Interventions for fatigue in Parkinson's disease.
CONCLUSIONS: Based on the current evidence, no clear recommendations for the treatment of subjective fatigue in PD can be provided. Doxepin may reduce the impact of fatigue on ADL and fatigue severity; however, this finding has to be confirmed in high quality studies. Rasagiline may be effective in reducing levels of physical fatigue in PD. No evidence was found for the effectiveness of levodopa-carbidopa, memantine, caffeine, methylphenidate, modafinil or exercise. Studies are needed to investigate the effect of exercise intensity on exercise capacity and subjective fatigue. Future studies should focus on interventions th...
Source: Cochrane Database of Systematic Reviews - October 8, 2015 Category: Journals (General) Authors: Elbers RG, Verhoef J, van Wegen EE, Berendse HW, Kwakkel G Tags: Cochrane Database Syst Rev Source Type: research
An evidence‐based review of systemic treatments for itch
ConclusionsThe findings from this study suggest the effective therapeutic approaches for itch. The major limitations are that there are small numbers of available RCTs and methodological differences across studies. (Source: European Journal of Pain)
Source: European Journal of Pain - September 29, 2015 Category: Anesthesiology Authors: P. Pongcharoen, A.B. Fleischer Tags: Mini Review Source Type: research
New clinical trials for nonmotor manifestations of Parkinson's disease
ABSTRACT
Nonmotor manifestations in Parkinson's disease (PD) encompass a range of clinical features, including neuropsychiatric problems, autonomic dysfunction, sleep disorders, fatigue, and pain. Despite their importance for patients' quality of life, the evidence base for their treatment is relatively sparse. Nevertheless, the last few years have seen a number of new trials starting that specifically address nonmotor features as an outcome measure in clinical trials. Large randomized, controlled trials in the last 3 years reported improvement of psychosis with the new selective serotonin 5‐HT2A inverse agonist pimavans...
Source: Movement Disorders - September 15, 2015 Category: Neurology Authors: Anette Schrag, Anna Sauerbier, Kallol Ray Chaudhuri Tags: Review Source Type: research
Treatment of bladder pain syndrome and interstitial cystitis: a systematic review
Conclusion
Existing studies were not able to define the best approach for the treatment of BPS/IC. The lack of standardized treatment may be related to the diversity of interventions used; therefore, further studies with better methodological quality are needed. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - August 14, 2015 Category: OBGYN Source Type: research
Doxepin and imipramine but not fluoxetine reduce the activity of the rat glutamate transporter EAAT3 expressed in Xenopus oocytes
Conclusions:
We showed that doxepin and imipramine, but not fluoxetine, inhibited EAAT3 activity at clinically relevant concentrations. This reveals a novel mechanism of action for doxepin and imipramine; that they increase glutamatergic neurotransmission. PKC may be involved in the effects of doxepin on EAAT3, but is not involved in the effects of imipramine at the concentrations studied. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - August 7, 2015 Category: Epidemiology Authors: Hye ParkHee BaikDong KimGuie LeeJae WooZhiyi ZuoRack Chung Source Type: research
Histamine H 1 receptor occupancy by the new-generation antipsychotics olanzapine and quetiapine: a positron emission tomography study in healthy volunteers
Conclusions
Olanzapine and quetiapine have high H1RO values in the human brain under their clinical minimum doses. This study provides a foundation of the properties by which new-generation antipsychotics block the central histaminergic system in humans. (Source: Psychopharmacology)
Source: Psychopharmacology - July 7, 2015 Category: Psychiatry Source Type: research
Interactions between histamine H1 receptor and its antagonists by using cell membrane chromatography method
ConclusionsThe studies showed CMC could be applied to investigate drug–receptor interactions. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 1, 2015 Category: Drugs & Pharmacology Authors: Weina Ma, Dongdong Zhang, Jing Li, Delu Che, Rui Liu, Jie Zhang, Yanmin Zhang Tags: Research Paper Source Type: research
Effect of Antidepressant Doxepin on Ca²⁺ Homeostasis and Viability in PC3 Human Prostate Cancer Cells.
Authors: Lu T, Chou CT, Liang WZ, Yu CC, Chang HT, Kuo CC, Chen WC, Kuo DH, Ho CM, Shieh P, Jan CR
Abstract
The effect of the antidepressant doxepin on cytosolic Ca²⁺ concentrations ([Ca²⁺]i) and viability in PC3 human prostate cancer cells was explored. The Ca²⁺-sensitive fluorescent dye fura-2 was applied to measure [Ca²⁺]i. Doxepin at concentrations of 500-1000 μM induced a [Ca²⁺]i rise in a concentration-dependent manner. The response was reduced partly by removing Ca²⁺. Doxepin-evoked Ca²⁺ entry was suppressed by Ca²⁺ entry blockers (nifedipine, econazole, SK&F96365), and ...
Source: The Chinese Journal of Physiology - June 3, 2015 Category: Physiology Tags: Chin J Physiol Source Type: research
Doxepin may be a useful pharmacotherapeutic agent in chronic urticaria
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - June 1, 2015 Category: Allergy & Immunology Authors: Zoe Adhya, Yousuf Karim Tags: Correspondence Source Type: research
Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model
Publication date: 21 May 2015 Source:Neuroscience, Volume 294 Author(s): J. Mika , A.M. Jurga , J. Starnowska , M. Wasylewski , E. Rojewska , W. Makuch , K. Kwiatkowski , N. Malek , B. Przewlocka Neuropathic pain is a severe clinical problem, often appearing as a co-symptom of many diseases or manifesting as a result of damage to the nervous system. Many drugs and agents are currently used for the treatment of neuropathic pain, such as tricyclic antidepressants (TCAs). The aims of this paper were to test the effects of two classic TCAs, doxepin and amitriptyline, in naïve animals and in a model of neuropathic...
Source: Neuroscience - April 6, 2015 Category: Neuroscience Source Type: research
Dopamine Receptor Antagonists as New Mode-of-Action Insecticide Leads for Control of Aedes and Culex Mosquito Vectors
Conclusions DAR antagonists represent a putative new insecticide class with activity against C. quinquefasciatus and Ae. aegypti, the two most important mosquito vectors of NTDs. There has been limited change in the sequence and pharmacological properties of the DOP2 DARs of these species since divergence of the tribes Culicini and Aedini. We identified antagonists selective for mosquito versus human DARs and observed a correlation between DAR pharmacology and the in vivo larval toxicity of antagonists. These data demonstrate that sequence similarity can be predictive of target potential. On this basis, we propose expanded...
Source: PLoS Neglected Tropical Diseases - March 20, 2015 Category: Tropical Medicine Authors: Andrew B. Nuss et al. Source Type: research
Doxepin for radiation therapy-induced mucositis pain in the treatment of oral cancers
Radiotherapy (RT), an integral part of the oncologic treatment for patients with head and neck cancer, can cause adverse side effects such as oral mucositis (OM). Pain from OM can impact a patient’s quality of life and interrupt RT treatment schedules, which decreases the probability for achieving cancer cure. Conventionally, RT-induced OM pain is treated with analgesics and/or mouthwash rinses. Doxepin, a traditional tricyclic antidepressant with analgesic and anesthetic properties when applied topically to the mucosa, has been shown to lower OM pain in multiple single-arm trials (Epstein et al.) and more recently, in a...
Source: Oncology Reviews - February 10, 2015 Category: Cancer & Oncology Source Type: research
Sleep self-intoxication and sleep driving as rare zolpidem-induced complex behaviour
Conclusion
Amnesia and incoherence of speech, disorganization of behaviour, inability to realize the situation and mood changes may indicate a zolpidem-induced somnambulism-like state with sleep-related complex behaviour. (Source: International Journal of Legal Medicine)
Source: International Journal of Legal Medicine - January 1, 2015 Category: Medical Law Source Type: research
Doxepin and diphenhydramine increased non-rapid eye movement sleep through blockade of histamine H1 receptors
Publication date: Available online 11 December 2014 Source:Pharmacology Biochemistry and Behavior Author(s): Yi-Qun Wang , Yohko Takata , Rui Li , Ze Zhang , Meng-qi Zhang , Yoshihiro Urade , Wei-Min Qu , Zhi-Li Huang Histaminergic neurons have been reported to play an important role in the regulation of sleep-wake behavior through the histamine H1 receptor (R, H1R). First generation H1R antagonists, such as doxepin and diphenhydramine, produce drowsiness in humans, and are occasionally used to treat insomnia. However, if H1R antagonists function via physically blocking the H1R remains unclear. In the current s...
Source: Pharmacology Biochemistry and Behavior - December 11, 2014 Category: Biochemistry Source Type: research
The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain.
Abstract
The analgesic properties of antidepressants are often used in the treatment of neuropathy, however their influence on glial cells in maintaining neuropathic pain is unknown. Our studies examined the neuropathic pain-relieving properties after intraperitoneal injection of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine 7 days after sciatic nerve injury (CCI) in rats and its influence on microglia/macrophages (IBA-1) and astroglia (GFAP) activation in the spinal cord and dorsal root ganglia (DRG) using Western blot. All tested antidepressants significantly reduced CCI-induced allodyn...
Source: European Journal of Pharmacology - November 25, 2014 Category: Drugs & Pharmacology Authors: Zychowska M, Rojewska E, Makuch W, Przewlocka B, Mika J Tags: Eur J Pharmacol Source Type: research
