Phenytoin toxicity due to drug interaction with doxepin and changes in patient factors
No abstract available (Source: The Nurse Practitioner)
Source: The Nurse Practitioner - May 22, 2019 Category: Nursing Tags: Department: Clinical Case Report Source Type: research
Inhibitory Effect of Tricyclic Antidepressant Doxepin on Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells.
Abstract
Doxepin, tricyclic antidepressant, is widely used for the treatment of depressive disorders. Our present study determined the inhibitory effect of doxepin on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Vascular Kv currents were inhibited by doxepin in a concentration-dependent manner, with a half-maximal inhibitory concentration (IC50) value of 6.52 ± 1.35 μM and a Hill coefficient of 0.72 ± 0.03. Doxepin did not change the steady-state activation curve or inactivation curve, suggesting th...
Source: Cardiovascular Toxicology - April 26, 2019 Category: Cardiology Authors: Li H, Kang H, An JR, Seo MS, Jung WK, Lee DS, Choi G, Yim MJ, Lee JM, Bae YM, Son YK, Choi IW, Park WS Tags: Cardiovasc Toxicol Source Type: research
Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo for Oral Mucositis Pain
This phase 3 randomized trial compares the effect of doxepin mouthwash or diphenhydramine-lidocaine-antacid mouthwash on oral mucositis –related pain among patients who underwent definitive head and neck radiotherapy. (Source: JAMA)
Source: JAMA - April 16, 2019 Category: General Medicine Source Type: research
Histamine and Delirium: Current Opinion
This study indicated that switch from H2 blockers to PPIs reduced delirium and, thus, providing an appropriate strategy to combat drug-induced delirium using antiulcer drugs (Fujii et al., 2012). The ventrolateral preoptic nucleus is a sleep-promoting nucleus located in the basal forebrain. A commonly used intravenous anesthetic, propofol, had been reported to induce sleep and augment the firing rate of neurons in ventrolateral GABAergic preoptic nucleus, but the underlining mechanism is yet to be clearly determined. Interestingly, the propofol-induced inhibition of inhibitory postsynaptic currents on noradrenalin-inhibite...
Source: Frontiers in Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Source Type: research
Extent and Predictors of Potentially Inappropriate Antidepressant Use Among Older Adults With Dementia and Major Depressive Disorder.
CONCLUSION: More than 7% of older adults in the study sample initiated a potentially inappropriate antidepressant, and the authors identified a few individual-level factors significantly associated with it. Appropriately tailored interventions to address modifiable and nonmodifiable factors significantly associated with potentially inappropriate antidepressant prescribing are required to minimize risks in this vulnerable population.
PMID: 30926273 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - March 31, 2019 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
[The interesting anti-H1 Â effects in maintenance insomnia: A reflection on the comparative advantages of doxylamine and doxepin].
[The interesting anti-H1Â effects in maintenance insomnia: A reflection on the comparative advantages of doxylamine and doxepin].
Encephale. 2019 Mar 14;:
Authors: Dupuis G, Vaugeois JM
Abstract
Doxylamine (Donormyl®, Lidene®, Generics) is commonly proposed by pharmacists as a sleeping pill which does not require a prescription. In France, today it is only prescribed for occasional insomnia in adults. In light of knowledge about the role of the histamine H1 inverse agonist drugs in the treatment of insomnia, and specifically the low dose doxepin (3 mg and 6 mg) marketed in the...
Source: L Encephale - March 20, 2019 Category: Psychiatry Tags: Encephale Source Type: research
Acid sphingomyelinase mediates the noise induced liver disorder in mice.
This article is protected by copyright. All rights reserved.
PMID: 30854677 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - March 9, 2019 Category: Drugs & Pharmacology Authors: Meng X, Gu Z, Xie X, Su Y, Zhang X, Ma H, Guo Y, Liu X, Cheng Y, Chang Y, Bao J Tags: Clin Exp Pharmacol Physiol Source Type: research
Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2
Smoking is common among psychiatric patients and has been shown to accelerate the metabolism of different drugs. We aimed to determine the effect of smoking on the serum concentrations of psychopharmacological drugs in a naturalistic clinical setting. Dose-corrected, steady-state serum concentrations of individual patients were analyzed retrospectively by linear regression including age, sex, and smoking for amitriptyline (n=503), doxepin (n=198), mirtazapine (n=572), venlafaxine (n=534), clozapine (n=106), quetiapine (n=182), and risperidone (n=136). Serum levels of amitriptyline (P=0.038), clozapine (P=0.02), and mirtaza...
Source: International Clinical Psychopharmacology - March 1, 2019 Category: Psychiatry Tags: ORIGINAL ARTICLES Source Type: research
Treatment Strategies for Clozapine-Induced Sialorrhea: A Systematic Review and Meta-analysis
ConclusionClozapine-induced sialorrhea is a potentially serious adverse event. Included studies in this meta-analysis were limited by poor study quality. Diphenhydramine, chlorpheniramine and benzamide derivatives appear to have the best supporting evidence and lowest reported adverse events. Caution should be exercised when using propantheline given its increased risk of constipation. (Source: CNS Drugs)
Source: CNS Drugs - February 13, 2019 Category: Neurology Source Type: research
Treatment of chronic spontaneous urticaria with an inadequate response to H1-antihistamine.
Authors: Curto-Barredo L, Giménez-Arnau AM
Abstract
The second-generation H1-antihistamines (sgAH) are the first-line symptomatic treatment of patients with chronic spontaneous urticaria (CSU). Up to 50% of the patients will not respond to licensed doses of sgAH. According to the guidelines, the dose of sgAH may be increased up to 4 times the conventional dose. However, even at higher doses, there is a subgroup of patients, are refractory to the antihistamine treatment. The purpose of this article is to review the different treatment options of antihistaminerefractory CSU patients. This revision examines ...
Source: Giornale Italiano di Dermatologia e Venereologia - February 6, 2019 Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2
Smoking is common among psychiatric patients and has been shown to accelerate the metabolism of different drugs. We aimed to determine the effect of smoking on the serum concentrations of psychopharmacological drugs in a naturalistic clinical setting. Dose-corrected, steady-state serum concentrations of individual patients were analyzed retrospectively by linear regression including age, sex, and smoking for amitriptyline (n=503), doxepin (n=198), mirtazapine (n=572), venlafaxine (n=534), clozapine (n=106), quetiapine (n=182), and risperidone (n=136). Serum levels of amitriptyline (P=0.038), clozapine (P=0.02), and mirtaza...
Source: International Clinical Psychopharmacology - February 5, 2019 Category: Psychiatry Tags: ORIGINAL ARTICLES Source Type: research
Electrochemical Behavior and Highly Sensitive Voltammetric Determination of Doxepin in ...
In this manuscript, the electrocatalytic oxidation of doxepin (DOX) was studied at a carbon ionic liquid electrode, fabricated using graphite, and the ionic liquid 1-octylpyridinium hexaflourophosphate (OPFP). The surface of the proposed electrode was characterized by scanning electron microscopy. Differential pulse voltammetry was applied as an analytical technique for quantification of sub-micromolar concentration of doxepin. Various parameters were optimized for practical application. Under the optimal conditions, the proposed electrode exhibited interesting sensitivity toward determination of doxepin compared to the ot...
Source: Iranian Journal of Pharmaceutical Research - December 31, 2018 Category: Drugs & Pharmacology Source Type: research
Design of High-Performance Adsorption Cross-linked Organic Functional Polymers Towards Tricyclic Antidepressants Using Computational Simulation
Publication date: Available online 21 December 2018Source: Journal of Environmental Chemical EngineeringAuthor(s): Fernanda Midori de Oliveira, Marcello Ferreira da Costa, Clésia Cristina Nascentes, César Ricardo Teixeira TarleyAbstractComputational simulations of eighteen functional monomers to produce cross-linked polymers containing high adsorption efficiency to tricyclic antidepressants [amitriptyline (AMT), clomipramine (CLO), doxepin (DOX), imipramine (IMI) and nortriptyline (NOR)] in aqueous medium were evaluated and selected to polymers synthesis. Among them, acrylic acid (AA) and methacrylic acid (MA) were chose...
Source: Journal of Environmental Chemical Engineering - December 21, 2018 Category: Chemistry Source Type: research
Use of Systemic Treatment in Patients with Chronic Pruritus: A Survey of Dermatologists in the Netherlands.
Abstract
Treatment of chronic pruritus can be a challenge for clinicians. Several systemic treatments have been suggested to reduce itch, such as gabapentinoids and antidepressants. The aim of this study was to assess the current practice of dermatologists regarding systemic treatment in patients with chronic pruritus, and to identify possible barriers in the prescription of these treatments. An online survey was sent to all dermatologists and dermatology residents in the Netherlands between July 2017 and April 2018. A total of 193 physi-cians completed the questionnaire (response rate 27.0%). Overall, 61....
Source: Acta Dermato-Venereologica - December 6, 2018 Category: Dermatology Authors: Kouwenhoven TA, van der Kerkhof PCM, Kamsteeg M Tags: Acta Derm Venereol Source Type: research
Toxicological findings in suicides – frequency of antidepressant and antipsychotic substances
AbstractThe role of psychoactive substances in the treatment of mental disorders and the risk of suicide are major public health issues. This cross-sectional study examined the prevalence of antidepressants and antipsychotics detected in toxicological screenings in suicides. Cases from the Institute of Legal Medicine of the Charit é-University Medicine Berlin were reviewed over a 4-year-period. All cases (n = 477) with positive toxicology for antidepressants and antipsychotics in blood or organ tissue were included. Frequencies of the detected substances in non-suicide cases (n = 212; malen = 177, 55.2%; femalenÂ...
Source: Forensic Science, Medicine, and Pathology - November 5, 2018 Category: Forensic Medicine Source Type: research
