Cognitive Agency in Music Interventions: Increased perceived control of music predicts increased pain tolerance
ConclusionsThis study demonstrates that the reason self ‐selected music is particularly effective in reducing pain is related to the act of making a choice over the music itself. This study provides support for the cognitive vitality model and emphasises the importance of giving people as much control as possible in music interventions. (Source: European Journal of Pain)
Source: European Journal of Pain - April 17, 2021 Category: Anesthesiology Authors: C. Howlin, B. Rooney Tags: ORIGINAL ARTICLE Source Type: research

Self ‐reported prognostic factors in adults reporting neck or low back pain: An umbrella review
AbstractNumerous systematic reviews have attempted to synthesise evidence on prognostic factors for predicting future outcomes such as pain, disability and return ‐to‐work/work absence in neck and low back pain populations. An umbrella review of systematic reviews was conducted to summarise the magnitude and quality of the evidence for each prognostic factor investigated. Searches were limited to the last 10 years (2008‐11th April 2018, updated 28th Sep tember 2020). A two‐stage approach was undertaken: in stage one, data on prognostic factors was extracted from systematic reviews identified from the systematic sea...
Source: European Journal of Pain - April 17, 2021 Category: Anesthesiology Authors: Gemma Mansell, Nadia Corp, Gwenllian Wynne ‐Jones, Jonathan Hill, Siobhán Stynes, Daniëlle van der Windt Tags: REVIEW ARTICLE Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - April 16, 2021 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Neurophysiological mechanisms of chiropractic spinal manipulation for spine pain
AbstractTogether, neck pain and back pain are the first cause of disability worldwide, accounting for more than 10% of the total years lived with disability. In this context, chiropractic care provides a safe and effective option for the management of a large proportion of these patients. Chiropractic is a healthcare profession mainly focused on the spine and the treatment of spinal disorders, including spine pain. Basic studies have examined the influence of chiropractic spinal manipulation (SM) on a variety of peripheral, spinal and supraspinal mechanisms involved in spine pain. While spinal cord mechanisms of pain inhib...
Source: European Journal of Pain - April 16, 2021 Category: Anesthesiology Authors: Carlos Gevers ‐Montoro, Benjamin Provencher, Martin Descarreaux, Arantxa Ortega de Mues, Mathieu Piché Tags: REVIEW ARTICLE Source Type: research

Prevalence and characteristics of new ‐onset pain in COVID‐19 survivours, a controlled study
AbstractBackgroundWe assessed whether COVID ‐19 is associated with de novo pain and de novo chronic pain (CP).MethodsThis controlled cross ‐sectional study was based on phone interviews of patients discharged from hospital after COVID‐19 compared to the control group composed of individuals hospitalized during the same period due to non‐COVID‐19 causes. Patients were classified as having previous CP based on the ICD‐11/IASP c riteria, de novopain (i.e. any new type of pain, irrespective of the pain status before hospital stay), and de novo CP (i.e. persistent or recurring de novo pain, lasting more than 3  ...
Source: European Journal of Pain - April 9, 2021 Category: Anesthesiology Authors: Felipe Henriques Carvalho Soares, Gabriel Taricani Kubota, Ana M ércia Fernandes, Bruno Hojo, Catarina Couras, Bárbara Venturoti Costa, Jorge Dornellys da Silva Lapa, Luíza Mansur Braga, Matheus Merula de Almeida, Pedro Henrique Martins da Cun Tags: ORIGINAL ARTICLE Source Type: research

Broadening the scope of pediatric intensive interdisciplinary pain treatment to promote future resilience and psychological flexibility
AbstractThis journal recently published a paper by Wager and colleagues, entitled "Long ‐term outcomes of children with severe chronic pain: Comparison of former patients with a community sample” (Wager et al., in press). This paper demonstrates the lasting positive effects of intensive interdisciplinary pain treatment (IIPT) in children, and adds confidence in the duration of trea tment effects through its unprecedented, controlled, 7‐year follow‐up design. Youth treated in IIPT are those with the most impairing pain; thus, these results are particularly encouraging, with almost 60% of the clinical sample...
Source: European Journal of Pain - April 8, 2021 Category: Anesthesiology Authors: Dustin P. Wallace, Jeremy Gauntlett ‐Gilbert Tags: COMMENTARY Source Type: research

Perception of repeated pain relief with controllable and uncontrollable pain
ConclusionThe perception of pain relief can be modulated similar to the perception of pain by stimulus characteristics and psychological factors. Mechanistic knowledge about such modulating factors is important, because they can determine, for example, the amount of requested pain killers in clinical settings and the efficacy of pain relief as a reinforcing stimulus. (Source: European Journal of Pain)
Source: European Journal of Pain - April 8, 2021 Category: Anesthesiology Authors: S Becker, K Schakib ‐Ekbatan, D Wroblewski, M Schweiker Tags: ORIGINAL ARTICLE Source Type: research

High ‐frequency spinal cord stimulation as rescue therapy for chronic pain patients with failure of conventional spinal cord stimulation
ConclusionsOur results suggest that analgesic rescue with HF10 ‐SCS is an effective therapeutic option for non‐responders to conventional SCS, although obesity might be a limiting factor for treatment success. Nevertheless, more comprehensive studies are needed to corroborate our findings.SignificanceThis study shows that high ‐frequency stimulation may be useful in patients with failure of conventional tonic stimulation for chronic pain, both in the trial phase and in previously implanted subjects. The novelty of this study lies in the use of the implanted epidural electrodes, which avoids the need for further surge...
Source: European Journal of Pain - April 8, 2021 Category: Anesthesiology Authors: N Cordero Tous, C S ánchez Corral, IM Ortiz García, A Jover Vidal, R Gálvez Mateos, G Olivares Granados Tags: ORIGINAL ARTICLE Source Type: research

Opioids: A ‘crisis’ of too much or not enough – or simply how rich you are and where you live?
AbstractThe ‘Opioid Crisis’, which originated in Western countries, has been misrepresented and is misinforming the global public. For 20 years, since the advent of the synthetic opioids, 25,000 Americans, on average, have died annually from opioid‐related overdoses. The United States produces and consum es by far the greatest amounts of opioids. National regulations introduced to curb overdoses and restrict opioid availability have condemned many Americans, such as cancer patients or those in need of palliative care, to a life of extreme pain due to lack of access to adequate pain management. As is ofte...
Source: European Journal of Pain - April 7, 2021 Category: Anesthesiology Authors: Takashi Miyachi, Akihiko Ozaki, Hiroaki Saito, Toyoaki Sawano, Tetsuya Tanimoto, Andy Crump Tags: POSITION PAPER Source Type: research

Pain regulation during mindfulness meditation: phenomenological fingerprints in novices and experts practitioners
ConclusionThese findings need to be replicated in patients with severe and chronic pain and practicing MM. They also warrant the integration of this mixed ‐method approach with brain imaging data to refine the experiential neuroscience of pain. (Source: European Journal of Pain)
Source: European Journal of Pain - April 3, 2021 Category: Anesthesiology Authors: S. Poletti, O. Abdoun, J. Zorn, A. Lutz Tags: ORIGINAL ARTICLE Source Type: research

'Reassurance and healthcare seeking in people with persistent musculoskeletal low back pain consulting orthopaedic spine practitioners: A prospective cohort study'
ConclusionFindings suggest that better communication in consultations with orthopaedic spine clinicians might help reduce unnecessary subsequent healthcare utilization and distress.SignificanceLow back pain patients' perceptions of their communication with orthopaedic spine practitioners are associated with subsequent healthcare seeking and distress at follow ‐up. This study examines the intersection of two important but fairly neglected areas in the pain research: provider communication and patient healthcare utilization. (Source: European Journal of Pain)
Source: European Journal of Pain - April 2, 2021 Category: Anesthesiology Authors: Kathrin Braeuninger ‐Weimer, Hanna Rooslien, Naffis Anjarwalla, Tamar Pincus Tags: ORIGINAL ARTICLE Source Type: research

Commentary to “Challenges and opportunities in translational pain research—An opinion paper of the working group on translational pain research of the European Pain Federation (EFIC)” by Mouraux et al.
(Source: European Journal of Pain)
Source: European Journal of Pain - April 2, 2021 Category: Anesthesiology Authors: Per Hansson Tags: COMMENTARY Source Type: research

Neurophysiological mechanisms of chiropractic spinal manipulation for spine pain.
AbstractTogether, neck pain and back pain are the first cause of disability worldwide, accounting for more than 10% of the total years lived with disability. In this context, chiropractic care provides a safe and effective option for the management of a large proportion of these patients. Chiropractic is a healthcare profession mainly focused on the spine and the treatment of spinal disorders, including spine pain. Basic studies have examined the influence of chiropractic spinal manipulation on a variety of peripheral, spinal, and supraspinal mechanisms involved in spine pain. While spinal cord mechanisms of pain inhibitio...
Source: European Journal of Pain - March 31, 2021 Category: Anesthesiology Authors: C. Gevers ‐Montoro, B. Provencher, M. Descarreaux, A. Ortega de Mues, M. Piché Tags: REVIEW ARTICLE Source Type: research

Human surrogate models of central sensitization: a critical review and practical guide
ConclusionsWhile there is no single “optimal” model of central sensitization, the range of validated and easy‐to‐use procedures in humans should be able to inform preclinical researchers on helpful potential biomarkers, thereby narrowing the translation gap between basic and clinical data. (Source: European Journal of Pain)
Source: European Journal of Pain - March 24, 2021 Category: Anesthesiology Authors: Charles Quesada, Anna Kostenko, Idy Ho, Caterina Leone, Zahra Nochi, Alexandre Stouffs, Matthias Wittayer, Ombretta Caspani, Nanna Brix Finnerup, Andr é Mouraux, Gisèle Pickering, Irene Tracey, Andrea Truini, Rolf‐Detlef Treede, Luis Gar Tags: REVIEW ARTICLE Source Type: research

'Reassurance and health care seeking in people with persistent musculoskeletal low back pain consulting orthopaedic spine practitioners: A prospective cohort study'
ConclusionFindings suggest that better communication in consultations with orthopaedic spine clinicians might help reduce unnecessary subsequent health care utilization and distress. (Source: European Journal of Pain)
Source: European Journal of Pain - March 24, 2021 Category: Anesthesiology Authors: Kathrin Braeuninger ‐Weimer, Hanna Rooslien, Naffis Anjarwalla, Tamar Pincus Tags: ORIGINAL ARTICLE Source Type: research

Expanding frontiers in telehealth: video assisted at ‐home application of capsaicin 8% patch
AbstractIn recent years, the delivery of health services has undergone a major paradigm shift towards expanded outpatient services and widespread use of telemedicine. Post herpetic neuralgia (PHN) is a treatment recalcitrant neuropathic pain condition referring to pain persisting more than three months from the initial onset of an acute herpes zoster. QUTENZA ® (capsaicin 8% patch) is a single 1‐hour localized treatment for PHN and can provide several months of pain relief per application. However, patient access to capsaicin 8% patch is limited due to sensitive handling protocols that require the patch application t...
Source: European Journal of Pain - March 24, 2021 Category: Anesthesiology Authors: N. Shaparin, S. Nair, A. Vydyanathan, J. Hascalovici Tags: ORIGINAL ARTICLE Source Type: research

Commentary to “Challenges and opportunities in translational pain research – an opinion paper of the working group on translational pain research of the European Pain Federation (EFIC)” by Mouraux et al.
AbstractPreclinical and clinical pain science have since long suffered from lack of joint ventures that, as securely as possible, have approached problems that are relevant for the understanding of clinical pain phenomenologies and treatment (Yezierski& Hansson, 2018), the core of translational pain medicine. The uncoupling of the two has led to loss of momentum and few novel efficacious treatment remedies where needed the most, i.e., in long term pain states. Here, the area of translational pain medicine is craving for a road map so that preclinical and clinical scientists can walk hand in hand into the future with a ...
Source: European Journal of Pain - March 23, 2021 Category: Anesthesiology Authors: Per Hansson Tags: COMMENTARY Source Type: research

Unexpected injectate spread into the space of Okada during attempted epidural injection: yet another case
AbstractOur group previously presented a case series aided by a three ‐dimensional (3D) magnetic resonance imaging (MRI) reconstruction that described injection into the space of Okada as a possible cause of unsuccessful epidural analgesia or injection following the commonly used loss of resistance to air (LORA) technique (Reina et al., (2021). (Source: European Journal of Pain)
Source: European Journal of Pain - March 23, 2021 Category: Anesthesiology Authors: Irene Riquelme, Mart ín Avellanal, André P. Boezaart, Miguel A. Reina Tags: LETTER TO THE EDITOR Source Type: research

Cognitive Load and the Effectiveness of Distraction for Acute Pain in Children
ConclusionsResults demonstrate that distraction that places high demand on executive resources is more effective for acute pain management for children. Further research is needed to explore cognitive and affective moderators of the effectiveness of distraction for children. (Source: European Journal of Pain)
Source: European Journal of Pain - March 23, 2021 Category: Anesthesiology Authors: W.M. Gaultney, L.M. Dahlquist, R.L. Quiton Tags: ORIGINAL ARTICLE Source Type: research

N ‐acylethanolamine‐hydrolysing acid amidase: A new potential target to treat paclitaxel‐induced neuropathy
ConclusionsCollectively, these studies suggest that NAAA represents a promising target to treat and prevent PIPN.SignificanceThe present study demonstrates that the chemotherapeutic paclitaxel alters PEA levels in the spinal cord, whereas repeated exogenous PEA administration moderately alleviates PIPN in mice. Additionally, targeting NAAA, PEA's hydrolysing enzyme with a selective compound AM9053 reverses and prevents the PIPN via the PPAR ‐α mechanism. Overall, the data suggest that selective NAAA inhibitors denote promising future therapeutics to mitigate and prevent PIPN. (Source: European Journal of Pain)
Source: European Journal of Pain - March 23, 2021 Category: Anesthesiology Authors: Wisam Toma, Martial Caillaud, Nipa H. Patel, Tammy H. Tran, Giulia Donvito, Jane Roberts, Deniz Bagdas, Asti Jackson, Aron Lichtman, David A. Gewirtz, Alexandros Makriyannis, Michael S. Malamas, M. Imad Damaj Tags: ORIGINAL MANUSCRIPT Source Type: research

Visual illusions modulate body perception disturbance and pain in Complex Regional Pain Syndrome: A randomised trial
ConclusionsVisually changing the CRPS hand to a desired appearance modulates BPD and pain suggesting therapeutic potential for those with refractory CRPS. Further research to optimise this therapeutic effect is required. (Source: European Journal of Pain)
Source: European Journal of Pain - March 23, 2021 Category: Anesthesiology Authors: J.S. Lewis, R. Newport, G. Taylor, M. Smith, C.S. McCabe Tags: ORIGINAL ARTICLE Source Type: research

Abnormal sensory thresholds of dystonic patients are not affected by deep brain stimulation
ConclusionThe analgesic effects after DBS do not seem to depend on short ‐duration changes in cutaneous sensory thresholds in dystonic patients and may be related to changes in the central processing of nociceptive inputs. (Source: European Journal of Pain)
Source: European Journal of Pain - March 20, 2021 Category: Anesthesiology Authors: Clarice Listik, Rubens Gisbert Cury, Valquiria Aparecida Silva, Sara Carvalho Barbosa Casagrande, Eduardo Listik, Naira Link, Ricardo Galhardoni, Egberto Reis Barbosa, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - March 19, 2021 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Authors ’ reply to the comment by Riddle et al
(Source: European Journal of Pain)
Source: European Journal of Pain - March 19, 2021 Category: Anesthesiology Authors: Maren Falch Lindberg, Tone Rust øen, Bruce A. Cooper, Arild Aamodt, Anners Lerdal Tags: LETTER TO THE EDITOR Source Type: research

Efficacy of transforaminal epidural magnesium administration when combined with a local anaesthetic and steroid in the management of lower limb radicular pain
AbstractBackgroundLower limb radicular pain resulting from a herniated intervertebral disc is a cause of functional disability and could lead to increased consumption of opioids. We evaluated the efficacy of epidural magnesium combined with a local anaesthetic and steroid in the management of this pain.MethodsThis was a prospective, case ‐control, randomized, double‐blind study. Fifty patients each received 2 ml bupivacaine, 1 ml (40 mg) methylprednisolone and 1 ml saline (0.9%) (group C) or magnesium (200 mg) instead of saline (group M). The primary outcome measure was the improvement in the p...
Source: European Journal of Pain - March 17, 2021 Category: Anesthesiology Authors: Mohammed Awad, Mina M. Raouf, Hany K. Mikhail, Sohair A. Megalla, Tamer Y. Hamawy, Ahmed H. Mohamed Tags: ORIGINAL ARTICLE Source Type: research

Subcutaneous tanezumab for osteoarthritis: Is the early improvement in pain and function meaningful and sustained?
ConclusionsSubcutaneous tanezumab, compared with placebo, reduced pain within the first week, and pain and function were improved throughout 24 weeks. The proportions of responders and patients satisfied were higher with tanezumab than placebo. (Source: European Journal of Pain)
Source: European Journal of Pain - March 17, 2021 Category: Anesthesiology Authors: F. Berenbaum, R. Langford, S. Perrot, K. Miki, F.J. Blanco, T. Yamabe, N. Isogawa, R. Junor, W. Carey, L. Viktrup, C.R. West, M.T. Brown, K.M. Verburg Tags: ORIGINAL ARTICLE Source Type: research

The effect of optimism on the facial expression of pain: Implications for pain communication
ConclusionsAll Action Units, which were affected by the optimism induction, are known to be prevalent during pain stimulation. The increase in facial expression might reflect reduced inhibition of pain communication in temporarily optimistic participants. Optimism might lead to expecting positive and helpful reactions from others and, by that, to great readiness to elicit these reactions by non ‐verbal social behaviour.SignificanceThis study is the first to indicate that state optimism increases the facial expression of pain as a social signal for help and empathy without concomitant changes in the subjective pain experi...
Source: European Journal of Pain - March 16, 2021 Category: Anesthesiology Authors: Johanna Basten ‐Günther, Miriam Kunz, Madelon Peters, Stefan Lautenbacher Tags: ORIGINAL ARTICLE Source Type: research

Does muscular or mental fatigue have an influence on the nociceptive flexion reflex? a randomized cross ‐over study in healthy people
AbstractFatigue is a widespread complaint in both healthy and diseased individuals (Engberg et al., 2017; Finsterer et al., 2014) that is often described as an overwhelming sense of tiredness, lack of energy, and feeling of exhaustion (Gruet et al., 2013). Fatigue can be classified as mental fatigue, which relates to the cognitive or perceptual dimensions of fatigue, and physical fatigue, which concerns the performance of the motor system (Gruet et al., 2013). (Source: European Journal of Pain)
Source: European Journal of Pain - March 16, 2021 Category: Anesthesiology Authors: E Dhondt, L Danneels, J Rijckaert, T Palmans, S Van Oosterwijck, J Van Oosterwijck Tags: ORIGINAL ARTICLE Source Type: research

Feasibility Randomized ‐Controlled Trial of Online Acceptance and Commitment Therapy for Painful Peripheral Neuropathy in People Living with HIV: The OPEN Study
ConclusionsA full ‐scale RCT of online ACT for pain management in PLWH may be feasible with refinements to trial design to facilitate recruitment. (Source: European Journal of Pain)
Source: European Journal of Pain - March 13, 2021 Category: Anesthesiology Authors: Whitney Scott, Beth J. Guildford, James Badenoch, Elizabeth Driscoll, Joseph Chilcot, Sam Norton, Harriet I. Kemp, Ming J. Lee, Julianne Lwanga, Marta Boffito, Graeme Moyle, Frank A. Post, Lucy Campbell, Jo Josh, Paul Cift, Amanda C de C Wi Tags: ORIGINAL ARTICLE Source Type: research

Lower levels of physical activity are associated with pain progression in older adults, a longitudinal study.
ConclusionOlder adults who do not meet minimum physical activity guidelines for moderate intensity exercise are at increased risk of higher impact pain when followed over four years. (Source: European Journal of Pain)
Source: European Journal of Pain - March 9, 2021 Category: Anesthesiology Authors: Aoife O ’Neill, Kieran O’Sullivan, Karen McCreesh Tags: ORIGINAL ARTICLE Source Type: research

Role of the endocannabinoid system in a mouse model of Fragile X undergoing neuropathic pain
ConclusionsThis work shows that CB2 is necessary for the protection against neuropathic pain observed in Fmr1KO mice, raising the interest in targeting this receptor for the treatment of neuropathic pain.SignificanceNeuropathic pain is a complex chronic pain condition and current treatments are limited by the lack of efficacy and the incidence of important side effects. Our findings show that the pain ‐resistant phenotype of Fmr1KO mice against nociceptive and emotional manifestations triggered by persistent nerve damage requires the participation of the cannabinoid receptor CB2, raising the interest in targeting this re...
Source: European Journal of Pain - March 8, 2021 Category: Anesthesiology Authors: Angela Ram írez‐López, Antoni Pastor, Rafael Torre, Carmen La Porta, Andrés Ozaita, David Cabañero, Rafael Maldonado Tags: ORIGINAL ARTICLE Source Type: research

Preoperative Sleep Quality And Adverse Pain Outcomes After Total Hip Arthroplasty
AbstractBackgroundSleep disturbance is thought to aggravate acute postoperative pain. The influence of preoperative sleep problems on pain control in the long ‐term and development of chronic postsurgical pain is largely unknown.MethodsThis prospective, observational study aimed to examine the links between preoperative sleep disturbance (Pittsburgh Sleep Quality Index, PSQI) and pain severity (Brief Pain Inventory, BPI) 6 months postoperative (primary outcome), objective measures of pain and postoperative pain control variables (secondary outcomes). Patients (n=52) with disabling osteoarthritis (OA) pain undergoing tota...
Source: European Journal of Pain - March 8, 2021 Category: Anesthesiology Authors: Martin F. Bjurstr öm, Michael R. Irwin, Mikael Bodelsson, Michael T. Smith, Niklas Mattsson‐Carlgren Tags: ORIGINAL ARTICLE Source Type: research

N ‐acylethanolamine‐hydrolyzing acid amidase: a new potential target to treat paclitaxel‐induced neuropathy
ConclusionsCollectively, these studies suggest that NAAA represents a promising target to treat and prevent PIPN. (Source: European Journal of Pain)
Source: European Journal of Pain - March 6, 2021 Category: Anesthesiology Authors: Wisam Toma, Martial Caillaud, Nipa H. Patel, Tammy H. Tran, Giulia Donvito, Jane Roberts, Deniz Bagdas, Asti Jackson, Aron Lichtman, David A. Gewirtz, Alexandros Makriyannis, Michael S. Malamas, M. Imad Damaj Tags: ORIGINAL ARTICLE Source Type: research

Authors ’ Reply to the comment by Riddle et al.
AbstractWe appreciate Riddle et al ’s (Riddle and Dumenci 2021) interest in our article on pain profiles after total knee arthroplasty (TKA)(Lindberg et al., 2020) and the opportunity to discuss this important clinical problem of common concern. (Source: European Journal of Pain)
Source: European Journal of Pain - March 6, 2021 Category: Anesthesiology Authors: M.F. Lindberg, T. Rust øen, B.A. Cooper, A. Aamodt, A. Lerdal Tags: LETTER TO THE EDITOR Source Type: research

‘External timing’ of placebo analgesia in an experimental model of sustained pain
ConclusionsOur data suggest that ‘externally timing’ of placebo analgesia may be possible for prolonged types of pain.SignificanceResearch on placebo effects mainly focuses on the influence of information about direction (i.e., increase or decrease of pain) and magnitude (i.e., strong or weak) of the expected effect but ignores temporal aspects of expectations. In our study in healthy volunteers, the reported onset of placebo analgesia followed the temporal information provided. Such ‘external timing’ effects could not only aid the clinical use of placebo treatment (e.g., in open‐label placebos) b...
Source: European Journal of Pain - March 6, 2021 Category: Anesthesiology Authors: Eleonora Maria Camerone, Katja Wiech, Fabrizio Benedetti, Elisa Carlino, Mirko Job, Aldo Scafoglieri, Marco Testa Tags: ORIGINAL ARTICLE Source Type: research

Intact pain modulation through manipulation of controllability and expectations in aging
ConclusionsThese results suggest that although cognitive pain modulation is preserved during aging, neural processing of pain is reduced in older adults. (Source: European Journal of Pain)
Source: European Journal of Pain - March 5, 2021 Category: Anesthesiology Authors: Ana Mar ía González‐Roldán, Juan Lorenzo Terrasa, Maria Angeles Prats‐Sedano, Carolina Sitges, Marian van der Meulen, Fernand Anton, Pedro Montoya Tags: ORIGINAL ARTICLE Source Type: research

European* clinical practice recommendations on opioids for chronic noncancer pain – Part 1: Role of opioids in the management of chronic noncancer pain
ConclusionsOpioids remain a treatment option for some selected patients with CNCP under careful surveillance. (Source: European Journal of Pain)
Source: European Journal of Pain - March 3, 2021 Category: Anesthesiology Authors: Winfried H äuser, Bart Morlion, Kevin E. Vowles, Kirsty Bannister, Eric Buchser, Roberto Casale, Chenot Jean‐François, Gillian Chumbley, Asbjørn Mohr Drewes, Gert Dom, Liisa Jutila, Tony O'Brien, Esther Pogatzky‐Zahn, Martin Ragusa, C Tags: POSITION PAPER Source Type: research

European clinical practice recommendations on opioids for chronic noncancer pain – Part 2: Special situations*
ConclusionIf a trial with opioids for chronic noncancer pain is conducted, detailed knowledge and experience are needed to adapt the opioid treatment to a special patient group and/or clinical situation and to manage side effects effectively.SignificanceIf a trial with opioids for chronic noncancer pain is conducted, detailed knowledge and experience are needed to adapt the opioid treatment to a special patient group and/or clinical situation and to manage side effects effectively. A collaboration of medical specialties and of all health care professionals is needed for some special populations and clinical situations. (So...
Source: European Journal of Pain - March 3, 2021 Category: Anesthesiology Authors: Nevenka Krcevski –Škvarc, Bart Morlion, Kevin E. Vowles, Kirsty Bannister, Eric Buchsner, Roberto Casale, Chenot Jean‐François, Gillian Chumbley, Asbjørn Mohr Drewes, Gert Dom, Liisa Jutila, Tony O'Brien, Esther Pogatzky‐Zahn, Martin Tags: POSITION PAPER Source Type: research

The effect of experimental pain on the excitability of the corticospinal tract in humans: A systematic review and meta ‐analysis
ConclusionsOur results confirm the inhibitory effect of pain on corticospinal excitability for both tonic and phasic pain. This reduction was specific to hand and face pain. Also, both cutaneous and muscle hand pain reduced excitability. The strength of evidence remains limited/conflicting. More high ‐quality studies are needed to confirm our conclusions.SignificanceThis study adds evidence on the effect of specific factors on the modulation of corticospinal excitability during/after experimental pain. The reduction in corticospinal excitability was driven by hand and face pain. We confirmed previous results that muscle ...
Source: European Journal of Pain - February 28, 2021 Category: Anesthesiology Authors: Antoine Rohel, Jason Bouffard, Philippe Patricio, Nicolas Mavromatis, Maxime Billot, Jean ‐Sébastien Roy, Laurent Bouyer, Catherine Mercier, Hugo Masse‐Alarie Tags: REVIEW ARTICLE Source Type: research

Is opioid therapy for chronic non ‐cancer pain associated with a greater risk of all‐cause mortality compared to non‐opioid analgesics? A systematic review of propensity score matched observational studies
ConclusionsPossibly, opioids are associated with an increased all ‐cause mortality risk compared to non‐opioid analgesics. When considering treatment options for patients with CNCP, the possible risk of increased all‐cause mortality with opioids should be discussed.SignificanceAn increased all ‐cause mortality associated with opioid use compared to non‐opioid analgesics for CNCP was identified by a systematic review of four propensity score matched cohort studies in real‐world settings. The number needed to harm for an additional excess death per 10,000 person‐years was 116. Despi te extensive propensity scor...
Source: European Journal of Pain - February 28, 2021 Category: Anesthesiology Authors: Thomas T ölle, Mary‐Ann Fitzcharles, Winfried Häuser Tags: REVIEW ARTICLE Source Type: research

MiRNA ‐107 contributes to inflammatory pain by down‐regulating GLT‐1 expression in rat spinal dorsal horn
ConclusionsThese results suggest that an increase of miR ‐107 contributes to inflammatory pain through downregulating GLT‐1 expression, implying a promising strategy for pain therapy.SignificanceThe currently available treatments for inflammatory pain has limited effect even causes severe side effects. MiRNAs may have important diagnostic and therapeutic potential in inflammatory pain. In present study, we show a potential spinal mechanism of allodynia in rat inflammatory pain model induced by CFA. Increased miR ‐107 contribute to inflammatory pain by targeting and downregulating GLT‐1 expression, implying a promis...
Source: European Journal of Pain - February 28, 2021 Category: Anesthesiology Authors: Ling Zhang, Rui Wu, Mei ‐Jie Xu, Jie Sha, Guang‐Yin Xu, Jian Wu, Ping‐An Zhang Tags: ORIGINAL ARTICLE Source Type: research

Challenges and opportunities in translational pain research – An opinion paper of the working group on translational pain research of the European pain federation (EFIC)
AbstractFor decades, basic research on the underlying mechanisms of nociception has held promise to translate into efficacious treatments for patients with pain. Despite great improvement in the understanding of pain physiology and pathophysiology, translation to novel, effective treatments for acute and chronic pain has however been limited, and they remain an unmet medical need. In this opinion paper bringing together pain researchers from very different disciplines, the opportunities and challenges of translational pain research are discussed. The many factors that may prevent the successful translation of bench observa...
Source: European Journal of Pain - February 24, 2021 Category: Anesthesiology Authors: Andr é Mouraux, Kirsty Bannister, Susanne Becker, David P. Finn, Gisèle Pickering, Esther Pogatzki‐Zahn, Thomas Graven‐Nielsen Tags: Position Paper Source Type: research