Commentary on pupillometry and pain ratings
(Source: European Journal of Pain)
Source: European Journal of Pain - July 10, 2023 Category: Anesthesiology Authors: Merlin D. Larson Tags: COMMENTARY Source Type: research

Central generators of migraine and autonomic cephalalgias as targets for personalized pain management: Translational links
ConclusionIt is argued that a better understanding of homeostatic dysfunctional states appears fundamental and may benefit the development of personalized therapeutic approaches for improving clinical outcomes in primary headache disorders.SignificanceThis review focuses on the most relevant back and forward translational studies showing the crucial role of top-down brain modulation in triggering and maintaining primary headache states and how these central dysfunctions may interact with personalized pain management strategies. (Source: European Journal of Pain)
Source: European Journal of Pain - July 9, 2023 Category: Anesthesiology Authors: Rodrigo Noseda, Luis Villanueva Tags: REVIEW ARTICLE Source Type: research

Osteoporosis treatment and pain relief: A scoping review
ConclusionConsidering the limitations of the literature, there is a need for more rigorous trials and larger real-life studies taking into account the recommendations published for research in rheumatology and in pain medicine. The identification of responders, patient subtypes, and of analgesic-effect doses would allow optimization and individualization for pain relief in patients with OP.Significance StatementThis scoping review shows that anti-OP drugs may improve pain and quality of life of patients with OP. The heterogeneity in design, choice of endpoints, methodology, comparators and follow-up duration of included ra...
Source: European Journal of Pain - July 5, 2023 Category: Anesthesiology Authors: Marie ‐Eva Pickering, Rose‐Marie Javier, Sandrine Malochet, Gisele Pickering, Jules Desmeules Tags: REVIEW ARTICLE Source Type: research

Child appraisals of injustice in the context of acute and chronic pain: An interpretative phenomenological analysis
ConclusionsThis study offers the first exploration of the phenomenology of child pain-related injustice appraisals in both pain-free children and paediatric pain patients. Findings highlight the interpersonal nature of lived injustice experiences caused by chronic pain, which is not fully captured by existing child pain-related injustice measures. Findings further suggest that pain-related injustice notions may not be extrapolated from a chronic to an acute pain context.SignificanceThe current study offers the first exploration of the phenomenology of child pain-related injustice appraisals in both pain-free children and p...
Source: European Journal of Pain - June 29, 2023 Category: Anesthesiology Authors: F. Daenen, F. Baert, J. McParland, Z. Trost, A. Schillemans, A. Tanghe, T. Vervoort Tags: ORIGINAL ARTICLE Source Type: research

Intra ‐ and interindividual reliability of muscle pain induced by an intramuscular injection of hypertonic saline injection into the quadriceps
ConclusionsIntramuscular injections of 1  mL of hypertonic saline into the vastus lateralis display substantial levels of interindividual variability, but MDC is below the clinically important changes in pain. This model of experimental pain is suitable for studies involving repeated exposures.SignificanceMany pain research studies have performed intramuscular injections of hypertonic saline to investigate responses to muscle pain. However, the reliability of this technique is not well established. We examined the pain response over three repeated sessions of a hypertonic saline injection. The pain induced by hypertonic ...
Source: European Journal of Pain - June 28, 2023 Category: Anesthesiology Authors: Samuel A. Smith, Ryan Norbury, Adam J. Hunt, Alexis R. Mauger Tags: ORIGINAL ARTICLE Source Type: research

Chronic pain is associated with less grey matter volume in the anterior cingulum, anterior and posterior insula and hippocampus across three different chronic pain conditions
ConclusionsChronic pain across three different pain conditions was characterized by less GMV in brain regions consistently described for different chronic pain conditions before. Less GMV in the left hippocampus mediated by experienced stress during the last year might be related to altered pain learning mechanisms in chronic pain patients.SignificanceGrey matter reorganization could serve as a diagnostic biomarker for chronic pain. In a large cohort, we here replicated findings of less grey matter volume across three pain conditions in the left anterior and posterior insula, anterior cingulate and left hippocampus. Less h...
Source: European Journal of Pain - June 27, 2023 Category: Anesthesiology Authors: Nicola Neumann, Martin Domin, Carsten ‐Oliver Schmidt, Martin Lotze Tags: ORIGINAL ARTICLE Source Type: research

Cognitive ‐affective changes mediate the mindfulness‐based intervention effect on endometriosis‐related pain and mental health: A path analysis approach
ConclusionsOur findings showed that bMBI impacts pain through changes in pain-related cognitive-affective factors. bMBI can improve QoL-MH by multiple pathways, including but not limited to pain reduction, highlighting the independent potential of improvement in affect to restore mental health in endometriosis.SignificanceBrief mindfulness-based intervention improves endometriosis pain through pain-related cognitive-affective factors and quality of life mental health via pain and affect changes unrelated to pain. (Source: European Journal of Pain)
Source: European Journal of Pain - June 27, 2023 Category: Anesthesiology Authors: Marcelo de Fran ça Moreira, Olga Lucia Gamboa, Marco Aurelio Pinho Oliveira Tags: ORIGINAL ARTICLE Source Type: research

Influence of skin type and laser wavelength on laser ‐evoked potentials
ConclusionsThis study shows that LEP elicitation depends on the combination of laser penetrance and skin type. Low penetrance stimuli, from a CO2 laser, elicited significantly lower LEPs and perceived intensities in the palm.SignificanceThis study showed that the elicitation of laser-evoked potentials in healthy humans greatly depends on the combination of laser stimulator type and skin type. It was shown that high penetrance laser stimuli are capable of eliciting responses in both hairy and glabrous skin, whereas low penetrance stimuli barely elicited responses from the glabrous skin. Computational modelling was used to d...
Source: European Journal of Pain - June 26, 2023 Category: Anesthesiology Authors: Ken Steffen Frahm, Sabata Gervasio, Federico Arguissain, Andr é Mouraux Tags: ORIGINAL ARTICLE Source Type: research

Sex differences in lifetime prevalence of low back pain: A multinational study of opposite ‐sex twin pairs
ConclusionsWe found no evidence of the association between sex and LBP in our merged sample. Between-population differences (i.e. cultural background or health system characteristics) are likely to be major factors leading to variation in the sex association with LBP when familial factors are accounted for.SignificanceOur study of adult opposite-sex twin pairs found no evidence of an association between female sex and lifetime prevalence of low back pain after controlling for familial factors in the merged sample from Australia, Spain and USA, contrary to findings from previous studies of unrelated individuals. Our finding...
Source: European Journal of Pain - June 26, 2023 Category: Anesthesiology Authors: Lucas Calais ‐Ferreira, Daniel Pozzobon, Marina B. Pinheiro, Fiona M. Blyth, Juan R. Ordoñana, Glen E. Duncan, John L. Hopper, Paulo H. Ferreira, Manuela L. Ferreira Tags: ORIGINAL ARTICLE Source Type: research

Where does it hurt? Small area estimates and inequality in the prevalence of chronic pain
ConclusionsPrevalence of chronic and high-impact chronic pain in adults aged 35+ varies substantially between neighbourhoods within local authorities. Further insight into small-area level variation will help target resources to improve the management and prevention of chronic and high-impact chronic pain to reduce the impact on individuals, communities, workplaces, services and the economy.SignificancePost-stratified multilevel model predictions can produce small-area estimates of pain prevalence and impact. The evidence of substantial variation indicates a need to collect local-level data on pain and its impact to unders...
Source: European Journal of Pain - June 22, 2023 Category: Anesthesiology Authors: Marty Lynch, George Peat, Kelvin Jordan, Dahai Yu, Ross Wilkie Tags: ORIGINAL ARTICLE Source Type: research

Communication of pain intensity and unpleasantness through magnitude ratings: Influence of scale type, but not gender of the participant
ConclusionsThese findings confirm differences in rating scale usage; however, the different usage might not contribute significantly to gender differences in pain.SignificanceThere are differences in the usage of rating scales in which ratings for auditory, visual and noxious somatosensory stimuli are higher with NRS compared to VAS. Choosing a rating scale for research or clinical use should take this different item functioning into account. (Source: European Journal of Pain)
Source: European Journal of Pain - June 22, 2023 Category: Anesthesiology Authors: Hadas Nahman ‐Averbuch, Cassidy Hughes, Marie‐Eve Hoeppli, Kristina White, James Peugh, Eric Leon, Christopher D. King, Robert C. Coghill Tags: ORIGINAL ARTICLE Source Type: research

Task ‐dependent functional connectivity of pain is associated with the magnitude of placebo analgesia in pain‐free individuals
ConclusionsResults suggest that stronger expectancy-based placebo responses might be underpinned by greater FC among attentional and somatosensory regions.SignificanceThis article provides support and insight for task-dependent functional connectivity differences related to the magnitude of placebo analgesia. Our findings provide key support that the magnitude of expectation-based placebo response depends on the coupling of regions associated with somatosensory and attentional processing. (Source: European Journal of Pain)
Source: European Journal of Pain - June 22, 2023 Category: Anesthesiology Authors: Nicholas J. Bush, Jeff Boissoneault, Janelle Letzen, Roland Staud, Michael E. Robinson Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: European Journal of Pain)
Source: European Journal of Pain - June 12, 2023 Category: Anesthesiology Tags: ISSUE INFORMATION Source Type: research

Comparison between pupillometry and numeric pain rating scale for pain assessments in communicating adult patients in the emergency department
ConclusionsPupillometry does not appear to be an effective tool to evaluate pain in the ED environment. Indeed, too many factors influencing the sympathetic system —and thus the dynamic pupillary measures—are not controllable in the ED.SignificancePupillometry does not appear to be an effective tool to evaluate pain in the ED environment.There are several possible explanations for these negative results. The factors influencing the sympathetic system —and thus the PD fluctuations—are controllable in the postoperative period but not in the ED (e.g. full bladder, hypothermia). In addition, numerous psychological phen...
Source: European Journal of Pain - June 12, 2023 Category: Anesthesiology Authors: Charles Gregoire, David Charier, Romane de  Bergeyck, André Mouraux, Floor Van Ouytsel, Romain Lambert, Nicole Zhou, Patricia Lavand'homme, Andrea Penaloza, Gisele Pickering Tags: ORIGINAL ARTICLE Source Type: research

Women authorship in pain research: A bibliometric analysis from 2002 to 2021
DiscussionOur data demonstrated increasing women authorship in pain journals in the past 20  years, largely driven by an increase in first authorships. There still remains a large gap between first and senior authorship, indicative of disparity in the role that women play in research. (Source: European Journal of Pain)
Source: European Journal of Pain - June 12, 2023 Category: Anesthesiology Authors: Haoyan Zhong, Jashvant Poeran, Crispiana Cozowicz, Alex Illescas, Jiabin Liu, Stavros G. Memtsoudis Tags: SHORT COMMUNICATION Source Type: research