical costs in terms of adverse events, of which cardiotoxicity is one of the most serious and challenging. Anthracyclines (doxorubicin, epirubicin) are a class of cytotoxic agents used in treatment of breast cancer, sarcomas, or hematological malignancies that are associated with high risk of cardi...
Source: Heart Failure Reviews - May 30, 2020 Category: Cardiology Source Type: research

The utility of growth differentiation factor-15, galectin-3, and sST2 as biomarkers for the diagnosis of heart failure with preserved ejection fraction and compared to heart failure with reduced ejection fraction: a systematic review
The objective was to evaluate the diagnosis of heart failure with preserved ejection fraction (HFpEF) using the biomarkers, growth differentiation factor-15 (GDF-15), galectin-3 (Gal-3), and soluble ST2 (sST2), and to determine whether they can differentiate HFpEF from heart failure with reduced ejection fraction (HFrEF). Medline and Embase databases were searched with the terms diastolic heart failure or HFpEF, biomarkers, and diagnosis, limited to years 2000 to 2019. There were significantly and consistently higher levels of GDF-15, Gal-3, and sST2 in HFpEF compared to no heart failure. Importantly, the magnitude of the ...
Source: Heart Failure Reviews - May 29, 2020 Category: Cardiology Source Type: research

Transplant and mechanical circulatory support in patients with adult congenital heart disease
AbstractAdvances in surgery and pediatric care over the past decades have achieved improved survival for children born with congenital heart disease (CHD) and have produced a large, growing population of patients with adult congenital heart disease (ACHD). Heart failure has emerged as the leading cause of death and a major cause of morbidity among the ACHD population, while as little evidence supports the efficacy of guideline-directed medical therapies in this population. It is increasingly important that clinicians caring for these patients understand how to utilize mechanical circulatory support (MCS) in ACHD. In this r...
Source: Heart Failure Reviews - May 29, 2020 Category: Cardiology Source Type: research

Heart failure in the adult Ebstein patient
AbstractEbstein anomaly comprises approximately 1% of all congenital heart diseases. It occurs when the tricuspid valve fails to properly delaminate from the right ventricle, resulting in a clinical spectrum of abnormal tricuspid valve morphology and right ventricular dysfunction. Due to the anatomy of the tricuspid valve and right ventricle, as well as associated right- and left-sided pathology, patients are at risk for both right and left ventricular failure and the associated symptoms of each. Ebstein patients are also at risk for atrial arrhythmias, due to the atrial enlargement intrinsic to the anatomy, as well as the...
Source: Heart Failure Reviews - May 29, 2020 Category: Cardiology Source Type: research

The management of atrial fibrillation in heart failure: an expert panel consensus
AbstractHeart failure (HF) and atrial fibrillation (AF) often coexist, being closely interrelated as the one increases the prevalence and incidence and worsens the prognosis of the other. Their frequent coexistence raises several challenges, including under-diagnosis of HF with preserved ejection fraction in AF and of AF in HF, characterization and diagnosis of atrial cardiomyopathy, target and impact of rate control therapy on outcomes, optimal rhythm control strategy in the era of catheter ablation, HF-related thromboembolic risk and management of anticoagulation in patients with comorbidities, such as chronic kidney dis...
Source: Heart Failure Reviews - May 28, 2020 Category: Cardiology Source Type: research

Impact of right ventricular impairment on morbidity and mortality in takotsubo syndrome —a meta-analysis of observational trials
AbstractThe impact of right ventricular impairment (RVI) on the morbidity and mortality of patients with Takotsubo syndrome (TTS) is well-debated. We conducted a meta-analysis to evaluate the mortality and morbidity risk associated with RVI compared with those without RVI in patients with TTS. A comprehensive search was performed in PubMed and Embase from inception to April 19, 2019. Our primary outcome of interest was in-hospital and long-term mortality. Other outcomes of interest were acute heart failure, left ventricular systolic function, tricuspid and mitral regurgitation, and length of hospital stay (LOS). We are rep...
Source: Heart Failure Reviews - May 28, 2020 Category: Cardiology Source Type: research

Outcomes of percutaneous temporary biventricular mechanical support: a systematic review
AbstractPercutaneous biventricular assist devices (BiVAD) are a recently developed treatment option for severe cardiogenic shock. This systematic review sought to identify indications and outcomes of patients placed on percutaneous BiVAD support. An electronic search was performed to identify all appropriate studies utilizing a percutaneous BiVAD configuration. Fifteen studies comprising of 20 patients were identified. Individual patient survival and outcomes data were combined for statistical analysis. All 20 patients were supported with a microaxial LVAD, 12/20 (60%) of those patients were supported with a microaxial (RM...
Source: Heart Failure Reviews - May 26, 2020 Category: Cardiology Source Type: research

Definition of left ventricular remodelling following ST-elevation myocardial infarction: a systematic review of cardiac magnetic resonance studies in the past decade
AbstractAn increase in left ventricular volumes between baseline and follow-up imaging is the main criteria for the quantification of left ventricular remodelling (LVR) after ST-elevation myocardial infarction (STEMI), but without consensual definition. We aimed to review the criteria used for the definition of LVR based on cardiac magnetic resonance imaging (CMR) in STEMI patients. A systematic literature search was conducted using MEDLINE and the Cochrane Library from January 2010 to August 2019. Thirty-seven studies involving 4209 patients were included. Among these studies, 30 (81%) used a cut-off value for defining LV...
Source: Heart Failure Reviews - May 26, 2020 Category: Cardiology Source Type: research

Consensus document: management of heart failure in type 2 diabetes mellitus
AbstractType 2 diabetes mellitus (T2DM) is a known predisposing factor for heart failure (HF). The growing burden of these two conditions and their impact on health of the individual and on society in general needs urgent attention from the health care professionals. Availability of multiple treatment choices for managing T2DM and HF may make therapeutic decisions more complex for clinicians. Recent cardiovascular outcome trials of antidiabetic drugs have added very robust evidence to effectively manage subjects with this dual condition. This consensus statement provides the prevalence trends and the impact of this dual bu...
Source: Heart Failure Reviews - May 24, 2020 Category: Cardiology Source Type: research

Maintenance immunosuppression in heart transplantation: insights from network meta-analysis of various immunosuppression regimens
AbstractPrevious studies have reported superiority of mechanistic target-of-rapamycin (mTOR) antagonists (mTA) over calcineurin inhibitors (CNI) as part of maintenance immunosuppression (IS) in mitigating cardiac allograft vasculopathy (CAV) after heart transplantation (HT). MEDLINE and EMBASE were searched through October 2019 for studies comparing maintenance IS with mTA  + antimetabolites (AM), CNI + mTA or CNI + AM post HT. The main outcomes were all-cause mortality, CAV, acute rejection, CMV infections, and change in eGFR. To compare different IS antagonists, a random-effects ...
Source: Heart Failure Reviews - May 18, 2020 Category: Cardiology Source Type: research

Effect of exercise on epicardial adipose tissue in adults: a systematic review and meta-analyses
AbstractAccording to previous epidemiological studies, we can reduce the thickness of epicardial fat and improve cardiovascular risk factors through exercise, and the changes may depend on the form of exercise. We systemically reviewed published studies that evaluated exercise intervention on epicardial adipose tissue (EAT) levels. We included randomized controlled trials (RCTs) comparing one exercise with another exercise or diet for the treatment to reduce EAT. We used fixed effects models for meta-analyses; effects of exercise on outcomes were described as mean differences (MD) or standardized difference of means (SMD) ...
Source: Heart Failure Reviews - May 16, 2020 Category: Cardiology Source Type: research

Anthracycline-induced cardiotoxicity: mechanisms of action, incidence, risk factors, prevention, and treatment
AbstractAnthracycline is a mainstay in treatment of many cancers including lymphoma and breast cancer among many others. However, anthracycline treatment can be cardiotoxic. Although anthracycline-induced cardiotoxicity is dose dependent, it can also occur early at the onset of treatment and even up to several years following completion of treatment. This review article focuses on the understanding of mechanisms of anthracycline-induced cardiotoxicity, the treatments, and recommended follow-up and preventive approaches. (Source: Heart Failure Reviews)
Source: Heart Failure Reviews - May 14, 2020 Category: Cardiology Source Type: research

Cost-effectiveness analyses of sacubitril-valsartan for heart failure
The objective of this study was to evaluate the pharmacoeconomic value of sacubitril-valsartan for the treatment of heart failure (HF). PubMed, Embase, Cochrane Library, ScienceDirect, Scopus, CNKI, Wanfang, and VIP databases were searched systematically and the retrieval time ended in August 2019. According to the criteria of inclusion and exclusion, the quality of studies included was evaluated as per the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) scale, and the results were extracted and analyzed systematically. The total of 11 cost-effectiveness studies was identified, 10 were performed in the...
Source: Heart Failure Reviews - May 14, 2020 Category: Cardiology Source Type: research

Prognostic significance of T1 mapping parameters in heart failure with preserved ejection fraction: a systematic review
AbstractHeart failure with preserved ejection fraction (HFpEF) accounts for almost one-half of all heart failure (HF) patients and continues to increase in prevalence. While mortality with heart failure with reduced ejection fraction (HFrEF) has decreased over the past few decades with use of evidence-based HFrEF therapy, mortality related to heart failure with HFpEF has not changed significantly over the same time period. The combination of poor prognosis and lack of effective treatment options creates a pressing need for novel strategies for better patient characterization. We conducted a systematic review to evaluate th...
Source: Heart Failure Reviews - May 13, 2020 Category: Cardiology Source Type: research

Effects of catheter-based renal denervation on heart failure with reduced ejection fraction: a meta-analysis of randomized controlled trials
AbstractDespite the major progress in the treatment of heart failure, the burden of heart failure is steadily increasing in the Western world. Heart failure is characterized by increased sympathetic activity, and chronic sympathetic activation is involved in the maintenance of the pathological state. Recent studies have shown that catheter-based renal denervation (RDN) presents a safe and minimally invasive treatment option for uncontrolled hypertension, a condition that is driven by increased sympathetic activity. Although randomized controlled trials (RCTs) have examined the effect of RDN in heart failure patients, resul...
Source: Heart Failure Reviews - May 11, 2020 Category: Cardiology Source Type: research

Research progress of biomarkers in early detection of chemotherapy-induced cardiotoxicity
AbstractWith the advances of drug therapy, the prognosis of cancer patients has seen remarkable improvements, and cancer-related mortality has decreased significantly. However, the followed drug-related cardiotoxicity becomes a serious threat to patients ’ living quality and survival rate. Cardiovascular toxicity associated with some chemotherapy drugs is reversible and dose-dependent. If early identification is possible, early cardiovascular protection measures or adjustment of chemotherapy regimens can be taken to improve the prognosis of patien ts. Therefore, early prevention and monitoring of chemotherapy-related...
Source: Heart Failure Reviews - May 11, 2020 Category: Cardiology Source Type: research

Physical activity and exercise training in heart failure with preserved ejection fraction: gathering evidence from clinical and pre-clinical studies
In conclusion, while the impact of physical activity/exercise training on exerc ise intolerance and quality of life is already well known, its effect on mortality and hospitalization is not well documented, and whether it benefits diastolic function needs further investigation. Some clinical studies showed that exercise training can improve diastolic function, and evidences fro m pre-clinical studies suggest that this effect is mediated through reduced myocardial stiffness. (Source: Heart Failure Reviews)
Source: Heart Failure Reviews - May 8, 2020 Category: Cardiology Source Type: research

Noncardiac comorbidity clustering in heart failure: an overlooked aspect with potential therapeutic door
AbstractHeart failure is associated with a range of comorbidities that have the potential to impair both quality of life and clinical outcome. Unfortunately, noncardiac diseases are underrepresented in large randomized clinical trials, and their management remains poorly understood. In clinical practice, the prevalence of comorbidities in heart failure is high. Although the prognostic impact of comorbidities is well known, their prevalence and impact in specific heart failure settings have been overlooked. Many studies have described specific single noncardiac conditions, but few have examined their overall burden and grad...
Source: Heart Failure Reviews - May 8, 2020 Category: Cardiology Source Type: research

Correction to: Crosstalk between GSK-3 β-actuated molecular cascades and myocardial physiology
The original version of this article unfortunately contained a mistake. Fig.  4 image and its citation must be deleted from the manuscript as the content for the same has already deleted during revision by a suggestion of reviewers. (Source: Heart Failure Reviews)
Source: Heart Failure Reviews - May 8, 2020 Category: Cardiology Source Type: research

Congestion occurrence and evaluation in acute heart failure scenario: author ’s replay to the letter
(Source: Heart Failure Reviews)
Source: Heart Failure Reviews - May 7, 2020 Category: Cardiology Source Type: research

Soluble CD146 —an underreported novel biomarker of congestion: a comment on a review concerning congestion assessment and evaluation in acute heart failure
AbstractIn spite of high prevalence, congestion remains a poorly understood phenomenon in heart failure pathophysiology. Its negative impact on outcome has been widely recognised. Still, data from various registries reveal the failure of the contemporary treatment strategies to overcome congestion. This shortcoming is closely related to the fact that there are no universe means for congestion assessment and grading, making it a difficult process to recognise. CD146 is a novel blood biomarker of congestion that has been shown to reflect intravascular fluid accumulation in a number of experimental and clinical studies. This ...
Source: Heart Failure Reviews - May 6, 2020 Category: Cardiology Source Type: research

Diagnostic algorithm for HFpEF: how much is the recent consensus applicable in clinical practice?
AbstractHeart failure with preserved ejection fraction (HFpEF) represents an important cardiovascular entity with increasing prevalence and relatively high mortality. The agreement about diagnostic algorithm for HFpEF is still missing. Echocardiographic approach remains the cornerstone in HFpEF diagnosis. Echocardiographic diastolic stress test provides numerous useful parameters that correlated well with indexes obtained by cardiac catheterization. Recently published consensus recommended new scoring system that included functional and structural echocardiographic parameters, as well as biomarkers. The new score for evalu...
Source: Heart Failure Reviews - April 28, 2020 Category: Cardiology Source Type: research

The role of non-invasive devices for the telemonitoring of heart failure patients
AbstractHeart failure (HF) patients represent one of the most prevalent as well as one of the most fragile population encountered in the cardiology and internal medicine departments nowadays. Estimated to account for around 26 million people worldwide, diagnosed patients present a poor prognosis and quality of life with a clinical history accompanied by repeated hospital admissions caused by an exacerbation of their chronic condition. The frequent hospitalizations and the extended hospital stays mean an extremely high economic burden for healthcare institutions. Meanwhile, the number of chronically diseased and elderly pat...
Source: Heart Failure Reviews - April 27, 2020 Category: Cardiology Source Type: research

The transverse aortic constriction heart failure animal model: a systematic review and meta-analysis
AbstractThe transverse aortic constriction (TAC) model is frequently used to study adverse cardiac remodeling upon pressure overload. We set out to define the most important characteristics that define the degree of cardiac remodeling in this model. A systematic review and meta-analyses were performed on studies using the TAC mouse/rat model and reporting echocardiographic outcome parameters. We included all animal studies in which a constriction around the transverse aorta and at least one of the predefined echocardiography or MRI outcome parameters were assessed. A total of 502 articles and>  3000 wild-type, un...
Source: Heart Failure Reviews - April 25, 2020 Category: Cardiology Source Type: research

How His bundle pacing prevents and reverses heart failure induced by right ventricular pacing
AbstractIdeal heart performance demands vigorous systolic contractions and rapid diastolic relaxation. These sequential events are precisely timed and interdependent and require the rapid synchronous electrical stimulation provided by the His-Purkinje system. Right ventricular (RV) pacing creates slow asynchronous electrical stimulation that disrupts the timing of the cardiac cycle and results in left ventricular (LV) mechanical asynchrony. Long-term mechanical asynchrony produces LV dysfunction, remodeling, and clinical heart failure. His bundle pacing preserves synchronous electrical and mechanical LV function, prevents ...
Source: Heart Failure Reviews - April 21, 2020 Category: Cardiology Source Type: research

Literacy critical to heart failure management: a scoping review
AbstractHeart failure is a complex clinical syndrome most commonly encountered among older adults. This complex clinical syndrome is associated with poor health outcomes such as frequent admissions and mortality. These adverse outcomes are commonly associated with poor self-care and lower health literacy. Literacy is a combination of knowledge and skills and often reflected by appropriate interaction with the community, while health literacy is the cognitive and social skills reflected by accessing and comprehending health information and making appropriate health decisions. These decisions are common and challenging to pa...
Source: Heart Failure Reviews - April 20, 2020 Category: Cardiology Source Type: research

The Elabela-APJ axis: a promising therapeutic target for heart failure
This article gives an overview of the characteristics of the ELA–apelin–APJ axis and summarizes the current knowledge on its cardioprotective roles, potential mechanisms, and prospective application for acute and chronic HF. (Source: Heart Failure Reviews)
Source: Heart Failure Reviews - April 20, 2020 Category: Cardiology Source Type: research

Crosstalk between GSK-3 β-actuated molecular cascades and myocardial physiology
AbstractThe finding of “glycogen synthase kinase-3” (GSK-3) was initially identified as a protein kinase that phosphorylate and inhibited glycogen synthase. However, it was soon discovered that GSK-3 also has significant impact in regulation of truly astonishing number of critical intracellular signaling pathways rang ing from regulation of cell growth, neurology, heart failure, diabetes, aging, inflammation, and cancer. Recent studies have validated the feasibility of targeting GSK-3 for its vital therapeutic potential to maintain normal myocardial homeostasis, conversely, its loss is incompatible with life as...
Source: Heart Failure Reviews - April 20, 2020 Category: Cardiology Source Type: research