Exploring pain mechanisms in hypermobile Ehlers ‐Danlos syndrome: A case–control study
ConclusionThe results demonstrate increased TSP in hEDS, suggesting increased central pain facilitation. EIH should be studied more extensively but may be disturbed when evaluated in the muscles that are activated during exercise. The CPM results are inconclusive and require more research.SignificanceStudies regarding the mechanisms that underlie pain in hEDS are scarce, although it is the most prevalent and disabling symptom in this patient population. This study demonstrates increased temporal summation in hEDS and suggests that exercise-induced hypoalgesia may be reduced. Because exercise is a cornerstone in the multidi...
Source: European Journal of Pain - May 12, 2022 Category: Anesthesiology Authors: Inge De Wandele, Marlies Colman, Linda Hermans, Jessica Van Oosterwijck, Mira Meeus, Lies Rombaut, Griet Brusselmans, Delfien Syx, Patrick Calders, Fransiska Malfait Tags: ORIGINAL ARTICLE Source Type: research

Nature and nurture. Genetic and environmental factors on the relationship between back pain and sleep quality
ConclusionsNP and LBP share most of their genetic variance, while environmental effects show greater specificity for each of the back pain locations. Associations with SQ were of a limited magnitude. (Source: European Journal of Pain)
Source: European Journal of Pain - May 10, 2022 Category: Anesthesiology Authors: Juan J Madrid ‐Valero, Alessandro Andreucci, Eduvigis Carrillo, Paulo H. Ferreira, Jose M Martínez‐Selva, Juan R Ordoñana Tags: ORIGINAL ARTICLE Source Type: research

Predictors of Outcomes Following Interdisciplinary Acceptance and Commitment Therapy for Chronic Pain: Profiling Psychological Flexibility
ConclusionsPeople with chronic pain demonstrate different PF profiles, but appear to respond to ACT similarly regardless of these profiles. Future studies with a more individualized focus are needed to further understand which components of ACT work for whom on which outcome, and how. (Source: European Journal of Pain)
Source: European Journal of Pain - May 10, 2022 Category: Anesthesiology Authors: Lin Yu, Lance M. McCracken, Whitney Scott Tags: ORIGINAL ARTICLE Source Type: research

Temporal properties of pain contrast enhancement using repetitive stimulation
ConclusionsTPCE can be induced by repetitive stimulation. This finding may be explained by a combination of the mechanisms underlying the OA and a facilitated pain habituation. (Source: European Journal of Pain)
Source: European Journal of Pain - May 10, 2022 Category: Anesthesiology Authors: Tibor M. Szikszay, Waclaw M. Adamczyk, Juliette L. M. L événez, Philip Gouverneur, Kerstin Luedtke Tags: ORIGINAL ARTICLE Source Type: research

Crying does not alleviate acute pain perception: Evidence from an experimental study
ConclusionsResults do not support the idea that crying has pain-alleviating effects, either via distraction or direct biological mechanisms. (Source: European Journal of Pain)
Source: European Journal of Pain - May 6, 2022 Category: Anesthesiology Authors: Asmir Gra čanin, Michelle C. P. Hendriks, Ad J. J. M. Vingerhoets Tags: ORIGINAL ARTICLE Source Type: research

“Botulinum toxin A brands are not the same medications. A comment on Hary et al.”
Abstract- (Source: European Journal of Pain)
Source: European Journal of Pain - May 5, 2022 Category: Anesthesiology Authors: Jaroslaw Slawek Tags: LETTER TO THE EDITOR Source Type: research

Long ‐term observational studies with cannabis‐based medicines for chronic non‐cancer pain: A systematic review and meta‐analysis of effectiveness and safety
ConclusionsInformation included in observational studies should be regarded with caution.Within the context of observational studies, CbMs had positive effects on multiple symptoms for some CNCP patients and were generally well tolerated and safe. (Source: European Journal of Pain)
Source: European Journal of Pain - April 26, 2022 Category: Anesthesiology Authors: Patric Bialas, Mary ‐Ann Fitzcharles, Petra Klose, Winfried Häuser Tags: REVIEW ARTICLE Source Type: research

P2X7 receptor ‐mediated release of microglial prostanoids and miRNAs correlates with reversal of neuropathic hypersensitivity in rats
ConclusionsWe have identified a pain-relevant P2X7 receptor-regulated mechanism in neuropathic rats, which could hold promise as a translatable biomarker and by association enhance the clinical progression of P2X7 receptor antagonists in neuropathic pain.SignificanceSub-optimal translation of preclinical molecules has hindered the clinical development of novel mechanism of action analgesics. We have undertaken a comprehensive in vitro analysis of migroglial signalling mechanisms recruited upon P2X7 receptor activation, a number of which were shown to be modulated by a selective P2X7 receptor antagonist in a well characteri...
Source: European Journal of Pain - April 23, 2022 Category: Anesthesiology Authors: Roland Staal, Tanzilya Khayrullina, Rie Christensen, Sara Hestehave, Hua Zhou, Manuel Cajina, Megan E. Nattini, Adarsh Gandhi, Shaun M. Fallon, Megan Schmidt, Stevin H. Zorn, Robbin M. Brodbeck, Gamini Chandrasena, M ärta Segerdahl, Nathali Tags: ORIGINAL ARTICLE Source Type: research

Limited prognostic value of pain duration in non ‐specific neck pain patients seeking chiropractic care
ConclusionsPain duration did not emerge as an important predictor of outcome in this database of 720 neck pain patients receiving chiropractic treatment. (Source: European Journal of Pain)
Source: European Journal of Pain - April 22, 2022 Category: Anesthesiology Authors: D. Guill én, A. Guekos, N. Graf, B.K. Humphreys, C. Peterson, P. Schweinhardt Tags: ORIGINAL ARTICLE Source Type: research

Impact of the COVID ‐19 pandemic on patients with chronic pain in Germany: associations with expectations and control beliefs
ConclusionsThese findings illustrate the complexity of chronic pain, suggesting that not only the impact of the pandemic on various areas of life but also the severity of the pain-symptoms themselves and psychological factors influence the course of patients ’ symptoms during the pandemic. (Source: European Journal of Pain)
Source: European Journal of Pain - April 21, 2022 Category: Anesthesiology Authors: Diana M üßgens, Lisa Carolin Burgard, Julian Kleine‐Borgmann, Jule Frettlöh, Hardo Sorgatz, Ulrike Bingel Tags: ORIGINAL ARTICLE Source Type: research

Exploring pain mechanisms in hypermobile Ehlers ‐Danlos syndrome: a case‐control study
ConclusionThe results demonstrate increased TSP in hEDS, suggesting increased central pain facilitation. EIH should be studied more extensively, but may be disturbed when evaluated in working muscles. The CPM results are inconclusive and require more research. (Source: European Journal of Pain)
Source: European Journal of Pain - April 20, 2022 Category: Anesthesiology Authors: Inge De Wandele, Marlies Colman, Linda Hermans, Jessica Van Oosterwijck, Mira Meeus, Lies Rombaut, Griet Brusselmans, Delfien Syx, Patrick Calders, Fransiska Malfait Tags: ORIGINAL ARTICLE Source Type: research

Verbascoside administered intrathecally attenuates hyperalgesia via activating mu ‐opioid receptors in a rat chronic constriction injury model
ConclusionsThese findings imply that verbascoside exerts an antihyperalgesic effect by activating µ-opioid receptors in the spinal cord, and that neither caffeic acid nor hydroxytyrosol alone mediates its activity. Verbascoside shows promise for the treatment of neuropathic pain. (Source: European Journal of Pain)
Source: European Journal of Pain - April 20, 2022 Category: Anesthesiology Authors: Koji Hara, Yasunori Haranishi, Tadanori Terada Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - April 19, 2022 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Complex regional pain syndrome what is the outcome? ‐ a systematic review of the course and impact of CRPS at 12 months from symptom onset and beyond
ConclusionsResults provide first time quantitative data specific evidence about losses to motor function and long-term compromises to work status. Results demonstrate the ongoing impact of CRPS on hand function and work status is relatively high. (Source: European Journal of Pain)
Source: European Journal of Pain - April 18, 2022 Category: Anesthesiology Authors: Selina Johnson, Fiona Cowell, Sharon Gillespie, Andreas Goebel Tags: REVIEW ARTICLE Source Type: research

Values ‐based cognitive behavioural therapy for the prevention of chronic whiplash associated disorders: A randomized controlled trial
ConclusionsWhile this indicates that an intervention window for early prevention of disability after whiplash injury may exist, this needs to be tested in a truly early intervention.SignificanceAn early Values-based Cognitive Behavioural Therapeutic intervention delivered within 6  months post-injury (mean days 117) was effective in reducing pain-related disability and psychological distress compared to the control group that received the intervention later after a three months wait-list period. The effects were sustained at 12 months follow-up. The early intervention was s ignificantly more effective in reducing pain-re...
Source: European Journal of Pain - April 11, 2022 Category: Anesthesiology Authors: Tonny Elmose Andersen, Sophie L. Ravn, Anna Mejldal, Kirsten Kaya Roessler Tags: ORIGINAL ARTICLE Source Type: research