Recommendations on the management of pudendal nerve entrapment syndrome: A formalised expert consensus
ConclusionThese recommendations should allow rational and homogeneous management of patients suffering from PNE. They should also allow to shorten the delays of management by directing the primary care.SignificancePudendal nerve entrapment (PNE) has only been known for about 20  years and its management is heterogeneous from one practitioner to another. This work offers a synthesis of the literature and international experts' opinions on the diagnosis and management of PNE. (Source: European Journal of Pain)
Source: European Journal of Pain - October 13, 2021 Category: Anesthesiology Authors: Am élie Levesque, Eric Bautrant, Virginie Quistrebert, Guy Valancogne, Thibault Riant, Marc Beer Gabel, Anne‐Marie Leroi, Katleen Jottard, Luc Bruyninx, Gerard Amarenco, Lara Quintas, Pascale Picard, Thierry Vancaillie, Christine Leveque, Tags: POSITION PAPER Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - October 11, 2021 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Comment on `The value of interdisciplinary treatment for sickness absence in chronic pain: A nationwide register ‐based cohort study`
AbstractLoMartire et al. (2021) investigate the impact of interdisciplinary treatment (IDR) on sickness absence, by analyzing extensive information from a nationwide pain register, linked to the sickness leave ’ nationwide database. However, their ambition to find a control group to ensure sound conclusions is a major problem. (Source: European Journal of Pain)
Source: European Journal of Pain - October 9, 2021 Category: Anesthesiology Authors: M Rivano Fischer, Britt ‐Marie Stålnacke Tags: LETTER TO THE EDITOR Source Type: research

Longitudinal outcome evaluations of interdisciplinary multimodal pain treatment programs for patients with chronic primary musculoskeletal pain: a systematic review and meta ‐analysis
ConclusionsThis study shows that participation in an IMPT program is associated with considerable improvements in wellbeing that are generally maintained at follow-up. The current study also found substantial heterogeneity in dose and treatment content, which suggests different viewpoints on how to optimally design an IMPT program. (Source: European Journal of Pain)
Source: European Journal of Pain - October 8, 2021 Category: Anesthesiology Authors: S. Elbers, H. Wittink, S. Konings, U. Kaiser, J. Kleijnen, J. Pool, A. K öke, R. Smeets Tags: REVIEW ARTICLE Source Type: research

Cannabis ‐based medicines and medical cannabis for patients with neuropathic pain and other pain disorders: Nationwide register‐based pharmacoepidemiologic comparison with propensity score matched controls
ConclusionsBM/MC were generally safe and even displayed some positive effects among patients with neuropathic pain. We conclude that CBM/MC are safe and possibly efficacious for patients with neuropathic pain but not patients with other pain disorders. (Source: European Journal of Pain)
Source: European Journal of Pain - October 8, 2021 Category: Anesthesiology Authors: Carsten Hjorth øj, Peter La Cour, Merete Nordentoft, Christine Merrild Posselt Tags: ORIGINAL ARTICLE Source Type: research

Insight into Pain Syndromes in Acute Phase of Mild ‐to‐Moderate COVID‐19: Frequency, Clinical Characteristics, and Associated Factors
ConclusionPain is a frequently observed symptom of mild-to-moderate COVID-19. There are significant relationships between pain syndromes in COVID-19, which may be due to a sequence of common etiologic factors.SignificanceThis study described the main pain syndromes associated acute phase of mild-to-moderate COVID-19 and its associated features. Headaches and pain of neuropathic characteristics were prevalent in this sample. (Source: European Journal of Pain)
Source: European Journal of Pain - October 8, 2021 Category: Anesthesiology Authors: Emel Oguz ‐Akarsu, Gizem Gullu, Erhan Kilic, Yasemin Dinç, Ahmet Ursavas, Emel Yilmaz, Mehmet Zarifoglu, Necdet Karli, Pandemic Study Team, Halis Akalın, Mustafa Hacı Mustafaoglu, Erol Armagan, Cagri Hunutlu, Aynur Urhan, Esra Kazak, Y Tags: ORIGINAL ARTICLE Source Type: research

Pain catastrophizing mediates rapid benefits of accessing in ‐person chiropractic care during the COVID–19 lockdown
ConclusionAccess to in-person chiropractic care may provide pain relief, associated with reductions in interference and pain cognitions. Prioritizing in-person care for patients with maladaptive pain cognitions may help dampen the detrimental consequences of the pandemic on physical and psychological well-being. (Source: European Journal of Pain)
Source: European Journal of Pain - October 8, 2021 Category: Anesthesiology Authors: C. Gevers ‐Montoro, Z. Deldar, F.M. Conesa‐Buendía, E.A. Lazar, I. Mahillo‐Fernandez, A. Khatibi, A. Ortega de Mues Tags: ORIGINAL ARTICLE Source Type: research

Dyadic analysis of adolescent friendships behaviours during pain: Comparison of those with chronic pain versus those without chronic pain
ConclusionsStrategies aimed at improving social interactions for adolescents with chronic pain while they are experiencing pain are discussed. Research is needed to understand how different peer relationships influence pain tolerance in adolescents with chronic pain. (Source: European Journal of Pain)
Source: European Journal of Pain - October 6, 2021 Category: Anesthesiology Authors: P. A. Forgeron, C. Chambers, B. D. Dick, J. Cohen, G. A. Finley, C. Lamontagne Tags: ORIGINAL ARTICLE Source Type: research

Central sensitization of dorsal root potentials and dorsal root reflexes: An in vitro study in the mouse spinal cord.
ConclusionsOur findings suggest the existence of independent spinal circuits at the origin of PAD and DRRs. Inflammation modulates these circuits differentially, unveiling varied mechanisms of spinal sensitization. Thisin vitro approach provides an isolated model for the study of the mechanisms of central sensitization and for the performance of pharmacological assays with the purpose of identifying and testing novel antinociceptive targets.SignificanceSpinal circuits modulate activity of primary afferents acting on central terminals. Underin vitro conditions, dorsal roots show spontaneous activity in the form of depolariz...
Source: European Journal of Pain - October 5, 2021 Category: Anesthesiology Authors: Jorge Vicente ‐Baz, Jose Antonio Lopez‐Garcia, Ivan Rivera‐Arconada Tags: ORIGINAL ARTICLE Source Type: research

Metabolomic and proteomic characterization of sng and pain phenotypes in fibromyalgia
ConclusionsIn this study, we identified potential biomarkers from FM patients. The selected biomarkers could discriminate sng and pain phenotypes in FM patients. These results could help elucidate the underlying pathological mechanisms for more effective diagnosis and therapy for FM. (Source: European Journal of Pain)
Source: European Journal of Pain - October 5, 2021 Category: Anesthesiology Authors: Wei ‐Hsiang Hsu, Der‐Sheng Han, Wei‐Chi Ku, Yen‐Ming Chao, Chih‐Cheng Chen, Yun‐Lian Lin Tags: ORIGINAL ARTICLE Source Type: research

Patients ’ self‐reported physical and psychological effects of opioid use in chronic noncancer pain – a retrospective cross‐sectional analysis
ConclusionsIn addition to the well-known physical side-effects, CNCP patients taking strong opioids experience significant psychological effects. In view of these effects, discontinuation of opioid therapy should be discussed early to ensure their benefits do not outweigh their harm. (Source: European Journal of Pain)
Source: European Journal of Pain - October 1, 2021 Category: Anesthesiology Authors: Erika Schulte, Claudia Spies, Claudia Denke, Joerg J. Meerpohl, Norbert Donner ‐Banzhoff, Frank Petzke, Ralph Hertwig, Michael Schäfer, Odette Wegwarth Tags: ORIGINAL ARTICLE Source Type: research

Pain Relief by Movement Representation Strategies: An Umbrella and Mapping Review with Meta ‐Meta‐Analysis of Motor Imagery, Action Observation and Mirror Therapy
ConclusionResults show that MRM could be effective for chronic musculoskeletal pain, with low to moderate-quality evidence. The results also show a reduction in pain intensity through MT interventions in patients with CRPS, although these results were not found in patients with PLP or poststroke pain. (Source: European Journal of Pain)
Source: European Journal of Pain - September 30, 2021 Category: Anesthesiology Authors: Ferran Cuenca ‐Martínez, Álvaro Reina‐Varona, Juan Castillo‐García, Roy La Touche, Santiago Angulo‐Díaz‐Parreño, Luis Suso‐Martí Tags: REVIEW ARTICLE Source Type: research

Effectiveness of self ‐myofascial release combined with biofeedback and electrical stimulation for the management of myofascial pelvic pain: a randomized controlled trial
ConclusionsThis study confirmed that the addition of SMFR to BES treatment resulted in superior outcomes compared to those with BES alone in patients with MFPP. (Source: European Journal of Pain)
Source: European Journal of Pain - September 30, 2021 Category: Anesthesiology Authors: Jingyun Xu, Kai Chen, Bo Ding, Mingyue Zhu, Shanshan Yao, Mulan Ren, Yang Shen Tags: ORIGINAL ARTICLE Source Type: research

Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: a multicentre observational cross ‐sectional study
AbstractBackgroundDespite the high prevalence of depression and anxiety in chronic pain conditions, current knowledge concerning emotional distress among painful diabetic polyneuropathy (pDSPN) and other diabetes mellitus (DM) sufferers is limited.MethodsThis observational multi-centre cohort study employed the Hospital Anxiety and Depression Scale, the Beck Depression Inventory II and the State-Trait Anxiety Inventory to assess symptoms of depression and anxiety in several groups with diabetes, as well as in a control group. The study cohort included 347 pDSPN patients aged 63.4 years (median), 55.9% males; 311 pain-free ...
Source: European Journal of Pain - September 30, 2021 Category: Anesthesiology Authors: David Kec, Aneta Rajdova, Jana Raputova, Blanka Adamova, Iva Srotova, Eva Kralickova Nekvapilova, Radka Neuzilova Michalcakova, Magda Horakova, Jana Belobradkova, Jindrich Olsovsky, Pavel Weber, Gabriel Hajas, Michaela Kaiserova, Radim Mazane Tags: ORIGINAL ARTICLE Source Type: research

Five ‐year Observational Study of Internet‐Delivered Cognitive Behavioural Pain Management when offered as Routine Care by an Online Therapy Clinic
ConclusionsThis longitudinal observational study provides support for internet-delivered cognitive behavioural PMPs when offered as routine care by an online therapy clinic. (Source: European Journal of Pain)
Source: European Journal of Pain - September 30, 2021 Category: Anesthesiology Authors: Heather D. Hadjistavropoulos, Vanessa Peynenburg, David Thiessen, Luke H. Schneider, Marcie Nugent, Andrew Wilhelms, Eyal Karin, Nickolai Titov, Blake F. Dear Tags: ORIGINAL ARTICLE Source Type: research

Central sensitisation of dorsal root potentials and dorsal root reflexes: An in vitro study in the mouse spinal cord
ConclusionsOur findings suggest the existence of independent spinal circuits at the origin of PAD and DRRs. Inflammation modulates these circuits differentially, unveiling varied mechanisms of spinal sensitisation. Thisin vitro approach provides an isolated model for the study of the mechanisms of central sensitisation and for the performance of pharmacological assays with the purpose of identifying and testing novel antinociceptive targets. (Source: European Journal of Pain)
Source: European Journal of Pain - September 29, 2021 Category: Anesthesiology Authors: J Vicente ‐Baz, JA Lopez‐Garcia, I Rivera‐Arconada Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - September 17, 2021 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Dance and Yoga Reduced Functional Abdominal Pain in Young Girls: A Randomized Controlled Trial
ConclusionsAn intervention using dance and yoga is likely a feasible and beneficial complementary treatment to standard health care for 9- to 13-year-old girls with FAPDs. (Source: European Journal of Pain)
Source: European Journal of Pain - September 16, 2021 Category: Anesthesiology Authors: S H ögström, A Philipson, L Ekstav, M Eriksson, U L. Fagerberg, E Falk, M Möller, E Sandberg, S Särnblad, A Duberg Tags: ORIGINAL ARTICLE Source Type: research

Auditory change ‐related cortical response is associated with hypervigilance to pain in healthy volunteers
ConclusionsGeneralized hypervigilance may be observed even in healthy subjects. ACR may be a useful index to evaluate the hypervigilance state in the human brain. (Source: European Journal of Pain)
Source: European Journal of Pain - September 16, 2021 Category: Anesthesiology Authors: N Otsuru, M Ogawa, H Yokota, S Miyaguchi, S Kojima, K Saito, Y Inukai, H Onishi Tags: ORIGINAL ARTICLE Source Type: research

Body Representation among Adults with Phantom Limb Pain: Results from a Foot Identification Task
ConclusionsAdults with phantom limb pain demonstrate body representation impairments as compared to controls with intact limbs. Body representation impairments, however, may not be unique to phantom limb pain, given similar performance between adults with and without phantom limb pain following lower-limb loss. (Source: European Journal of Pain)
Source: European Journal of Pain - September 7, 2021 Category: Anesthesiology Authors: E.H. Beisheim, R.T. Pohlig, J. Medina, G.E. Hicks, J.M. Sions Tags: ORIGINAL ARTICLE Source Type: research

Intraoperative pain during caesarean delivery: Incidence, risk factors and physician perception
ConclusionsWe found a substantial incidence (11.9%) of intraoperative pain during caesarean delivery. Preoperative anxiety did not predict intraoperative pain. Physicians did not accurately identify parturients ’ intraoperative pain.SignificanceIntraoperative pain occurred in 11.9% and severe intraoperative pain occurred in 1.11% of parturients undergoing elective caesarean delivery under spinal anaesthesia. We did not find any preoperative variables that could reliably predict intraoperative pain. Obstetricians and anaesthesiologists underestimated the incidence of intraoperative pain in our cohort and thus, more at...
Source: European Journal of Pain - September 1, 2021 Category: Anesthesiology Authors: Amir Keltz, Philip Heesen, Daniel Katz, Ido Neuman, Anna Morgenshtein, Karem Azem, Yair Binyamin, Eran Hadar, Leonid A. Eidelman, Sharon Orbach ‐Zinger Tags: ORIGINAL ARTICLE Source Type: research

Mirror therapy for phantom limb pain in moderate intellectual disability. A case report
ConclusionsThis is a unique case-report on the use of MT with an individual with IDD suffering from PLP. The findings show that MT helped to significantly reduce the intensity of the PLP in this patient. (Source: European Journal of Pain)
Source: European Journal of Pain - August 31, 2021 Category: Anesthesiology Authors: Annabel Folch, Daniel Gallo, Jordi Mir ó, Luis Salvador‐Carulla, Rafael Martínez‐Leal Tags: ORIGINAL ARTICLE Source Type: research

Temporal changes in pain processing after whiplash injury, based on Quantitative Sensory Testing: a systematic review
ConclusionsDifferences in pain processing between recovering and non-recovering patients can be observed already in the acute phase. Early screening for signs of altered pain processing can identify patients with high risk for chronification. These insights in temporal changes show the importance of rehabilitation in the acute phase. Future research should target to develop a standardized (bed-site) QST protocol and collect normative data which could, in relation with self-reported pain parameters, allow clinicians to identify the risk for chronification. (Source: European Journal of Pain)
Source: European Journal of Pain - August 31, 2021 Category: Anesthesiology Authors: J. Bontinck, D. Lenoir, B. Cagnie, C. Murillo, I. Timmers, E. Cnockaert, L. Bernaers, M. Meeus, I. Coppieters Tags: ORIGINAL ARTICLE Source Type: research

Spinal beta ‐amyloid1‐42 acts as an endogenous analgesic peptide in CCI‐induced neuropathic pain
ConclusionsThese findings suggest that spinal A β1–42 acts as an endogenous analgesic peptide through regulating cytokines and Wnt pathways. This study may provide a potential target for the development of novel analgesic peptides.SignificanceThis study provides an explanation of reduced pain sensitivity associated with Alzheimer ’s disease. Furthermore, our findings propose a possible physiological function of beta-amyloid1–42 to regulate pain. This study may provide a potential target for the development of novel analgesics based on an existing endogenous peptide. (Source: European Journal of Pain)
Source: European Journal of Pain - August 31, 2021 Category: Anesthesiology Authors: Dong Cui, Ze ‐Hua. Li, Cheng Li, Chengjie Qiu, Pingchuan Ma, Mingzheng Wu, Xue‐Jun Song Tags: ORIGINAL ARTICLE Source Type: research

Commentary on “The role of psychological flexibility, perceived injustice, and body‐image in Vulvodynia: a longitudinal study" by Chisari et al.
AbstractThis journal recently published a paper by Chisari et al., entitled “The role of psychological flexibility, perceived injustice, and body-image in Vulvodynia: a longitudinal study” (Chisari, Budhraja, et al., 2021). The study found that committed action positively predicted depression at 3 months and pain acceptance positively predicted pain interference at 3 mo nths. Neither present moment awareness, perceived injustice, nor body exposure anxiety and avoidance during sexual activities were significant predictors of any outcome measures. Research into psychological factors in vulvodynia is lacking (Chis...
Source: European Journal of Pain - August 29, 2021 Category: Anesthesiology Authors: Chalmers K Jane Tags: COMMENTARY Source Type: research

Intraoperative pain during Cesarean delivery: Incidence, risk factors and physician perception
ConclusionsWe found a substantial incidence (11.9%) of intraoperative pain during Cesarean delivery. Preoperative anxiety did not predict intraoperative pain. Physicians did not accurately identify parturients ’ intraoperative pain. (Source: European Journal of Pain)
Source: European Journal of Pain - August 27, 2021 Category: Anesthesiology Authors: A. Keltz, P. Heesen, D. Katz, I. Neuman, A. Morgenshtein, K. Azem, Y. Binyamin, E. Hadar, L. A. Eidelman, S. Orbach ‐Zinger Tags: ORIGINAL ARTICLE Source Type: research

Morning and evening salivary cortisol levels in patients with chronic widespread pain and those at high risk
ConclusionsThis study indicates elevated salivary cortisol in FM and those at high risk, and identifies anxiety, depression, and sleep problems as potential contributing factors. The results shed light on the dynamic relationship between stress, mood and sleep disorders and the brain ’s resilience to pain. (Source: European Journal of Pain)
Source: European Journal of Pain - August 26, 2021 Category: Anesthesiology Authors: Nayab Begum, Jason Taylor, Christopher Brown, Jonathan Rajan, Brian Keevil, Emily Pye, Timothy Rainey, Anthony Jones Tags: ORIGINAL ARTICLE Source Type: research

Comment on ‘Intrathecal dexmedetomidine and postoperative pain: A systematic review and meta‐analysis of randomized controlled trials’
(Source: European Journal of Pain)
Source: European Journal of Pain - August 19, 2021 Category: Anesthesiology Authors: Guolong Jia, Yanping Li, Feng Yang Tags: LETTER TO THE EDITOR Source Type: research

When one suffers less, all suffer less: individual pain ratings are more effective than group ratings in producing placebo hypoalgesia
ConclusionsVerbal modeling can produce placebo hypoalgesia and reduce pain sensations. It may be effectively used in clinical practice to modify patients ’ responses to pain treatment. (Source: European Journal of Pain)
Source: European Journal of Pain - August 16, 2021 Category: Anesthesiology Authors: E.A. Bajcar, K. Wiercioch ‐Kuzianik, J. Brączyk, D. Farley, H. Bieniek, P. Bąbel Tags: ORIGINAL ARTICLE Source Type: research

The effects of attentional and interpretation biases on later pain outcomes among younger and older adults: a prospective study
ConclusionsThe present study provided evidence for pain status and age group differences in injury-/illness-related interpretation biases. Results also revealed distinct roles of interpretation and attentional biases in pain chronicity. (Source: European Journal of Pain)
Source: European Journal of Pain - August 16, 2021 Category: Anesthesiology Authors: Frederick H. F. Chan, Hin Suen, Antoni B. Chan, Janet H. Hsiao, Tom J. Barry Tags: ORIGINAL ARTICLE Source Type: research

Mechanisms of Change in Acceptance and Commitment Therapy for Primary Headaches
ConclusionsThese findings demonstrate that changes in certain PF processes lower disability and improve quality of life in headache sufferers, supporting that ACT works via its proposed mechanisms of change. Interventions for headache management may be optimized if they target increases in headache acceptance,  defusion from thoughts, and mindfulness. (Source: European Journal of Pain)
Source: European Journal of Pain - August 11, 2021 Category: Anesthesiology Authors: Vasilis S. Vasiliou, Evangelos C. Karademas, Yiolanda Christou, Savvas Papacostas, Maria Karekla Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - August 10, 2021 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Are mindfulness treatments effective for pain in cancer patients? A systematic review and meta ‐analysis
AbstractMindfulness-based interventions (MBIs) have been recently applied in pain management and cancer care. However, inconsistencies exist concerning the effectiveness of MBIs on pain control among cancer patients. Therefore, this study aimed to examine the efficacy of MBIs on pain in cancer patients via a systematic review and meta-analysis of randomized controlled trials (RCTs). Databases (MEDLINE, PubMed, Embase, CINAHL, PsycINFO, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov) were searched using key terms related to pain, cancer, and mindfulness. The primary outcome was pain intensity. Standa...
Source: European Journal of Pain - August 9, 2021 Category: Anesthesiology Authors: B. Feng, X. Hu, W.W. Lu, Y. Wang, W.Y. Ip Tags: REVIEW ARTICLE Source Type: research

Comment on "Intrathecal dexmedetomidine and postoperative pain: A systematic review and meta ‐analysis of randomized controlled trials"
AbstractWe had the great pleasure of reading the article titled "Intrathecal dexmedetomidine and postoperative pain: A systematic review and meta-analysis of randomized controlled trials" written by Paramasivan et al. The authors concluded that “the analgesic role of intrathecal dexmedetomidine is promising due to its ability to significantly increase postoperative analgesic duration when compared with placebo” (Paramasivan et al., 2020). At the outset, the authors should be congratulated for conducting a well-designed study and examin ing a very important topic in perioperative medicine. Nevertheless...
Source: European Journal of Pain - August 9, 2021 Category: Anesthesiology Authors: Guolong Jia, Yanping Li, Feng Yang Tags: LETTER TO THE EDITOR Source Type: research

Motor performance and back pain in children and adolescents: a systematic review
AbstractBackground and ObjectiveMotor performance during childhood and adolescence is recognized as a relevant determinant of present and future health, but its effects on back pain (BP) remain unclear. In this systematic review, we aimed to identify the association between motor performance and BP in children and adolescents.Databases and Data TreatmentA literature search was performed in the MEDLINE, Scopus, Embase, SPORTDiscus, and CINAHL databases. We included cross-sectional, cohort, case-control, and controlled clinical trials (data from control groups). The inclusion criteria were as follows: (a) participants aged 6...
Source: European Journal of Pain - August 8, 2021 Category: Anesthesiology Authors: Matias Noll, Per Kjaer, Carolina Mendon ça, Niels Wedderkopp Tags: REVIEW ARTICLE Source Type: research

The role of psychological flexibility, perceived injustice and body image in Vulvodynia: A longitudinal study
ConclusionsAmong women with Vulvodynia, pain acceptance and committed action are prospectively associated with pain interference and depression. The reliability and generalizability of these results needs to be established given the overlap with the COVID-19 pandemic. Future studies should investigate whether targeting these factors enhances outcomes in Vulvodynia.SignificanceThis longitudinal study explored the role of PF, perceived injustice and body image during sexual activities in predicting pain severity, pain interference, sexual functioning, sexual satisfaction and depression in women with Vulvodynia. The study fin...
Source: European Journal of Pain - August 3, 2021 Category: Anesthesiology Authors: Claudia Chisari, Mahira Budhraja, Mani B. Monajemi, Fiona Lewis, Rona Moss ‐Morris, Whitney Scott, Lance M. McCracken Tags: ORIGINAL ARTICLE Source Type: research

Will Persistent Spinal Pain Syndrome replace Failed Back Surgery Syndrome?
AbstractFailed back surgery syndrome (FBSS) is a stigmatizing and misleading term, and in many cases surgery is not relevant to the development, persistence, worsening or recurrence of the symptoms. An international panel recently proposed the notion of Persistent spinal pain syndrome (PSPS) as the preferred option to replace FBSS. The new label avoids ambiguity and inappropriately-implied causation. PSPS type 1 applies when there was no spinal surgery; type 2 applies when surgery had occurred. PSPS is therefore broader than FBSS but more accurate. (Source: European Journal of Pain)
Source: European Journal of Pain - August 2, 2021 Category: Anesthesiology Authors: B. A. Simpson, N. Christelis, M. Russo, M. Stanton ‐Hicks, G. Barolat, S. Thomson Tags: LETTER TO THE EDITOR Source Type: research

Conditioned pain modulation and pain sensitivity in functional somatic disorders: The DanFunD study
The objective of this study was to examine a general population sample, encompassing three delimitations of FSD while assessing pain sensitivity and conditioning pain modulation (CPM).Pressure pain thresholds (PPTs) at the tibialis and trapezius muscles were recorded at baseline. During cold pressor stimulation of the hand, the tibialis PPTs were re-assessed and the difference from baseline measures defined the CPM effect. Participants (n=2,198, 53% females) were randomly selected from the adult Danish population. FSD was established by self-reported symptom questionnaires.With a few exceptions, only weak associations were...
Source: European Journal of Pain - July 26, 2021 Category: Anesthesiology Authors: M.W. Petersen, S. Skovbjerg, J.S. Jensen, T. Carstensen, T.M. Dantoft, P. Fink, M.E. Benros, E.L. Mortensen, T. J ørgensen, L.K. Gormsen Tags: ORIGINAL ARTICLE Source Type: research

Comment on “Dexmedetomidine versus clonidine adjuvants to levobupivacaine for ultrasound‐guided transversus abdominis plane block in paediatric laparoscopic orchiopexy: Randomized, double‐blind study”
(Source: European Journal of Pain)
Source: European Journal of Pain - July 22, 2021 Category: Anesthesiology Authors: Dongdong Yu, Li Jiang, Xiaoyu Wang, Jianli Li Tags: LETTER TO THE EDITOR Source Type: research

Platelet ‐rich plasma and cytokines in neuropathic pain: a narrative review and a clinical perspective
ABSTRACTNeuropathic pain arises as a direct consequence of a lesion or disease affecting the somatosensory system. A number of preclinical studies have provided evidence for the involvement of cytokines, predominantly secreted by a variety of immune cells and by glial cells from the nervous system, in neuropathic pain conditions. Clinical trials and use of anti-cytokine drugs in different neuropathic etiologies support the relevance of cytokines as treatment targets. However, the use of such drugs, in particularly biotherapies, can provoke notable adverse effects. Moreover, it is challenging to select one given cytokine as...
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: Yohann Bohren, Daniel Ionut Timbolschi, Andr é Muller, Michel Barrot, Ipek Yalcin, Eric Salvat Tags: REVIEW ARTICLE Source Type: research

Phantom limb pain after unilateral arm amputation is associated with decreased heat pain thresholds in the face
In this study, we applied QST in 37 unilateral upper-limb amputees (23 with, 14 without PLP) and 19 healthy controls. We assessed heat pain (HPT), pressure pain (PPT), warmth detection (WDT), and two-point discrimination thresholds at the residual limb, a homologous point and the thenar of the intact limb as well as both corners of the mouth. We did not find significant differences in any of the thresholds between the groups. However, PLP intensity was negatively associated with HPT at all measured body sites except for the residual limb, indicating lower pain thresholds with higher PLP levels. Correlations between HPT and...
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: Xaver Fuchs, Martin Diers, J örg Trojan, Pinar Kirsch, Christopher Milde, Robin Bekrater‐Bodmann, Mariela Rance, Jens Foell, Jamila Andoh, Susanne Becker, Herta Flor Tags: ORIGINAL ARTICLE Source Type: research

The role of psychological flexibility, perceived injustice, and body ‐image in Vulvodynia: a longitudinal study
ConclusionsAmong women with Vulvodynia, pain acceptance and committed action are prospectively associated with pain-interference and depression. The reliability and generalisability of these results needs to be established given the overlap with the COVID-19 pandemic. Future studies should investigate whether targeting these factors enhances outcomes in Vulvodynia. (Source: European Journal of Pain)
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: Claudia Chisari, Mahira Budhraja, Mani B. Monajemi, Fiona Lewis, Rona Moss ‐Morris, Whitney Scott, Lance M. McCracken Tags: ORIGINAL ARTICLE Source Type: research

Original article: Spinal beta ‐amyloid1‐42 acts as an endogenous analgesic peptide in CCI‐induced neuropathic pain
ConclusionsThese findings suggest that spinal A β1-42 acts as an endogenous analgesic peptide through regulating cytokines and Wnt pathways. This study may provide a potential target for the development of novel analgesic peptides. (Source: European Journal of Pain)
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: Dong Cui, Ze ‐Hua. Li, Cheng Li, Chengjie Qiu, Pingchuan Ma, Mingzheng Wu, Xue‐Jun. Song Tags: ORIGINAL ARTICLE Source Type: research

Association of Temporomandibular Disorders with Pain Sensitivity: a cohort study
ConclusionsThe pain regulatory mechanisms behind TMD act differently between the sexes as local TMD among females and MSP-linked TMD among males associated with pain sensitivity. (Source: European Journal of Pain)
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: J Knuutila, J Kivipuro, R N äpänkangas, J Auvinen, P Pesonen, J Karppinen, M Paananen, P Pirttiniemi, A Raustia, K Sipilä Tags: ORIGINAL ARTICLE Source Type: research

Transcutaneous electrical stimulation in neck pain: a systematic review and meta ‐analysis
ConclusionsES combined with other intervention seems to be useful to relieve pain and to improve disability in people with NP, however more studies are needed. (Source: European Journal of Pain)
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: É. P. Rampazo, C.C. S. Martignago, M. de Noronha, R. E. Liebano Tags: REVIEW ARTICLE Source Type: research

Modulatory role of the orexin system in stress ‐induced analgesia: Involvement of the ventral tegmental area
ConclusionThe findings suggest that OX1 and OX2 receptors in the VTA might modulate the antinociceptive behaviors induced by FSS in part. (Source: European Journal of Pain)
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: Kobra Askari, Shahrbanoo Oryan, Akram Eidi, Jalal Zaringhalam, Abbas Haghparast Tags: ORIGINAL ARTICLE Source Type: research

Early age at menarche is associated with post ‐menarche back pain: An analysis of the Raine Study
ConclusionThere is evidence of an association, in this cohort, of early AAM with post-menarche BP. This result identifies an area for future exploration, including understanding this mechanism which may lead to the development of effective intervention measures.SignificanceAge at menarche is related to a range of health issues. This study sought to investigate if it was a risk factor for spinal pain. We used an existing Australian data base to explore this possibility and found an association with early age onset and post-menarche back pain. This result identifies an area for future exploration, including understanding thi...
Source: European Journal of Pain - July 19, 2021 Category: Anesthesiology Authors: Stanley Innes, Angela Jacques, Karin Scott, Bruce Walker Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - July 16, 2021 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Early and late visual deprivation induce hypersensitivity to mechanical and thermal noxious stimuli in the ZRDBA mouse.
AbstractVisual deprivation leads to behavioral adaptations. Early visual deprivation has greater effects on sensory systems compared with late visual deprivation. Although this has been well studied, the impact of visual deprivation on pain sensitivity has scarcely been investigated. In humans, one study indicates that pain sensitivity is increased in early, but not late-onset blindness. In animals, one study indicates that sensitivity to noxious stimulation is increased in anophthalmic mice, but the impact of late visual deprivation on sensitivity remains unknown. The aim of this behavioral study was to examine sensitivit...
Source: European Journal of Pain - July 15, 2021 Category: Anesthesiology Authors: Sara Touj, Thierry Paquette, Gilles Bronchti, Mathieu Pich é Tags: ORIGINAL ARTICLE Source Type: research

Economic long ‐term effects of intensive interdisciplinary pain treatment in paediatric patients with severe chronic pain: Analysis of claims data
ConclusionThe results of this study support prior findings on the high economic burden of paediatric chronic pain. IIPT may contribute to a transition in healthcare utilization from somatic-focused treatments to more psychological treatments. Overall costs were reduced as soon as the first year after discharge and decreased even further in the second year.SignificanceThis study analyses original claims data from paediatric chronic pain patients in the year before and up to 2  years after intensive interdisciplinary pain treatment in a specialized paediatric pain centre. The analysis of long-term data reveals a continu...
Source: European Journal of Pain - July 13, 2021 Category: Anesthesiology Authors: Susanne Lopez Lumbi, Ann ‐Kristin Ruhe, Ingo Pfenning, Julia Wager, Boris Zernikow Tags: ORIGINAL ARTICLE Source Type: research