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The European Pain Federation Diplomas in Pain Medicine (EDPM) and Pain Physiotherapy (EDPP) are open for registration
(Source: European Journal of Pain)
Source: European Journal of Pain - February 21, 2018 Category: Anesthesiology Tags: Announcement Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - February 21, 2018 Category: Anesthesiology Tags: Issue Information Source Type: research

Commentary on a paper by Holden et  al.
(Source: European Journal of Pain)
Source: European Journal of Pain - February 19, 2018 Category: Anesthesiology Authors: R.J. Lacey, P. Campbell, Z. Michaleff Tags: Commentary Source Type: research

Pain and sensitization after total knee replacement or nonsurgical treatment in patients with knee osteoarthritis: Identifying potential predictors of outcome at 12  months
ConclusionLow PPTs at baseline predicted worse pain outcome after TKR, but did not predict outcome after nonsurgical interventions. The number of painful sites was weakly associated with pain and PPTs, and the higher pain/lower PPTs, the higher pain/lower PPTs at 12 months with females showing the lowest PPT values. SignificanceHuman experimental pain assessment was used to assess the degree of pain sensitization in patients with painful knee osteoarthritis. High sensitization before TKR predicted worse outcome. Outcome after nonsurgical interventions could not be predicted. (Source: European Journal of Pain)
Source: European Journal of Pain - February 15, 2018 Category: Anesthesiology Authors: L. Arendt ‐Nielsen, O. Simonsen, M.B. Laursen, E.M. Roos, M.S. Rathleff, S. Rasmussen, S.T. Skou Tags: Original Article Source Type: research

Cumulative effects of multiple pains sites in youth with chronic pain
ConclusionsPotentially due to the MPS load and the inverse effects that such a pain state has on function, such patients may be at‐risk for poorer health and school‐related outcomes. The mechanisms influencing these relationships appear to extend beyond psychological/emotional factors and warrant further investigation in order to aid in our understanding of youth with MPS. SignificanceYouth with MPS may be at risk for experiencing poorer physical and school functioning in comparison to single‐site peers, despite treatment initiation. Further research is warranted in order to inform assessment and treatment approaches...
Source: European Journal of Pain - February 13, 2018 Category: Anesthesiology Authors: Molly C. Basch, Erika T. Chow, Deirdre E. Logan, David Borsook, Neil L. Schechter, Laura E. Simons Tags: Original Article Source Type: research

The impact of a short educational movie on promoting chronic pain health literacy in school: a feasibility study
ConclusionsThis feasibility study provides first evidence that a short educational movie on recurrent and chronic pain may increase chronic pain health literacy in students. Future studies should investigate the long‐term retention of pain knowledge and any associated effects on behavior change. Due to barriers to implementation of interventional studies in the school setting, these studies should use a waitlist control group design and online data collection.This article is protected by copyright. All rights reserved. (Source: European Journal of Pain)
Source: European Journal of Pain - February 13, 2018 Category: Anesthesiology Authors: J. Wager, L. Stahlschmidt, F. Heuer, S. Troche, B. Zernikow Tags: Original Article Source Type: research

Assessing neuropathic pain in patients with low back ‐related leg pain: Comparing the painDETECT Questionnaire with the 2016 NeuPSIG grading system
ConclusionOur results do not support the use of painDETECT as a screening tool to classify or grade neuropathic components in patients with low back‐related leg pain.This article is protected by copyright. All rights reserved. (Source: European Journal of Pain)
Source: European Journal of Pain - February 13, 2018 Category: Anesthesiology Authors: Eivind Hasvik, Anne Julsrud Haugen, Johannes Gjerstad, Lars Gr øvle Tags: Original Article Source Type: research

Randomized double ‐blind controlled study of bedtime low dose amitriptyline in chronic neck pain
Abstract BackgroundAmitriptyline has well‐established efficacy in several chronic pain conditions. While optimal treatment for chronic neck pain (CNP) remains controversial, amitriptyline was not tested for CNP. We evaluated the effect of bedtime amitriptyline in the management of CNP. Methods220 patients suffering from idiopathic CNP were randomized to receive either placebo pill (n = 108) or 5 mg of amitriptyline (n = 112) at bedtime for two months. Primary outcome measure was visual analog scale (VAS) for pain. Secondary outcome measures were Neck pain Disability Index (NPDI), Bergen Insomnia ...
Source: European Journal of Pain - February 13, 2018 Category: Anesthesiology Authors: J. Maarrawi, J. Abdel Hay, S. Kobaiter ‐Maarrawi, P. Tabet, R. Peyron, L. Garcia‐Larrea Tags: Original Article Source Type: research

Effects of a Standard American Diet and an Anti ‐inflammatory Diet in Male and Female Mice
ConclusionsPoor diet prolonged recovery from inflammatory injury. Substitution of SAD with AID or REG promoted faster recovery. These findings suggest diet can be used as a non‐pharmacological intervention following injury.This article is protected by copyright. All rights reserved. (Source: European Journal of Pain)
Source: European Journal of Pain - February 13, 2018 Category: Anesthesiology Authors: S. K. Totsch, R. Y. Meir, T. L. Quinn, S. A. Lopez, B. A. Gower, R. E. Sorge Tags: Original Article Source Type: research

Anterior insular volume decrease is associated with dysfunction of the reward system in patients with chronic pain
Abstract BackgroundChronification of pain is associated with both anatomical and functional alterations of the brain. Alteration in regional gray matter volume might potentially be associated with modified activity of specific brain networks. In this cross‐sectional, observational study, we sought to identify brain regions with gray matter volume changes in patients with chronic pain and to reveal its significance by analysing alteration in functional connectivity from those regions. We further explored relevance of such alterations with psychometrics of chronic pain. MethodsWe recruited 23 patients with chronic pain and...
Source: European Journal of Pain - February 13, 2018 Category: Anesthesiology Authors: E. Ikeda, T. Li, H. Kobinata, S. Zhang, J. Kurata Tags: Original Article Source Type: research

Dipyrone is the preferred nonopioid analgesic for the treatment of acute and chronic pain. A survey of clinical practice in German ‐speaking countries
ConclusionsDipyrone is the preferred nonopioid analgesic in the perioperative and chronic pain setting. Although cases of agranulocytosis occur, benefits apparently outweigh the risks according to anaesthesiologists. Measures like patient information may improve safety. SignificanceA survey of anaesthesiologist in German‐speaking countries revealed dipyrone as preferred nonopioid analgesic for the treatment of acute and chronic pain. Benefits seem to outweigh the risks, specifically the risk of agranulocytosis. Information of medical staff and patients on adverse drug reactions and symptoms of agranulocytosis should be i...
Source: European Journal of Pain - February 12, 2018 Category: Anesthesiology Authors: L. Reist, J. Erlenwein, W. Meissner, T. Stammschulte, F. St über, U.M. Stamer Tags: Original Article Source Type: research

Physiological and pathological characterization of capsaicin ‐induced reversible nerve degeneration and hyperalgesia
ConclusionsThere were differential restoration of IENF density, CHEP and thermal thresholds, and changed CHEP–IENF relationships during skin reinnervation. CHEP can be a physiological signature of acute hyperalgesia. SignificanceThese observations suggested the relationship between nociceptive nerve terminals and brain responses to thermal stimuli changed during different degree of skin denervation, and CHEP to low‐intensity heat stimulus can reflect the physiology of hyperalgesia. (Source: European Journal of Pain)
Source: European Journal of Pain - February 2, 2018 Category: Anesthesiology Authors: H. Chiang, K. ‐C. Chang, H.‐W. Kan, S.‐W. Wu, M.‐T. Tseng, H.‐W. Hsueh, Y.‐H. Lin, C.‐C. Chao, S.‐T. Hsieh Tags: Original Article Source Type: research

Authors ’ reply to the comment by Kendall et al
This article is protected by copyright. All rights reserved. (Source: European Journal of Pain)
Source: European Journal of Pain - February 1, 2018 Category: Anesthesiology Authors: Falk von Dincklage, Axel Jakuscheit, Johannes Weth, Gregor Lichtner, Carlo Jurth, Benno Rehberg ‐Klug Tags: Letter to the Editor Source Type: research

Catastrophizing, pain and traumatic stress symptoms following burns: A prospective study
ConclusionA negative cognitive‐affective response to a burn event, such as catastrophizing, mediated the relationship acute and chronic PTSD symptoms and later chronic pain. Screening for catastrophizing and acute PTSD symptoms is recommended to identify persons at risk for chronic PTSD symptoms and pain.This article is protected by copyright. All rights reserved. (Source: European Journal of Pain)
Source: European Journal of Pain - February 1, 2018 Category: Anesthesiology Authors: N. E. Van Loey, I. Klein, A. E. E. de Jong, H. W. C. Hofland, E. Vandermeulen, I. M. Engelhard Tags: Original Article Source Type: research

Psychological factors not strength deficits are associated with severity of gluteal tendinopathy: a cross ‐sectional study
ConclusionsIndividuals with severe gluteal tendinopathy present with psychological distress, poorer quality of life, greater BMI and waist girth. Given these features, the consideration of psychological factors in more severe patients may be important to optimise patient outcomes and reduce health care utilisation.This article is protected by copyright. All rights reserved. (Source: European Journal of Pain)
Source: European Journal of Pain - February 1, 2018 Category: Anesthesiology Authors: M. L. Plinsinga, B. K. Coombes, R. Mellor, P. Nicolson, A. Grimaldi, P. Hodges, K. Bennell, B. Vicenzino Tags: Original Article Source Type: research

Effect of local wound infiltration with ketamine versus dexmedetomidine on postoperative pain and stress after abdominal hysterectomy, a randomized trial
Abstract Background and ObjectivesPostoperative pain and stress elicit hormonal changes. We aimed at comparing the effects of wound infiltration with ketamine versus dexmedetomidine on postoperative pain and stress response. MethodsThis double‐blinded study included ninety patients scheduled for total abdominal hysterectomy and were randomly assigned into three groups to receive local wound infiltration with 40 mL of 0.25% bupivacaine (group C), plus 2 mg/kg ketamine (group K) or 2 μg/kg dexmedetomidine (group D). Primary outcome was postoperative morphine consumption; secondary outcomes included first ...
Source: European Journal of Pain - February 1, 2018 Category: Anesthesiology Authors: S.A. Mohamed, D.M. Sayed, F.A. El Sherif, A.M. Abd El ‐Rahman Tags: Original Article Source Type: research

Pain ‐relieving effectiveness, quality of life and tolerability of repeated capsaicin 8% patch treatment of peripheral neuropathic pain in Scandinavian clinical practice
Abstract ContextClinical trials have demonstrated the efficacy and safety of the capsaicin 8% patch in patients with peripheral neuropathic pain (PNP); however, few studies have assessed this treatment in a clinical practice. ObjectiveTo determine whether treatment and re‐treatment with the capsaicin 8% patch reduce PNP intensity in clinical practice. MethodsThree non‐interventional, observational studies were concurrently conducted in Denmark, Norway and Sweden. Patients with probable or definite PNP received one or two treatments with the capsaicin 8% patch according to usual clinical practice. All analyses were perf...
Source: European Journal of Pain - February 1, 2018 Category: Anesthesiology Authors: P. Hansson, T.S. Jensen, G. Kvarstein, M. Str ömberg Tags: Original Article Source Type: research

Validation of the Pain Coping Questionnaire in Finnish
ConclusionThe exploratory factor analysis of the PCQ provided a both culturally and statistically satisfactory structure in the Finnish translation. This supports the reliability and validity of the PCQ in future national use and the value of the questionnaire also outside English‐speaking countries. SignificanceThis study showed both culturally and statistically satisfactory factor structure of PCQ in the Finnish translation. This result supports reliability and validity of the PCQ in the national use in the future. The result shows that the PCQ is a reliable method to be used in different linguistic and cultural surrou...
Source: European Journal of Pain - February 1, 2018 Category: Anesthesiology Authors: M.K. Marttinen, N. Santavirta, M.J. Kauppi, H. Pohjankoski, H. Vuorimaa Tags: Original Article Source Type: research

Thermal pain tolerance and pain rating in normal subjects: Gender and age effects
ConclusionsWomen were more sensitive to tolerance heat pain stimuli. Younger participants reported more pain for thermal pain and tolerance tests. SignificanceThermal pain tolerance and pain rating for the thermal pain tolerance temperature depend on gender and age. Women are more sensitive to heat temperatures, young people rate more pain, and the pain ratings of heat and cold are strongly correlated. (Source: European Journal of Pain)
Source: European Journal of Pain - February 1, 2018 Category: Anesthesiology Authors: Y. ‐J. Lue, H.‐H. Wang, K.‐I. Cheng, C.‐H. Chen, Y.‐M. Lu Tags: Original Article Source Type: research

Dipyrone is the preferred non ‐opioid analgesic for the treatment of acute and chronic pain. A survey of clinical practice in German speaking countries
ConclusionsDipyrone is the preferred non‐opioid analgesic in the perioperative and chronic pain setting. Although cases of agranulocytosis occur, benefits apparently outweigh the risks according to anaesthesiologists. Measures like patient information may improve safety.This article is protected by copyright. All rights reserved. (Source: European Journal of Pain)
Source: European Journal of Pain - January 29, 2018 Category: Anesthesiology Authors: L. Reist, J. Erlenwein, W. Meissner, T. Stammschulte, F. St über, U.M. Stamer Tags: Original Article Source Type: research

Medical cannabis: A forward vision for the clinician
Abstract Medical cannabis has entered mainstream medicine and is here to stay. Propelled by public advocacy, the media and mostly anecdote rather than sound scientific study, patients worldwide are exploring marijuana use for a vast array of medical conditions including management of chronic pain. Contrary to the usual path of drug approval, medical cannabis has bypassed traditional evidence‐based study and has been legalized as a therapeutic product by legislative bodies in various countries. While there is a wealth of basic science and preclinical studies demonstrating effects of cannabinoids in neurobiological systems...
Source: European Journal of Pain - January 29, 2018 Category: Anesthesiology Authors: M.A. Fitzcharles, E. Eisenberg Tags: Review Article Source Type: research

A qualitative analysis of patient ‐identified adaptive behaviour changes following interdisciplinary Acceptance and Commitment Therapy for chronic pain
ConclusionsThese data provide initial insights into the patient's perspective of adaptive behavioural changes gained as part of an interdisciplinary programme of chronic pain rehabilitation. Overall, the data suggest the importance of a mix of both ACT‐specific and more universal coping/pain rehabilitation elements. Future research may examine how these processes relate more directly to treatment outcome. SignificanceThis study provides new qualitative insights into the patient's perspective of adaptive behavioural changes gained as part of interdisciplinary pain rehabilitation. This and future work may help provide a mo...
Source: European Journal of Pain - January 26, 2018 Category: Anesthesiology Authors: M. Thompson, K.E. Vowles, G. Sowden, J. Ashworth, J. Levell Tags: Original Article Source Type: research

Preclinical characterization of three transient receptor potential vanilloid receptor 1 antagonists for early use in human intradermal microdose analgesic studies
ConclusionThe investigated model compounds displayed ideal compound characteristics as pharmacological and translational tools to address efficacy on the human native TRPV1 target in human skin in situ. SignificanceThis work details the pharmaceutical work‐up of three TRPV1‐active investigational compounds, to obtain regulatory approval, for subsequent use in humans. This fast and cost‐effective preclinical development path may impact research beyond the pain management area, as it allows human target engagement information gathering early in drug development. (Source: European Journal of Pain)
Source: European Journal of Pain - January 26, 2018 Category: Anesthesiology Authors: E. Sj ögren, M.M. Halldin, O. Stålberg, A.K. Sundgren‐Andersson Tags: Original Article Source Type: research

Reciprocal associations of pain and post ‐traumatic stress symptoms after whiplash injury: A longitudinal, cross‐lagged study
The objectives of the current study were to investigate (1) the longitudinal, reciprocal associations between pain and post‐traumatic stress symptoms as proposed by the mutual maintenance model, and (2)  to assess the predictive value of the three clusters of post‐traumatic stress, where the model revealed that post‐traumatic stress symptoms maintained pain in a consecutive cohort of whiplash‐injured. MethodsParticipants (n = 253; 66.4% women) were people with WAD grades I–III following motor vehicle crashes in Australia. Pain and post‐traumatic stress symptoms were assessed by questionn...
Source: European Journal of Pain - January 26, 2018 Category: Anesthesiology Authors: S.L. Ravn, M. Sterling, Y. Lahav, T.E. Andersen Tags: Original Article Source Type: research

Blockade of dopamine D2 receptors disrupts intrahippocampal connectivity and enhances pain ‐related working memory deficits in neuropathic pain rats
ConclusionsTogether, these results suggest that disruption of the dopaminergic balance in the intrahippocampal networks may be important for the development of cognitive deficits experienced during painful conditions. SignificanceThis study provides new insights into the role of D2r in the manifestation of pain‐related sWM deficits. Our findings support that selective blockade of D2r produces a significant decrease in intrahippocampal connectivity mediated by theta‐oscillations, and amplifies pain‐related sWM deficits. These results suggest that further characterization of intrahippocampal dopaminergic modulation may...
Source: European Journal of Pain - January 26, 2018 Category: Anesthesiology Authors: H. Cardoso ‐Cruz, M. Dourado, C. Monteiro, V. Galhardo Tags: Original Article Source Type: research

Gene transfer of a naked plasmid (pUDK ‐HGF) encoding human hepatocyte growth factor attenuates skin/muscle incision and retraction‐induced chronic post‐surgical pain in rats
ConclusionspUDK‐HGF has a strong analgesic potency and efficacy in CPSP induced by SMIR in rats. This study highlights a new strategy for the treatment of CPSP. SignificanceThe CPSP occurs following various surgical procedures and remains a major clinical problem due to the lack of study on the mechanisms of CPSP. Our findings provide the first evidence that pUDK‐HGF attenuates SMIR‐induced pain behaviuors through peripheral or central mechanisms. The peripheral analgesic effect of pUDK‐HGF is associated with promoting tissue repair and inhibiting inflammatory response; furthermore, pUDK‐HGF inhibits activation o...
Source: European Journal of Pain - January 26, 2018 Category: Anesthesiology Authors: C. Hu, Y. Lu, X. Chen, Z. Wu, Q. Zhang Tags: Original Article Source Type: research

Comparative pharmacology and toxicology of tramadol and tapentadol
ConclusionsAlthough more studies are needed to provide clear guidance on the opioid of choice, tapentadol shows some advantages, as it does not require CYP450 system activation and has minimal serotonergic effects. In addition, it leads to less side effects and lower abuse liability. However, in vivo and in vitro studies have shown that tramadol and tapentadol cause similar toxicological damage. In this context, it is important to underline that the choice of opioid should be individually balanced and a tailored decision, based on previous experience and on the patient's profile, type of pain and context of treatment.This ...
Source: European Journal of Pain - January 25, 2018 Category: Anesthesiology Authors: J Faria, J Barbosa, R Moreira, O Queir ós, F Carvalho, R. J Dinis‐Oliveira Tags: Review Article Source Type: research

Objective assessment of induced acute pain in neonatology with the Newborn Infant Parasympathetic Evaluation (NIPE) index
Abstract BackgroundObjective tools are needed to improve pain assessment in newborns. The aim of this study was to assess the correlation between the Newborn Infant Parasympathetic Evaluation (NIPE) index and two pain scales during a painful procedure in premature infants. MethodEach baby born at least at 26 weeks of gestational age (GA) undergoing a planned painful procedure in the Neonatal Intensive Care Unit (NICU) was eligible. NIPE index, heart rate variability (HRV) indices and Neonatal Acute Pain scale (DAN) were recorded across three periods: the first at rest 5 min before the painful procedure (T1), the second dur...
Source: European Journal of Pain - January 25, 2018 Category: Anesthesiology Authors: C. Cremillieux, A. Makhlouf, V. Pichot, B. Trombert, H. Patural Tags: Original Article Source Type: research

Pain and Sensitisation after Total Knee Replacement or Non ‐Surgical Treatment in Patients with Knee Osteoarthritis: Identifying Potential Predictors of Outcome at 12 Months
ConclusionLow PPTs at baseline predicted worse pain outcome after TKR, but did not predict outcome after non‐surgical interventions. The number of painful sites was weakly associated with pain and PPTs, and the higher pain/lower PPTs, the higher pain/lower PPTs at 12 months with females showing the lowest PPT values.This article is protected by copyright. All rights reserved. (Source: European Journal of Pain)
Source: European Journal of Pain - January 25, 2018 Category: Anesthesiology Authors: L. Arendt ‐Nielsen, O. Simonsen, M. B. Laursen, E. M. Roos, M. S. Rathleff, S. Rasmussen, S. T. Skou Tags: Original Article Source Type: research

Assessment of efficacy and safety of eslicarbazepine acetate for the treatment of trigeminal neuralgia
Abstract BackgroundAntiepileptic drugs are the first line treatment for trigeminal neuralgia (TN). Carbamazepine and oxcarbazepine are the most studied with well‐known efficacy. Eslicarbazepine acetate is a third‐generation antiepileptic drug that has not previously been evaluated for the treatment of TN. We aim to assess the efficacy, tolerability, and safety of eslicarbazepine for TN. Design and MethodsRetrospective, open‐label, multicentric, intention‐to‐treat study. We included patients older than 18 years who met the ICHD‐3 beta diagnostic criteria for TN. We evaluated the variation of intensity and freque...
Source: European Journal of Pain - January 25, 2018 Category: Anesthesiology Authors: A. Sanchez ‐Larsen, D. Sopelana‐Garay, I. Diaz‐Maroto, A.B. Perona‐Moratalla, J. Gracia‐Gil, S. García‐Muñozguren, E. Palazón‐García, T. Segura Tags: Original Article Source Type: research

Comment on a paper by Dincklage et  al. entitled “Higher doses of intraoperative analgesia are associated with lower levels of persistent pain and less analgesic consumption six months after total hip arthroplasty.”
This article is protected by copyright. All rights reserved. (Source: European Journal of Pain)
Source: European Journal of Pain - January 24, 2018 Category: Anesthesiology Authors: Mark C. Kendall, Lucas J. Castro ‐Alves Tags: Letter to Editor Source Type: research

Effects of Higher versus Lower Threat Contexts on Pain ‐Related Attention Biases: An Eye‐Tracking Study
ConclusionsResults underscored stronger overall attention maintenance on visual pain cues in a higher threat (impending pain) context.This article is protected by copyright. All rights reserved. (Source: European Journal of Pain)
Source: European Journal of Pain - January 24, 2018 Category: Anesthesiology Authors: Todd Jackson, Lin Su, Yang Wang Tags: Original Article Source Type: research

Commentary on a paper by Holden et al
This article is protected by copyright. All rights reserved. (Source: European Journal of Pain)
Source: European Journal of Pain - January 24, 2018 Category: Anesthesiology Authors: Rosemary J Lacey, Zoe Michaleff, Paul Campbell Tags: Commentary Source Type: research

Predicting drug efficacy in chronic low back pain by quantitative sensory tests
ConclusionsThermal QST have the potential to predict imipramine effect in chronic low back pain. Oxycodone and clobazam effects could not be predicted by any of the selected QST or genetic variants. SignificancePredicting drug efficacy in chronic low back pain remains difficult. There is some evidence that patients more sensitive to heat and cold pain respond better to imipramine. (Source: European Journal of Pain)
Source: European Journal of Pain - January 23, 2018 Category: Anesthesiology Authors: J. Schliessbach, A. Siegenthaler, L. B ütikofer, P. Vuilleumier, P. Jüni, U. Stamer, L. Arendt‐Nielsen, M. Curatolo Tags: Original Article Source Type: research

Pain in severe dementia: A comparison of a fine ‐grained assessment approach to an observational checklist designed for clinical settings
ConclusionThe results suggest that easy‐to‐use observational approaches for clinical settings are valid and that there may not be any clinically important advantages to using more resource‐intensive coding approaches based on FACS. We acknowledge, as a limitation of our study, that we used as baseline a quiet condition that did not involve significant patient movement. In contrast, our pain condition involved systematic patient movement. Future research should be aimed at replicating our results using a baseline condition that involves non‐painful movements. SignificanceExamining older adults with and without demen...
Source: European Journal of Pain - January 23, 2018 Category: Anesthesiology Authors: T. Hadjistavropoulos, M.E. Browne, K.M. Prkachin, B. Taati, A. Ashraf, A. Mihailidis Tags: Original Article Source Type: research

Clinical course and prognostic factors across different musculoskeletal pain sites: A secondary analysis of individual patient data from randomised clinical trials
ConclusionsDespite some differences in prognostic factors for trial participants with knee OA who were older and had more chronic conditions, similarity of outcome predictors across regional MSK pain sites provides evidence to support targeting of treatment based on prognostic factors rather than site of pain.This article is protected by copyright. All rights reserved. (Source: European Journal of Pain)
Source: European Journal of Pain - January 22, 2018 Category: Anesthesiology Authors: D.J. Green, M. Lewis, G. Mansell, M. Artus, K.S. Dziedzic, E.M. Hay, N.E. Foster, D.A. van der Windt Tags: Original Article Source Type: research

Differential gene expression in trigeminal ganglia of male and female rats following chronic constriction of the infraorbital nerve
ConclusionsOur findings suggest sex‐dependent gene regulation in response to nerve injury, which may contribute to sex dimorphism of trigeminal neuropathic pain. Further studies are needed to establish gene expression changes over time and correlate these with hormonal and other physiological parameters in male and female. SignificanceWe present novel sex‐specific transcriptional regulation in trigeminal ganglia that may contribute to male‐/female‐based differences in trigeminal neuropathic pain. These findings are expected to open new research horizons, particularly in male versus female targeted therapeutic regim...
Source: European Journal of Pain - January 19, 2018 Category: Anesthesiology Authors: O.A. Korczeniewska, S. Husain, J. Khan, E. Eliav, P. Soteropoulos, R. Benoliel Tags: Original Article Source Type: research

Robert F. Schmidt Ph.D., Prof. Dr. med. D. Sc. h.c. 1932 –2017 Facets of a life for science
(Source: European Journal of Pain)
Source: European Journal of Pain - January 19, 2018 Category: Anesthesiology Authors: C. Belmonte, N. Birbaumer, J. Carmody, W. J änig, K. Messlinger, Y. Sato, S. Uchida, H.O. Handwerker Tags: Obituary Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - January 19, 2018 Category: Anesthesiology Tags: Issue Information Source Type: research

Increased pain sensitivity in migraine and tension ‐type headache coexistent with low back pain: A cross‐sectional population study
Abstract BackgroundLow back pain is common in the general population and in individuals with primary headaches. We assessed the relative frequency of self‐reported back pain in persons with and without primary headaches and examined pain sensitivity. MethodA population of 796 individuals completed a headache interview based on ICHD criteria and provided data of interest in a self‐administered questionnaire. Headache cases were classified into chronic (≥15) (CH) or episodic (
Source: European Journal of Pain - January 19, 2018 Category: Anesthesiology Authors: S. Ashina, R.B. Lipton, L. Bendtsen, N. Hajiyeva, D.C. Buse, A.C. Lyngberg, R. Jensen Tags: Original Article Source Type: research

Machine ‐learned analysis of quantitative sensory testing responses to noxious cold stimulation in healthy subjects
ConclusionThresholds at, roughly, 25 and 18 °C agree with known working temperatures of TRPM8 and TRPA1 ion channels, respectively, and hint at relative local dominance of either channel in respective subjects. Data patterns suggest involvement of further distinct mechanisms in cold pain perception at lower temperatures. Findings support data science approaches to identify biologically plausible hints at complex molecular mechanisms underlying human pain phenotypes. SignificanceSensitivity to pain is heterogeneous. Data‐driven computational research approaches allow the identification of subgroups of subjects wi...
Source: European Journal of Pain - January 16, 2018 Category: Anesthesiology Authors: I. Weyer ‐Menkhoff, M.C. Thrun, J. Lötsch Tags: Original Article Source Type: research

Signalling transduction events involved in agonist ‐induced PGE2/EP4 receptor externalization in cultured rat dorsal root ganglion neurons
ConclusionsTaken together, these data suggest that mobilization of extracellular and intracellular calcium as well as the activation of CaMKII, cAMP/PKA, cAMP/Epac, PKC/PKCε, MAPKs, PI3K‐Akt and PLC signalling transduction pathways are involved in agonist‐induced EP4 externalization. Agonist‐enhanced EP4 externalization increases EP4 cell surface abundance and activity, thus enhancing nociceptor sensitization. SignificanceThis study adds mechanistic information regarding signalling transduction events involved in agonist‐induced EP4 cell surface trafficking. EP4 and EP2 (to lesser extent) receptors, extra...
Source: European Journal of Pain - January 16, 2018 Category: Anesthesiology Authors: W. Ma, B. St ‐Jacques Tags: Original Article Source Type: research

Short communication: Persistent socio ‐economic inequality in frequent headache among Danish adolescents from 1991 to 2014
This study combines data from seven data survey years from 1991 to 2014, participation rate 88.6%, n = 31,102. We report absolute inequality as per cent difference in frequent headache between high and low OSC and relative inequality as odds ratio for frequent headache by OSC. ResultsIn the entire study population, 10.4% reported frequent headache. There was a significant increase in frequent headache from 8.0% in 1991 to 12.9% in 2014, test for trend, p 
Source: European Journal of Pain - January 1, 2018 Category: Anesthesiology Authors: B.E. Holstein, A. Andersen, A.M. Denb æk, A. Johansen, S.I. Michelsen, P. Due Tags: Short Communication Source Type: research

Quadratus lumborum block in management of severe pain after uterine artery embolization
ConclusionA randomized control clinical trial is warranted to assess the efficacy of QL blockade and to compare it with other analgesic options in uterine artery embolization. Bilateral quadratus lumborum blockade may be an excellent pain control option after uterine artery embolization. SignificanceUterine artery embolization is associated with significant postprocedural pain which can prove difficult to manage with opioids. Bilateral quadratus lumborum block may be an excellent pain control option ‐ one that might significantly reduce not only pain, but also the need for opioids and perhaps even the need for hospitaliz...
Source: European Journal of Pain - January 1, 2018 Category: Anesthesiology Authors: B. Ben ‐David, Z. Kaligozhin, D. Viderman Tags: Short Communication Source Type: research

Meta ‐analysis of transcutaneous electrical nerve stimulation for relief of spinal pain
Abstract We conducted a systematic review and meta‐analysis analysing the existing data on transcutaneous electrical nerve stimulation (TENS) or interferential current (IFC) for chronic low back pain (CLBP) and/or neck pain (CNP) taking into account intensity and timing of stimulation, examining pain, function and disability. Seven electronic databases were searched for TENS or IFC treatment in non‐specific CLBP or CNP. Four reviewers independently selected randomized controlled trials (RCTs) of TENS or IFC intervention in adult individuals with non‐specific CLBP or CNP. Primary outcomes were for self‐reported pain...
Source: European Journal of Pain - December 28, 2017 Category: Anesthesiology Authors: L. Resende, E. Merriwether, É.P. Rampazo, D. Dailey, J. Embree, J. Deberg, R.E. Liebano, K.A. Sluka Tags: Review Article Source Type: research

Operant self ‐administration of pregabalin in a mouse model of neuropathic pain
ConclusionsPregabalin showed reinforcing effects both in PSNL and sham‐operated mice and attenuated the nociceptive and emotional manifestations of neuropathic pain in mice self‐administering this drug. Therefore, pregabalin self‐administration was related to neuropathic pain relief, but also to reinforcing properties related to psychotropic drug effects. This study reveals the improvement in nociceptive and emotional manifestations of neuropathic pain after operant pregabalin self‐medication in mice and suggests the reinforcing effects of this drug in an operant paradigm. SignificanceThis study shows that mice wit...
Source: European Journal of Pain - December 27, 2017 Category: Anesthesiology Authors: S.A. Bura, D. Caba ñero, R. Maldonado Tags: Original Article Source Type: research

Blocking of cytokines signalling attenuates evoked and spontaneous neuropathic pain behaviours in the paclitaxel rat model of chemotherapy ‐induced neuropathy
ConclusionsThe findings support the notion that cytokines/chemokines, particularly TNF‐α, IL‐1 and MCP‐1, are involved in the pathophysiology of CIPNP and suggest that strategies that target their inhibition may be effective in treating CIPNP. SignificanceThis study demonstrates that paclitaxel‐treated rats exhibit, in addition to indices of mechanical and cold hypersensitivity, a behavioural sign of spontaneous pain, the principal compliant of patients with neuropathic pain. This was accompanied by upregulation in plasma levels of key cytokines/chemokines (IL‐1α, IL‐1β, IL‐6, TNF‐α, ...
Source: European Journal of Pain - December 27, 2017 Category: Anesthesiology Authors: S. Al ‐Mazidi, M. Alotaibi, T. Nedjadi, A. Chaudhary, M. Alzoghaibi, L. Djouhri Tags: Original Article Source Type: research

A biopsychosocial understanding of lower back pain: Content analysis of online information
ConclusionOnline LBP information retrieved through a Google search has limited to no integration of psychosocial or pain biology information. The focus on tissue pathology is further supported by the inaccurate descriptions of pain as equal to tissue damage and as an input to the central nervous system (CNS). Online LBP information needs to be guided by criteria more sensitive to the psychosocial contributors to pain. SignificanceThe online LBP information retrieved from a Google search needs to be guided by information more sensitive to the psychosocial contributors to pain and disability. This study also highlights the p...
Source: European Journal of Pain - December 27, 2017 Category: Anesthesiology Authors: N.M. Black, S.J. Sullivan, R. Mani Tags: Original Article Source Type: research

Pain patterns during adolescence can be grouped into four pain classes with distinct profiles: A study on a population based cohort of 2953 adolescents
This study examines the patterns of pain in adolescents, and whether these are associated with sports participation, health‐related quality of life (HRQoL), and sex. MethodsIn previously collected cohort data (‘Adolescent Pain in Aalborg‐2011’), adolescents (aged 12–19) completed an online questionnaire, including demographic data, current pain sites, sports participation and HRQoL (assessed by Euro‐QoL 5D‐3L). Latent class analysis was used to classify spatial pain patterns, based on the pain sites. The analysis included 2953 adolescents. ResultsFour classes were identified as follows: (1) little...
Source: European Journal of Pain - December 27, 2017 Category: Anesthesiology Authors: S. Holden, M.S. Rathleff, E.M. Roos, M.B. Jensen, N. Pourbordbari, T. Graven ‐Nielsen Tags: Original Article Source Type: research

The effect of visual feedback of body parts on pain perception: A systematic review of clinical and experimental studies
Abstract The aim of this systematic review was to evaluate the effect of visual feedback techniques on pain perception by analysing the effect of normal‐sized, magnified or minified visual feedback of body parts on clinical and experimentally‐induced pain. Databases searched: Medline, Embase, PsychInfo, PEDro, CINAHL, CENTRAL and OpenSIGLE. Studies investigating pain patients and pain‐free participants exposed to experimentally‐induced pain were analysed separately. Risk of bias was assessed and data were meta‐analysed. Thirty four studies were included. A meta‐analysis of clinical data favoured mirror visual f...
Source: European Journal of Pain - December 22, 2017 Category: Anesthesiology Authors: P.G. Wittkopf, D.M. Lloyd, M.I. Johnson Tags: Review Article Source Type: research