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Role of central versus peripheral opioid system in antinociceptive and anti ‐inflammatory effect of botulinum toxin type A in trigeminal region
ConclusionsMorphine acts on pain in trigeminal region both peripherally and centrally, whereas the effect on dural plasma protein extravasation seems to be only centrally mediated. However, the interaction of BT‐A with endogenous opioid system, with consequent inhibition of nociceptive transmission as well as the DNI, occurs primarily centrally. SignificanceBotulinum toxin type A (BT‐A)'s axonal transport and potential transcytosis suggest that its antinociceptive effect might involve diverse neurotransmitters at different sites of trigeminal system. Here we discovered that the reduction in pain and accompanying DNI in...
Source: European Journal of Pain - November 13, 2017 Category: Anesthesiology Authors: V. Drinovac Vlah, B. Filipovi ć, L. Bach‐Rojecky, Z. Lacković Tags: Original Article Source Type: research

Chronic intensive care ‐related pain: Exploratory analysis on predictors and influence on health‐related quality of life
ConclusionsChronic intensive care‐related pain is associated with specific decrements in HRQOL. Knowledge about the identified predictors is of clinical and scientific importance and might help to reduce the incidence of CIRP. SignificanceChronic intensive care‐related pain is associated with specific decrements in health‐related quality of life. While most of the identified predictors for CIRP can only be considered as risk factors, especially adequate (post‐) acute pain management should be studied as preventive strategy. (Source: European Journal of Pain)
Source: European Journal of Pain - November 5, 2017 Category: Anesthesiology Authors: P. Baumbach, T. G ötz, A. Günther, T. Weiss, W. Meissner Tags: Original Article Source Type: research

Commentary on Karsdorp et  al.
(Source: European Journal of Pain)
Source: European Journal of Pain - November 5, 2017 Category: Anesthesiology Authors: D. J. Moore, N. Attridge Tags: Commentary Source Type: research

Availability and approval of cannabis ‐based medicines for chronic pain management and palliative/supportive care in Europe: A survey of the status in the chapters of the European Pain Federation
ConclusionsThere are marked differences between the countries represented in EFIC in the approval and availability of cannabis‐based products for medical use. EFIC countries are encouraged to collaborate with the European Medicines Agency to publish a common document on cannabis‐based medicines. SignificanceThere are striking differences between European countries in the availability of plant‐derived and synthetic cannabinoids and of medical cannabis for pain management and for symptom control in palliative care and in the covering of costs by health insurance companies or state social security systems. (Source: Euro...
Source: European Journal of Pain - November 1, 2017 Category: Anesthesiology Authors: N. Krcevski ‐Skvarc, C. Wells, W. Häuser Tags: Original Article Source Type: research

The research gap in chronic paediatric pain: A systematic review of randomised controlled trials
ConclusionsEvaluation of analgesics targeting chronic pain relief in children and adolescents through RCTs is marginal. Infants and children with long‐lasting painful conditions are insufficiently represented in RCTs. We discuss possible research constraints and challenges as well as methodologies to circumvent them. SignificanceThere is a substantial research gap regarding analgesic interventions for children and adolescents with chronic pain. Most clinical trials in the field focus on the evaluation of non‐pharmacological interventions and are of low methodological quality. There is also a specific lack of trials inv...
Source: European Journal of Pain - November 1, 2017 Category: Anesthesiology Authors: R. Boulkedid, A.Y. Abdou, E. Desselas, M. Man égat, T.G. Leeuw, J. Avez‐Couturier, S. Dugue, C. Mareau, B. Charron, C. Alberti, F. Kaguelidou, Tags: Review Article Source Type: research

Assessment and manifestation of central sensitisation across different chronic pain conditions
Abstract Different neuroplastic processes can occur along the nociceptive pathways and may be important in the transition from acute to chronic pain and for diagnosis and development of optimal management strategies. The neuroplastic processes may result in gain (sensitisation) or loss (desensitisation) of function in relation to the incoming nociceptive signals. Such processes play important roles in chronic pain, and although the clinical manifestations differ across condition processes, they share some common mechanistic features. The fundamental understanding and quantitative assessment of particularly some of the cent...
Source: European Journal of Pain - November 1, 2017 Category: Anesthesiology Authors: L. Arendt ‐Nielsen, B. Morlion, S. Perrot, A. Dahan, A. Dickenson, H.G. Kress, C. Wells, D. Bouhassira, A. Mohr Drewes Tags: Position Paper Source Type: research

The role of peripheral vasopressin 1A and oxytocin receptors on the subcutaneous vasopressin antinociceptive effects
ConclusionsSubcutaneous AVP produces antinociception and behavioural analgesia. Both V1a and OTR participate in those effects. Our findings suggest that antinociception could be produced in a local manner using a novel vasopressin receptor located in cutaneous sensorial fibres. Additionally, subcutaneous AVP also produces important systemic effects such as respiratory and locomotor impairment. SignificanceOur findings support that AVP produces peripheral antinociception and behavioural analgesia in a local manner; nevertheless, systemic effects are also presented. Additionally, this is the first detailed electrophysiologic...
Source: European Journal of Pain - October 30, 2017 Category: Anesthesiology Authors: A. Manzano ‐García, A. González‐Hernández, I.A. Tello‐García, G. Martínez‐Lorenzana, M. Condés‐Lara Tags: Original Article Source Type: research

Paeoniflorin attenuates postoperative pain by suppressing Matrix Metalloproteinase ‐9/2 in mice
ConclusionThese results indicated that MMP‐9/2 activation in spinal microglia plays a key role in incision‐induced mechanical allodynia in mice. Moreover, utilizing paeniflorin blockage of the microglia MMP‐9/2 activity might represent a valuable alternative for treating postoperative pain. SignificanceOur results provided direct evidence for the first time that paeoniflorin can inhibit plantar incision‐induced microglia TLR4/MMP‐9/2/IL‐1β signalling pathway and suppress postoperative pain. Thus, regulation of microglia MMP‐9/2 may provide a new strategy for ameliorating postoperative pain. (Source: Euro...
Source: European Journal of Pain - October 30, 2017 Category: Anesthesiology Authors: Y. ‐x. Fan, L. Hu, S.‐h. Zhu, Y. Han, W.‐t. Liu, Y.‐j. Yang, Q.‐p. Li Tags: Original Article Source Type: research

The effect of changes in pain expectations on persistent pain following a road traffic crash
ConclusionsAssessment of patterns of pain expectancy change is a superior means of determining long‐term pain levels. Understanding expectancy change patterns will help provide more nuanced targets for pain intervention. SignificanceThis study extends previous work by investigating persistent pain expectancies over time in a compensation‐seeking cohort with non‐catastrophic injuries. It identifies factors that are associated with changing expectations, providing targets for clinical intervention. The study shows that expectations can change over time. Conversations with patients about their expectations should be ong...
Source: European Journal of Pain - October 30, 2017 Category: Anesthesiology Authors: S.L. Edmed, K.M. Moss, J. Warren, J. Kenardy Tags: Original Article Source Type: research

Changing the size of a mirror ‐reflected hand does not affect pain perception: A repeated measures study on healthy human participants
ConclusionObserving a reflection of the hand in front of a mirror did not alter heat pain threshold nor tolerance when compared with a no‐reflection condition, and altering the size of the reflection did not affect pain perception. Researchers and clinicians using visual feedback techniques may consider including an adaptive phase with visuo‐motor feedback to facilitate embodiment of the viewed body part. SignificanceAn adaptive phase with visuo‐motor feedback enhances the perceptual experience of embodiment of a reflection of a hand and a painful stimulus does not weaken the experience. This should be considered whe...
Source: European Journal of Pain - October 30, 2017 Category: Anesthesiology Authors: P.G. Wittkopf, D.M. Lloyd, M.I. Johnson Tags: Original Article Source Type: research

The contribution of pain in determining the health status of cancer patients with bone metastases: A secondary analysis of data from three Phase III registration trials
Abstract BackgroundWe aimed to provide a simple, descriptive health‐status profile for cancer patients with bone metastases, based on the EuroQol EQ‐5D, a tool commonly used to measure health utility scores, and to evaluate its association with the Brief Pain Inventory (BPI), a legacy pain‐assessment tool. Although pain is one of five health‐status dimensions measured by the EQ‐5D, our understanding of how pain relates to the other EQ‐5D dimensions is limited. MethodsWe derived data from 5500 patients with bone metastases who completed the EQ‐5D and BPI. Regression analyses examined how BPI severity and inter...
Source: European Journal of Pain - October 30, 2017 Category: Anesthesiology Authors: T. R. Mendoza, A. C. Dueck, Q. Shi, H. Ma, J. Zhang, Y. Qian, C. S. Cleeland Tags: Original Article Source Type: research

Electroacupuncture alleviates chemotherapy ‐induced pain through inhibiting phosphorylation of spinal CaMKII in rats
ConclusionsElectroacupuncture activates 5‐HT 1A receptors in the spinal cord and inhibits p‐CaMKII to alleviate both allodynia and hyperalgesia. The data support acupuncture/EA as a complementary therapy for CIP. SignificanceElectroacupuncture (EA) activates spinal 5‐HT1A receptors to inhibit p‐CaMKII to alleviate paclitaxel‐induced pain. Acupuncture/EA may be used as a complementary therapy for CIP. (Source: European Journal of Pain)
Source: European Journal of Pain - October 16, 2017 Category: Anesthesiology Authors: Y. Zhang, A. Li, J. Xin, K. Ren, B.M. Berman, L. Lao, R. ‐X. Zhang Tags: Original Article Source Type: research

Efficacy, tolerability and safety of cannabis ‐based medicines for chronic pain management – An overview of systematic reviews
Abstract Medicinal cannabis has already entered mainstream medicine in some countries. This systematic review (SR) aimed at evaluating the efficacy, acceptability and safety of cannabis‐based medicines for chronic pain management. Qualitative systematic review of SRs of randomized controlled trials with cannabis‐based medicines for chronic pain management. The Cochrane databases of SRs, Database of Abstracts of Reviews of Effects and PubMed were searched for SR published in the period January 2009 to January 2017. Assessment of the methodological quality of SR was performed by the AMSTAR checklist. Out of 748 papers id...
Source: European Journal of Pain - October 16, 2017 Category: Anesthesiology Authors: W. H äuser, F. Petzke, M.‐A. Fitzcharles Tags: Review Article Source Type: research

Association of insomnia severity with well ‐being, quality of life and health care costs: A cross‐sectional study in older adults with chronic pain (PainS65+)
ConclusionsOur results determine an independent association of insomnia with low health‐related quality of life and increased health care costs in older adults with chronic pain. SignificanceThe concurrence and the severity of insomnia among older adults with chronic pain were associated with decreased well‐being and quality of life, and increased health care costs to society. (Source: European Journal of Pain)
Source: European Journal of Pain - October 16, 2017 Category: Anesthesiology Authors: E. Dragioti, L. Bernfort, B. Larsson, B. Gerdle, L. Å. Levin Tags: Original Article Source Type: research

Bradykinin system is involved in endometriosis ‐related pain through endothelin‐1 production
ConclusionsThe present study demonstrated the presence and the function of the BK axis in endometriosis, and established a potential new therapy target for endometriosis‐related pain. SignificanceThe present study demonstrated (1) the presence and the function of the BK system in endometriosis, (2) activation of BKR induced endothelin‐1 in endometriotic lesion and (3) blocking endothelin‐1 was effective to decrease pain. (Source: European Journal of Pain)
Source: European Journal of Pain - October 16, 2017 Category: Anesthesiology Authors: O. Yoshino, K. Yamada ‐Nomoto, M. Kobayashi, T. Andoh, M. Hongo, Y. Ono, A. Hasegawa‐Idemitsu, A. Sakai, Y. Osuga, S. Saito Tags: Original Article Source Type: research

γ‐Aminobutyric acid (GABA) oral rinse reduces capsaicin‐induced burning mouth pain sensation: An experimental quantitative sensory testing study in healthy subjects
ConclusionsCapsaicin‐induced burning tongue pain and decreases in WDT and HPT can be ameliorated by rinsing the mouth with lidocaine and GABA solutions. SignificanceRinsing the mouth with an oral GABA containing solution ameliorated burning pain and increased heat sensitivity produced by application of capsaicin to the tongue. This finding suggests that GABA can act as a local analgesic agent in the oral cavity. (Source: European Journal of Pain)
Source: European Journal of Pain - October 11, 2017 Category: Anesthesiology Authors: Y. Zhang, K. Wang, L. Arendt ‐Nielsen, B.E. Cairns Tags: Original Article Source Type: research

Corrigendum
(Source: European Journal of Pain)
Source: European Journal of Pain - October 9, 2017 Category: Anesthesiology Tags: Corrigendum Source Type: research

Comment on a paper by Dupoiron et  al. “A phase III randomized controlled study on the efficacy and improved bowel function of prolonged‐release (PR) oxycodone‐ naloxone (up to 160/80 mg daily) versus oxycodone PR”
(Source: European Journal of Pain)
Source: European Journal of Pain - October 9, 2017 Category: Anesthesiology Authors: Joanne Patel, Jennifer H. Martin, Catherine J. Lucas Tags: Letter to the Editor Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - October 9, 2017 Category: Anesthesiology Tags: Issue Information Source Type: research

Efficacy, acceptability and safety of cognitive behavioural therapies in fibromyalgia syndrome – A systematic review and meta‐analysis of randomized controlled trials
Abstract This updated systematic review aimed at evaluating the efficacy, acceptability and safety of cognitive behavioural therapies (CBTs) in fibromyalgia syndrome (FMS). Clinicaltrials.gov, Cochrane Library, MEDLINE, PsycINFO and SCOPUS were searched from September 2013 to May 2017. Randomized controlled trials (RCTs) comparing CBTs with controls were analysed. Primary outcomes were ≥50% pain relief, ≥20% improvement of health‐related quality of life (HRQoL), negative mood, fatigue, disability, acceptability and safety at end of therapy and at 6 months follow‐up. Effects were summarized by a random effect...
Source: European Journal of Pain - October 6, 2017 Category: Anesthesiology Authors: K. Bernardy, P. Klose, P. Welsch, W. H äuser Tags: Review Article Source Type: research

Characterization of a novel capsaicin/heat ongoing pain model
ConclusionThe CHOP model reproduces some aspects of clinical pain, such as longer duration, sensitization, secondary allodynia and hyperalgesia. SignificanceHere we demonstrate a novel pain model that can be applied for up to an hour without tissue damage. The CHOP model allows for investigation of primary and secondary hyperalgesia as well as top‐down influences on sensitization, thereby providing an experimental model that can be used to assess clinically‐oriented questions. (Source: European Journal of Pain)
Source: European Journal of Pain - October 6, 2017 Category: Anesthesiology Authors: R.C. Price, W. Gandhi, C. Nadeau, R. Tarnavskiy, A. Qu, E. Fahey, L. Stone, P. Schweinhardt Tags: Original Article Source Type: research

The β‐lactam clavulanic acid mediates glutamate transport‐sensitive pain relief in a rat model of neuropathic pain
ConclusionsThus, clavulanic acid up‐regulates GluTs in cultured rodent‐ and human astroglia and alleviates CCI‐induced hypersensitivity, most likely through up‐regulation of GLT1b in spinal dorsal horn. SignificanceChronic dosing of clavulanic acid alleviates neuropathic pain in rats and up‐regulates glutamate transporters both in vitro and in vivo. Crucially, a similar up‐regulation of glutamate transporters in human spinal astrocytes by clavulanic acid supports the development of novel β‐lactam‐based analgesics, devoid of antibacterial activity, for the clinical treatment of chronic pain. (Sourc...
Source: European Journal of Pain - October 1, 2017 Category: Anesthesiology Authors: P.J. Kristensen, G. Gegelashvili, G. Munro, A.M. Heegaard, O.J. Bjerrum Tags: Original Article Source Type: research

Salvinorin A reduces neuropathic nociception in the insular cortex of the rat
ConclusionSalvinorin A has a potent antinociceptive effect when is administered centrally in the IC by the interaction with KOR and CB1 receptors. SignificanceWe show evidence on the effectiveness of the administration of salvinorin A in the IC in a rodent model of neuropathic pain. These results support the use of novel compounds like SA as a therapeutic alternative for neuropathic pain relief. (Source: European Journal of Pain)
Source: European Journal of Pain - October 1, 2017 Category: Anesthesiology Authors: U. Coffeen, A. Canseco ‐Alba, K. Simón‐Arceo, A. Almanza, F. Mercado, M. León‐Olea, F. Pellicer Tags: Original Article Source Type: research

Ten ‐year prevalence of mental disorders in patients presenting with chronic pain in secondary care: A register linkage cohort study
ConclusionsAlthough depression and anxiety were noted more frequently among patients with chronic pain than the general population, prevalence rates were lower than previously reported. The most frequent diagnoses were adjustment disorders. SignificancePrevalence rates of anxiety and depression diagnosed by psychiatrists in patients with chronic pain were found to be lower than previous findings using screening instruments. Adjustment disorders were the most frequent disorders diagnosed, as this study is the first to investigate. (Source: European Journal of Pain)
Source: European Journal of Pain - October 1, 2017 Category: Anesthesiology Authors: S. S øndergård, H.B. Vaegter, A. Erlangsen, E. Stenager Tags: Original Article Source Type: research

Children with migraine: Provocation of headache via pressure to myofascial trigger points in the trapezius muscle? – A prospective controlled observational study
The objective was to evaluate a supposed clinical interdependency of myofascial trigger points and migraine in children. Such interdependency would support an interaction of spinal and trigeminal afferences in the trigemino‐cervical complex as a contributing factor in migraine. MethodsChildren ≤18 years with the confirmed diagnosis of migraine were prospectively investigated. Comprehensive data on medical history, clinical neurological and psychological status were gathered. Trigger points in the trapezius muscle were identified by palpation and the threshold of pressure pain at these points was measured. Manual ...
Source: European Journal of Pain - September 27, 2017 Category: Anesthesiology Authors: M.N. Landgraf, J.T. Biebl, T. Langhagen, I. Hannibal, T. Eggert, K. Vill, L. Gerstl, L. Albers, R. Kries, A. Straube, F. Heinen Tags: Original Article Source Type: research

Attentional control and the competition between nonpain goals and the threat of pain
ConclusionsThe findings suggest that the unintentional allocation of attention towards events related to a temporary (nonpain) goal prevails over attentional bias to events predicting pain. Trait attentional control predicts stronger attentional allocation towards events related to a temporary goal. SignificanceThese findings indicate that treatment interventions facilitating goal pursuit in patients with chronic pain are beneficial in reducing attentional biases towards pain‐related events. (Source: European Journal of Pain)
Source: European Journal of Pain - September 26, 2017 Category: Anesthesiology Authors: P.A. Karsdorp, M.G.S. Schrooten, R. Geenen Tags: Original Article Source Type: research

Effects of duloxetine on pain and walking distance in neuropathic pain models via modulation of the spinal monoamine system
ConclusionsThese findings suggest that the analgesic effects of duloxetine are mainly mediated by the spinal monoamine system, independent of the antidepressant effects of this agent. SignificanceThe findings of this study suggest that duloxetine may be an effective treatment of broad neuropathic pain states, including neuropathic low back pain. The analgesic effects of duloxetine might be mediated by alterations of the descending pain modulatory pathways in the spinal cord, independent of the antidepressant effects. (Source: European Journal of Pain)
Source: European Journal of Pain - September 26, 2017 Category: Anesthesiology Authors: K. Minami, R. Tamano, E. Kasai, H. Oyama, M. Hasegawa, S. Shinohara, T. Asaki Tags: Original Article Source Type: research

New approach for the treatment of neuropathic pain: Fibroblast growth factor 1 gene ‐transfected adipose‐derived mesenchymal stem cells
ConclusionThe intravenous administration of AD‐MSCs FGF1 could be considered as a potential remedy for the management of neuropathic pain. SignificanceAD‐MSCs FGF1 attenuated the CCI‐induced mechanical and thermal hypersensitivity. Spinal structural alterations and apoptosis were significantly decreased in the AD‐MSCs FGF1 group. Elevated levels of FGF1 were detected in the spinal tissue. (Source: European Journal of Pain)
Source: European Journal of Pain - September 26, 2017 Category: Anesthesiology Authors: F. Forouzanfar, B. Amin, A. Ghorbani, H. Ghazavi, F. Ghasemi, K. Sadri, S. Mehri, H.R. Sadeghnia, H. Hosseinzadeh Tags: Original Article Source Type: research

Diversity in the emotional modulation of pain perception: An account of individual variability
ConclusionOverall, inducing a positive emotional state mitigates pain perception, while negative emotional state amplifies it. The magnitudes of these separate pain‐modulating effects, however, vary across individuals, and are associated with individual levels of depressive and anxious feelings, even within a non‐clinical population. SignificanceThe opposite effects of valence on pain amplification and modulation revealed in this study are novel. This study shows that emotional modulation of pain varies markedly across individuals and is related to psychological factors including depression and anxiety. Examining this ...
Source: European Journal of Pain - September 20, 2017 Category: Anesthesiology Authors: T.A. McIver, J. Kornelsen, P.W. Stroman Tags: Original Article Source Type: research

Prediction of persistent post ‐operative pain: Pain‐specific psychological variables compared with acute post‐operative pain and general psychological variables
ConclusionsPain‐related psychological variables derived from the fear‐avoidance model contributed significantly to the prediction of persistent post‐operative pain. The best possible compilation of these measures requires further research. More general psychological variables may become relevant predictors later in the medical history. SignificanceOur results suggest that pain‐specific psychological variables such as pain anxiety and pain hypervigilance add significantly to the prediction of persistent post‐operative pain and might even outperform established predictors such as acute pain and general psychologica...
Source: European Journal of Pain - September 20, 2017 Category: Anesthesiology Authors: C. Horn ‐Hofmann, J. Scheel, V. Dimova, A. Parthum, R. Carbon, N. Griessinger, R. Sittl, S. Lautenbacher Tags: Original Article Source Type: research

Physical pain increases interpersonal trust in females
ConclusionsThese findings demonstrate an effect of pain on interpersonal trust and suggest a reciprocity mechanism that the effect may be driven by self‐interest rather than altruistic motivation. The pain effect on trust was evident only in females, implying distinct pain coping strategies used by both genders. SignificanceThe present work highlights the social component of pain and extends our understanding of mutual interactions between pain and social cognition. (Source: European Journal of Pain)
Source: European Journal of Pain - September 15, 2017 Category: Anesthesiology Authors: C. Wang, J. Gao, Y. Ma, C. Zhu, X ‐W. Dong Tags: Original Article Source Type: research

Preoperative ultraviolet B inflammation in skin: Modelling individual differences in acute postoperative pain and neuro ‐immune interactions
ConclusionIt may be possible to use this simple model to study and predict the nature of neuro‐immune responses at more remote, clinically relevant sites. SignificanceA simple model of UVB inflammation in the skin might predict the degree of a patient's neuro‐immune response and the extent of their postoperative pain after total knee arthroplasty. (Source: European Journal of Pain)
Source: European Journal of Pain - September 14, 2017 Category: Anesthesiology Authors: T.H. Lunn, J.M. Dawes, F. Denk, D.L. Bennett, H. Husted, H. Kehlet, S.B. McMahon Tags: Original Article Source Type: research

Skin denervation does not alter cortical potentials to surface concentric electrode stimulation: A comparison with laser evoked potentials and contact heat evoked potentials
ConclusionThe suppression of LEPs and CHEPs after nociceptive nerve fibre loss in the epidermis indicates that these techniques are selectively mediated by nociceptive system. Conversely, the lack of SE‐PREP changes suggests that SE‐PREPs do not provide selective information on nociceptive system function. SignificanceCapsaicin‐induced epidermal denervation abolishes laser evoked potentials (LEPs) and contact heat evoked potentials (CHEPs), but leaves unaffected pain‐related evoked potentials by surface concentric electrode (SE‐PREPs). These findings suggest that unlike LEPs and CHEPs, SE‐PREPs are not selectiv...
Source: European Journal of Pain - September 12, 2017 Category: Anesthesiology Authors: S. La Cesa, G. Di Stefano, C. Leone, A. Pepe, E. Galosi, F. Alu, A. Fasolino, G. Cruccu, M. Valeriani, A. Truini Tags: Original Article Source Type: research

Offset analgesia: The role of peripheral and central mechanisms
Abstract BackgroundOffset Analgesia (OA) can be evoked by a three‐heat‐stimulus train (T1‐T2‐T3), with T1 (5 s) and T3 (20 s) having the same temperature (e.g. 48 °C) and T2 (5 s) being slightly higher (1–3 °C). OA is defined as a disproportional pain reduction caused by the slight temperature decrease from T2 to T3. As the pain modulatory mechanisms behind OA are still poorly understood, the current study aimed to investigate the role of peripheral and central mechanisms by applying heat stimuli to the same location and to different unilateral and bilateral locations. MethodY...
Source: European Journal of Pain - September 12, 2017 Category: Anesthesiology Authors: D. Ligato, K.K. Petersen, C.D. M ørch, L. Arendt‐Nielsen Tags: Original Article Source Type: research

Pectoral nerves and serratus plane block for persistent post surgical pain after video ‐assisted thoracic surgery
(Source: European Journal of Pain)
Source: European Journal of Pain - September 7, 2017 Category: Anesthesiology Authors: E. Piraccini, H. Byrne, M. Calli, P. Poggi, S. Maitan Tags: Letter to the Editor Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - September 7, 2017 Category: Anesthesiology Tags: Issue Information Source Type: research

Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats
ConclusionsThese results highlight the interest of S 38093 to relieve neuropathic pain and warrant clinical trials especially in chemotherapeutic agent‐induced neuropathic pain. SignificanceS 38093, a new H3 antagonist/inverse agonist, displays antiallodynic and antihyperalgesic effect in neuropathic pain, especially in oxaliplatin‐induced neuropathy after chronic administration. This effect of S 38093 in neuropathic pain could be partly mediated by α2 receptors desensitization in the locus coeruleus. (Source: European Journal of Pain)
Source: European Journal of Pain - September 1, 2017 Category: Anesthesiology Authors: T. Chaumette, E. Chapuy, E. Berrocoso, M. Llorca ‐Torralba, L. Bravo, J.A. Mico, M. Chalus, A. Eschalier, D. Ardid, F. Marchand, A. Sors Tags: Original Article Source Type: research

Long ‐term trajectories of patients with neck pain and low back pain presenting to chiropractic care: A latent class growth analysis
ConclusionsMost patients with NP or LBP presenting in chiropractic care show a trajectory of symptoms characterized by persistent or fluctuating pain of low or medium intensity. Only a minority either experience a rapid complete recovery or develop chronic severe pain. SignificanceNinety percentage of patients with neck pain or low back pain presenting to chiropractors have a 30% improvement within 6 weeks and then show a trajectory of symptoms characterized by persistent or fluctuating pain of low or medium intensity. Only a minority either experience a rapid complete recovery or develop chronic severe pain. (Source:...
Source: European Journal of Pain - September 1, 2017 Category: Anesthesiology Authors: L. Ailliet, S.M. Rubinstein, T. Hoekstra, M.W. Tulder, H.C.W. Vet Tags: Original Article Source Type: research

Exercise for the prevention of low back and pelvic girdle pain in pregnancy: A meta ‐analysis of randomized controlled trials
ConclusionExercise appears to reduce the risk of low back pain in pregnant women, and sick leave because of lumbopelvic pain, but there is no clear evidence for an effect on pelvic girdle pain. SignificanceExercise has a small protective effect against low back pain during pregnancy. (Source: European Journal of Pain)
Source: European Journal of Pain - September 1, 2017 Category: Anesthesiology Authors: R. Shiri, D. Coggon, K. Falah ‐Hassani Tags: Review Article Source Type: research

The association between sleep quality, low back pain and disability: A prospective study in routine practice
ConclusionsImprovement in SQ is associated with improvements in LBP and in disability at 3‐month follow‐up, suggesting that they may reflect or be influenced by common factors. However, baseline SQ does not predict improvements in pain or disability. SignificanceIn clinical practice, sleep quality, low back pain and disability are associated. However, sleep quality at baseline does not predict improvement in pain and disability. (Source: European Journal of Pain)
Source: European Journal of Pain - August 28, 2017 Category: Anesthesiology Authors: F.M. Kovacs, J. Seco, A. Royuela, J.N. Betegon, S. S ánchez‐Herráez, M. Meli, M.E. Martínez Rodríguez, M. Núñez, L. Álvarez‐Galovich, J. Moyá, C. Sánchez, S. Luna, P. Borrego, J. Moix, V. Rodríguez‐Pérez, J. Torres‐Unda, N. Burgos‐Alo Tags: Original Article Source Type: research

Altered pain sensitivity and axioscapular muscle activity in neck pain patients compared with healthy controls
Abstract BackgroundPrevious studies have indicated that neck pain patients feel increased symptoms following upper limb activities, and altered axioscapular muscle function has been proposed as a contributing factor. MethodsPain sensitivity and muscle activity, during arm movements, were assessed in neck pain patients and controls. Patients with ongoing insidious‐onset neck pain (IONP, N = 16) and whiplash‐associated disorders (WAD, N = 9) were included along with sex‐ and age‐matched controls (N = 25). Six series of repeated arm abductions were performed during electromyographic (EMG)...
Source: European Journal of Pain - August 27, 2017 Category: Anesthesiology Authors: S.W. Christensen, R.P. Hirata, T. Graven ‐Nielsen Tags: Original Article Source Type: research

Beyond weakness: Characterization of pain, sensory profile and conditioned pain modulation in patients with motor neuron disease: A controlled study
Abstract BackgroundMotor neuron diseases (MND) represent a group of disorders that evolve with inexorable muscle weakness and medical management is based on symptom control. However, deeper characterization of non‐motor symptoms in these patients have been rarely reported. MethodsThis cross‐sectional study aimed to describe non‐motor symptoms in MND and their impact on quality of life and functional status, with a focus on pain and sensory changes. Eighty patients (31 females, 55.7 ± 12.9 years old) with MND underwent a neurological examination, pain, mood, catastrophizing and psychophysics asse...
Source: European Journal of Pain - August 22, 2017 Category: Anesthesiology Authors: L.C.G. Lopes, R. Galhardoni, V. Silva, F.M.H. Jorge, L.T. Yeng, D. Callegaro, G. Chadi, M.J. Teixeira, D. Ciampi de Andrade Tags: Original Article Source Type: research

Chronic widespread pain prevalence in the general population: A systematic review
Abstract Chronic widespread pain (CWP) is a significant burden in communities. Understanding the impact of population‐dependent (e.g., age, gender) and contextual‐dependent (e.g. survey method, region, inequality level) factors have on CWP prevalence may provide a foundation for population‐based strategies to address CWP. Therefore, the purpose of this study was to estimate the global prevalence of CWP and evaluate the population and contextual factors associated with CWP. A systematic review of CWP prevalence studies (1990–2017) in the general population was undertaken. Meta‐analyses were conducted to determ...
Source: European Journal of Pain - August 17, 2017 Category: Anesthesiology Authors: P. Andrews, M. Steultjens, J. Riskowski Tags: Systematic Review Source Type: research

Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain
ConclusionsThe present results suggest that allosteric modulation of α4β2 nAChR may provide new strategies in chronic neuropathic pain. Significanceα4β2 nAChRs are involved in pain modulation. dFBr, a PAM at α4β2 nAChRs, potentiates the nicotine response dose‐dependently in neuropathic pain. Thus, the present results suggest that allosteric modulation of α4β2* nAChR may provide new strategies in chronic neuropathic pain. (Source: European Journal of Pain)
Source: European Journal of Pain - August 15, 2017 Category: Anesthesiology Authors: D. Bagdas, D. Ergun, A. Jackson, W. Toma, M.K. Schulte, M.I. Damaj Tags: Original Article Source Type: research

Efficacy and safety of a fixed ‐dose combination of ibuprofen and caffeine in the management of moderate to severe dental pain after third molar extraction
ConclusionThis study demonstrated clinically relevant superiority of ibuprofen/caffeine over monotherapy with ibuprofen in patients with acute dental pain. All treatments were well tolerated. SignificanceThis trial showed superior efficacy of 400/100 mg ibuprofen/caffeine, compared to 400 mg ibuprofen alone, for treating acute pain, reflecting that caffeine is an effective analgesic adjuvant. Data on efficacy of 400 mg ibuprofen combined with caffeine for the treatment of acute pain were not available yet. (Source: European Journal of Pain)
Source: European Journal of Pain - August 14, 2017 Category: Anesthesiology Authors: T. Weiser, E. Richter, A. Hegewisch, D.D. Muse, R. Lange Tags: Original Article Source Type: research

Conditioned pain modulation is affected by occlusion cuff conditioning stimulus intensity, but not duration
ConclusionsThis study demonstrated that an occlusion cuff of 5/10 conditioning stimulus intensity, when compared to 2/10, significantly increased CPM magnitude. Maintaining 2/10 conditioning stimulus for 3 min did not increase CPM magnitude. SignificanceDysfunctional conditioned pain modulation (CPM) has been associated with poor health outcomes. Various factors can influence CPM outcomes. The role of occlusion cuff conditioning stimulus intensity and duration has not been previously investigated. Intensity (5/10), but not duration of lower intensity (2/10) conditioning stimulus, affects CPM magnitude. (Source: European Journal of Pain)
Source: European Journal of Pain - August 14, 2017 Category: Anesthesiology Authors: A. Smith, A. Pedler Tags: Original Article Source Type: research

Matrix stimulation in cancer pain: Methodology, safety and effectiveness
ConclusionFindings are consistent with the concept of synaptic long‐term depression in cancer pain induced after conditioning LFS. Despite the short, but well‐tolerated, treatment duration of 2 × 5 min/day, effects persisted throughout the 3‐day follow‐up. SignificanceCutaneous neuromodulation using LFS via a matrix electrode has been shown to be a safe intervention for effectively reducing cancer pain in palliative care patients. (Source: European Journal of Pain)
Source: European Journal of Pain - August 14, 2017 Category: Anesthesiology Authors: M. M ücke, M. Tils, R. Conrad, D. Kravchenko, H. Cuhls, L. Radbruch, M. Marinova, V. Peuckmann‐Post, R. Rolke Tags: Original Article Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - August 10, 2017 Category: Anesthesiology Tags: Issue Information Source Type: research

Was it less painful for knights? Influence of appearance on pain perception
ConclusionsAccording to the pain ratings, participants felt significantly less pain in the covered arm condition compared with the unprotected and the neutral arm condition. Subjective pain perception was decreased by a virtual protection of the arm in VR. The simplicity of the manipulation suggests possible practical uses in pain therapy by strengthening the patients’ own capacities to influence their pain using simple cognitive manipulations via virtual reality. SignificanceA virtual, covered arm causes differences in reported pain ratings. Physiological measurements do not confirm the findings. Visual information ...
Source: European Journal of Pain - July 31, 2017 Category: Anesthesiology Authors: A. Weeth, A. M ühlberger, Y. Shiban Tags: Original Article Source Type: research

Fear of Pain Questionnaire ‐9: Brief assessment of pain‐related fear and anxiety
Abstract BackgroundFear and anxiety are important considerations in both acute and chronic pain. Effectively and efficiently measuring fear and anxiety associated with pain in healthcare settings is critical for identifying vulnerable patients. The length and administration time of current measures of pain‐related fear and anxiety inhibit their routine use, as screening tools and otherwise, suggesting the need for a shorter, more efficient instrument. MethodsA 9‐item shortened version of the Fear of Pain Questionnaire – III (FPQ‐III), the Fear of Pain Questionnaire‐9 (FPQ‐9), was developed based upon statis...
Source: European Journal of Pain - July 31, 2017 Category: Anesthesiology Authors: D.W. McNeil, S.G. Kennedy, C.L. Randall, S.H. Addicks, C.D. Wright, K.G. Hursey, R. Vaglienti Tags: Original Article Source Type: research