Spinal voltage ‐gated potassium channel Kv1.3 contributes to neuropathic pain via the promotion of microglial M1 polarization and activation of the NLRP3 inflammasome
ConclusionOur research indicates that the Kv1.3 channel in the spinal cord contributes to neuropathic pain by promoting microglial M1 polarization and activating the NLRP3 inflammasome. (Source: European Journal of Pain)
Source: European Journal of Pain - December 8, 2022 Category: Anesthesiology Authors: Xiaoman Yuan,
Siyi Han,
Anne Manyande,
Feng Gao,
Jie Wang,
Wen Zhang,
Xuebi Tian Tags: ORIGINAL ARTICLE Source Type: research
The Relationship of Alexithymia to Pain and Other Symptoms in Fibromyalgia: A Systematic Review and Meta ‐analysis
ConclusionsDue to the high level of alexithymia in people with FM and the positive relationship of alexithymia with pain and psychological distress, interventions to improve emotional awareness, expression, and processing in FM are recommended. (Source: European Journal of Pain)
Source: European Journal of Pain - December 6, 2022 Category: Anesthesiology Authors: Mojtaba Habibi Asgarabad,
Pardis Salehi Yegaei,
Fatemeh Jafari,
Saber Azami ‐Aghdash,
Mark A. Lumley Tags: REVIEW ARTICLE Source Type: research
From past pain to future pain through the pain of others: Information about other people's pain ratings can alleviate our subsequent pain
ConclusionsInformation on pain derived from other people not only shapes the response to a novel stimulation but also substantially modifies the subsequent experience of that stimulation. (Source: European Journal of Pain)
Source: European Journal of Pain - December 6, 2022 Category: Anesthesiology Authors: E. A. Bajcar,
H. Bieniek,
J. Br ączyk,
P. Bąbel Tags: ORIGINAL ARTICLE Source Type: research
Investigating the relationship between pain indicators and observers ’ judgements of pain
ConclusionsWe found that in situations where incongruent information was presented about an individual's pain, participants relied on pain indicators that they perceived to be objective. The current study provides important insights about biases that people hold when making judgements of pain in others.SignificanceInterpretation and assessment of pain remains one of the largest barriers to pain management and involves complex, idiosyncratic processing. This study provides insights into what information participants view as critical in making attributions of pain when presented with multiple, seemingly incongruent sources o...
Source: European Journal of Pain - December 5, 2022 Category: Anesthesiology Authors: Lindsey R. Yessick,
Justine Tanguay,
Wiebke Gandhi,
Richard Harrison,
Ruxandra Dinu,
Bhismadev Chakrabarti,
Emma Borg,
Tim V. Salomons Tags: ORIGINAL ARTICLE Source Type: research
The temporal expression of circulating microRNAs after acute experimental pain in humans
ConclusionsThis exploratory study is the first to report on the temporal expression of circulating miRNAs after an acute, human experimental muscle pain model. (Source: European Journal of Pain)
Source: European Journal of Pain - December 1, 2022 Category: Anesthesiology Authors: R. Giordano,
M. C. Gerra,
H. Okutani,
S. Lo Vecchio,
A. Stensballe,
K. K. Petersen,
L. Arendt ‐Nielsen Tags: ORIGINAL ARTICLE Source Type: research
Temple cooling increases parasympathetic activity and decreases pressure pain on the hand
ConclusionsThese findings indicate that temple cooling evokes pain inhibition that is stronger in males than females. Cardiac parasympathetic activity does not appear to mediate this response. (Source: European Journal of Pain)
Source: European Journal of Pain - December 1, 2022 Category: Anesthesiology Authors: Di Ye,
Lechi Vo,
Timothy J. Fairchild,
Peter D. Drummond Tags: ORIGINAL ARTICLE Source Type: research
Modulation of central pain mechanisms using high definition transcranial direct current stimulation: A double ‐blind, sham‐controlled study
AbstractThe use of high definition transcranial direct current stimulation (HD-tDCS) has shown analgesic effects in some chronic pain patients, but limited anti-nociceptive effects in healthy asymptomatic subjects. This double-blinded sham-controlled study assessed the effects of HD-tDCS applied on three consecutive days on central pain mechanisms in healthy participants with (N=40) and without (N=40) prolonged experimental pain induced by intramuscular injection of nerve growth factor into the right hand on Day1. Participants were randomly assigned to Sham-tDCS (N=20 with pain, N=20 without) or Active-tDCS (N=20 with pain...
Source: European Journal of Pain - December 1, 2022 Category: Anesthesiology Authors: Sebastian Kold,
Thomas Graven ‐Nielsen Tags: ORIGINAL ARTICLE Source Type: research
Molecular and clinical markers of pain relief in complex regional pain syndrome: An observational study
ConclusionWe identified progressively reduced miR-223 as putative biomarker of chronic CRPS pain. Clinically, this study underlines the importance of early diagnosis and treatment showing that high initial pain does not predict unfavourable outcome. Finally, pain relief and recovery of sensory disturbances seem independent processes. (Source: European Journal of Pain)
Source: European Journal of Pain - November 29, 2022 Category: Anesthesiology Authors: Ann Kristin Reinhold,
Gudrun ‐Karin Kindl,
Christopher Dietz,
Nathalie Scheu,
Katharina Mehling,
Alexander Brack,
Frank Birklein,
Heike L. Rittner Tags: ORIGINAL ARTICLE Source Type: research
Spinal voltage ‐gated potassium channel Kv1.3 contributes to neuropathic pain via promotion of microglial M1 polarization and activation of the NLRP3 inflammasome
AbstractStudies have shown that activation of microglia is the main mechanism of neuropathic pain. Kv1.3 channel is a novel therapeutic target for treating neuroinflammatory disorders due to its crucial role in subsets of microglial cells. As such, it may be involved in the processes of neuropathic pain, however, whether Kv1.3 plays a role in neuroinflammation following peripheral nerve injury is unclear. The spared nerve injury model (SNI) was used to establish neuropathic pain. Western blot and immunofluorescence were used to examine the effect of Kv1.3 in the SNI rats. PAP-1, a Kv1.3 specific blocker was administered to...
Source: European Journal of Pain - November 28, 2022 Category: Anesthesiology Authors: Yuan Xiaoman,
Siyi Han,
Anne Manyande,
Feng Gao,
Jie Wang,
Wen Zhang,
Xuebi Tian Tags: ORIGINAL ARTICLE Source Type: research
Independent research on long ‐term spinal cord stimulation outcomes: Comment on “Short‐and long‐term effects of conventional spinal cord stimulation on chronic pain and health perceptions: A longitudinal controlled trial” by Brill and colleagues
(Source: European Journal of Pain)
Source: European Journal of Pain - November 25, 2022 Category: Anesthesiology Authors: James Hitt,
Oscar A. deLeon ‐Casasola Tags: LETTER TO THE EDITOR Source Type: research
A systematic review and meta ‐analysis of neuropathic pain associated with coronavirus disease 2019
ConclusionsThe pooled estimated frequency of neuropathic pain associated with COVID-19 should be considered with caution due to the high heterogeneity across studies and the poor description of the neuropathic pain diagnostic criteria applied.SignificanceEmerging evidence supports the development of neuropathic pain as a complication of COVID-19. However, longitudinal studies enrolling consecutive patients with COVID-19 that detail the diagnostic criteria for neuropathic pain are needed to better assess the frequency of this condition. (Source: European Journal of Pain)
Source: European Journal of Pain - November 24, 2022 Category: Anesthesiology Authors: Giulia Di Stefano,
Pietro Falco,
Eleonora Galosi,
Giuseppe Di Pietro,
Caterina Leone,
Andrea Truini Tags: REVIEW ARTICLE Source Type: research
Extensive sensorimotor training enhances nociceptive cortical responses in healthy individuals
ConclusionsThese novel findings indicate that the mechanisms by which extensive sensorimotor training promotes use-dependent plasticity in multisensory neural structures may also shape the neural signatures of nociceptive processing in healthy individuals. (Source: European Journal of Pain)
Source: European Journal of Pain - November 18, 2022 Category: Anesthesiology Authors: A. M. Zamorano,
B. Kleber,
F. Arguissain,
P. Vuust,
H. Flor,
T. Graven ‐Nielsen Tags: ORIGINAL ARTICLE Source Type: research
Safety and Effectiveness of Cannabinoids to Danish Patients with Treatment Refractory Chronic Pain – A Retrospective Observational Real‐world Study
ConclusionOral cannabinoid therapy seems to be safe and mildly effective in patients with TRCP. Randomized controlled trials with focus on comparable pain characteristics in diagnostical homogenous patient subgroups are needed for further improvement of evidence level for relief of chronic pain using oral cannabinoids. (Source: European Journal of Pain)
Source: European Journal of Pain - November 17, 2022 Category: Anesthesiology Authors: Tina Horsted,
Karoline Lichon Hesthaven,
Peter Derek Christian Leutscher Tags: ORIGINAL ARTICLE Source Type: research
Behaviour ‐based pain scales: Validity and interrater reliability of BPS‐NI and PAINAD‐G on general wards
ConclusionThe BPS-NI shows a good validity in measuring pain intensity in patients on general wards and may possibly be used for patients unable to communicate. Using defined cut-off values for BPS-NI and PAINAD-G, clinically relevant pain intensities in patients can reliably be detected.SignificanceMeasuring the pain intensity in patients unable to communicate is a common challenge on general wards. This study assessed reliability and applicability BPS-NI and the PAINAD-G in a general ward setting. Furthermore, it provides cut-off values in order to estimate pain intensity and support analgesic response. (Source: European Journal of Pain)
Source: European Journal of Pain - November 16, 2022 Category: Anesthesiology Authors: Jan D. Wandrey,
Niklas Behnel,
Elisa Weidner,
Ulrike Dummin,
Falk Dincklage,
Sascha Tafelski Tags: ORIGINAL ARTICLE Source Type: research
Investigating the Relationship Between Pain Indicators and Observers ’ Judgments of Pain
ConclusionsWe found that in situations where incongruent information was presented about an individual's pain, participants relied on pain indicators that they perceived to be objective. The current study provides important insights about biases that people hold when making judgments of pain in others. (Source: European Journal of Pain)
Source: European Journal of Pain - November 15, 2022 Category: Anesthesiology Authors: Lindsey R. Yessick,
Justine Tanguay,
Wiebke Gandhi,
Richard Harrison,
Ruxandra Dinu,
Bhismadev Chakrabarti,
Emma Borg,
Tim V. Salomons Tags: ORIGINAL ARTICLE Source Type: research
