The Pharmacokinetics, Efficacy, and Safety of a Novel Selective ‐Dose Cannabis Inhaler in Patients with Chronic Pain: A Randomized, Double‐Blinded, Placebo‐Controlled Trial
ConclusionThis feasibility trial demonstrated that a metered ‐dose cannabis inhaler delivered precise and low THC doses, produced a dose‐dependent and safe analgesic effect in patients with neuropathic pain/ complex‐regional pain syndrome (CRPS). Thus, it enables individualization of medical cannabis regimens that can be evaluated pharmacokinetically an d pharmacodynamically by accepted pharmaceutical models. (Source: European Journal of Pain)
Source: European Journal of Pain - May 23, 2020 Category: Anesthesiology Authors: S. Almog, J. Aharon ‐Peretz, S. Vulfsons, M. Ogintz, H. Abalia, T. Lupo, Y. Hayon, E. Eisenberg Tags: ORIGINAL ARTICLE Source Type: research

Interplay between body schema, visuospatial perception and pain in patients with spinal cord injury
ConclusionThese results suggest an interplay between lower body scheme distorsions and pain in patients with spinal cord injury. (Source: European Journal of Pain)
Source: European Journal of Pain - May 20, 2020 Category: Anesthesiology Authors: Thomas Osinski, Valeria Martinez, Djamel Bensmail, Samar Hatem, Didier Bouhassira Tags: ORIGINAL ARTICLE Source Type: research

A hidden mesencephalic variant of central pain
ConclusionPostero ‐lateral midbrain lesions should be added to potential causes of CPSP. Because pain and spinothalamic deficits may be the only clinical sign, and because small lateral midbrain lesions may be difficult to trail with MRI, mesencephalic CPSP can be misdiagnosed as malingering or psychogenic pain for years. (Source: European Journal of Pain)
Source: European Journal of Pain - May 18, 2020 Category: Anesthesiology Authors: P. Convers, C. Creac ’h, A. Beschet, B. Laurent, L. Garcia‐Larrea, R. Peyron Tags: ORIGINAL ARTICLE Source Type: research

Headache attributed to craniocervical dystonia: a prospective cohort study
ConclusionsHeadaches are highly prevalent amongst cervical dystonia patients, have an impact on their quality of life and improves after BoNT ‐A injections. (Source: European Journal of Pain)
Source: European Journal of Pain - May 18, 2020 Category: Anesthesiology Authors: Marcos Eug ênio Ramalho Bezerra, Pedro Augusto Sampaio Rocha‐Filho Tags: ORIGINAL ARTICLE Source Type: research

Musculoskeletal pain phenotyping: Our end point should be clinical feasibility ‐ A commentary to Meisingset et al. “Novel approach towards musculoskeletal phenotypes”
European Journal of Pain, EarlyView. (Source: European Journal of Pain)
Source: European Journal of Pain - May 18, 2020 Category: Anesthesiology Authors: Siobh án Stynes Tags: COMMENTARY Source Type: research

Comorbidities of self ‐reported fibromyalgia in United States adults: A cross‐sectional study from The National Epidemiological Survey on Alcohol and Related Conditions (NESARC‐III)
ConclusionsParticipants with self ‐reported fibromyalgia have a higher prevalence of comorbid mental and physical disorders, and lower mean levels of mental and physical quality of life than their counterparts without fibromyalgia.SignificanceWe showed here a strong association of self ‐reported fibromyalgia with both mental and physical comorbidities. We showed that among participants with self‐reported fibromyalgia, more than 8 out of 10 had at least three other physical comorbidities, and almost half had at least three mental comorbidities. This is a cross‐sectional study using a representative sample of the US ...
Source: European Journal of Pain - May 18, 2020 Category: Anesthesiology Authors: David Sleurs, Sarah Tebeka, Claire Scognamiglio, Caroline Dubertret, Yann Le Strat Tags: ORIGINAL ARTICLE Source Type: research

A systematic review of cross ‐cultural validation of the pain catastrophizing scale
ConclusionsThese results indicate that the total score of the PCS could be compared across each translated version, however, caution is warranted when each subdomain of the PCS is compared between countries. (Source: European Journal of Pain)
Source: European Journal of Pain - May 16, 2020 Category: Anesthesiology Authors: Tatsunori Ikemoto, Kazuhiro Hayashi, Yukiko Shiro, Youn ‐Chang Arai, Anna Marcuzzi, Daniel Costa, Paul Wrigley Tags: REVIEW ARTICLE Source Type: research

Radiotherapy for pain relief from bone metastases during Coronavirus (COVID ‐19) pandemic
AbstractThe worldwide pandemic of coronavirus disease (COVID ‐19) has drammatically and rapidly spread in Italy the last month.By now, nevertheless Italian government efforts to contain the outbreak with escalating restrictive measures, 205463 cases were confirmed, with 27967 deaths (Source: European Journal of Pain)
Source: European Journal of Pain - May 16, 2020 Category: Anesthesiology Authors: Carla Germana Rinaldi, Edy Ippolito, Carlo Greco, Paolo Matteucci, Rolando Maria D ’Angelillo, Sara Ramella Tags: LETTER TO THE EDITOR Source Type: research

Insomnia is a risk factor for spreading of chronic pain: A Swedish longitudinal population study (SwePain)
ConclusionOur findings show a strong prospective relationship between insomnia symptoms and the transition from relatively localized to generalized pain. (Source: European Journal of Pain)
Source: European Journal of Pain - May 9, 2020 Category: Anesthesiology Authors: T. Wiklund, B. Gerdle, S.J. Linton, E. Dragioti, B. Larsson Tags: ORIGINAL ARTICLE Source Type: research

Stuck on pain? Assessing children ’s vigilance and awareness of pain sensations
ConclusionsThe PVAQ ‐C shows strong indices of internal reliability and criterion validity, and indicates unique predictive utility. It will be important to study the role of pain‐related attention in youth within developmental and functional‐motivational frameworks. (Source: European Journal of Pain)
Source: European Journal of Pain - May 7, 2020 Category: Anesthesiology Authors: L.C. Heathcote, L.E. Simons Tags: ORIGINAL ARTICLE Source Type: research

Association of quantitative sensory testing parameters with clinical outcome in patients with lumbar radiculopathy undergoing microdiscectomy
This study aimed to establish the somatosensory profile of patients with lumbar radiculopathy at pre ‐and post‐microdiscectomy and to explore any association between pre‐surgical quantitative sensory test (QST) parameters and post‐surgical clinical outcomes.A standardized QST protocol was performed in 53 patients (mean age 38 ±11years, 26 females) with unilateral L5/S1 radiculopathy in the main pain area (MPA), affected dermatome and contralateral mirror sites and in age‐ and gender‐,and body site matched healthy controls. Repeat measures at three months included QST, the Oswestry Disability Index (ODI) ...
Source: European Journal of Pain - May 7, 2020 Category: Anesthesiology Authors: B. Tampin, H. Slater, A. Jacques, C.R.P. Lind Tags: ORIGINAL ARTICLE Source Type: research

The N2pc Component as a Neural Index of Early Attention Allocation among Adults with Chronic Musculoskeletal Pain
AbstractRecent evidence from event ‐related potentials (ERPs) has identified N2 posterior contralateral (pc) amplitudes as a neural marker of early attention allocation. The N2pc has been used to evaluate attention biases (ABs) in samples with anxiety‐based problems but its utility has yet to be considered among persons with chro nic pain, another group theorized to display ABs that perpetuate their difficulties. To address this gap, we assessed N2pc responses of adults with chronic pain (N = 70) and pain‐free controls (N = 70) during a dot‐probe task comprising painful‐neutral and happy‐neutral facial expressi...
Source: European Journal of Pain - May 7, 2020 Category: Anesthesiology Authors: Yang Wang, Yanci Liu, Davood Gozli, Yu ‐Tao Xiang, Todd Jackson Tags: ORIGINAL ARTICLE Source Type: research

Comorbidities of self ‐reported fibromyalgia in United‐States adults: A cross‐sectional study from The National Epidemiological Survey on Alcohol and Related Conditions (NESARC‐III)
ConclusionsParticipants with self ‐reported fibromyalgia have a higher prevalence of comorbid mental and physical disorders, and lower mean levels of mental and physical quality of life than their counterparts without fibromyalgia. (Source: European Journal of Pain)
Source: European Journal of Pain - May 7, 2020 Category: Anesthesiology Authors: David Sleurs, Sarah Tebeka, Claire Scognamiglio, Caroline Dubertret, Yann Le Strat Tags: ORIGINAL ARTICLE Source Type: research

Beyond Pain Intensity and catastrophizing: The Association between Self ‐Enhancing Humor Style and the Adaptation of Individuals with Chronic Pain
ConclusionsSelf ‐enhancing humor style could potentially help individuals with chronic pain to gain perspective and distance themselves from the situation through the acceptance of pain‐related negative emotions.SignificanceVery few studies have investigated the relationship between humor styles and adjustment in chronic pain samples. The results of the current study support the idea that adaptive dispositional traits, such as patient ’s self‐ enhancing humor style, play a role in the adaptation of individuals with chronic pain. Given that the association between self‐enhancing humor style and adjustment evid...
Source: European Journal of Pain - May 7, 2020 Category: Anesthesiology Authors: Carmen Ram írez‐Maestre, Rosa Esteve, Alicia E. López‐Martínez, Jordi Miró, Mark P. Jensen, Rocío de la Vega Tags: ORIGINAL ARTICLE Source Type: research

Heterogeneous presentation of caspr2 antibody ‐associated peripheral neuropathy – A case series
AbstractContactin ‐associated protein 2–like (caspr2) antibodies have been discovered recently. Since then a multitude of patients with caspr2 antibodies presenting with different neurological symptoms have been reported. Here, we describe three patients with caspr2 antibodies with different types of pain/no pain in combination with peripheral neuropathy. The first patient, a 33‐year‐old woman, presented with erythromelalgia‐like pain and autonomic symptoms; the second patient, a 58‐year‐old man, with paresthesia and pain while walking together with signs of peripheral motor neuron hyperexcitabili ty in c...
Source: European Journal of Pain - April 30, 2020 Category: Anesthesiology Authors: Erik Ellwardt, Christian Geber, Johannes Lotz, Frank Birklein Tags: SHORT COMMUNICATION Source Type: research

Activation of the descending pain modulatory system using cuff pressure algometry: Back translation from man to rat
AbstractBackgroundDiffuse noxious inhibitory controls (DNIC) as measured in rat and conditioned pain modulation (CPM), the supposed psychophysical paradigm of DNIC measured in humans, are unique manifestations of an endogenous descending modulatory pathway that is activated by application of a noxious conditioning stimulus. The predictive value of the human CPM processing is crucial when deliberating the translational worth of the two phenomena.MethodsFor CPM or DNIC measurement, test and conditioning stimuli were delivered using a computer ‐controlled cuff algometry system or manual inflation of neonate blood pressure c...
Source: European Journal of Pain - April 29, 2020 Category: Anesthesiology Authors: TM Cummins, M Kucharczyk, T Graven ‐Nielsen, K Bannister Tags: ORIGINAL ARTICLE Source Type: research

Musculoskeletal pain phenotyping: our end point should be clinical feasibility ‐A commentary to Meisingset et al.'s "Novel approach towards musculoskeletal phenotypes
AbstractThe study ’s aim was to identify and validate phenotypes of patients with musculoskeletal (MSK) pain based on eleven common prognostic factors across the biopsychosocial domains. Using a sample of n=435 patients attending physiotherapy in primary care, latent class analysis identified five groups. The five groups mainly differed in terms of severity across the well‐established prognostic factors. Outcomes at 3 months reflected baseline scores; those with a more severe profile had worse clinical outcomes. Two of the five groups were separated on differing patterns of mental distress and fear avoidanc e. (Sou...
Source: European Journal of Pain - April 27, 2020 Category: Anesthesiology Authors: Siobhan Stynes Tags: COMMENTARY Source Type: research

Peripheral input and phantom limb pain: a somatosensory event ‐related potential study
ConclusionsPeripheral input can modulate PLP but seems insufficient to cause PLP. These findings suggest the multifactorial complexity of PLP and different mechanisms for PLP and RLP. (Source: European Journal of Pain)
Source: European Journal of Pain - April 26, 2020 Category: Anesthesiology Authors: Hongcai Liu, Jamila Andoh, Yuanyuan Lyu, Christopher Milde, Simon Desch, Francesca Zidda, Martin Schmelz, Gabriel Curio, Herta Flor Tags: ORIGINAL ARTICLE Source Type: research

Intrathecal Dexmedetomidine and Postoperative Pain: A Systematic Review and Meta ‐analysis of Randomised Controlled Trials
ConclusionsCompared to placebo, intrathecal DEX prolonged postoperative analgesic duration, reduced 24 ‐hour pain intensity and reduced the incidence of shivering without an increase in other adverse effects. (Source: European Journal of Pain)
Source: European Journal of Pain - April 25, 2020 Category: Anesthesiology Authors: Ambika Paramasivan, Angeles M. Lopez ‐Olivio, Theng Wai Foong, Yi Wei Tan, Andrea Pek Anne Yap Tags: REVIEW ARTICLE Source Type: research

Commentary on “Effectiveness of motor imagery and action observation training on musculoskeletal pain intensity: A systematic review and meta‐analysis” by Suso‐Martí et al.
European Journal of Pain, EarlyView. (Source: European Journal of Pain)
Source: European Journal of Pain - April 24, 2020 Category: Anesthesiology Authors: Sarah B. Wallwork, Felicity A. Braithwaite Tags: COMMENTARY Source Type: research

Mindfulness meditation is related to sensory ‐affective uncoupling of pain in trained novice and expert practitioners
ConclusionThese findings suggest that mindfulness meditation specifically down ‐regulates pain affect as opposed to pain intensity, and that pain catastrophizing undermines sensory‐affective uncoupling of pain.SignificanceIn this study, we found that a style of mindfulness meditation referred to as Open Monitoring reduced unpleasantness but not intensity ratings compared to attentional distraction in trained novice (state effect) and expert meditators (state and trait effects). We also observed that trait pain catastrophizing scores predicted this sensory ‐affective uncoupling. These findings advance our understandin...
Source: European Journal of Pain - April 20, 2020 Category: Anesthesiology Authors: Jelle Zorn, Oussama Abdoun, Romain Bouet, Antoine Lutz Tags: ORIGINAL ARTICLE Source Type: research

Response to Comment by Bhatia
AbstractWe thank Dr Bhatia for their commentary (Bhatia, 2020) on our review Efficacy and harms of orally, intramuscularly or intravenously administered glucocorticoids for sciatica: A systematic review and meta ‐analysis (Abdel Shaheed et al., 2020).Dr Bhatia raised the point that if steroids have a role in the treatment of sciatica what route would be most effective and should studies be done to compare the epidural route (especially transforaminal approach) against oral and other parenteral routes? We agree it will not be easy to answer these questions. (Source: European Journal of Pain)
Source: European Journal of Pain - April 20, 2020 Category: Anesthesiology Authors: Chang Liu, Christina Abdel Shaheed, Chris G Maher, Andrew J McLachlan, Jane Latimer, Chung ‐Wei Christine Lin Tags: LETTER TO THE EDITOR Source Type: research

A multi ‐center international study of Acupuncture for lateral elbow pain ‐ Results of a randomized controlled trial
ConclusionsAcupuncture was shown to be efficacious in improving the function of the arm associated with lateral elbow tendinosis. Both the DASH score and the VAS pain on two occasions (at rest and during motion) showed a significant change over time indicating acupuncture as a potential treatment for LEP due to tendinosis. (Source: European Journal of Pain)
Source: European Journal of Pain - April 17, 2020 Category: Anesthesiology Authors: Marcus Gadau, Shi Ping Zhang, Fu Chun Wang, Stefano Liguori, Christopher Zaslawski, Wei Hong Liu, Sergio Bangrazi, Christine Berle, Shohreh Razavy, Zhao Xiang Bian, Petti Filomena, Yang Hao, Hai Lin Jiang, Li Lei, Tie Li, Wei Hong Li, Aldo Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
European Journal of Pain, Volume 24, Issue 5, Page 873-874, May 2020. (Source: European Journal of Pain)
Source: European Journal of Pain - April 13, 2020 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Commentary on “Effectiveness of motor imagery and action observation training on musculoskeletal pain intensity: A systematic review and meta‐analysis” by Suso‐Marti et al
AbstractThis journal recently published a paper by Suso ‐Marti et al., entitled “Effectiveness of motor imagery and action observation training on musculoskeletal pain intensity: A systematic review and meta‐analysis” (2020). Motor imagery training and action observation training are rehabilitation approaches that involve imagining oneself e xecuting a particular action, and watching actions that are performed by others, respectively. Both are thought to activate similar neural substrates that are responsible for the actual execution of an action (Eaves et al., 2016). Motor imagery ...
Source: European Journal of Pain - April 12, 2020 Category: Anesthesiology Authors: Sarah B Wallwork, Felicity A Braithwaite Tags: COMMENTARY Source Type: research

Lack of relationship between epidermal denervation by capsaicin and incisional pain behaviours: A laser scanning confocal microscopy study in rats
ConclusionsSubcutaneous infiltration of capsaicin prior to surgical incision attenuated incision ‐induced pain behaviours and reduced epidermal innervation around the incision site. The long‐lasting epidermal denervation by capsaicin had no impact in the rate of wound healing and recovery from pain behaviours.SignificancePre ‐operative capsaicin infiltration attenuated spontaneous pain‐like behaviour and prevented the development of heat hyperalgesia following plantar skin incision. While capsaicin caused long‐lasting and widespread loss of epidermal and dermal nerve fibres, there was no measurable impact on the ...
Source: European Journal of Pain - April 12, 2020 Category: Anesthesiology Authors: Megan L. Uhelski, Brian McAdams, Malcolm E. Johns, Rajiv A. Kabadi, Donald A. Simone, Ratan K. Banik Tags: ORIGINAL ARTICLE Source Type: research

Heterogeneous presentation of caspr2 antibody associated peripheral neuropathy – a case series
AbstractPainful peripheral neuropathies are common. The most prevalent causes of peripheral neuropathies are diabetes, toxins like alcohol or chemotherapeutics, or autoimmune diseases (Visser et al., 2015). However, routine tests do not usually uncover the underlying cause of a significant proportion of peripheral neuropathies. This is in particular true for small fiber neuropathies. (Source: European Journal of Pain)
Source: European Journal of Pain - April 11, 2020 Category: Anesthesiology Authors: Erik Ellwardt, Christian Geber, Johannes Lotz, Frank Birklein Tags: SHORT COMMUNICATION Source Type: research

Neuropathic pain after thoracotomy: tracking signs and symptoms before and at monthly intervals following surgery
ConclusionsClinical routine should focus on the individual ’s physiological state, including pre‐existing neuropathic pain and sleep quality to identify patients early who might be at risk to develop chronic post‐surgical neuropathic pain. (Source: European Journal of Pain)
Source: European Journal of Pain - April 8, 2020 Category: Anesthesiology Authors: W. Gandhi, F.B. Pomares, L. Naso, J.F. Asenjo, P. Schweinhardt Tags: ORIGINAL ARTICLE Source Type: research

Treatment preferences in fibromyalgia patients: A cross ‐sectional web‐based survey
ConclusionsTreatment preferences of FM individuals reveal an ambivalent combination of heavy reliance on pharmacological treatment with lower but consistent reliance on non ‐pharmacological treatment for those individuals who used it in the past and present. This finding may inform longitudinal research into the relationship between pharmacological and non‐pharmacological treatment preference in FM patients, which could in turn inform guidelines for individualised therapeutic plans for clinicians. (Source: European Journal of Pain)
Source: European Journal of Pain - April 8, 2020 Category: Anesthesiology Authors: Elia Valentini, Eleonora Fetter, Sheina Orbell Tags: ORIGINAL ARTICLE Source Type: research

Strong opioid consumption and its correlation with pain intensity and inpatient complexity. A 6 ‐year analysis in a tertiary hospital
ConclusionsConsumption of strong opioids has remained stable, both in medical and surgical area, during last years. A correlation between prescription of opioids and pain intensity is observed in case of repeated and severe pain in medical departments.SignificanceThis study shows a stable consumption of strong opioid analgesics in a hospital setting in contrast to what appears to be the extrahospitalary trend during last years. The association between consumption of opioids and pain intensity seems to indicate a good control of pain in the clinical setting, showing a significant correlation between the consumption of opioi...
Source: European Journal of Pain - April 4, 2020 Category: Anesthesiology Authors: In és Monge‐Escartín, Antonio Montes, Merce Comas, Santiago Grau Tags: ORIGINAL ARTICLE Source Type: research

Breakthrough pain is not a fixed fraction of constant cancer pain
AbstractThis journal recently published a paper by Currow et al., entitled "A randomised, double ‐blind, crossover, dose ranging study to determine the optimal dose of oral opioid to treat breakthrough pain for patients with advanced cancer already established on regular opioids” (Currow et al., 2010). Currow et al. demonstrated that for breakthrough pain (BTP) there were no differences bet ween giving rescue opioids doses of 1/6, 1/8 or 1/12 of the scheduled daily opioid dose. (Source: European Journal of Pain)
Source: European Journal of Pain - March 31, 2020 Category: Anesthesiology Authors: P ål Klepstad, Morten Thronæs, Erik Torbjørn Løhre Tags: COMMENTARY Source Type: research

Dissociation proneness and pain hyposensitivity in current and remitted borderline personality disorder
ConclusionDissociation proneness is enhanced in both BPD groups. This feature is clearly positively related to pain hyposensitivity in cBPD, but not in rBPD. However, the data indicate that stress causes the pain perception in rBPD to drift away from that obtained in HC. These results highlight the volatile state of BPD remission and might have important implications for the care of BPD patients in the remitted stage. (Source: European Journal of Pain)
Source: European Journal of Pain - March 31, 2020 Category: Anesthesiology Authors: Boo Young Chung, Saskia Hensel, Ilinca Schmidinger, Robin Bekrater ‐Bodmann, Herta Flor Tags: ORIGINAL ARTICLE Source Type: research

Necessary Components of Psychological Treatment for Chronic Pain: More Packages for Groups or Process ‐Based Therapy for Individuals?
AbstractThis journal recently published a paper by Sharpe et al., entitled “Necessary components of psychological treatments in chronic pain management programs: A Delphi study” (Sharpe, Jones, Ashton‐James, Nicholas,& Refshauge, 2020). These researcher sought the views of authors of relevant RCTs published up to September 2016 and supplemented these with input from psychologists working in pain management programs in Australia. (Source: European Journal of Pain)
Source: European Journal of Pain - March 31, 2020 Category: Anesthesiology Authors: Lance M. McCracken Tags: COMMENTARY Source Type: research

Interpretation biases and visual attention in the processing of ambiguous information in chronic pain
ConclusionsIn sum, the present study provided evidence for the interplay between multiple forms of cognitive biases. Future studies should investigate whether this interaction might influence subsequent functioning in people with chronic pain. (Source: European Journal of Pain)
Source: European Journal of Pain - March 30, 2020 Category: Anesthesiology Authors: Frederick H.F. Chan, Hin Suen, Janet H. Hsiao, Antoni B. Chan, Tom J. Barry Tags: ORIGINAL ARTICLE Source Type: research

Psychological and pain profiles in persons with patellofemoral pain as the primary symptom
This study compares psychological and somatosensory characteristics between those with persistent PFP and controls.Methods150 adults with PFP were compared to 61 controls. All participants completed a survey evaluating participant characteristics, PFP ‐related constructs and psychological factors: anxiety, depression, pain catastrophizing, kinesiophobia, pain self‐efficacy. Participants also attended a session of somatosensory testing, which included knee and elbow thermal and mechanical detection and pain thresholds, conditioned pain modulat ion (CPM), and temporal summation of pain (TSP). Differences were evaluated u...
Source: European Journal of Pain - March 30, 2020 Category: Anesthesiology Authors: L.R. Maclachlan, N.J. Collins, P.W. Hodges, B. Vicenzino Tags: ORIGINAL ARTICLE Source Type: research

Lack of relationship between epidermal denervation by capsaicin and incisional pain behaviors: a laser scanning confocal microscopy study in rats
ConclusionsSubcutaneous infiltration of capsaicin prior to surgical incision attenuated incision ‐induced pain behaviors and reduced epidermal innervation around the incision site. The long‐lasting epidermal denervation by capsaicin had no impact in the rate of wound healing and recovery from pain behaviors. (Source: European Journal of Pain)
Source: European Journal of Pain - March 27, 2020 Category: Anesthesiology Authors: M.L. Uhelski, B. McAdams, M.E. Johns, R.A. Kabadi, D.A. Simone, R.K. Banik Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
European Journal of Pain, Volume 24, Issue 4, Page 667-668, April 2020. (Source: European Journal of Pain)
Source: European Journal of Pain - March 21, 2020 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Appropriate referral and selection of patients with chronic pain for Spinal Cord Stimulation: European consensus recommendations and e ‐health tool
ConclusionsThe RUAM was useful to establish a consensus on patient ‐specific criteria for referral/selection for SCS in chronic pain. The e‐health tool may help physicians learn to apply an integrated approach of clinical and psychosocial factors.SignificanceDetermining the eligibility of Spinal Cord Stimulation in patients with chronic pain requires careful consideration of a variety of clinical and psychosocial factors. Using a systematic approach to combine evidence from clinical studies and expert opinion, a multidisciplinary European expert panel developed detailed recommendations to support appropriate referral a...
Source: European Journal of Pain - March 19, 2020 Category: Anesthesiology Authors: Simon Thomson, Frank Huygen, Simon Prangnell, Jos é De Andrés, Ganesan Baranidharan, Hayat Belaïd, Neil Berry, Bart Billet, Jan Cooil, Giuliano De Carolis, Laura Demartini, Sam Eldabe, Kliment Gatzinsky, Jan Willem Kallewaard, Kaare Meier Tags: ORIGINAL ARTICLE Source Type: research

Strong opioid consumption and its correlation with pain intensity and inpatient complexity. A six ‐year analysis in a tertiary hospital
ConclusionsConsumption of strong opioids has remained stable, both in medical and surgical area, during last years. A correlation between prescription of opioids and pain intensity is observed in case of repeated and severe pain in medical departments. (Source: European Journal of Pain)
Source: European Journal of Pain - March 19, 2020 Category: Anesthesiology Authors: I Monge ‐Escartín, A Montes, M Comas, S Grau Tags: ORIGINAL ARTICLE Source Type: research

Necessary components of psychological treatment in pain management programs: A Delphi study
ConclusionsThere was a consensus that there were many desirable strategies to include in psychological chronic pain management approaches, but that treatments should include psychoeducation, approaches to increase activity and cognitive approaches as a first line of intervention. Where patients fail to benefit from these approaches, experts identified other desirable strategies that could be utilized. (Source: European Journal of Pain)
Source: European Journal of Pain - March 19, 2020 Category: Anesthesiology Authors: Louise Sharpe, Emma Jones, Claire E. Ashton ‐James, Michael K. Nicholas, Kathryn Refshauge Tags: ORIGINAL ARTICLE Source Type: research

Pain modulation by illusory body rotation: a new way to disclose the interaction between the vestibular system and pain processing
ConclusionsVestibular information present in static visual cues can modulate experimental pain according to a side ‐dependent manner and bypassing supramodal attentional mechanisms. These findings may help refining pain management approaches based on multimodal stimulation. (Source: European Journal of Pain)
Source: European Journal of Pain - March 15, 2020 Category: Anesthesiology Authors: A. Daniel, L. Barker, M. Martini Tags: ORIGINAL ARTICLE Source Type: research

The roles of race, sex and cognitions in response to experimental pain
This study reports a multivariate test of sex and race differences in experimental pain, and the degree to which these differences could be uniquely attributable to three levels of cognition: primary appraisals (threat, challenge), secondary appraisals (pain catastrophizing) and/or cognitive processes (mindful observing, non ‐reactivity). Both the predictive and mediator role of the cognitive variables was of interest.MethodsThe study employed a cross ‐sectional experimental design, with the cold pressor task employed as the pain stimulus. The total sample includedN = 355 healthy adults (67% female, 33% male;...
Source: European Journal of Pain - March 15, 2020 Category: Anesthesiology Authors: Melissa A. Day, L. Charles Ward, Michelle P. Grover, Dawn M. Ehde, Oliver R. Illingworth, Mark P. Jensen Tags: ORIGINAL ARTICLE Source Type: research

Anodal transcranial direct current stimulation over the primary motor cortex attenuates capsaicin ‐induced dynamic mechanical allodynia and mechanical pain sensitivity in humans
AbstractBackgroundAnodal transcranial direct current stimulation over the primary cortex has been shown to activate regions of the brain involved in the descending modulation of pain sensitivity. However, more research is required in order to dissect the spinal cord analgesic mechanisms associated with the development of central sensitisation.MethodsIn this randomised, double blind, cross over study 12 healthy participants had baseline mechanical stimulus response (S/R) functions measured before and after the development of capsaicin ‐induced ongoing pain sensitivity. The effects of 20 min of either real or sham tra...
Source: European Journal of Pain - March 15, 2020 Category: Anesthesiology Authors: SW Hughes, G Ward, PH. Strutton Tags: ORIGINAL ARTICLE Source Type: research

Acute pain measured with the modified Bernese Pain Scale for Neonates is influenced by individual contextual factors
ConclusionsPostmenstrual age, behavioural state, caffeine and ventilation status have an influence on neonates ’ pain response and should be incorporated in the revised BPSN to enhance clinical pain assessment in neonates with different GAs. (Source: European Journal of Pain)
Source: European Journal of Pain - March 15, 2020 Category: Anesthesiology Authors: K. Schenk, L. Stoffel, R. B ürgin, B. Stevens, D. Bassler, S. Schulzke, M. Nelle, E. Cignacco Tags: ORIGINAL ARTICLE Source Type: research

Minocycline reduces experimental muscle hyperalgesia induced by repeated nerve growth factor injections in humans: A placebo ‐controlled double‐blind drug‐crossover study
ConclusionsThis study indicates that the administration of minocycline can reduce experimentally induced muscle pain regardless of the time of administration. (Source: European Journal of Pain)
Source: European Journal of Pain - March 15, 2020 Category: Anesthesiology Authors: James.S. Dunn, Saad.S. Nagi, David.A Mahns Tags: ORIGINAL ARTICLE Source Type: research

GABAergic modulation of Secondary hyperalgesia: A randomized controlled 4 ‐way crossover trial with the α2‐subunit preferring GABA positive allosteric modulator, N‐Desmethyl‐Clobazam in healthy volunteers
AbstractThe antihyperalgesic and sedative effects of the α2‐subunit preferring GABAA positive allosteric modulator (GAM), N ‐Desmethyl‐Clobazam (NDMC), 20 and 60 mg, were assessed in a randomized, placebo and active‐controlled (clonazepam 1,5 mg), 4‐way crossover study, in healthy volunteers, using the UVB‐induced experimental pain model. Single (20, 40, 60 mg) and repeated doses (20mg over 15 days) NDMC pharma cokinetic were evaluated.Thirty ‐two subjects participated to the study. Primary outcome parameter was maximal change in the area of cutaneous UVB irradiation‐induced secondary hyperalgesia (AS...
Source: European Journal of Pain - March 15, 2020 Category: Anesthesiology Authors: Alain Matthey, Youssef Daali, Fran çois Curtin, Antoine Poncet, Jules Desmeules, Marie Besson Tags: ORIGINAL ARTICLE Source Type: research

Effectiveness of Percutaneous Electrical Nerve Stimulation for Musculoskeletal Pain: A Systematic Review and Meta ‐analysis
ConclusionThere is low level of evidence suggesting the effects of PENS alone or in combination for pain, but not related ‐disability, in musculoskeletal pain. (Source: European Journal of Pain)
Source: European Journal of Pain - March 15, 2020 Category: Anesthesiology Authors: Gustavo Plaza ‐Manzano, Guido F Gómez‐Chiguano, Joshua A Cleland, Jose L Arías‐Buría, César Fernández‐de‐las‐Peñas, Marcos J. Navarro‐Santana Tags: REVIEW ARTICLE Source Type: research

Identifying pain perceptual biases related to fear of pain and threat in a pain ‐free sample
ConclusionsThe current research emphasized that participants with higher FOP level showed pain perceptual biases to specific threatening painful stimulus. Threat appraisal of pain played a key role in the positive association between pain ‐related fear and pain perceptual biases. (Source: European Journal of Pain)
Source: European Journal of Pain - March 5, 2020 Category: Anesthesiology Authors: Zhou Yang, Bateer Tags: ORIGINAL ARTICLE Source Type: research

Viscero ‐visceral hyperalgesia in dysmenorrhoea plus previous urinary calculosis: Role of myofascial trigger points and their injection treatment in the referred area
AbstractBackgroundWomen with dysmenorrhoea plus symptomatic urinary calculosis experience enhanced pain and referred muscle hyperalgesia from both conditions than women with one condition only (viscero ‐visceral hyperalgesia). The study aimed at verifying if enhanced dysmenorrhoea persists after urinary stone elimination in comorbid women and if local anaesthetic inactivation of myofascial trigger points (TrPs) in the lumbar area (of urinary pain referral) also relieves dysmenorrhoea.MethodsThirty ‐one women with dysmenorrhoea plus previous urinary calculosis (Dys+PrCal) and lumbar TrPs, and 33 women with dysmenorrhoea...
Source: European Journal of Pain - March 5, 2020 Category: Anesthesiology Authors: Raffaele Costantini, Giannapia Affaitati, Michele Fiordaliso, Maria Adele Giamberardino Tags: ORIGINAL ARTICLE Source Type: research

The roles of race, sex, and cognitions in response to experimental pain
This study reports a multivariate test of sex and race differences in experimental pain, and the degree to which these differences could be uniquely attributable to three levels of cognition: primary appraisals (threat, challenge), secondary appraisals (pain catastrophizing) and/or cognitive processes (mindful observing, non ‐reactivity). Both the predictive and mediator role of the cognitive variables was of interest.MethodsThe study employed a cross ‐sectional experimental design, with the cold pressor task employed as the pain stimulus. The total sample included N = 355 healthy adults (67% female, 33% male; 70% Cauc...
Source: European Journal of Pain - March 4, 2020 Category: Anesthesiology Authors: Melissa A. Day, L. Charles Ward, Michelle P. Grover, Dawn M. Ehde, Oliver R. Illingworth, Mark P. Jensen Tags: ORIGINAL ARTICLES Source Type: research