Homotopic reduction of laser evoked potential amplitude and laser ‐pain rating by abdominal acupuncture
ConclusionOur findings showing an AA effect on LEP components to both the ipsilateral and contralateral region homotopic to the treated area, without any LEP change to stimulation of a heterotopic region, suggest that the AA analgesia is mediated by a segmental spinal mechanism. (Source: European Journal of Pain)
Source: European Journal of Pain - December 1, 2020 Category: Anesthesiology Authors: Massimiliano Valeriani, Stefano Liguori, Catello Vollono, Elisa Testani, Sergio Bangrazi, Filomena Petti, Aldo Liguori, Marco Germanotta, Luca Padua, Costanza Pazzaglia Tags: ORIGINAL ARTICLE Source Type: research

A linguistic analysis of future narratives in adolescents with Complex Regional Pain Syndrome and their pain ‐free peers
ConclusionsSubstantial differences in cognitive and affective words were found between adolescents with and without CRPS. Findings provide novel insights into current understandings of cognitive, affective and social processes in adolescents living with chronic pain, particularly with regard to adolescent developmental trajectories, and may in turn highlight potential targets in psychosocial interventions for adolescents living with chronic pain. (Source: European Journal of Pain)
Source: European Journal of Pain - December 1, 2020 Category: Anesthesiology Authors: Emy Nimbley, Line Caes, Abigail Jones, Emma Fisher, Melanie Noel, Abbie Jordan Tags: ORIGINAL ARTICLE Source Type: research

Altered regulation of negative affect in patients with fibromyalgia: A diary study
ConclusionsCurrent findings support the idea that patients with fibromyalgia are confronted with fluctuating emotions. These results may have important implications for treatment as they provide support for the use of emotion regulation skills training in patients with fibromyalgia to impact upon NA instability. (Source: European Journal of Pain)
Source: European Journal of Pain - December 1, 2020 Category: Anesthesiology Authors: Silke Rost, Geert Crombez, Stefan S ütterlin, Claus Vögele, Elke Veirman, Dimitri M.L. Van Ryckeghem Tags: ORIGINAL ARTICLE Source Type: research

Pain catastrophizing as a treatment process variable in cognitive behavioural therapy for adults with chronic pain
ConclusionsImplications for our findings, in relation to the CBT model, are discussed. (Source: European Journal of Pain)
Source: European Journal of Pain - November 27, 2020 Category: Anesthesiology Authors: Wesley P. Gilliam, Matthew E. Schumann, Julie L. Cunningham, Michele M. Evans, Connie A. Luedtke, Eleshia J. Morrison, Jeannie A. Sperry, Kevin E. Vowles Tags: Original Article Source Type: research

Predicting long ‐term postsurgical pain by examining the evolution of acute pain
ConclusionsClinically, these results suggest that individual pain ‐state transitions, even within patient or procedural strata associated with PPP, may not alone offer good predictive information regarding PPP. Longitudinal observation in the immediate postoperative period and consideration of patient‐ and surgery‐specific factors may help indicate which pat ients are at increased risk of PPP. (Source: European Journal of Pain)
Source: European Journal of Pain - November 10, 2020 Category: Anesthesiology Authors: C.R. Smith, R. Baharloo, P. Nickerson, M. Wallace, B. Zou, R.B. Fillingim, P. Crispen, H. Parvataneni, C. Gray, H. Prieto, T. Machuca, S. Hughes, G. Murad, P. Rashidi, P.J. Tighe Tags: ORIGINAL ARTICLE Source Type: research

Nerve growth factor sensitizes nociceptors to C ‐fibre selective supra‐threshold electrical stimuli in human skin
AbstractBackgroundIntradermal injection of 1  µg nerve growth factor (NGF) causes sustained nociceptor sensitization. Slowly depolarizing electrical current preferentially activates C‐nociceptors.MethodsWe explored the differential contribution of A ‐delta and C‐nociceptors in NGF‐sensitized skin using slowly depolarizing transcutaneous electrical current stimuli, CO2 laser heat, mechanical impact, and A‐fibre compression block. In 14 healthy volunteers, pain rating was recorded on a numeric scale at days 1–14 after NGF treatment. Rat ings during A‐fibre conduction block were investigated at da...
Source: European Journal of Pain - November 10, 2020 Category: Anesthesiology Authors: Mark Schnakenberg, Christian Thomas, Martin Schmelz, Roman Rukwied Tags: ORIGINAL ARTICLE Source Type: research

Clinical, psychological and quality of life differences in fibromyalgia patients from secondary and tertiary healthcare
ConclusionsOur study supports the “funnel effect” hypothesis among patients of different healthcare levels, with patients from tertiary healthcare services revealing worst clinical status, more somatic and psychological symptoms, and worst HRQL than patients from secondary healthcare services. (Source: European Journal of Pain)
Source: European Journal of Pain - November 10, 2020 Category: Anesthesiology Authors: R.P. Campos, M.I. V ázquez, E. Vilhena Tags: ORIGINAL ARTICLE Source Type: research

Conditioned Pain Modulation affects the N2/P2 complex but not the N1 wave: a pilot study with Laser ‐Evoked Potentials
ConclusionsOur results indicate that CPM affects only the medial pain system. The spinothalamic tract (STT) transmits to both the LT and the MT, while the spinoreticulothalamic (SRT) projects only to the MT. The reduction in the amplitude of the N2/P2 complex and the absence of change in the N1 wave suggest that DNIC inhibition on the dorsal horn neurons affects only pain transmission via the SRT, while the neurons that give rise to the STT are not involved. The N1 wave can be a reliable neurophysiological parameter for assessment of STT function in clinical practice, as it does not seem to be influenced by CPM. (Source: E...
Source: European Journal of Pain - November 10, 2020 Category: Anesthesiology Authors: G Squintani, A Rasera, A Segatti, E Concon, B Bonetti, M Valeriani, M Tinazzi Tags: ORIGINAL ARTICLE Source Type: research

The serotonin receptor 2A (HTR2A) rs6313 variant is associated with higher ongoing pain and signs of central sensitization in neuropathic pain patients
AbstractBackgroundThe serotonin receptor 2A (HTR2A) has been described as an important facilitation mediator of spinal nociceptive processing leading to central sensitization (CS) in animal models of chronic pain. However, whetherHTR2A single nucleotide variants (SNVs) modulate neuropathic pain states in patients has not been investigated so far. The aim of this study was to elucidate the potential association ofHTR2A variants with sensory abnormalities or ongoing pain in neuropathic pain patients.MethodsAt total of 240 neuropathic pain patients and 253 healthy volunteers were included. Patients were phenotypically charact...
Source: European Journal of Pain - November 10, 2020 Category: Anesthesiology Authors: Juliane Sachau, Henrike Bruckmueller, Janne Gierthm ühlen, Walter Magerl, Denisa May, Andreas Binder, Julia Forstenpointner, Judith Koetting, Christoph Maier, Thomas R. Tölle, Rolf‐Detlef Treede, Achim Berthele, Amke Caliebe, Carolin Dies Tags: ORIGINAL ARTICLE Source Type: research

Sensory and pain modulation profiles of ongoing central neuropathic extremity pain in multiple sclerosis
AbstractCentral neuropathic extremity pain (CNEP) is the most frequent type of pain in multiple sclerosis (MS). The aim of the present study was to evaluate sensory and pain modulation profiles in MS patients with CNEP. In a single ‐centre observational study, a group of 56 CNEP MS patients was compared with 63 pain‐free MS patients and with a sex‐ and age‐adjusted control group. Standardized quantitative sensory testing (QST) and dynamic QST (dQST) protocols comprising temporal summation and conditioned pain modulatio n tests were used to compare sensory profiles. Loss‐type QST abnormalities in both thermal and ...
Source: European Journal of Pain - November 10, 2020 Category: Anesthesiology Authors: I. Srotova, J. Kocica, J. Vollert, J. Kolcava, M. Hulova, J. Jarkovsky, L. Dusek, J. Bednarik, E. Vlckova Tags: ORIGINAL ARTICLE Source Type: research

Modulation of SI and ACC response to noxious and non ‐noxious electrical stimuli after the spared nerve injury model of neuropathic pain
ConclusionsWe found different response in SI and ACC to different intensity electrical stimulation based on two features and changes in these features following peripheral nerve injury. We believe that these features may be able to assist to track cortical changes during the chronification of pain in future animal studies. (Source: European Journal of Pain)
Source: European Journal of Pain - November 9, 2020 Category: Anesthesiology Authors: L. T øttrup, G. Diaz‐Valencia, E.N. Kamavuako, W. Jensen Tags: ORIGINAL ARTICLE Source Type: research

Physical activity and cold pain tolerance in the general population
AbstractBackgroundThe relationship between habitual physical activity (PA) and experimental pain tolerance has been investigated in small samples of young, healthy, and/or single ‐sex volunteers. We used a large, population‐based sample to assess this relationship in men and women with and without chronic pain.MethodsWe used data from the sixth and seventh Troms ø Study surveys (2007‐08; 2015‐16), with assessed pain tolerance of participants with the cold‐pressor test (CPT: dominant hand in circulating cold water at 3°C, maximum test‐time 106 seconds), and self‐reported total amount of habitual PA ...
Source: European Journal of Pain - November 9, 2020 Category: Anesthesiology Authors: AP Årnes, CS Nielsen, A Stubhaug, MK Fjeld, LA Hopstock, A Horsch, A Johansen, B Morseth, T Wilsgaard, ÓA Steingrímsdóttir Tags: ORIGINAL ARTICLE Source Type: research

How do patients with Alzheimer's disease imagine their pain?
AbstractIntroductionPain is underdiagnosed and undertreated in patients with Alzheimer's disease (AD). Pain management is of major importance in this population to limit behavioural and functional consequences. Our study aimed to assess the capacity of AD patients to represent pain using a questionnaire exploring daily painful situations and to determine the most appropriate pain scale assessment.MethodsTwenty ‐eight patients with mild AD, 21 with moderate AD and 28 matched controls underwent the Situation Pain Questionnaire (SP‐Q) and assessed imaginary pain with four pain scales. Two scores were compared between the ...
Source: European Journal of Pain - November 7, 2020 Category: Anesthesiology Authors: C éline Borg, Emilie Sala, Hanna Chainay, Julien Labouré, Jean‐Claude Getenet, Jean‐Michel Dorey, Bernard Laurent, Isabelle Rouch Tags: ORIGINAL ARTICLE Source Type: research

‘Drawing a line in the sand’: Physician diagnostic uncertainty in paediatric chronic pain
ConclusionsHow physicians manage diagnostic uncertainty must be understood, as it is likely to critically impact how a diagnosis of chronic pain is communicated, the diagnostic investigations undertaken, the wait time to receiving a diagnosis, and ultimately youths ’ pain experiences. (Source: European Journal of Pain)
Source: European Journal of Pain - November 3, 2020 Category: Anesthesiology Authors: Alexandra Neville, Melanie Noel, Jacqueline Clinch, Tamar Pincus, Abbie Jordan Tags: ORIGINAL ARTICLE Source Type: research

Analgesic effect of music during wound care among patients with diaphyseal tibial fractures: Randomized controlled trial
AbstractBackgroundEvidence is scarce regarding the analgesic effect of music for the relief of acute pain during the care of surgical tibial fracture wounds.ObjectiveTo evaluate the analgesic effect of music on acute procedural pain during the care of surgical tibial fracture wounds.MethodThis was a randomized, controlled, blinded clinical trial with 70 patients in the immediate postoperative period for diaphyseal tibial fracture surgery. Participants were randomly allocated to two groups: a control group (CG), in which patients received only the institution's standard analgesia, and an intervention group (IG) composed of ...
Source: European Journal of Pain - November 1, 2020 Category: Anesthesiology Authors: Maria Cristina Leite Ferraz, Eduesley Santana ‐Santos, Jonas Santana, Caíque Jordan Nunes Ribeiro, Joyce Francielle Nei Bomfim Santana, José Antonio Barreto Alves, Maria do Carmo de Oliveira Ribeiro Tags: ORIGINAL ARTICLE Source Type: research

Faces of clinical pain: inter ‐individual facial activity patterns in shoulder pain patients
ConclusionsThese findings corroborate the hypothesis that facial expressions of acute pain are not uniform. Instead, they are composed of different combinations of pain ‐indicative facial responses, with one omnipresent response, namely “narrowed eyes”. Raising awareness about these inter‐individually different “faces of pain” could improve the recognition and, thereby, its diagnostic training for professionals, like nurses and physicians. (Source: European Journal of Pain)
Source: European Journal of Pain - November 1, 2020 Category: Anesthesiology Authors: Miriam Kunz, Kenneth Prkachin, Patricia E. Solomon, Stefan Lautenbacher Tags: ORIGINAL ARTICLE Source Type: research

Validation of the Questionnaire for Symptom Assessment in Pain disorders for Back pain patients (Q ‐SAP)
ConclusionsThe Q ‐SAP was tested as a useful, valid, and reliable tool. This new questionnaire records classical nociceptive and neuropathic pain symptoms of chronic low back pain patients depending on their local distribution. Furthermore, the questionnaire records the intensity of these symptoms and their influe nce on quality of life and functionality and can be used for the evaluation of treatment. (Source: European Journal of Pain)
Source: European Journal of Pain - October 31, 2020 Category: Anesthesiology Authors: Jan Carl Otto, Janne Gierthm ühlen, Viktoria Kirchhofer, Christoph Borzikowsky, Ralf Baron Tags: ORIGINAL ARTICLE Source Type: research

Dexmedetomidine versus Clonidine Adjuvants to Levobupivacaine for Ultrasound ‐Guided Transversus Abdominis Plane Block in Pediatric Laparoscopic Orchiopexy: Randomized, Double‐Blind Study
AbstractBackgroundLaparoscopic surgeries are associated with less postoperative pain and adverse events compared to open procedures. But, it still reduces quality of life in children. Transversus abdominis plane (TAP) block is used to reduce pain. We hypothesized that dexmedetomidine or clonidine could improve the analgesic profile of levobupivacaine to the same extent during TAP block in children.MethodsNinety children were randomly allocated in a randomized double ‐blind trial to receive bilateral TAP block with levobupivacaine plus normal saline (Group‐B, n=30), or dexmedetomidine (Group‐D, n=30), or clonidine (Gr...
Source: European Journal of Pain - October 31, 2020 Category: Anesthesiology Authors: Mohamed F. Mostafa, Esam Hamed, Ahmed H. Amin, Ragaa Herdan Tags: ORIGINAL ARTICLE Source Type: research

Digital manikins to self ‐report pain on a smartphone: a systematic review of mobile apps
ConclusionsSeveral publically available apps incorporated a manikin for pain reporting, but only few enabled recording of location ‐specific pain aspects, calculating manikin‐derived quantitative scores, or generating summary feedback. For smartphone‐based manikins to become adopted more widely, future developments should harness manikins’ digital nature and include robust validation studies. Involving end users in the development may increase manikins’ acceptability as a tool to self‐report pain. (Source: European Journal of Pain)
Source: European Journal of Pain - October 28, 2020 Category: Anesthesiology Authors: Syed Mustafa Ali, Wei J Lau, John McBeth, William G Dixon, Sabine N van der Veer Tags: REVIEW ARTICLE Source Type: research

Measures of central sensitization and their measurement properties in musculoskeletal trauma: A systematic review
ConclusionsMany measures are used to evaluate CS but with limited established measurement properties in musculoskeletal trauma. High quality research to establish measurement properties of CS outcome measures is required. (Source: European Journal of Pain)
Source: European Journal of Pain - October 27, 2020 Category: Anesthesiology Authors: Nicola Middlebrook, Alison B Rushton, Deepa Abichandani, Pauline Kuithan, Nicola R. Heneghan, Deborah Falla Tags: REVIEW ARTICLE Source Type: research

Identifying participants with knee osteoarthritis likely to benefit from physical therapy education and exercise: a hypothesis ‐generating study
ConclusionsSuch findings suggest that both body perception and osteoarthritis severity may play a role in treatment outcome with exercise. It also raises the possibility that those with higher levels of disrupted body perception may need additional treatment targeted at restoring body perception prior to undertaking exercise. (Source: European Journal of Pain)
Source: European Journal of Pain - October 27, 2020 Category: Anesthesiology Authors: So Tanaka, Tomohiko Nishigami, Benedict Martin Wand, Tasha R Stanton, Akira Mibu, Masami Tokunaga, Takaaki Yoshimoto, Takahiro Ushida Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
European Journal of Pain, Volume 24, Issue 10, Page 1863-1864, November 2020. (Source: European Journal of Pain)
Source: European Journal of Pain - October 22, 2020 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Some like it hot: preference for temperature and pungency consumption is associated with sensitivity to noxious heat
ConclusionsThe association of the reported and measured preferences with noxious heat sensitivity in both relevant and irrelevant body regions, and lack of an ethnicity effect may suggest that these qualities are innate. The association of HPT and spiciness preferences correspond with the mutual activation of the tongue vanilloid receptors by noxious heat and capsaicin.SignificancePeople vary with regard to their temperature and spiciness preferences for reasons yet unknown. The study revealed that these preferences correlate with one another and were associated with the sensitivity to noxious heat but not with age, gender...
Source: European Journal of Pain - October 21, 2020 Category: Anesthesiology Authors: Ruth Defrin, Michal Dekel ‐Steinkeller, Gideon Urca Tags: ORIGINAL ARTICLE Source Type: research

How do patients with Alzheimer ’s disease imagine their pain?
AbstractIntroductionPain is underdiagnosed and undertreated in patients with Alzheimer ’s disease (AD). Pain management is of major importance in this population to limit behavioral and functional consequences. Our study aimed to assess the capacity of AD patients to represent pain using a questionnaire exploring daily painful situations and to determine the most appropriate pain sc ale assessment.MethodsTwenty ‐eight patients with mild AD, 21 with moderate AD and 28 matched controls underwent the Situation Pain Questionnaire (SP‐Q) and assessed imaginary pain with 4 pain scales. Two scores were compared between ...
Source: European Journal of Pain - October 19, 2020 Category: Anesthesiology Authors: C éline Borg, Emilie Sala, Hanna Chainay, Julien Labouré, Jean‐Claude Getenet, Jean‐Michel Dorey, Bernard Laurent, Isabelle Rouch Tags: ORIGINAL ARTICLE Source Type: research

Algomania by Henry Lemesle
AbstractHenry Lemesle (1871 ‐1947), French psychiatrist, graduated from both Angers Medical School (1891) and Caen Law School (1894). He then worked for two years at the Salpêtrière Hospital in Paris. He became a lawyer at Paris Court of Appeals (1894) and promoted the role of the psychiatrist as an expert in criminal case s. (Source: European Journal of Pain)
Source: European Journal of Pain - October 19, 2020 Category: Anesthesiology Authors: E. Drouin, Y. P éréon, P. Hautecoeur Tags: LETTER TO THE EDITOR Source Type: research

Polymorphisms of the μ‐opioid receptor gene influence cerebral pain processing in fibromyalgia
ConclusionsG ‐allele carriers showed increased activation in PCC/precentral gyrus but decreased functional connectivity with the frontal control network during pressure stimulation, suggesting different pain modulatory processes between OPRM1 genotypes involving altered fronto‐parietal network involvement. F urthermore, our results suggest that the overall effects of the OPRM1 G‐allele may be driven by FM subjects. (Source: European Journal of Pain)
Source: European Journal of Pain - October 16, 2020 Category: Anesthesiology Authors: Isabel Ellerbrock, Angelica Sandstr öm, Jeanette Tour, Diana Kadetoff, Martin Schalling, Karin B. Jensen, Eva Kosek Tags: ORIGINAL ARTICLE Source Type: research

Nerve growth factor sensitizes nociceptors to C ‐fiber selective
AbstractBackgroundIntradermal injection of 1 µg nerve growth factor (NGF) causes sustained nociceptor sensitization. Slowly depolarizing electrical current preferentially activates C‐nociceptors.MethodsWe explored the differential contribution of A ‐delta and C‐nociceptors in NGF sensitized skin using slowly depolarizing transcutaneous electrical current stimuli, CO2 laser heat, mechanical impact, and A‐fiber compression block. In 14 healthy volunteers pain rating was recorded on a numeric scale at days 1 – 14 after NGF treatment. Rati ngs during A‐ fiber conduction block were investigated at days 3 a...
Source: European Journal of Pain - October 16, 2020 Category: Anesthesiology Authors: Mark Schnakenberg, Christian Thomas, Martin Schmelz, Roman Rukwied Tags: ORIGINAL ARTICLE Source Type: research

Interpretation of cluster structures in pain ‐related phenotype data using explainable artificial intelligence (XAI)
ConclusionsAssessing the variable importance in clustering is important for understanding any cluster structure. XAI models are able to provide a human ‐understandable interpretation of the cluster structure. Model selection must be adapted individually to the clustering problem. The advantage of comprehensibility comes at an expense of accuracy. (Source: European Journal of Pain)
Source: European Journal of Pain - October 16, 2020 Category: Anesthesiology Authors: J örn Lötsch, Sebastian Malkusch Tags: ORIGINAL ARTICLE Source Type: research

Evidence ‐based treatment recommendations for neck and low back pain across Europe: a systematic review of guidelines
ConclusionsThis review of European CPGs identified a range of mainly non ‐pharmacological recommended treatment options for NLBP that have broad consensus for use across Europe. (Source: European Journal of Pain)
Source: European Journal of Pain - October 16, 2020 Category: Anesthesiology Authors: N. Corp, G. Mansell, S. Stynes, G. Wynne ‐Jones, L. Morsø, J.C. Hill, D.A. van, der Windt Tags: REVIEW ARTICLE Source Type: research

Medical Cannabis Treatment for Chronic Pain: Outcomes and Prediction of Response
AbstractBackgroundAlthough studied in a few randomized controlled trials (RCTs), the efficacy of medical cannabis (MC) for chronic pain remains controversial. Using an alternative approach, this multicenter, questionnaire ‐based prospective cohort was aimed to assess the long‐term effects of MC on chronic pain of various etiologies and to identify predictors for MC treatment success.MethodsPatients with chronic pain, licensed to use MC in Israel reported weekly average pain intensity (primary outcome) and related symptoms before and at 1, 3, 6, 9 and 12 months following MC treatment initiation. A general linear model w...
Source: European Journal of Pain - October 16, 2020 Category: Anesthesiology Authors: Joshua Aviram, Dorit Pud, Tamar Gershoni, Bareket Schiff ‐Keren, Miriam Ogintz, Simon Vulfsons, Tamar Yashar, Adahan Haim‐Moshe, Silviu Brill, Howard Amital, Itay Goor‐Aryeh, Dror Robinson, Leslie Green, Refael Segal, Yacov Fogelman, Tags: ORIGINAL ARTICLE Source Type: research

Metabolomics in Chronic Pain Research
ConclusionsMetabolomics research in chronic pain is at its infancy. Most studies are at the pilot stage. Metabolomics research has been successful in other areas of medicine. These achievements should motivate investigators to expand metabolomics research to improve understanding of the basic mechanisms of human pain, as well as provide tools to diagnose, predict and monitor chronic pain conditions. Metabolomics research can lead to the identification of biomarkers to support the development and testing of treatments, thereby facilitating personalized pain medicine. (Source: European Journal of Pain)
Source: European Journal of Pain - October 16, 2020 Category: Anesthesiology Authors: S. Teckchandani, G.A. Nagana Gowda, D. Raftery, M. Curatolo Tags: REVIEW ARTICLE Source Type: research

The impact of paradigm and stringent analysis parameters on measuring a net conditioned pain modulation effect: A test, re ‐test, control study
AbstractBackgroundReporting in conditioned pain modulation (CPM) studies is not standardised. Here, two CPM protocols were performed in populations of healthy human subjects in order to investigate the influence of CPM paradigm and stringent analyses parameters on identification of a net CPM effect.MethodsA standard thermal or mechanical CPM protocol was carried out on 25 and 17 subjects, respectively. The standard error of measurement (SEM) of the CPM effect was calculated in order to determine a change in pain thresholds greater than that due to measurement error or ‘real’ change in test scores. In addition, ...
Source: European Journal of Pain - October 16, 2020 Category: Anesthesiology Authors: Tatum M Cummins, Stephen B McMahon, Kirsty Bannister Tags: ORIGINAL ARTICLE Source Type: research

‘Drawing a line in the sand’: Physician diagnostic uncertainty in pediatric chronic pain
AbstractMany patients with chronic pain do not receive a diagnosis that precisely explains a pathological cause of their pain (Butow& Sharpe, 2013; Serbic& Pincus, 2013). Over 40% of adults with chronic pain experience diagnostic uncertainty (DU), the perception that a label or explanation for a patient ’s health problem is missing or inaccurate (Serbic& Pincus, 2013), which is associated with elevated levels of anxiety, depression, pain intensity (Serbic et al., 2016), and disability (Geisser& Roth, 1998). (Source: European Journal of Pain)
Source: European Journal of Pain - October 16, 2020 Category: Anesthesiology Authors: Alexandra Neville, Melanie Noel, Jacqueline Clinch, Tamar Pincus, Abbie Jordan Tags: ORIGINAL ARTICLE Source Type: research

Differential effects of visually induced analgesia and attention depending on the pain stimulation site
ConclusionThese data suggest that the modulation of perceived acute pain by visually induced analgesia may be influenced by a simultaneous somatosensory attention task.SignificanceSomatosensory attention reduced experimental pain intensity in the thumb and back in the presence of both congruent and incongruent visual feedback. We found no significant visual feedback effect on the complex interplay between visual feedback and somatosensory attention. (Source: European Journal of Pain)
Source: European Journal of Pain - October 15, 2020 Category: Anesthesiology Authors: Larissa Cordier, Eva Marie Ullrich, Stephan Herpertz, Walter Zieglg änsberger, Jörg Trojan, Martin Diers Tags: ORIGINAL ARTICLE Source Type: research

Time course of DNA methylation in pain conditions: from experimental models to humans
ConclusionsNo time frame can currently be made for the DNA methylation response to pain in any of the reviewed conditions, highlighting an important focus area for future research. (Source: European Journal of Pain)
Source: European Journal of Pain - October 15, 2020 Category: Anesthesiology Authors: Lonnie M øller Johansen, Maria Carla Gerra, Lars Arendt‐Nielsen Tags: REVIEW ARTICLE Source Type: research

Which passengers are on your bus? A taxonomy of the barriers adolescents with chronic pain face in achieving functional recovery
ConclusionThe findings reveal a variety of barriers that were perceived to hinder functional recovery through reduced engagement with age ‐appropriate activities and thereby hamper progress within IIPT. The passenger‐on‐the‐bus metaphor can be used to identify similar barriers faced by adolescents in an individualized treatment approach, thereby making it possible for clinicians to target their IIPT more precisely. (Source: European Journal of Pain)
Source: European Journal of Pain - October 15, 2020 Category: Anesthesiology Authors: Konrad Jacobs, Alisha Smith, Lauren C. Heathcote, Line Caes Tags: ORIGINAL ARTICLE Source Type: research

Acceptance is not acceptance, but acceptance!
AbstractThis journal recently published a paper by Vowles et al., entitled "Initial Evaluation of the Chronic Pain Acceptance Questionnaire – 2. The authors discuss the development of a two‐item measure to assess chronic pain acceptance. Items for this tool were derived from the Chronic Pain Acceptance Questionnaire (CPAQ) 20, and aim to map two key features of acceptance: (1) Activity Engagement, which entails participating in impo rtant or meaningful activities with continued pain and (2) Pain Willingness, which entails a willingness to experience pain without the need to reduce, avoid, or otherwise change i...
Source: European Journal of Pain - October 9, 2020 Category: Anesthesiology Authors: Dimitri M.L. Van Ryckeghem Tags: COMMENTARY Source Type: research

Measures of central sensitisation and their measurement properties in musculoskeletal trauma: A systematic review
ConclusionsMany measures are used to evaluate CS but with limited established measurement properties in musculoskeletal trauma. High quality research to establish measurement properties of CS outcome measures is required. (Source: European Journal of Pain)
Source: European Journal of Pain - October 8, 2020 Category: Anesthesiology Authors: N Middlebrook, AB Rushton, D Abichandani, P Kuithan, NR Heneghan, D Falla Tags: REVIEW ARTICLE Source Type: research

Pain catastrophizing as a treatment process variable in cognitive behavioral therapy for adults with chronic pain
ConclusionsImplications for our findings, in relation to the CBT model, are discussed. (Source: European Journal of Pain)
Source: European Journal of Pain - October 8, 2020 Category: Anesthesiology Authors: Wesley P. Gilliam, Matthew E. Schumann, Julie L. Cunningham, Michele M. Evans, Connie A. Luedtke, Eleshia J. Morrison, Jeannie A. Sperry, Kevin E. Vowles Tags: ORIGINAL ARTICLE Source Type: research

Pain, sensitization and physical performances in patients with chronic painful knee osteoarthritis or chronic pain following total knee arthroplasty: An explorative study
ConclusionsSimilar profiles for pain intensity, signs of sensitization and conditioned pain modulation were observed. Patients with TKA seems to have impaired physical performances compared with the OA group, underlining the importance of targeting physical performances. Only the OA patients showed an association between sensitization (TS) and physical performance.SignificanceQuantitative pain profiling assessment was used to assess pain intensities and pain mechanisms. We observed associations between physical performances and temporal summation in the OA group underlining the importance of assessing motor functions and p...
Source: European Journal of Pain - October 7, 2020 Category: Anesthesiology Authors: Jesper Bie Larsen, Lars Arendt ‐Nielsen, Ole Simonsen, Pascal Madeleine Tags: ORIGINAL MANUSCRIPT Source Type: research

Psychosocial factors associated with Pain and Sexual Function in women with Vulvodynia: A Systematic Review
ConclusionA range of general/pain ‐related distress and avoidance processes, and sex/intimacy avoidance or engagement processes were significantly associated with pain, sexual functioning or sexual distress and sexual satisfaction, supporting the role of a psychosocial approach to PVD. Depression, anxiety, catastrophising, pain‐ anxiety, pain acceptance, body‐exposure anxiety, attention to sexual cues, partner hostility and solicitousness, self‐efficacy, and penetration cognitions are highlighted as potentially important treatment targets in PVD. Due to the limited data available, developing a psychosocial model wa...
Source: European Journal of Pain - September 30, 2020 Category: Anesthesiology Authors: Claudia Chisari, Mani B. Monajemi, Whitney Scott, Rona Moss ‐Morris, Lance M. McCracken Tags: REVIEW ARTICLE Source Type: research

Exploring the contextual role of pain severity as a moderator of the relationship between activity patterns and the physical and mental functioning of women with fibromyalgia
ConclusionsThe results here reported suggest that the context in which behavior occurs is relevant when the utility of certain behavior patterns is considered. The clinical implications of this are clear, as it would justify adapting the recommendations given to patients according to their pain severity status. (Source: European Journal of Pain)
Source: European Journal of Pain - September 29, 2020 Category: Anesthesiology Authors: Carlos Suso ‐Ribera, Patricia Catalá, Carmen Ecija, Lucía Sanromán, Irene López‐Gómez, Ángeles Pastor‐Mira, Cecilia Peñacoba‐Puente Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
European Journal of Pain, Volume 24, Issue 9, Page 1649-1650, October 2020. (Source: European Journal of Pain)
Source: European Journal of Pain - September 26, 2020 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Prescription of exercises for the treatment of chronic pain along the continuum of nociplastic pain: a systematic review with meta ‐analysis
ConclusionsThe choice of parameters regarding exercises should emphasize global exercises in nociplastic pain conditions (such as fibromyalgia and CWAD) and specific exercises in non ‐nociplastic pain conditions (such as CINP) and be based on patient's preference and therapist's skills. (Source: European Journal of Pain)
Source: European Journal of Pain - September 24, 2020 Category: Anesthesiology Authors: Katherinne Ferro Moura Franco, Dorine Lenoir, Yuri Rafael dos Santos Franco, Felipe Jos é Jandre Reis, Cristina Maria Nunes Cabral, Mira Meeus Tags: REVIEW ARTICLE Source Type: research

Six ‐year trends in postoperative prescribing and use of multimodal analgesics following total hip and knee arthroplasty: A single‐site observational study of pain management
AbstractBackgroundGuidelines for acute postoperative pain management recommend administering analgesics in multimodal combination to facilitate synergistic benefit, reduce opioid requirements and decrease side ‐effects. However, limited observational research has examined the extent to which multimodal analgesics are prescribed and administered postoperatively following joint replacement.MethodsIn this longitudinal study, we used three ‐point prevalence surveys to observe the 6‐year trends in prescribing and use of multimodal analgesics on the orthopaedic wards of a single Australian private hospital. We collected ba...
Source: European Journal of Pain - September 23, 2020 Category: Anesthesiology Authors: Damien Khaw, Tracey Bucknall, Julie Considine, Maxine Duke, Ana Hutchinson, Bernice Redley, Richard Steiger, Mari Botti Tags: ORIGINAL ARTICLE Source Type: research

Blockade of Bradykinin Receptors or Angiotensin II Type 2 Receptor Prevents Paclitaxel ‐Associated Acute Pain Syndrome in Mice
ConclusionOur results demonstrated the involvement of bradykinin receptors B1 and B2 as well as AT2R in the induction of P ‐APS in mice and suggest the use of AT2R antagonists as a potential therapy for the prevention of P‐APS in humans. (Source: European Journal of Pain)
Source: European Journal of Pain - September 22, 2020 Category: Anesthesiology Authors: Graziele C. Zanata, Larissa G. Pinto, Nicole R. da Silva, Alexandre H.P. Lopes, Francisco F.B. de Oliveira, Ieda R.S. Schivo, Fernando Q. Cunha, Peter McNaughton, Thiago M. Cunha, Rangel L. Silva Tags: ORIGINAL ARTICLE Source Type: research

Overactivity assessment in chronic pain: the development and psychometric evaluation of a multifaceted self ‐report assessment
ConclusionThe results of this study reinforce the potentially important role of overactivity in the maintenance of pain ‐related suffering and supports a corresponding assessment tool with preliminary psychometric evidence for clinical and research applications. (Source: European Journal of Pain)
Source: European Journal of Pain - September 22, 2020 Category: Anesthesiology Authors: N.E. Andrews, C.W. Chien, D. Ireland, M. Varnfield Tags: ORIGINAL ARTICLE Source Type: research

The impact of parental contact upon cortical noxious ‐related activity in human neonates
ConclusionsThese results show the importance of considering contextual factors in determining infant brain activity and reveal the powerful influence of parental contact upon noxious ‐related activity across the developing human brain.SignificanceThis observational study found that the way in which the neonatal brain processes a noxious stimulus is altered by the type of contact the infant has with their mother. Specifically, being held in skin ‐to‐skin reduces the magnitude of noxious‐related cortical activity. This work has also shown that different neural mechanisms are engaged depending on the mother/infant con...
Source: European Journal of Pain - September 22, 2020 Category: Anesthesiology Authors: Laura Jones, Maria Pureza Laudiano ‐Dray, Kimberley Whitehead, Judith Meek, Maria Fitzgerald, Lorenzo Fabrizi, Rebecca Pillai Riddell Tags: ORIGINAL ARTICLE Source Type: research

Comparison of five conditioned pain modulation paradigms and influencing personal factors in healthy adults
ConclusionsCPT and HWI seem to be the most appropriate conditioned pain modulation paradigms for research settings, while single and double ischemic occlusion seem to be more useful for clinical settings. Influencing factors to be considered are gender, age, stress, physical activity, perceived pain and attentional focus to the conditioning stimulus, but depend on the test site and exerted method. (Source: European Journal of Pain)
Source: European Journal of Pain - September 22, 2020 Category: Anesthesiology Authors: Michel GCAM Mertens, Linda Hermans, Geert Crombez, Lisa Goudman, Patrick Calders, Jessica Van Oosterwijck, Mira Meeus Tags: ORIGINAL ARTICLE Source Type: research

Physiologic osteoclasts are not sufficient to induce skeletal pain in mice
ConclusionThese findings suggest activation of homeostatic osteoclasts alone is not sufficient to induce skeletal pain in mice. (Source: European Journal of Pain)
Source: European Journal of Pain - September 20, 2020 Category: Anesthesiology Authors: Larissa de Clauser, Sonia Santana ‐Varela, John Wood, Shafaq Sikandar Tags: ORIGINAL ARTICLE Source Type: research