Pathogenesis ‐targeted therapeutic strategies in Parkinson's disease
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 28, 2018 Category: Neurology Authors: Joseph Jankovic Tags: Viewpoint Source Type: research

A paradoxical relationship between family history, onset age, and genetic risk in Parkinson's disease
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 28, 2018 Category: Neurology Authors: Madeleine Kristiansen, Jodi Maple ‐Grødem, Guido Alves, Sampath Arepalli, Dena G. Hernandez, Hirotaka Iwaki, Mike A. Nalls, Andrew Singleton, Ole‐Bjørn Tysnes, Mathias Toft, Lasse Pihlstrøm Tags: Letters: New Observations Source Type: research

Baseline predictors for progression 4 years after Parkinson's disease diagnosis in the De Novo Parkinson Cohort (DeNoPa)
Conclusion: Cardiovascular risk factors, deregulated blood glucose, uric acid metabolism, and inflammation were identified as risk markers for faster disease progression. Our panel of risk parameters needs validation during our continuing follow ‐up and also in independent patient cohorts. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 23, 2018 Category: Neurology Authors: Brit Mollenhauer, Johannes Zimmermann, Friederike Sixel ‐Döring, Niels K. Focke, Tamara Wicke, Jens Ebentheuer, Martina Schaumburg, Elisabeth Lang, Tim Friede, Claudia Trenkwalder, on behalf of the DeNoPa Study Group Tags: Research Article Source Type: research

MRI Outperforms [18F]AV ‐1451 PET as a Longitudinal Biomarker in Progressive Supranuclear Palsy
Conclusions: [18F]AV ‐1451 tau‐PET measures increase over time in subjects with PSP, but longitudinal [18F]AV ‐1451 measures may not perform as well as rate of midbrain atrophy as biomarkers for PSP clinical trials. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 23, 2018 Category: Neurology Authors: Jennifer L. Whitwell, Nirubol Tosakulwong, Christopher G. Schwarz, Hugo Botha, Matthew L. Senjem, Anthony J. Spychalla, J. Eric Ahlskog, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Val J. Lowe, Keith A. Josephs Tags: Research Article Source Type: research

Baseline predictors for progression 4 years after Parkinson's disease diagnosis in the De Novo Parkinson Cohort (DeNoPa)
Conclusion: Cardiovascular risk factors, deregulated blood glucose, uric acid metabolism, and inflammation were identified as risk markers for faster disease progression. Our panel of risk parameters needs validation during our continuing follow ‐up and also in independent patient cohorts. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 23, 2018 Category: Neurology Authors: Brit Mollenhauer, Johannes Zimmermann, Friederike Sixel ‐Döring, Niels K. Focke, Tamara Wicke, Jens Ebentheuer, Martina Schaumburg, Elisabeth Lang, Tim Friede, Claudia Trenkwalder, on behalf of the DeNoPa Study Group Tags: Research Article Source Type: research

MRI Outperforms [18F]AV ‐1451 PET as a Longitudinal Biomarker in Progressive Supranuclear Palsy
Conclusions: [18F]AV ‐1451 tau‐PET measures increase over time in subjects with PSP, but longitudinal [18F]AV ‐1451 measures may not perform as well as rate of midbrain atrophy as biomarkers for PSP clinical trials. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 23, 2018 Category: Neurology Authors: Jennifer L. Whitwell, Nirubol Tosakulwong, Christopher G. Schwarz, Hugo Botha, Matthew L. Senjem, Anthony J. Spychalla, J. Eric Ahlskog, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Val J. Lowe, Keith A. Josephs Tags: Research Article Source Type: research

MRI ‐guided laser interstitial thermal thalamotomy for medically intractable tremor disorders
Conclusion: Medically intractable tremor treated with laser interstitial thermal thalamotomy may be a useful addition to the treatment armamentarium for medically intractable tremor disorders. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Meghan Harris, John Steele, Rebecca Williams, Jim Pinkston, Richard Zweig, Jessica Anne Wilden Tags: Brief Report Source Type: research

Anle138b modulates α‐synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy
Conclusions: Anle138b reduces α‐synuclein accumulation in PLP‐hαSyn mice, leading to neuroprotection, reduction of microglial activation, and preservation of motor function supporting the use of anle138b in a future clinical trial for MSA. © 2018 The Authors.Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Antonio Heras ‐Garvin, Daniel Weckbecker, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Armin Giese, Gregor K. Wenning, Nadia Stefanova Tags: Research Article Source Type: research

Identification of a large homozygous VPS13C deletion in a patient with early ‐onset Parkinsonism
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Hossein Darvish, Paloma Bravo, Abbas Tafakhori, Luis J. Azcona, Sakineh Ranji ‐Burachaloo, Amir Hossein Johari, Coro Paisán‐Ruiz Tags: Letters: New Observations Source Type: research

Wild ‐type LRRK2 as a new potential therapeutic target in idiopathic Parkinson's disease
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Hossein Sanjari Moghaddam, Mohammad Hadi Aarabi Tags: Hot Topics Source Type: research

Identification of a large homozygous VPS13C deletion in a patient with early ‐onset Parkinsonism
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Hossein Darvish, Paloma Bravo, Abbas Tafakhori, Luis J. Azcona, Sakineh Ranji ‐Burachaloo, Amir Hossein Johari, Coro Paisán‐Ruiz Tags: Letters: New Observations Source Type: research

Wild ‐type LRRK2 as a new potential therapeutic target in idiopathic Parkinson's disease
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Hossein Sanjari Moghaddam, Mohammad Hadi Aarabi Tags: Hot Topics Source Type: research

MRI ‐guided laser interstitial thermal thalamotomy for medically intractable tremor disorders
Conclusion: Medically intractable tremor treated with laser interstitial thermal thalamotomy may be a useful addition to the treatment armamentarium for medically intractable tremor disorders. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Meghan Harris, John Steele, Rebecca Williams, Jim Pinkston, Richard Zweig, Jessica Anne Wilden Tags: Brief Report Source Type: research

Anle138b modulates α‐synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy
Conclusions: Anle138b reduces α‐synuclein accumulation in PLP‐hαSyn mice, leading to neuroprotection, reduction of microglial activation, and preservation of motor function supporting the use of anle138b in a future clinical trial for MSA. © 2018 The Authors.Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Antonio Heras ‐Garvin, Daniel Weckbecker, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Armin Giese, Gregor K. Wenning, Nadia Stefanova Tags: Research Article Source Type: research

Suggestive association between OPRM1 and impulse control disorders in Parkinson's disease
AbstractBackground: Impulse control disorders are frequently associated with dopaminergic therapy in Parkinson's disease. Genetic studies have suggested a high heritability of impulse control disorders in the general population and in PD. The aim of this study was to identify candidate gene variants associated with impulse control disorders and related behaviors in PD.Methods: We performed a multicenter case ‐control study in PD patients with (cases) or without impulse control disorders and related behaviors despite significant dopamine agonist exposure of>300  mg levodopa‐equivalent daily dose during 12 mont...
Source: Movement Disorders - November 16, 2018 Category: Neurology Authors: Florence Cormier ‐Dequaire, Samir Bekadar, Mathieu Anheim, Said Lebbah, Antoine Pelissolo, Paul Krack, Lucette Lacomblez, Eugénie Lhommée, Anna Castrioto, Jean‐Philippe Azulay, Luc Defebvre, Alexandre Kreisler, Franck Durif, Ana Marques Tags: Research Article Source Type: research

Pallidal beta bursts in Parkinson's disease and dystonia
In this study, we test whether prolonged bursts are disease specific for beta activity in PD by comparison to oscillatory activity in dystonia.Methods: Pallidal local field potentials were recorded from 5 PD patients ON and OFF dopaminergic medication and 5 dystonia patients. Synchronization of beta and low ‐frequency oscillations in bursts was compared between groups with respect to their duration, amplitude, and rate.Results: Pallidal beta bursts were longer in PD ‐OFF than PD‐ON or dystonia (P 
Source: Movement Disorders - November 15, 2018 Category: Neurology Authors: Roxanne Lofredi, Wolf ‐Julian Neumann, Christof Brücke, Julius Huebl, Joachim K. Krauss, Gerd‐Helge Schneider, Andrea A. Kühn Tags: Brief Report Source Type: research

BDNF provides many routes toward STN DBS ‐mediated disease modification
AbstractThe concept that subthalamic nucleus deep brain stimulation (STN DBS) may be disease modifying in Parkinson's disease (PD) is controversial. Several clinical trials that enrolled subjects with late ‐stage PD have come to disparate conclusions on this matter. In contrast, some clinical studies in early‐ to midstage subjects have suggested a disease‐modifying effect. Dopaminergic innervation of the putamen is essentially absent in PD subjects within 4 years after diagnosis, indicating that any neuroprotective therapy, including STN DBS, will require intervention within the immediate postdiagnosis interval. Prec...
Source: Movement Disorders - November 15, 2018 Category: Neurology Authors: D. Luke Fischer, Caryl E. Sortwell Tags: Scientific Perspectives Source Type: research

α‐Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies
The objective of this study was to investigate the discriminating value of a range of CSF α‐synuclein species for dementia with Lewy bodies compared with Alzheimer's disease, PD, and cognitively normal controls.Methods: We applied our recently published enzyme ‐linked immunosorbent assays to measure the CSF levels of total α‐synuclein, oligomeric α‐synuclein, and phosphorylated α‐synuclein in dementia with Lewy bodies (n = 42), Alzheimer's disease (n = 39), PD (n = 46), and controls (n = 78). General linear models corrected for age an...
Source: Movement Disorders - November 15, 2018 Category: Neurology Authors: Inger Steenoven, Nour K. Majbour, Nishant N. Vaikath, Henk W. Berendse, Wiesje M. Flier, Wilma D.J. Berg, Charlotte E. Teunissen, Afina W. Lemstra, Omar M.A. El ‐Agnaf Tags: Research Article Source Type: research

Progressively Disrupted Somatodendritic Morphology in Dopamine Neurons in a Mouse Parkinson's Model
Conclusions: A progressive and severe decline in somatodendritic morphology occurs prior to cell death, but is not responsible for the subtle decrements observable in the earliest stages of neurodegeneration. This work could help identify the ideal time window for specific treatments to halt disease progression and avert debilitating motor deficits in Parkinson's patients. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 15, 2018 Category: Neurology Authors: William B. Lynch, Christopher W. Tschumi, Amanda L. Sharpe, Sarah Y. Branch, Cang Chen, Guo Ge, Senlin Li, Michael J. Beckstead Tags: Research Article Source Type: research

Pallidal beta bursts in Parkinson's disease and dystonia
In this study, we test whether prolonged bursts are disease specific for beta activity in PD by comparison to oscillatory activity in dystonia.Methods: Pallidal local field potentials were recorded from 5 PD patients ON and OFF dopaminergic medication and 5 dystonia patients. Synchronization of beta and low ‐frequency oscillations in bursts was compared between groups with respect to their duration, amplitude, and rate.Results: Pallidal beta bursts were longer in PD ‐OFF than PD‐ON or dystonia (P 
Source: Movement Disorders - November 15, 2018 Category: Neurology Authors: Roxanne Lofredi, Wolf ‐Julian Neumann, Christof Brücke, Julius Huebl, Joachim K. Krauss, Gerd‐Helge Schneider, Andrea A. Kühn Tags: Brief Report Source Type: research

BDNF provides many routes toward STN DBS ‐mediated disease modification
AbstractThe concept that subthalamic nucleus deep brain stimulation (STN DBS) may be disease modifying in Parkinson's disease (PD) is controversial. Several clinical trials that enrolled subjects with late ‐stage PD have come to disparate conclusions on this matter. In contrast, some clinical studies in early‐ to midstage subjects have suggested a disease‐modifying effect. Dopaminergic innervation of the putamen is essentially absent in PD subjects within 4 years after diagnosis, indicating that any neuroprotective therapy, including STN DBS, will require intervention within the immediate postdiagnosis interval. Prec...
Source: Movement Disorders - November 15, 2018 Category: Neurology Authors: D. Luke Fischer, Caryl E. Sortwell Tags: Scientific Perspectives Source Type: research

α‐Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies
The objective of this study was to investigate the discriminating value of a range of CSF α‐synuclein species for dementia with Lewy bodies compared with Alzheimer's disease, PD, and cognitively normal controls.Methods: We applied our recently published enzyme ‐linked immunosorbent assays to measure the CSF levels of total α‐synuclein, oligomeric α‐synuclein, and phosphorylated α‐synuclein in dementia with Lewy bodies (n = 42), Alzheimer's disease (n = 39), PD (n = 46), and controls (n = 78). General linear models corrected for age an...
Source: Movement Disorders - November 15, 2018 Category: Neurology Authors: Inger Steenoven, Nour K. Majbour, Nishant N. Vaikath, Henk W. Berendse, Wiesje M. Flier, Wilma D.J. Berg, Charlotte E. Teunissen, Afina W. Lemstra, Omar M.A. El ‐Agnaf Tags: Research Article Source Type: research

Progressively Disrupted Somatodendritic Morphology in Dopamine Neurons in a Mouse Parkinson's Model
Conclusions: A progressive and severe decline in somatodendritic morphology occurs prior to cell death, but is not responsible for the subtle decrements observable in the earliest stages of neurodegeneration. This work could help identify the ideal time window for specific treatments to halt disease progression and avert debilitating motor deficits in Parkinson's patients. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 15, 2018 Category: Neurology Authors: William B. Lynch, Christopher W. Tschumi, Amanda L. Sharpe, Sarah Y. Branch, Cang Chen, Guo Ge, Senlin Li, Michael J. Beckstead Tags: Research Article Source Type: research

Glial GLP1R: A novel neuroprotector?
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 14, 2018 Category: Neurology Authors: Aubrey M. Schonhoff, Ashley S. Harms Tags: Hot Topics Source Type: research

Earlier onset of motor complications in Parkinson's patients with comorbid diabetes mellitus
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 14, 2018 Category: Neurology Authors: Norlinah Mohamed Ibrahim, Roshila Ramli, Shahedah Koya Kutty, Shamsul Azhar Shah Tags: Letters: New Observations Source Type: research

Glial GLP1R: A novel neuroprotector?
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 14, 2018 Category: Neurology Authors: Aubrey M. Schonhoff, Ashley S. Harms Tags: Hot Topics Source Type: research

Earlier onset of motor complications in Parkinson's patients with comorbid diabetes mellitus
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 14, 2018 Category: Neurology Authors: Norlinah Mohamed Ibrahim, Roshila Ramli, Shahedah Koya Kutty, Shamsul Azhar Shah Tags: Letters: New Observations Source Type: research

Life span pigmentation changes of the substantia nigra detected by neuromelanin ‐sensitive MRI
Conclusions: Using optimized neuromelanin MRI in a life span sample, we demonstrate a strong age effect with inverted U ‐shaped SNpc pigmentation‐related contrast from childhood to old age. This age trajectory of physiological SNpc pigmentation needs to be taken into account for diagnostic applications of depigmentation. The study also paves the way for systematic investigations of the mechanisms of neuromelanin in healthy and pathological brain development and aging. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Yue Xing, Abdul Sapuan, Rob A. Dineen, Dorothee P. Auer Tags: Research Article Source Type: research

Sensing α‐Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration
AbstractParkinson's disease and other synucleinopathies are characterized by the accumulation of aggregated α‐synuclein in intracellular proteinaceous inclusions. The progressive nature of synucleinopathies seems to be related to the cell‐to‐cell spreading of α‐synuclein pathology, and several possible mechanisms have been put forward to explain this phenomenon. In our recent study, we found tha t α‐synuclein oligomers interact with cellular prion protein in glutamatergic synapses. This interaction triggered a signaling cascade involving phosphorylation of Fyn kinase and activation of the N‐me...
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: In ês Caldeira Brás, Luísa V. Lopes, Tiago Fleming Outeiro Tags: Scientific Perspectives Source Type: research

Ultra ‐high‐frequency deep brain stimulation at 10,000 Hz improves motor function
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Irene E. Harmsen, Darrin J. Lee, Robert F. Dallapiazza, Philippe De Vloo, Robert Chen, Alfonso Fasano, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano Tags: Letters: New Observations Source Type: research

Parkinsonism due to A53E α‐synuclein gene mutation: Clinical, genetic, epigenetic, and biochemical features
Conclusions: A53E as a cause of parkinsonism is not restricted to Finnish individuals. DNA methylation may contribute to disease age at onset. A53E enriches α‐synuclein oligomers and fibrils dependent on the phosphorylation state. (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Marina Picillo, Karlo J. Lizarraga, Erik L. Friesen, Hien Chau, Ming Zhang, Christine Sato, Grace Rooke, Renato P. Munhoz, Ekaterina Rogaeva, Paul E. Fraser, Suneil K. Kalia, Lorraine V. Kalia Tags: Brief Report Source Type: research

Prodromal features of Parkinson's disease: Self ‐reported symptoms versus clinically assessed signs
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Anja Friederich, Aminah Flinspach, Ulrike Suenkel, Gerhard W. Eschweiler, Katharina Greulich, the TREND study team, Walter Maetzler, Daniela Berg, Sebastian Heinzel Tags: Letters: New Observations Source Type: research

Ratios of proteins in cerebrospinal fluid in Parkinson's disease cognitive decline: prospective study
Conclusion: Ratios of the main proteins found in PD patient brain inclusions that can be measured in the CSF appear to have value as short ‐ to mid‐term predictors of dementia. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Manuel Delgado ‐Alvarado, Rosalía Dacosta‐Aguayo, Irene Navalpotro‐Gómez, Belén Gago, Ana Gorostidi, Haritz Jiménez‐Urbieta, Ana Quiroga‐Varela, Javier Ruiz‐Martínez, Alberto Bergareche, María C. Rodríguez‐Oroz Tags: Brief Report Source Type: research

Anodal tDCS over prefrontal cortex improves dual ‐task walking in Parkinsonian patients with freezing
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Martina Putzolu, Elisa Pelosin, Carla Ogliastro, Giovanna Lagravinese, Gaia Bonassi, Andrea Ravaschio, Giovanni Abbruzzese, Laura Avanzino Tags: Letters: Published Article Source Type: research

Life span pigmentation changes of the substantia nigra detected by neuromelanin ‐sensitive MRI
Conclusions: Using optimized neuromelanin MRI in a life span sample, we demonstrate a strong age effect with inverted U ‐shaped SNpc pigmentation‐related contrast from childhood to old age. This age trajectory of physiological SNpc pigmentation needs to be taken into account for diagnostic applications of depigmentation. The study also paves the way for systematic investigations of the mechanisms of neuromelanin in healthy and pathological brain development and aging. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Yue Xing, Abdul Sapuan, Rob A. Dineen, Dorothee P. Auer Tags: Research Article Source Type: research

Sensing α‐Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration
AbstractParkinson's disease and other synucleinopathies are characterized by the accumulation of aggregated α‐synuclein in intracellular proteinaceous inclusions. The progressive nature of synucleinopathies seems to be related to the cell‐to‐cell spreading of α‐synuclein pathology, and several possible mechanisms have been put forward to explain this phenomenon. In our recent study, we found tha t α‐synuclein oligomers interact with cellular prion protein in glutamatergic synapses. This interaction triggered a signaling cascade involving phosphorylation of Fyn kinase and activation of the N‐me...
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: In ês Caldeira Brás, Luísa V. Lopes, Tiago Fleming Outeiro Tags: Scientific Perspectives Source Type: research

Ultra ‐high‐frequency deep brain stimulation at 10,000 Hz improves motor function
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Irene E. Harmsen, Darrin J. Lee, Robert F. Dallapiazza, Philippe De Vloo, Robert Chen, Alfonso Fasano, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano Tags: Letters: New Observations Source Type: research

Parkinsonism due to A53E α‐synuclein gene mutation: Clinical, genetic, epigenetic, and biochemical features
Conclusions: A53E as a cause of parkinsonism is not restricted to Finnish individuals. DNA methylation may contribute to disease age at onset. A53E enriches α‐synuclein oligomers and fibrils dependent on the phosphorylation state. (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Marina Picillo, Karlo J. Lizarraga, Erik L. Friesen, Hien Chau, Ming Zhang, Christine Sato, Grace Rooke, Renato P. Munhoz, Ekaterina Rogaeva, Paul E. Fraser, Suneil K. Kalia, Lorraine V. Kalia Tags: Brief Report Source Type: research

Prodromal features of Parkinson's disease: Self ‐reported symptoms versus clinically assessed signs
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Anja Friederich, Aminah Flinspach, Ulrike Suenkel, Gerhard W. Eschweiler, Katharina Greulich, the TREND study team, Walter Maetzler, Daniela Berg, Sebastian Heinzel Tags: Letters: New Observations Source Type: research

Ratios of proteins in cerebrospinal fluid in Parkinson's disease cognitive decline: prospective study
Conclusion: Ratios of the main proteins found in PD patient brain inclusions that can be measured in the CSF appear to have value as short ‐ to mid‐term predictors of dementia. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Manuel Delgado ‐Alvarado, Rosalía Dacosta‐Aguayo, Irene Navalpotro‐Gómez, Belén Gago, Ana Gorostidi, Haritz Jiménez‐Urbieta, Ana Quiroga‐Varela, Javier Ruiz‐Martínez, Alberto Bergareche, María C. Rodríguez‐Oroz Tags: Brief Report Source Type: research

Anodal tDCS over prefrontal cortex improves dual ‐task walking in Parkinsonian patients with freezing
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 13, 2018 Category: Neurology Authors: Martina Putzolu, Elisa Pelosin, Carla Ogliastro, Giovanna Lagravinese, Gaia Bonassi, Andrea Ravaschio, Giovanni Abbruzzese, Laura Avanzino Tags: Letters: Published Article Source Type: research

Abnormal sensory gating in patients with different types of focal dystonias
Conclusions: Somatosensory temporal discrimination threshold changes induced by movement execution are abnormal in focal dystonias. This abnormality is related to the type of dystonia. Abnormal gating of sensory information is likely involved in movement ‐induced triggering or worsening of different forms focal dystonia. (Source: Movement Disorders)
Source: Movement Disorders - November 7, 2018 Category: Neurology Authors: Antonella Conte, Daniele Belvisi, Maria Ilenia Bartolo, Nicoletta Manzo, Francesca Natalia Cortese, Matteo Tartaglia, Gina Ferrazzano, Giovanni Fabbrini, Alfredo Berardelli Tags: Research Article Source Type: research

Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 6, 2018 Category: Neurology Authors: Roger L. Albin, D. James Surmeier, Cecilia Tubert, Martin Sarter, Martijn L.T.M. M üller, Nicolaas I. Bohnen, William T. Dauer Tags: Viewpoint Source Type: research

Mediterranean diets and prodromal Parkinson's disease: A causal line, or a confound circle?
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 6, 2018 Category: Neurology Authors: Ronald B. Postuma Tags: Editorial Source Type: research

Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 6, 2018 Category: Neurology Authors: Marta Le ńska‐Mieciek, Agnieszka Charzewska, Leszek Królicki, Dorota Hoffman‐Zacharska, Zhefan Stephen Chen, Kwok‐Fai Lau, Ho Yin Edwin Chan, Tomasz Gambin, Urszula Fiszer Tags: Letters: New Observations Source Type: research

PTRHD1 Loss ‐of‐function mutation in an african family with juvenile‐onset Parkinsonism and intellectual disability
Conclusion: Together with the previous reports, we provide conclusive evidence that loss ‐of‐function mutations inPTRHD1 cause autosomal ‐recessive juvenile parkinsonism and intellectual disability. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 6, 2018 Category: Neurology Authors: Demy J.S. Kuipers, Jonathan Carr, Soraya Bardien, Pearl Thomas, Boiketlo Sebate, Guido J. Breedveld, Rick van Minkelen, Rutger W.W. Brouwer, Wilfred F.J. van Ijcken, Marjon A. van Slegtenhorst, Vincenzo Bonifati, Marialuisa Quadri Tags: Brief Report Source Type: research

Targeting the pedunculopontine nucleus in Parkinson's disease: Time to go back to the drawing board
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 6, 2018 Category: Neurology Authors: Roger L. Albin, D. James Surmeier, Cecilia Tubert, Martin Sarter, Martijn L.T.M. M üller, Nicolaas I. Bohnen, William T. Dauer Tags: Viewpoint Source Type: research

Mediterranean diets and prodromal Parkinson's disease: A causal line, or a confound circle?
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 6, 2018 Category: Neurology Authors: Ronald B. Postuma Tags: Editorial Source Type: research