Angiotensin receptor-neprilysin inhibition in patients with acute decompensated heart failure: an expert consensus position paper
AbstractThe short-term mortality and rehospitalization rates after admission for acute heart failure (AHF) remain high, despite the high level of adherence to contemporary practice guidelines. Observational data from non-randomized studies in AHF strongly support the in-hospital administration of oral evidence-based modifying chronic heart failure (HF) medications (i.e., b-blockers, ACE inhibitors, mineralocorticoid receptor antagonists) to reduce morbidity and mortality. Interestingly, a well-designed prospective randomized multicenter study (PIONEER-HF) showed an improved clinical outcome and stress/injury biomarker prof...
Source: Heart Failure Reviews - May 1, 2021 Category: Cardiology Source Type: research
Left atrial assist device for heart failure with preserved ejection fraction: initial results with torque control mode in diastolic heart failure model
In this study, we tested four different TC settings (TC modes 0.9, 1.0, 1.25, and 1.5) using an in vitro mock circulatory loop. Mild, moderate, and severe diastolic heart failure (DHF) conditions, as well as normal heart condition, were simulated with the four TC modes. Also, we evaluated the LAAD in vivo with three calves. The LAAD was implanted at the mitral position with four TC settings (TC modes 0.9, 1.0, 1.1, 1.2). With LAAD support, the in vitro cardiac output and aortic pressure recovered to normal heart levels at TC 1.25 and 1.5 even under severe DHF conditions with little pump regurgitation. The TC mode tested in...
Source: Heart Failure Reviews - May 1, 2021 Category: Cardiology Source Type: research
Serum potassium and heart failure: association, causation, and clinical implications
AbstractDyskalemia (hypo- and hyperkalemia) is a common clinical encounter in patients with heart failure (HF), linked to underlying pathophysiologic alterations, pharmacological treatments, and concomitant comorbidities. Both hypo- and hyperkalemia have been associated with a poor outcome in HF. However, it is not known if this association is causal. In order to investigate this relation, we implemented the Bradford Hill criteria for causation examining the available literature. Of note, hypokalemia and low-normal potassium levels (serum potassium< 4.0 mmol/L) appear to be associated with adverse clinical outcomes i...
Source: Heart Failure Reviews - April 6, 2021 Category: Cardiology Source Type: research
Etiology and pathophysiology of heart failure in people with HIV
AbstractHIV-associated cardiomyopathy is a well-established sequela in people infected with HIV (PHIV). Despite significant advances in HIV management through the use of highly active anti-retroviral therapy (HAART), PHIV on HAART continue to have elevated risk of cardiomyopathy and heart failure, even when accounting for known cardiovascular risk factors. This review article will explore the proposed mechanisms by which chronic HIV infection induces cardiomyopathy and heart failure in the setting of HAART. Evaluation, work-up, and management of cardiomyopathy in PHIV will also be briefly discussed. The advent of HAART has...
Source: Heart Failure Reviews - April 6, 2021 Category: Cardiology Source Type: research
Cardiac disease in mitochondrial disorders
(Source: Heart Failure Reviews)
Source: Heart Failure Reviews - April 6, 2021 Category: Cardiology Source Type: research
