Pathogenesis ‐targeted therapeutic strategies in Parkinson's disease
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 28, 2018 Category: Neurology Authors: Joseph Jankovic Tags: Viewpoint Source Type: research
A paradoxical relationship between family history, onset age, and genetic risk in Parkinson's disease
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 28, 2018 Category: Neurology Authors: Madeleine Kristiansen,
Jodi Maple ‐Grødem,
Guido Alves,
Sampath Arepalli,
Dena G. Hernandez,
Hirotaka Iwaki,
Mike A. Nalls,
Andrew Singleton,
Ole‐Bjørn Tysnes,
Mathias Toft,
Lasse Pihlstrøm Tags: Letters: New Observations Source Type: research
Baseline predictors for progression 4 years after Parkinson's disease diagnosis in the De Novo Parkinson Cohort (DeNoPa)
Conclusion: Cardiovascular risk factors, deregulated blood glucose, uric acid metabolism, and inflammation were identified as risk markers for faster disease progression. Our panel of risk parameters needs validation during our continuing follow ‐up and also in independent patient cohorts. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 23, 2018 Category: Neurology Authors: Brit Mollenhauer,
Johannes Zimmermann,
Friederike Sixel ‐Döring,
Niels K. Focke,
Tamara Wicke,
Jens Ebentheuer,
Martina Schaumburg,
Elisabeth Lang,
Tim Friede,
Claudia Trenkwalder,
on behalf of the DeNoPa Study Group Tags: Research Article Source Type: research
MRI Outperforms [18F]AV ‐1451 PET as a Longitudinal Biomarker in Progressive Supranuclear Palsy
Conclusions: [18F]AV ‐1451 tau‐PET measures increase over time in subjects with PSP, but longitudinal [18F]AV ‐1451 measures may not perform as well as rate of midbrain atrophy as biomarkers for PSP clinical trials. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 23, 2018 Category: Neurology Authors: Jennifer L. Whitwell,
Nirubol Tosakulwong,
Christopher G. Schwarz,
Hugo Botha,
Matthew L. Senjem,
Anthony J. Spychalla,
J. Eric Ahlskog,
David S. Knopman,
Ronald C. Petersen,
Clifford R. Jack,
Val J. Lowe,
Keith A. Josephs Tags: Research Article Source Type: research
Baseline predictors for progression 4 years after Parkinson's disease diagnosis in the De Novo Parkinson Cohort (DeNoPa)
Conclusion: Cardiovascular risk factors, deregulated blood glucose, uric acid metabolism, and inflammation were identified as risk markers for faster disease progression. Our panel of risk parameters needs validation during our continuing follow ‐up and also in independent patient cohorts. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 23, 2018 Category: Neurology Authors: Brit Mollenhauer,
Johannes Zimmermann,
Friederike Sixel ‐Döring,
Niels K. Focke,
Tamara Wicke,
Jens Ebentheuer,
Martina Schaumburg,
Elisabeth Lang,
Tim Friede,
Claudia Trenkwalder,
on behalf of the DeNoPa Study Group Tags: Research Article Source Type: research
MRI Outperforms [18F]AV ‐1451 PET as a Longitudinal Biomarker in Progressive Supranuclear Palsy
Conclusions: [18F]AV ‐1451 tau‐PET measures increase over time in subjects with PSP, but longitudinal [18F]AV ‐1451 measures may not perform as well as rate of midbrain atrophy as biomarkers for PSP clinical trials. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 23, 2018 Category: Neurology Authors: Jennifer L. Whitwell,
Nirubol Tosakulwong,
Christopher G. Schwarz,
Hugo Botha,
Matthew L. Senjem,
Anthony J. Spychalla,
J. Eric Ahlskog,
David S. Knopman,
Ronald C. Petersen,
Clifford R. Jack,
Val J. Lowe,
Keith A. Josephs Tags: Research Article Source Type: research
MRI ‐guided laser interstitial thermal thalamotomy for medically intractable tremor disorders
Conclusion: Medically intractable tremor treated with laser interstitial thermal thalamotomy may be a useful addition to the treatment armamentarium for medically intractable tremor disorders. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Meghan Harris,
John Steele,
Rebecca Williams,
Jim Pinkston,
Richard Zweig,
Jessica Anne Wilden Tags: Brief Report Source Type: research
Anle138b modulates α‐synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy
Conclusions: Anle138b reduces α‐synuclein accumulation in PLP‐hαSyn mice, leading to neuroprotection, reduction of microglial activation, and preservation of motor function supporting the use of anle138b in a future clinical trial for MSA. © 2018 The Authors.Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Antonio Heras ‐Garvin,
Daniel Weckbecker,
Sergey Ryazanov,
Andrei Leonov,
Christian Griesinger,
Armin Giese,
Gregor K. Wenning,
Nadia Stefanova Tags: Research Article Source Type: research
Identification of a large homozygous VPS13C deletion in a patient with early ‐onset Parkinsonism
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Hossein Darvish,
Paloma Bravo,
Abbas Tafakhori,
Luis J. Azcona,
Sakineh Ranji ‐Burachaloo,
Amir Hossein Johari,
Coro Paisán‐Ruiz Tags: Letters: New Observations Source Type: research
Wild ‐type LRRK2 as a new potential therapeutic target in idiopathic Parkinson's disease
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Hossein Sanjari Moghaddam,
Mohammad Hadi Aarabi Tags: Hot Topics Source Type: research
Identification of a large homozygous VPS13C deletion in a patient with early ‐onset Parkinsonism
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Hossein Darvish,
Paloma Bravo,
Abbas Tafakhori,
Luis J. Azcona,
Sakineh Ranji ‐Burachaloo,
Amir Hossein Johari,
Coro Paisán‐Ruiz Tags: Letters: New Observations Source Type: research
Wild ‐type LRRK2 as a new potential therapeutic target in idiopathic Parkinson's disease
Movement Disorders, EarlyView. (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Hossein Sanjari Moghaddam,
Mohammad Hadi Aarabi Tags: Hot Topics Source Type: research
MRI ‐guided laser interstitial thermal thalamotomy for medically intractable tremor disorders
Conclusion: Medically intractable tremor treated with laser interstitial thermal thalamotomy may be a useful addition to the treatment armamentarium for medically intractable tremor disorders. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Meghan Harris,
John Steele,
Rebecca Williams,
Jim Pinkston,
Richard Zweig,
Jessica Anne Wilden Tags: Brief Report Source Type: research
Anle138b modulates α‐synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy
Conclusions: Anle138b reduces α‐synuclein accumulation in PLP‐hαSyn mice, leading to neuroprotection, reduction of microglial activation, and preservation of motor function supporting the use of anle138b in a future clinical trial for MSA. © 2018 The Authors.Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. (Source: Movement Disorders)
Source: Movement Disorders - November 19, 2018 Category: Neurology Authors: Antonio Heras ‐Garvin,
Daniel Weckbecker,
Sergey Ryazanov,
Andrei Leonov,
Christian Griesinger,
Armin Giese,
Gregor K. Wenning,
Nadia Stefanova Tags: Research Article Source Type: research
Suggestive association between OPRM1 and impulse control disorders in Parkinson's disease
Conclusions: Our results are suggestive of a novel association of the opioid receptor geneOPRM1 with impulse control disorders and related behaviors in PD and confirm a previous association withDAT1. Although replication in independent studies is needed, our results bring potential new insights to the understanding of molecular mechanisms of impulse control disorders. © 2018 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - November 16, 2018 Category: Neurology Authors: Florence Cormier ‐Dequaire,
Samir Bekadar,
Mathieu Anheim,
Said Lebbah,
Antoine Pelissolo,
Paul Krack,
Lucette Lacomblez,
Eugénie Lhommée,
Anna Castrioto,
Jean‐Philippe Azulay,
Luc Defebvre,
Alexandre Kreisler,
Franck Durif,
Ana Marques Tags: Research Article Source Type: research
