The role of psychological flexibility, perceived injustice and body image in Vulvodynia: A longitudinal study
ConclusionsAmong women with Vulvodynia, pain acceptance and committed action are prospectively associated with pain interference and depression. The reliability and generalizability of these results needs to be established given the overlap with the COVID-19 pandemic. Future studies should investigate whether targeting these factors enhances outcomes in Vulvodynia.SignificanceThis longitudinal study explored the role of PF, perceived injustice and body image during sexual activities in predicting pain severity, pain interference, sexual functioning, sexual satisfaction and depression in women with Vulvodynia. The study fin...
Source: European Journal of Pain - August 3, 2021 Category: Anesthesiology Authors: Claudia Chisari, Mahira Budhraja, Mani B. Monajemi, Fiona Lewis, Rona Moss ‐Morris, Whitney Scott, Lance M. McCracken Tags: ORIGINAL ARTICLE Source Type: research

Will Persistent Spinal Pain Syndrome replace Failed Back Surgery Syndrome?
AbstractFailed back surgery syndrome (FBSS) is a stigmatizing and misleading term, and in many cases surgery is not relevant to the development, persistence, worsening or recurrence of the symptoms. An international panel recently proposed the notion of Persistent spinal pain syndrome (PSPS) as the preferred option to replace FBSS. The new label avoids ambiguity and inappropriately-implied causation. PSPS type 1 applies when there was no spinal surgery; type 2 applies when surgery had occurred. PSPS is therefore broader than FBSS but more accurate. (Source: European Journal of Pain)
Source: European Journal of Pain - August 2, 2021 Category: Anesthesiology Authors: B. A. Simpson, N. Christelis, M. Russo, M. Stanton ‐Hicks, G. Barolat, S. Thomson Tags: LETTER TO THE EDITOR Source Type: research

Conditioned pain modulation and pain sensitivity in functional somatic disorders: The DanFunD study
The objective of this study was to examine a general population sample, encompassing three delimitations of FSD while assessing pain sensitivity and conditioning pain modulation (CPM).Pressure pain thresholds (PPTs) at the tibialis and trapezius muscles were recorded at baseline. During cold pressor stimulation of the hand, the tibialis PPTs were re-assessed and the difference from baseline measures defined the CPM effect. Participants (n=2,198, 53% females) were randomly selected from the adult Danish population. FSD was established by self-reported symptom questionnaires.With a few exceptions, only weak associations were...
Source: European Journal of Pain - July 26, 2021 Category: Anesthesiology Authors: M.W. Petersen, S. Skovbjerg, J.S. Jensen, T. Carstensen, T.M. Dantoft, P. Fink, M.E. Benros, E.L. Mortensen, T. J ørgensen, L.K. Gormsen Tags: ORIGINAL ARTICLE Source Type: research

Comment on “Dexmedetomidine versus clonidine adjuvants to levobupivacaine for ultrasound‐guided transversus abdominis plane block in paediatric laparoscopic orchiopexy: Randomized, double‐blind study”
(Source: European Journal of Pain)
Source: European Journal of Pain - July 22, 2021 Category: Anesthesiology Authors: Dongdong Yu, Li Jiang, Xiaoyu Wang, Jianli Li Tags: LETTER TO THE EDITOR Source Type: research

Platelet ‐rich plasma and cytokines in neuropathic pain: a narrative review and a clinical perspective
ABSTRACTNeuropathic pain arises as a direct consequence of a lesion or disease affecting the somatosensory system. A number of preclinical studies have provided evidence for the involvement of cytokines, predominantly secreted by a variety of immune cells and by glial cells from the nervous system, in neuropathic pain conditions. Clinical trials and use of anti-cytokine drugs in different neuropathic etiologies support the relevance of cytokines as treatment targets. However, the use of such drugs, in particularly biotherapies, can provoke notable adverse effects. Moreover, it is challenging to select one given cytokine as...
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: Yohann Bohren, Daniel Ionut Timbolschi, Andr é Muller, Michel Barrot, Ipek Yalcin, Eric Salvat Tags: REVIEW ARTICLE Source Type: research

Phantom limb pain after unilateral arm amputation is associated with decreased heat pain thresholds in the face
In this study, we applied QST in 37 unilateral upper-limb amputees (23 with, 14 without PLP) and 19 healthy controls. We assessed heat pain (HPT), pressure pain (PPT), warmth detection (WDT), and two-point discrimination thresholds at the residual limb, a homologous point and the thenar of the intact limb as well as both corners of the mouth. We did not find significant differences in any of the thresholds between the groups. However, PLP intensity was negatively associated with HPT at all measured body sites except for the residual limb, indicating lower pain thresholds with higher PLP levels. Correlations between HPT and...
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: Xaver Fuchs, Martin Diers, J örg Trojan, Pinar Kirsch, Christopher Milde, Robin Bekrater‐Bodmann, Mariela Rance, Jens Foell, Jamila Andoh, Susanne Becker, Herta Flor Tags: ORIGINAL ARTICLE Source Type: research

The role of psychological flexibility, perceived injustice, and body ‐image in Vulvodynia: a longitudinal study
ConclusionsAmong women with Vulvodynia, pain acceptance and committed action are prospectively associated with pain-interference and depression. The reliability and generalisability of these results needs to be established given the overlap with the COVID-19 pandemic. Future studies should investigate whether targeting these factors enhances outcomes in Vulvodynia. (Source: European Journal of Pain)
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: Claudia Chisari, Mahira Budhraja, Mani B. Monajemi, Fiona Lewis, Rona Moss ‐Morris, Whitney Scott, Lance M. McCracken Tags: ORIGINAL ARTICLE Source Type: research

Original article: Spinal beta ‐amyloid1‐42 acts as an endogenous analgesic peptide in CCI‐induced neuropathic pain
ConclusionsThese findings suggest that spinal A β1-42 acts as an endogenous analgesic peptide through regulating cytokines and Wnt pathways. This study may provide a potential target for the development of novel analgesic peptides. (Source: European Journal of Pain)
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: Dong Cui, Ze ‐Hua. Li, Cheng Li, Chengjie Qiu, Pingchuan Ma, Mingzheng Wu, Xue‐Jun. Song Tags: ORIGINAL ARTICLE Source Type: research

Association of Temporomandibular Disorders with Pain Sensitivity: a cohort study
ConclusionsThe pain regulatory mechanisms behind TMD act differently between the sexes as local TMD among females and MSP-linked TMD among males associated with pain sensitivity. (Source: European Journal of Pain)
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: J Knuutila, J Kivipuro, R N äpänkangas, J Auvinen, P Pesonen, J Karppinen, M Paananen, P Pirttiniemi, A Raustia, K Sipilä Tags: ORIGINAL ARTICLE Source Type: research

Transcutaneous electrical stimulation in neck pain: a systematic review and meta ‐analysis
ConclusionsES combined with other intervention seems to be useful to relieve pain and to improve disability in people with NP, however more studies are needed. (Source: European Journal of Pain)
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: É. P. Rampazo, C.C. S. Martignago, M. de Noronha, R. E. Liebano Tags: REVIEW ARTICLE Source Type: research

Modulatory role of the orexin system in stress ‐induced analgesia: Involvement of the ventral tegmental area
ConclusionThe findings suggest that OX1 and OX2 receptors in the VTA might modulate the antinociceptive behaviors induced by FSS in part. (Source: European Journal of Pain)
Source: European Journal of Pain - July 20, 2021 Category: Anesthesiology Authors: Kobra Askari, Shahrbanoo Oryan, Akram Eidi, Jalal Zaringhalam, Abbas Haghparast Tags: ORIGINAL ARTICLE Source Type: research

Early age at menarche is associated with post ‐menarche back pain: An analysis of the Raine Study
ConclusionThere is evidence of an association, in this cohort, of early AAM with post-menarche BP. This result identifies an area for future exploration, including understanding this mechanism which may lead to the development of effective intervention measures.SignificanceAge at menarche is related to a range of health issues. This study sought to investigate if it was a risk factor for spinal pain. We used an existing Australian data base to explore this possibility and found an association with early age onset and post-menarche back pain. This result identifies an area for future exploration, including understanding thi...
Source: European Journal of Pain - July 19, 2021 Category: Anesthesiology Authors: Stanley Innes, Angela Jacques, Karin Scott, Bruce Walker Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - July 16, 2021 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Early and late visual deprivation induce hypersensitivity to mechanical and thermal noxious stimuli in the ZRDBA mouse.
AbstractVisual deprivation leads to behavioral adaptations. Early visual deprivation has greater effects on sensory systems compared with late visual deprivation. Although this has been well studied, the impact of visual deprivation on pain sensitivity has scarcely been investigated. In humans, one study indicates that pain sensitivity is increased in early, but not late-onset blindness. In animals, one study indicates that sensitivity to noxious stimulation is increased in anophthalmic mice, but the impact of late visual deprivation on sensitivity remains unknown. The aim of this behavioral study was to examine sensitivit...
Source: European Journal of Pain - July 15, 2021 Category: Anesthesiology Authors: Sara Touj, Thierry Paquette, Gilles Bronchti, Mathieu Pich é Tags: ORIGINAL ARTICLE Source Type: research

Economic long ‐term effects of intensive interdisciplinary pain treatment in paediatric patients with severe chronic pain: Analysis of claims data
ConclusionThe results of this study support prior findings on the high economic burden of paediatric chronic pain. IIPT may contribute to a transition in healthcare utilization from somatic-focused treatments to more psychological treatments. Overall costs were reduced as soon as the first year after discharge and decreased even further in the second year.SignificanceThis study analyses original claims data from paediatric chronic pain patients in the year before and up to 2  years after intensive interdisciplinary pain treatment in a specialized paediatric pain centre. The analysis of long-term data reveals a continu...
Source: European Journal of Pain - July 13, 2021 Category: Anesthesiology Authors: Susanne Lopez Lumbi, Ann ‐Kristin Ruhe, Ingo Pfenning, Julia Wager, Boris Zernikow Tags: ORIGINAL ARTICLE Source Type: research

Disruption to normal excitatory and inhibitory function within the medial prefrontal cortex in people with chronic pain
ConclusionThe dysregulation of glutamatergic and GABAergic neurotransmitter systems supports a model of disinhibition of chronic pain, which may play a key role in both the experience of persistent pain and its associated affective disturbances. (Source: European Journal of Pain)
Source: European Journal of Pain - July 10, 2021 Category: Anesthesiology Authors: David Kang, Negin Hesam ‐Shariati, James H. McAuley, Monzurul Alam, Zina Trost, Carolyn D. Rae, Sylvia M. Gustin Tags: ORIGINAL ARTICLE Source Type: research

Comment on "Dexmedetomidine versus clonidine adjuvants to levobupivacaine for ultrasound ‐guided transversus abdominis plane block in paediatric laparoscopic orchiopexy: Randomized, double‐blind study"
AbstractWe read with great interest the study by Dr Mostafa and colleagues comparing dexmedetomidine and clonidine for ultrasound-guided transversus abdominis plane (TAP) block in paediatric laparoscopic orchiopexy in a well-designed, multi-arm randomized controlled trial. The authors concluded that clonidine may be substituted for dexmedetomidine with a local anesthetic during TAP block for pediatric laparoscopy because of easy availability and lower cost (Mostafa et al., 2021). (Source: European Journal of Pain)
Source: European Journal of Pain - July 9, 2021 Category: Anesthesiology Authors: Dongdong Yu, ,Li Jiang, Xiaoyu Wang, Jianli Li Tags: LETTER TO THE EDITOR Source Type: research

Improvement in pain interference and function by an allied health pain management program: results of a randomised trial
ConclusionsThe study suggests that an expanded scope allied health model of care prioritising patient choice and group-based interventions, provides modest benefits for tertiary-referral chronic pain patients. TAP warrants further investigation as a potentially viable alternative for tertiary healthcare where traditional pain services are unavailable or have long waiting lists. (Source: European Journal of Pain)
Source: European Journal of Pain - July 9, 2021 Category: Anesthesiology Authors: M Vandermost, K S Bagraith, H Kennedy, D Doherty, S Kilner, M Sterling, D Henry, M Jones Tags: ORIGINAL ARTICLE Source Type: research

Revealing the time course of laser ‐evoked potential habituation by high temporal resolution analysis
ConclusionsIn young healthy subjects, HTR allows a shortening of the test protocol while providing a detailed information on the time course of LEP habituation. A shorter protocol might be useful for the applicability of the LEP paradigm for clinical and experimental settings as well as pharmacological studies.SignificanceThe usage of high temporal resolution (HTR) analysis in young healthy subjects enables a short test protocol and provides the exact time course of laser-evoked potential habituation. This can be useful for the examination of neurological conditions affecting younger patients and for pharmacological studie...
Source: European Journal of Pain - July 8, 2021 Category: Anesthesiology Authors: Dilara Kersebaum, Sophie ‐Charlotte Fabig, Manon Sendel, Alexandra Cristina Muntean, Ralf Baron, Philipp Hüllemann Tags: ORIGINAL ARTICLE Source Type: research

Early age at menarche is associated with post ‐menarche back pain: An analysis of Raine cohort data
ConclusionThere is evidence of an association, in this cohort, of early AAM with post-menarche BP. This result identifies an area for future exploration, including understanding this mechanism which may lead to the development of effective intervention measures. (Source: European Journal of Pain)
Source: European Journal of Pain - July 5, 2021 Category: Anesthesiology Authors: Stanley Innes, Angela Jacques, Karin Scott, Bruce Walker Tags: ORIGINAL ARTICLE Source Type: research

Yes, no, maybe: Replication and the importance of methodology
AbstractThis journal recently published a paper by Rong et al., entitled “Persistent moderate to severe pain and long-term cognitive decline.” (Rong et al., 2021). The authors demonstrate that, to a small but statistically significant degree, older adults with persistent moderate-to-severe pain (an approximation for chronic pain) experience a faster rate of late-life cognitive decline than older adults without pain. Given these findings, should clinicians be alert for accelerated cognitive decline in older adults with chronic pain? Rong and colleagues argue yes. But, interestingly, using the same data source, a...
Source: European Journal of Pain - July 4, 2021 Category: Anesthesiology Authors: Elizabeth L. Whitlock Tags: COMMENTARY Source Type: research

The role of G ‐protein‐coupled receptor kinase 2 in diabetic mechanical hyperalgesia in rats
ConclusionGRK2 expression regulated DMH progression and is expected to play a role in the development of targeted therapy for DMH. GRK2 and Epac1 expressions play a vital role in maintaining pain in DMH rats. (Source: European Journal of Pain)
Source: European Journal of Pain - July 3, 2021 Category: Anesthesiology Authors: Xiu ‐Hua Xu, Rui‐Qin Du, Lin Li, Lin‐Lin Yang, Yi Zhang, Quan‐Min Li Tags: ORIGINAL ARTICLE Source Type: research

Effectiveness of stratified treatment for back pain in Danish primary care: A randomized controlled trial
ConclusionsThere was no significant difference in clinical outcomes between patients with non-specific LBP receiving stratified care and those receiving current practice. However, stratified care may reduce total healthcare costs if implemented in Danish primary care.SignificanceStratified care for low back pain based on risk profile is recommended by recent evidence based clinical guidelines. This study is the first broad replication of the STarT Back Trial in Europe. Therefore, the study adds to the body of knowledge evaluating the effectiveness of stratified care for low back pain in primary care, and provides insight i...
Source: European Journal of Pain - July 2, 2021 Category: Anesthesiology Authors: Lars Mors ø, Kim Olsen Rose, Berit Schiøttz‐Christensen, Gail Sowden, Jens Søndergaard, David H. Christiansen Tags: ORIGINAL ARTICLE Source Type: research

Effects of Childhood Trauma on Pain ‐related Distress in Adults
ConclusionsAcute pain-related interference could be predicted by post-traumatic distress and threat appraisal. Threat appraisal could be further predicted through ACEs, more childhood adversities were associated with more threatening appraisal of trauma in adulthood. The disaggregated finding that the effects of childhood adversities was only significant in males requires further exploration. (Source: European Journal of Pain)
Source: European Journal of Pain - July 1, 2021 Category: Anesthesiology Authors: David M. Walton, Paul Tremblay, Wonjin Seo, James M. Elliott, Maryam Ghodrati, Curtis May, Joy C. MacDermid Tags: ORIGINAL ARTICLE Source Type: research

Spinal Cord Stimulation in Severe Cases of Complex Regional Pain Syndrome: A Retrospective Cohort Study with Long ‐Term Follow‐up
AbstractBackgroundComplex regional pain syndrome (CRPS) is a debilitating pain condition often resistant to standard treatment modalities. In these cases, spinal cord stimulation (SCS) can be an option, but the effect on CRPS remains disputed. We aimed to assess the long-term effect of SCS on CRPS.MethodsWe retrospectively analyzed 51 CRPS patients implanted with an SCS system at the University Hospitals in Aarhus or Odense, Denmark, with a median follow-up time of 4.4 years. Primary outcomes were pain intensity on a numeric rating scale (NRS) and the Patients' Global Impression of Change (PGIC). Secondary outcomes were pa...
Source: European Journal of Pain - July 1, 2021 Category: Anesthesiology Authors: Linda Elise Eriksen, Astrid Juhl Terkelsen, Morten Rune Blichfeldt ‐Eckhardt, Jens Christian H Sørensen, Kaare Meier Tags: ORIGINAL ARTICLE Source Type: research

The value of interdisciplinary treatment for sickness absence in chronic pain: a nationwide register ‐based cohort study
ConclusionIn line with much of the currently available research, we found no support for IDT decreasing sickness absence in chronic pain patients. (Source: European Journal of Pain)
Source: European Journal of Pain - June 30, 2021 Category: Anesthesiology Authors: R LoMartire, M Bj örk, Ö Dahlström, L Constan, P Frumento, L Vixner, B Gerdle, Bo Äng Tags: ORIGINAL ARTICLE Source Type: research

The disruptive effects of pain on the early allocation of attentional resources: An attentional blink study.
AbstractRecent evidence suggests that pain dampens attentional processes. However, much of this work has been based on higher-order attentional tasks that involve only spatial attention. Other aspects of the process through which pain engages and holds attention are relatively understudied, in particular, temporal attention. The present set of studies explored how naturally occurring pain (i.e., acute headache) and pain-valenced stimuli affect ability to recall the second of two targets presented in rapid succession. Across both experiments participants were required to indicate the presence of a predefined probe (T2) and,...
Source: European Journal of Pain - June 29, 2021 Category: Anesthesiology Authors: Scott P. Jones, Joseph Walsh Tags: ORIGINAL ARTICLE Source Type: research

Relevant factors for neurologists to define effectiveness of migraine preventive drugs and take decisions on treatment. My ‐LIFE European Delphi survey
ConclusionsThis survey identifies two relevant outcome measures: one objective (use of acute migraine treatment medications) and one subjective (positive patient perception) that guide the clinician decision to continue preventive treatment in migraine patients. (Source: European Journal of Pain)
Source: European Journal of Pain - June 26, 2021 Category: Anesthesiology Authors: P. Pozo ‐Rosich, R. Gil‐Gouveia, A. Donnet, A. C. Poole, A. Gendolla, S. Afridi, R. Sanchez‐De la Rosa, G. M. Terwindt, C. Tassorelli Tags: ORIGINAL ARTICLE Source Type: research

Comment on the paper: Evidence ‐based treatment recommendations for neck and low back pain across Europe: A systematic review of guidelines
AbstractCorp et al. conducted an important study to synthesize the evidence from European guidelines on neck and lower back pain to identify appropriate recommendations (Corp et al., 2021). The Appraisal of Guidelines for Research and Evaluation Instrument II (AGREE II) was used to critically appraise these guidelines (Corp et al., 2021). Although AGREE II is a concise and widely used tool in the appraisal of the methodological quality of guidelines, it has some major limitations, which should be considered by the abovementioned authors and health providers (Liu et al., 2021). (Source: European Journal of Pain)
Source: European Journal of Pain - June 23, 2021 Category: Anesthesiology Authors: Yuan Zhang, Shu Wang, Yueming Yang, Ling Liu, Yuguang Guan, Yali Liu Tags: LETTER TO THE EDITOR Source Type: research

Authors ’ reply to the comment by Zhang et al
AbstractWe thank Zhang et al. (2021) for their interest in our work (Corp et al 2021). As the authors point out these are new versions of the AGREE reporting tools and inevitably there will be some delay in their implementation.Overall, we concur that in the future teams conducting reviews of guidelines should take the points raised in this letter into consideration. (Source: European Journal of Pain)
Source: European Journal of Pain - June 22, 2021 Category: Anesthesiology Authors: N. Corp, G. Mansell, S. Stynes, G. Wynne ‐Jones, L. Morsø, J.C. Hill, D.A. van der Windt Tags: LETTER TO THE EDITOR Source Type: research

Economic long ‐term effects of intensive interdisciplinary pain treatment in pediatric patients with severe chronic pain: Analysis of claims data
ConclusionThe results of this study support prior findings on the high economic burden of pediatric chronic pain. IIPT may contribute to a transition in health care utilization from somatic-focused treatments to more psychological treatments. Overall costs were reduced as soon as the first year after discharge and decreased even further in the second year. (Source: European Journal of Pain)
Source: European Journal of Pain - June 22, 2021 Category: Anesthesiology Authors: Susanne Lopez Lumbi, Ann ‐Kristin Ruhe, Ingo Pfenning, Wager Julia, Boris Zernikow Tags: ORIGINAL ARTICLE Source Type: research

The Effect of a Pain Educational Video Intervention upon Child Pain ‐Related Outcomes: a Randomized Controlled Study
ConclusionsFurther investigation is needed to optimize pain educational video-interventions and to determine whether more beneficial outcomes can be found in clinical (i.e., non-experimental) situations and in children with persistent or recurring pain problems. (Source: European Journal of Pain)
Source: European Journal of Pain - June 22, 2021 Category: Anesthesiology Authors: E. Rheel, K. Ickmans, A. Wauters, D.M.L. Van Ryckeghem, A. Malfliet, T. Vervoort Tags: ORIGINAL ARTICLE Source Type: research

Online multidisciplinary interventions for paediatric chronic pain: a content analysis
ConclusionsThe content analysis revealed a lack of online interventions encompassing complete multidisciplinary pain management. It is important that new interventions for paediatric chronic pain management are evidence-based and reflect current best practice guidelines. Established intervention development approaches should be utilised and include a process evaluation to help identify which intervention components are effective in which contexts. (Source: European Journal of Pain)
Source: European Journal of Pain - June 22, 2021 Category: Anesthesiology Authors: A. L. Hurley ‐Wallace, E. Nowotny, D. E. Schoth, C. Liossi Tags: ORIGINAL ARTICLE Source Type: research

Persistent moderate to severe pain and long ‐term cognitive decline
AbstractBackgroundThe longitudinal association between persistent moderate to severe pain and subsequent long-term cognitive decline remains inconclusive.MethodsStudy population came from the English Longitudinal Study of Ageing, an ongoing prospective and nationally representative cohort of community-dwelling adults aged ≥50 years in England. At waves 1 (2002/2003) and 2 (2004/2005) of the study, pain severity was measured based on pain intensity scores ranged from 0 to 10. We defined moderate to severe pain as pain intensity scores ≥5 points. Persistent moderate to severe pain was defined as participants report ed ...
Source: European Journal of Pain - June 22, 2021 Category: Anesthesiology Authors: Wei Rong, Cheng Zhang, Fanfan Zheng, Songhua Xiao, Zhenchun Yang, Wuxiang Xie Tags: ORIGINAL ARTICLE Source Type: research

Revealing the time course of laser evoked potential habituation by high temporal resolution analysis
ConclusionsIn young healthy subjects, HTR allows a shortening of the test protocol while providing a detailed information on the time course of LEP habituation. A shorter protocol might be useful for the applicability of the LEP paradigm for clinical and experimental settings as well as pharmacological studies. (Source: European Journal of Pain)
Source: European Journal of Pain - June 22, 2021 Category: Anesthesiology Authors: D. Kersebaum, S. ‐C. Fabig, M. Sendel, A. C. Muntean, R. Baron, P. Hüllemann Tags: ORIGINAL ARTICLE Source Type: research

Placebo effects in low back pain: A systematic review and meta ‐analysis of the literature
ConclusionsThis review shows a significant contribution of placebo effects to chronic LBP symptom relief in clinical and experimental conditions. The meta-analysis revealed that placebo effects can influence chronic LBP intensity and disability. However, additional studies are required for more supporting evidence and evidence for placebo effects in acute or subacute LBP.SignificanceThis systematic review and meta-analysis provides evidence of true placebo effects in low back pain (LBP). It shows a significant contribution of placebo effects to chronic LBP symptom relief. The results highlight the importance of patient- an...
Source: European Journal of Pain - June 22, 2021 Category: Anesthesiology Authors: Johan (Hans) Peter Alexander Lennep, Faye Tross èl, Roberto Silvio Giovanni Maria Perez, René Hubert Joseph Otten, Henriët Middendorp, Andrea Walburga Maria Evers, Karolina Maria Szadek Tags: REVIEW ARTICLE Source Type: research

Pain evaluation and prosocial behaviour are affected by age and sex
ConclusionThe characteristics of the patients seem to have a greater impact on prosocial behavior and pain assessment compared to those of the observers, which bears significant implications for the treatment of pain in clinical contexts. (Source: European Journal of Pain)
Source: European Journal of Pain - June 21, 2021 Category: Anesthesiology Authors: Chlo é Gingras, Michel‐Pierre Coll, Marie‐Hélène Tessier, Pascale Tremblay, Philip L. Jackson Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - June 21, 2021 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Comment on “Analgesic effect of music during wound care among patients with diaphyseal tibial fractures: Randomized controlled trial”
(Source: European Journal of Pain)
Source: European Journal of Pain - June 18, 2021 Category: Anesthesiology Authors: Haiyan Jin, Ting Li, Meiduo He, Ping Xu, Guozhen Lin Tags: LETTER TO THE EDITOR Source Type: research

During capsaicin ‐induced central sensitization, brush allodynia is associated with baseline warmth sensitivity, whereas mechanical hyperalgesia is associated with painful mechanical sensibility, anxiety and somatization
ConclusionsThese findings support research in neuropathic pain patients and human experimental models that peripheral sensory input and individual sensibility are related to development of mechanical allodynia and hyperalgesia during central sensitization, whilst psychological factors play a lesser role.SignificanceWe evaluated differential relationships of psychological and perceptual sensitivity to the development of capsaicin-induced mechanical allodynia and hyperalgesia. Fifty percent of healthy volunteers failed to develop mechanical allodynia. Baseline pain sensitivity was greater in those developing allodynia and wa...
Source: European Journal of Pain - June 16, 2021 Category: Anesthesiology Authors: Timothy J. Meeker, Anne ‐Christine Schmid, Yiming Liu, Michael L. Keaser, Susan G. Dorsey, David A. Seminowicz, Joel D. Greenspan Tags: ORIGINAL ARTICLE Source Type: research

Seven ‐year follow‐up of persistent postsurgical pain in cardiac surgery patients: A prospective observational study of prevalence and risk factors
AbstractBackgroundOur aim was to describe the long-term prevalence, risk factors and impact on quality of life of persistent postsurgical pain (PPP) following cardiac surgery.MethodsAll patients undergoing sternotomy in a single centre over 6  months were prospectively interviewed by telephone at six months and seven years following surgery.ResultsWe analysed data from 174 patients at six months and 146 patients at seven years following surgery, revealing a PPP prevalence of 39.7% (n = 69) and 9.6% (n = 14) respectively.At six post-operative months, younger age, higher acute pain score, intraoperative remifentanil inf...
Source: European Journal of Pain - June 14, 2021 Category: Anesthesiology Authors: Suzanne R. Harrogate, Jackie A. Cooper, Mateusz Zawadka, Sibtain Anwar Tags: ORIGINAL ARTICLE Source Type: research

3D magnetic resonance spectroscopic imaging reveals links between brain metabolites and multidimensional pain features in fibromyalgia
ConclusionsThese findings support single voxel placement targeting nociceptive processing areas in prior1H-MRS studies, but also highlight other areas not as commonly targeted, such as PCC, as important for chronic pain pathophysiology. Identifying target brain regions linked to multidimensional symptoms of fibromyalgia (e.g., negative cognitive/affective response to pain, clinical pain, evoked pain sensitivity) may aid the development of neuromodulatory and individualized therapies. Furthermore, efficient multi-region sampling with 3D MRSI could reduce the burden of lengthy scan time for clinical research applications of ...
Source: European Journal of Pain - June 9, 2021 Category: Anesthesiology Authors: Jeungchan Lee, Ovidiu C. Andronesi, Angel Torrado ‐Carvajal, Eva‐Maria Ratai, Marco L. Loggia, Akila Weerasekera, Michael P. Berry, Dan‐Mikael Ellingsen, Laura Isaro, Asimina Lazaridou, Myrella Paschali, Arvina Grahl, Ajay D. Wasan, Rob Tags: ORIGINAL ARTICLE Source Type: research

Brief mindfulness training can mitigate the influence of prior expectations on pain perception
ConclusionsThese findings provide partial support for recently proposed predictive processing models, which posit that mindfulness may lead to a prioritisation of current sensory information over previous expectations. We explore potential explanations for the asymmetrical group differences in conditioned hypoalgesia vs. conditioned hyperalgesia, and discuss our results in light of recent neuroimaging insights into the neuropsychological mechanisms of mindfulness and expectancy-driven pain modulation. (Source: European Journal of Pain)
Source: European Journal of Pain - June 8, 2021 Category: Anesthesiology Authors: S. Vencatachellum, M. van der Meulen, D.M.L. Van Ryckeghem, S. Van Damme, C. V ögele Tags: ORIGINAL ARTICLE Source Type: research

The Role of G Protein ‐coupled Receptor Kinase 2 in Diabetic Mechanical Hyperalgesia in Rats
ConclusionGRK2 expression regulated DMH progression and is expected to play a role in the development of targeted therapy for DMH. GRK2 and Epac1 expressions play a vital role in maintaining pain in DMH rats. (Source: European Journal of Pain)
Source: European Journal of Pain - June 8, 2021 Category: Anesthesiology Authors: Xiu ‐Hua Xu, Rui‐Qin Du, Lin Li, Lin‐Lin Yang, Yi Zhang, Quan‐Min Li Tags: ORIGINAL ARTICLE Source Type: research

Effectiveness of Stratified Treatment for Back Pain in Danish Primary Care: A Randomised Controlled Trial
ConclusionsThere was no significant difference in clinical outcomes between patients with non-specific LBP receiving stratified care and those receiving current practice. However, stratified care may reduce total healthcare costs if implemented in Danish primary care. (Source: European Journal of Pain)
Source: European Journal of Pain - June 8, 2021 Category: Anesthesiology Authors: Lars Mors ø, Kim Olsen Rose, Berit Schiøttz‐Christensen, Gail Sowden, Jens Søndergaard, David Høyrup Christiansen Tags: ORIGINAL ARTICLE Source Type: research

The validity of skin conductance for assessing acute pain in mechanically ventilated infants: A cross ‐sectional observational study
ConclusionsSC showed good validity for assessing pain in critically ill infants requiring mechanical ventilation. (Source: European Journal of Pain)
Source: European Journal of Pain - June 8, 2021 Category: Anesthesiology Authors: Jiale Hu, JoAnn Harrold, Janet E. Squires, Shokoufeh Modanloo, Denise Harrison Tags: ORIGINAL ARTICLE Source Type: research

Refinement and validation of a tool for stratifying patients with musculoskeletal pain
ConclusionsThe Keele STarT MSK tool demonstrates good validity and acceptable predictive performance, and clearly identifies groups of musculoskeletal pain patients with different characteristics and prognosis. Using prognostic information for stratification and treatment matching may be clinically/cost-effective. (Source: European Journal of Pain)
Source: European Journal of Pain - June 8, 2021 Category: Anesthesiology Authors: KM Dunn, P Campbell, M Lewis, JC Hill, DA van der Windt, E Afolabi, J Protheroe, S Wathall, S Jowett, R Oppong, CD Mallen, EM Hay, NE Foster Tags: ORIGINAL ARTICLE Source Type: research

Dynamic network topological properties for classifying primary dysmenorrhoea in the pain ‐free phase
ConclusionsWomen with PDM in the pain-free phase have altered global DTP and nodal DTP, mainly involving pain-related neurocircuits. The highly variable brain network is helpful for identifying PDM in the pain-free phase.SignificanceThis study shows that women with primary dysmenorrhoea (PDM) have decreased stability of dynamic network topological properties (DTP) and increased DTP variability in the pain-free phase. The altered DTP can be used to identify PDM in the pain-free phase. These findings demonstrate the presence of unstable characteristics in the whole network and disrupted pain-related neurocircuits, which migh...
Source: European Journal of Pain - June 7, 2021 Category: Anesthesiology Authors: Xiaoyan Wu, Wenjun Yu, Huijun Hu, Yun Su, Zhiying Liang, Zhiqiang Bai, Xuwei Tian, Li Yang, Jun Shen Tags: ORIGINAL ARTICLE Source Type: research

Pain evaluation and prosocial behavior are affected by age and sex
ConclusionThe characteristics of the patients seem to have a greater impact on prosocial behavior and pain assessment compared to those of the observers, which bears significant implications for the treatment of pain in clinical contexts. (Source: European Journal of Pain)
Source: European Journal of Pain - May 31, 2021 Category: Anesthesiology Authors: C. Gingras, M. ‐P. Coll, M.‐H. Tessier, P. Tremblay, P. L. Jackson Tags: ORIGINAL ARTICLE Source Type: research

Placebo effects in low back pain; a systematic review and meta ‐analysis of the literature
ConclusionsThis review shows a significant contribution of placebo effects to chronic LBP symptom relief in clinical and experimental conditions. The meta-analysis revealed that placebo effects can influence chronic LBP intensity and disability. However, additional studies are required for more supporting evidence and evidence for placebo effects in acute or subacute LBP. (Source: European Journal of Pain)
Source: European Journal of Pain - May 30, 2021 Category: Anesthesiology Authors: J.P.A. van Lennep, F. Tross èl, R.S.G.M. Perez, R.H.J. Otten, H. van Middendorp, A.W.M. Evers, K.M. Szadek Tags: REVIEW ARTICLE Source Type: research