Electrochemical Behavior and Highly Sensitive Voltammetric Determination of Doxepin in ...
In this manuscript, the electrocatalytic oxidation of doxepin (DOX) was studied at a carbon ionic liquid electrode, fabricated using graphite, and the ionic liquid 1-octylpyridinium hexaflourophosphate (OPFP). The surface of the proposed electrode was characterized by scanning electron microscopy. Differential pulse voltammetry was applied as an analytical technique for quantification of sub-micromolar concentration of doxepin. Various parameters were optimized for practical application. Under the optimal conditions, the proposed electrode exhibited interesting sensitivity toward determination of doxepin compared to the ot...
Source: Iranian Journal of Pharmaceutical Research - October 15, 2018 Category: Drugs & Pharmacology Source Type: research
Insomnia in Elderly Patients: Recommendations for Pharmacological Management
AbstractChronic insomnia affects 57% of the elderly in the United States, with impairment of quality of life, function, and health. Chronic insomnia burdens society with billions of dollars in direct and indirect costs of care. The main modalities in the treatment of insomnia in the elderly are psychological/behavioral therapies, pharmacological treatment, or a combination of both. Various specialty societies view psychological/behavioral therapies as the initial treatment intervention. Pharmacotherapy plays an adjunctive role when insomnia symptoms persist or when patients are unable to pursue cognitive behavioral therapi...
Source: Drugs and Aging - September 1, 2018 Category: Geriatrics Source Type: research
Highly sensitive LC–MS/MS method to estimate doxepin and its metabolite nordoxepin in human plasma for a bioequivalence study
Publication date: Available online 16 June 2017Source: Journal of Pharmaceutical AnalysisAuthor(s): Nirav P. Patel, Mallika Sanyal, Naveen Sharma, Dinesh S. Patel, Pranav S. Shrivastav, Bhavin N. PatelAbstractA selective, sensitive and rugged liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay has been developed for the simultaneous determination of doxepin (Dox) and its pharmacologically active metabolite, nordoxepin (NDox) in human plasma. The analytes and their internal standards (IS) were extracted from 500 µL of human plasma by liquid-liquid extraction using methyl tert-butyl ether. Chromatograph...
Source: Journal of Pharmaceutical Analysis - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Antidepressants for insomnia in adults.
CONCLUSIONS: We identified relatively few, mostly small studies with short-term follow-up and design limitations. The effects of SSRIs compared with placebo are uncertain with too few studies to draw clear conclusions. There may be a small improvement in sleep quality with short-term use of low-dose doxepin and trazodone compared with placebo. The tolerability and safety of antidepressants for insomnia is uncertain due to limited reporting of adverse events. There was no evidence for amitriptyline (despite common use in clinical practice) or for long-term antidepressant use for insomnia. High-quality trials of antidepressa...
Source: Cochrane Database of Systematic Reviews - May 14, 2018 Category: General Medicine Authors: Everitt H, Baldwin DS, Stuart B, Lipinska G, Mayers A, Malizia AL, Manson CC, Wilson S Tags: Cochrane Database Syst Rev Source Type: research
Efficacy, acceptability, and tolerability of antidepressant treatments for patients with post-stroke depression: a network meta-analysis.
Authors: Qin B, Chen H, Gao W, Zhao LB, Zhao MJ, Qin HX, Chen W, Chen L, Yang MX
Abstract
The aim of this study was to investigate the efficacy, acceptability, and tolerability of antidepressants in treating post-stroke depression (PSD) by performing a network meta-analysis of randomized controlled trials of the current literature. Eligible studies were retrieved from online databases, and relevant data were extracted. The primary outcome was efficacy as measured by the mean change in overall depressive symptoms. Secondary outcomes included discontinued treatment for any reason and specifically due to adve...
Source: Brazilian Journal of Medical and Biological Research - May 10, 2018 Category: Research Tags: Braz J Med Biol Res Source Type: research
Tricyclic antidepressants inhibit hippocampal α7* and α9α10 nicotinic acetylcholine receptors by different mechanisms.
Abstract
The activity of tricyclic antidepressants (TCAs) at α7 and α9α10 nicotinic acetylcholine receptors (AChRs) as well as at hippocampal α7-containing (i.e., α7*) AChRs is determined by using Ca2+ influx and electrophysiological recordings. To determine the inhibitory mechanisms, additional functional tests and molecular docking experiments are performed. The results established that TCAs (a) inhibit Ca2+ influx in GH3-α7 cells with the following potency (IC50 in µM) rank: amitriptyline (2.7 ± 0.3) > doxepin (5.9 ± 1.1) ~ imipramine (6.6 ± 1.0). Interestingly, imipramine inhib...
Source: The International Journal of Biochemistry and Cell Biology - April 25, 2018 Category: Biochemistry Authors: Arias HR, Vázquez-Gómez E, Hernández-Abrego A, Gallino S, Feuerbach D, Ortells MO, Elgoyhen AB, García-Colunga J Tags: Int J Biochem Cell Biol Source Type: research
Antidepressants for the treatment of people with co-occurring depression and alcohol dependence.
CONCLUSIONS: We found low-quality evidence supporting the clinical use of antidepressants in the treatment of people with co-occurring depression and alcohol dependence. Antidepressants had positive effects on certain relevant outcomes related to depression and alcohol use but not on other relevant outcomes. Moreover, most of these positive effects were no longer significant when studies with high risk of bias were excluded. Results were limited by the large number of studies showing high or unclear risk of bias and the low number of studies comparing one antidepressant to another or antidepressants to other medication. In...
Source: Cochrane Database of Systematic Reviews - April 24, 2018 Category: General Medicine Authors: Agabio R, Trogu E, Pani PP Tags: Cochrane Database Syst Rev Source Type: research
Doxepin: Misuse and Abuse
No abstract available (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - April 18, 2018 Category: Psychiatry Tags: Letters to the Editors — Case Reports Source Type: research
Molecules, Vol. 23, Pages 681: Transdermal and Topical Drug Administration in the Treatment of Pain
liczek
The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key role. An effective therapy for pain depends on the intensity and type of pain, the patients’ age, comorbidities, and appropriate choice of analgesic, its dose and route of administration. This review is aimed at presenting current knowledge on analgesics administered by transdermal and topical routes for physicians, nurses, pharmacists, and other health care professionals dealing with patients suffering from pain. Analgesics administered transdermally or topically act through different mechanisms. Opioids administered trans...
Source: Molecules - March 17, 2018 Category: Chemistry Authors: Wojciech Leppert Malgorzata Malec –Milewska Renata Zajaczkowska Jerzy Wordliczek Tags: Review Source Type: research
Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery.
Abstract
Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have many side effects, including cognitive impairment, tolerance, rebound insomnia upon discontinuation, car accidents/falls, abuse, and dependence liability. Consequently, the clinical use of off-label drugs and novel drugs that do not target the GABAergic system is increasing. The purpose of this review is to analyze the neurobiological and clinical evidence of pharmacological treatments of insomnia, excluding the BZDs and Z-drug...
Source: Pharmacological Reviews - March 2, 2018 Category: Drugs & Pharmacology Authors: Atkin T, Comai S, Gobbi G Tags: Pharmacol Rev Source Type: research
Antidepressants as antipruritic agents: A review
Pruritus is a concomitant symptom of various underlying disorders viz. dermatological, systemic and psychiatric disorders that provoke the person to scratch the skin. Many natural as well as, antipruritic therapies are usually practiced in the treatment of pruritus including general preventive measures, topical therapies such as cooling agents, antihistamines, anesthetics, capsaicin, corticosteroids, immunomodulators and; systemic therapies including administration of antihistamines, opioid antagonists/agonists, antiepileptic drugs/neuroleptics (e.g., gabapentin and pregabalin), antidepressants (e.g., doxepin, amitriptylin...
Source: European Neuropsychopharmacology - February 15, 2018 Category: Psychiatry & Psychology Authors: Randeep Kaur, V.R. Sinha Tags: REVIEW Source Type: research
Music electric stimulation of points for anxiety: a multi-center randomized controlled clinical trial
ConclusionMusic electric stimulation of points can produce equivalent efficacy in treating anxiety compared to doxepin. Thus, it can be taken as a choice in the treatment of anxiety. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - February 1, 2018 Category: Complementary Medicine Source Type: research
Fast and easy extraction of antidepressants from whole blood using ionic liquids as extraction solvent.
In conclusion, this study proves the applicability of ILs as extraction solvents for a large group of antidepressants in complex whole blood matrices.
PMID: 29332813 [PubMed - in process] (Source: Talanta)
Source: Talanta - January 16, 2018 Category: Chemistry Authors: De Boeck M, Dubrulle L, Dehaen W, Tytgat J, Cuypers E Tags: Talanta Source Type: research
