Beneficial and harmful effects of antidepressants versus placebo, ‘active placebo’, or no intervention for adults with major depressive disorder: a protocol for a systematic review of published and unpublished data with meta-analyses and trial sequential analyses
DiscussionAs antidepressants are commonly used to treat major depressive disorder in adults, a systematic review evaluating their beneficial and harmful effects is urgently needed. This review will inform best practice in treatment and clinical research of this highly prevalent and burdensome disorder.Systematic review registrationPROSPEROCRD42020220279 (Source: Systematic Reviews)
Source: Systematic Reviews - May 25, 2021 Category: International Medicine & Public Health Source Type: research
A Novel Potent Sleep ‐promoting Effect of Turmeric: Turmeric Increases Non‐rapid Eye Movement Sleep in Mice Via H1‐receptor Blockade
ConclusionTE has a sleep-promoting effect owing to reduction in sleep latency and enhancement of NREMS via H1R blockade; therefore, it could be useful in insomnia.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - May 18, 2021 Category: Food Science Authors: Min Young Um,
Minseok Yoon,
Jaekwang Lee,
Jonghoon Jung,
Suengmok Cho Tags: Research Article Source Type: research
Impact of Body Mass Index on Serum Concentrations of Antidepressants and Antipsychotics
Background:
Rates of overweight and obesity are higher in patients suffering from psychiatric disorders than in the general population. Body composition and enzyme functions are affected by overweight, and consequently, the pharmacokinetics of drugs may vary in overweight patients. Thus, overweight and obesity are important factors in psychiatric disorders and their treatment. This analysis aimed to investigate the impact of body mass index (BMI) on serum concentrations of the antidepressant drugs amitriptyline, doxepin, escitalopram, mirtazapine, and venlafaxine, and the antipsychotic drugs clozapine, quetiapine, and ...
Source: Therapeutic Drug Monitoring - March 25, 2021 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat
This study demonstrates a proof-of-principle on how to include active renal excretion into generic PBK models.PMID:33639197 | DOI:10.1016/j.toxlet.2021.02.013 (Source: Toxicology Letters)
Source: Toxicology Letters - February 27, 2021 Category: Toxicology Authors: Annelies Noorlander Sebastiaan Wesseling Ivonne M C M Rietjens Bennard van Ravenzwaay Source Type: research
Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat
This study demonstrates a proof-of-principle on how to include active renal excretion into generic PBK models.PMID:33639197 | DOI:10.1016/j.toxlet.2021.02.013 (Source: Toxicology Letters)
Source: Toxicology Letters - February 27, 2021 Category: Toxicology Authors: Annelies Noorlander Sebastiaan Wesseling Ivonne M C M Rietjens Bennard van Ravenzwaay Source Type: research
Simulation of adsorption and release of doxepin onto ZIF-8 including in vitro cellular toxicity and viability
Publication date: 1 May 2021Source: Journal of Molecular Liquids, Volume 329Author(s): Xiaoliang Dou, Maryam Keywanlu, Reza Tayebee, Behnam Mahdavi (Source: Journal of Molecular Liquids)
Source: Journal of Molecular Liquids - February 6, 2021 Category: Molecular Biology Source Type: research
Meta-analysis of the clinical effectiveness of combined acupuncture and Western Medicine to treat post-stroke depression
CONCLUSION: The therapeutic effects of acupuncture combined with Western Medicine on post-stroke depression are often better than those of Western Medicine alone, and fewer adverse reactions occur. However, more high-quality RCTs are needed to further confirm these findings.PMID:33522192 | DOI:10.19852/j.cnki.jtcm.2021.01.002 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - February 1, 2021 Category: Complementary Medicine Authors: Xue Wang Jun Xiong Jun Yang Ting Yuan Yunfeng Jiang Xiaohong Zhou Kai Liao Lingling Xu Source Type: research
Meta-analysis of the clinical effectiveness of combined acupuncture and Western Medicine to treat post-stroke depression
CONCLUSION: The therapeutic effects of acupuncture combined with Western Medicine on post-stroke depression are often better than those of Western Medicine alone, and fewer adverse reactions occur. However, more high-quality RCTs are needed to further confirm these findings.PMID:33522192 | DOI:10.19852/j.cnki.jtcm.2021.01.002 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - February 1, 2021 Category: Complementary Medicine Authors: Xue Wang Jun Xiong Jun Yang Ting Yuan Yunfeng Jiang Xiaohong Zhou Kai Liao Lingling Xu Source Type: research
Meta-analysis of the clinical effectiveness of combined acupuncture and Western Medicine to treat post-stroke depression
CONCLUSION: The therapeutic effects of acupuncture combined with Western Medicine on post-stroke depression are often better than those of Western Medicine alone, and fewer adverse reactions occur. However, more high-quality RCTs are needed to further confirm these findings.PMID:33522192 | DOI:10.19852/j.cnki.jtcm.2021.01.002 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - February 1, 2021 Category: Complementary Medicine Authors: Xue Wang Jun Xiong Jun Yang Ting Yuan Yunfeng Jiang Xiaohong Zhou Kai Liao Lingling Xu Source Type: research
Meta-analysis of the clinical effectiveness of combined acupuncture and Western Medicine to treat post-stroke depression
CONCLUSION: The therapeutic effects of acupuncture combined with Western Medicine on post-stroke depression are often better than those of Western Medicine alone, and fewer adverse reactions occur. However, more high-quality RCTs are needed to further confirm these findings.PMID:33522192 | DOI:10.19852/j.cnki.jtcm.2021.01.002 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - February 1, 2021 Category: Complementary Medicine Authors: Xue Wang Jun Xiong Jun Yang Ting Yuan Yunfeng Jiang Xiaohong Zhou Kai Liao Lingling Xu Source Type: research
