Molecules, Vol. 23, Pages 681: Transdermal and Topical Drug Administration in the Treatment of Pain
liczek
The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key role. An effective therapy for pain depends on the intensity and type of pain, the patients’ age, comorbidities, and appropriate choice of analgesic, its dose and route of administration. This review is aimed at presenting current knowledge on analgesics administered by transdermal and topical routes for physicians, nurses, pharmacists, and other health care professionals dealing with patients suffering from pain. Analgesics administered transdermally or topically act through different mechanisms. Opioids administered trans...
Source: Molecules - March 17, 2018 Category: Chemistry Authors: Wojciech Leppert Malgorzata Malec –Milewska Renata Zajaczkowska Jerzy Wordliczek Tags: Review Source Type: research
Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery.
Abstract
Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have many side effects, including cognitive impairment, tolerance, rebound insomnia upon discontinuation, car accidents/falls, abuse, and dependence liability. Consequently, the clinical use of off-label drugs and novel drugs that do not target the GABAergic system is increasing. The purpose of this review is to analyze the neurobiological and clinical evidence of pharmacological treatments of insomnia, excluding the BZDs and Z-drug...
Source: Pharmacological Reviews - March 2, 2018 Category: Drugs & Pharmacology Authors: Atkin T, Comai S, Gobbi G Tags: Pharmacol Rev Source Type: research
Antidepressants as antipruritic agents: A review
Pruritus is a concomitant symptom of various underlying disorders viz. dermatological, systemic and psychiatric disorders that provoke the person to scratch the skin. Many natural as well as, antipruritic therapies are usually practiced in the treatment of pruritus including general preventive measures, topical therapies such as cooling agents, antihistamines, anesthetics, capsaicin, corticosteroids, immunomodulators and; systemic therapies including administration of antihistamines, opioid antagonists/agonists, antiepileptic drugs/neuroleptics (e.g., gabapentin and pregabalin), antidepressants (e.g., doxepin, amitriptylin...
Source: European Neuropsychopharmacology - February 15, 2018 Category: Psychiatry & Psychology Authors: Randeep Kaur, V.R. Sinha Tags: REVIEW Source Type: research
Music electric stimulation of points for anxiety: a multi-center randomized controlled clinical trial
ConclusionMusic electric stimulation of points can produce equivalent efficacy in treating anxiety compared to doxepin. Thus, it can be taken as a choice in the treatment of anxiety. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - February 1, 2018 Category: Complementary Medicine Source Type: research
Fast and easy extraction of antidepressants from whole blood using ionic liquids as extraction solvent.
In conclusion, this study proves the applicability of ILs as extraction solvents for a large group of antidepressants in complex whole blood matrices.
PMID: 29332813 [PubMed - in process] (Source: Talanta)
Source: Talanta - January 16, 2018 Category: Chemistry Authors: De Boeck M, Dubrulle L, Dehaen W, Tytgat J, Cuypers E Tags: Talanta Source Type: research
Qualitative and quantitative temporal analysis of licit and illicit drugs in wastewater in Australia using liquid chromatography coupled to mass spectrometry.
Abstract
The combination of qualitative and quantitative bimonthly analysis of pharmaceuticals and illicit drugs using liquid chromatography coupled to mass spectrometry is presented. A liquid chromatography-quadrupole time of flight instrument equipped with Sequential Window Acquisition of all THeoretical fragment-ion spectra (SWATH) was used to qualitatively screen 346 compounds in influent wastewater from two wastewater treatment plants in South Australia over a 14-month period. A total of 100 compounds were confirmed and/or detected using this strategy, with 61 confirmed in all samples including antide...
Source: Analytical and Bioanalytical Chemistry - December 6, 2017 Category: Chemistry Authors: Bade R, White JM, Gerber C Tags: Anal Bioanal Chem Source Type: research
Antidepressant polypharmacy and the potential of pharmacokinetic interactions: doxepin but not mirtazapine causes clinically relevant changes in venlafaxine metabolism
To uncover pharmacokinetic interactions between venlafaxine and doxepin or mirtazapine in a naturalistic sample. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - November 13, 2017 Category: Neurology Authors: Michael Paulzen, Ekkehard Haen, Christoph Hiemke, Bianca Fay, Sandra Unholzer, Gerhard Gr ünder, Georgios Schoretsanitis Tags: Research paper Source Type: research
Atopic Dermatitis: Managing the Itch.
Authors: Farmer WS, Marathe KS
Abstract
Atopic dermatitis has a substantial impact on sleep, appearance, psychological well-being, and other qualities of life. The visual appearance of lichenification, cheilitis, hyperpigmentation, ichthyosis, and erythema can be socially stigmatizing, and treatment of these symptoms is challenging. In managing pruritus in patients, practitioners should assess and document pruritus through questionnaires at each routine visit. Initially, practitioners should advise patients to employ non-pharmaceutical treatments such as emollients with wet wraps, elimination of triggers, ...
Source: Advances in Experimental Medicine and Biology - October 26, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research
In vitro genotoxic and cytotoxic effects of doxepin and escitalopram on human peripheral lymphocytes
. (Source: Drug and Chemical Toxicology)
Source: Drug and Chemical Toxicology - August 31, 2017 Category: Toxicology Authors: Hayal Cobanoglu Mahmut Coskun Akin Çayir Munevver Coskun Source Type: research
Doxepin Mitigates Noise ‐induced Neuronal Damage in Primary Auditory Cortex of Mice via Suppression of Acid Sphingomyelinase/Ceramide Pathway
ABSTRACT
Neuronal damage in primary auditory cortex (A1) underlies complex manifestations of noise exposure, prevention of which is critical for health maintenance. Acid sphingomyelinase (ASM) catalyzes generation of ceramide (Cer) which if over‐activated mediates neuronal disorders in various diseases. Tricyclic antidepressants (TCAs), by restraining ASM/Cer, benefits multiple neuronal anomalies, so we aimed to elucidate the effect of TCA on noise induced hearing loss and auditory cortex derangement, unraveling mechanism involved. The mice were exposed to noise with frequencies of 20–20 KHz and intensity of 95 dB. Dox...
Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - August 28, 2017 Category: Molecular Biology Authors: Yu ‐Ting Su, Xing‐Xing Meng, Xi Zhang, Yi‐Bin Guo, Hai‐Jun Zhang, Yao‐Ping Cheng, Xiao‐Ping Xie, Yao‐Ming Chang, Jun‐Xiang Bao Tags: Full Length Article Source Type: research
Doxepin mitigates noise induced neuronal damage in primary auditory cortex of mice via suppression of acid sphingomyelinase/ceramide pathway.
This article is protected by copyright. All rights reserved.
PMID: 28806500 [PubMed - as supplied by publisher] (Source: Anatomical Record)
Source: Anatomical Record - August 14, 2017 Category: Anatomy Authors: Su YT, Meng XX, Zhang X, Guo YB, Zhang HJ, Cheng YP, Xie XP, Chang YM, Bao JX Tags: Anat Rec (Hoboken) Source Type: research
Doxepin mitigates noise induced neuronal damage in primary auditory cortex of mice via suppression of acid sphingomyelinase/ceramide pathway
This article is protected by copyright. All rights reserved. (Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology)
Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - August 14, 2017 Category: Molecular Biology Authors: Yu ‐Ting Su, Xing‐Xing Meng, Xi Zhang, Yi‐Bin Guo, Hai‐Jun Zhang, Yao‐Ping Cheng, Xiao‐Ping Xie, Yao‐Ming Chang, Jun‐Xiang Bao Tags: Full Length Article Source Type: research
Effects of Antidepressants on Sleep
AbstractPurpose of ReviewThe aim of this review article was to summarize recent publications on effects of antidepressants on sleep and to show that these effects not only depend on the kind of antidepressant drugs but are also related to the dose, the time of drug administration, and the duration of the treatment.Recent FindingsComplaints of disrupted sleep are very common in patients suffering from depression, and they are listed among diagnostic criteria for this disorder. Moreover, midnocturnal insomnia is the most frequent residual symptom of depression. Thus, all antidepressants should normalize sleep. However, at le...
Source: Current Psychiatry Reports - August 9, 2017 Category: Psychiatry Source Type: research
Potentially Inappropriate Antidepressant Prescriptions Among Older Adults in Office-Based Outpatient Settings: National Trends from 2002 to 2012
AbstractUsing data from 2002 to 2012 National Ambulatory Medical Care Survey, we estimated that the prevalence of overall antidepressant prescriptions increased almost twofold from 5.2% in 2002 to 10.1% in 2012 in office-based outpatient visits made by older adults. In addition, older adults were exposed to the risk of potentially avoidable adverse drug events in approximately one in ten antidepressant-related visits, or 2.2 million visits annually. Amitriptyline and doxepin were the two most frequent disease-independent potentially inappropriate antidepressants. Racial/ethnic minorities, and Medicaid beneficiaries had h...
Source: Administration and Policy in Mental Health and Mental Health Services Research - July 20, 2017 Category: Psychiatry Source Type: research
