Effects of acupuncture on SATB1/p21 signaling pathway and SASPs in MPTP-induced Parkinson disease model mice
ConclusionAcupuncture can improve motor function and increase the number of TH-positive neurons in the SN of PD model mice. Its neuroprotective effect may relate to the regulation of the SATB1/p21 signaling pathway and the inhibition of cellular senescence-related biomarker expression in the SN. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - March 18, 2024 Category: Complementary Medicine Source Type: research

Study of the mechanism of acupuncture and moxibustion in protecting the intestinal mucosal barrier in DSS-induced UC rats based on the IL-9/IL-9R pathway
ConclusionBoth HM and EA can inhibit the protein expression levels of IL-9 and IL-9R in the UC colon by regulating the transcription factor PU.1, promote the repair of intestinal mucosal barrier, and down-regulate protein contents of proinflammatory factors IL-9, IL-6, and IL-1 β in the serum, which may be one of the key mechanisms of acupuncture and moxibustion in reducing the inflammation of UC colonic mucosa and protecting the intestinal mucosal barrier. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - March 15, 2024 Category: Complementary Medicine Source Type: research

Mechanism of moxibustion in treating chronic inflammatory visceral pain: regulation of the p38 MAPK/ELK1 signaling pathway in the spinal cord
ConclusionHPM exerted analgesic effects via downregulating the mRNA and phosphorylated protein expression of ASK1, MKK3, p38 MAPK, and ELK1 in the spinal cord of CIVP rats. The inhibition of spinal p38 MAPK/ELK1 signaling pathway activation may be one of the mechanisms by which HPM relieves pain in CIVP. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - March 15, 2024 Category: Complementary Medicine Source Type: research

Clinical study of electroacupuncture improving sleep electroencephalogram and event-related potential in patients with somatoform disorders
ConclusionSFD patients have a variety of clinical symptoms, and most of them show abnormal sleep EEG and ERP; EA can correct abnormal sleep EEG parameters and the MMN and P300 of ERP in SFD patients. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - February 1, 2024 Category: Complementary Medicine Source Type: research

Clinical study of electroacupuncture combined with exercise therapy in improving the balance function of patients with knee osteoarthritis
ConclusionEA combined with exercise therapy or exercise therapy alone can enhance the balance function, relieve joint pain, and improve joint function in patients with KOA. EA combined with exercise therapy is superior to exercise therapy alone in improving balance function and pain, but the two treatment protocols have similar effects in improving joint function. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - February 1, 2024 Category: Complementary Medicine Source Type: research

Effects of warming triple needling plus Chinese medication on inflammatory responses and daily functioning ability in knee osteoarthritis patients
ConclusionWarming triple needling plus Fang Feng Xi Bi Tang can reduce inflammatory responses, improve daily functioning ability, and enhance the quality of life in patients with KOA due to wind-cold-dampness Bi-impediment. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - February 1, 2024 Category: Complementary Medicine Source Type: research

Effects of Tuina static training on vascular endothelial cell dysfunction and adiponectin in obese rats
ConclusionTuina static training and aerobic exercise improved the aortic endothelial injury in obese rats, and the effect of Tuina static training was more significant. The mechanism of action may be related to regulating lipid metabolism and promoting APN secretion. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - February 1, 2024 Category: Complementary Medicine Source Type: research

Fascia is the “sensor” for the coupling response of manipulative therapies
AbstractFascia, the initial response site for mechanical stimulation in manipulations, is also the target of the effect of manipulations. As the essence of manipulation is “force”, how mechanical stimuli are transduced into neuroelectric and biochemical signals in the fascia and how physical and chemical signals of the fascia initiate the mechanical stimulation effect are the common key questions in the study of the principle of manipulation. The physical changes in the fascial connective tissue caused by the manipulation, such as the deformation and displacement of the fascial tissue, can act on the nerve end receptor...
Source: Journal of Acupuncture and Tuina Science - February 1, 2024 Category: Complementary Medicine Source Type: research

Study on the mechanism of herb cake-partitioned moxibustion inhibiting tumor growth in colitis-associated colorectal cancer based on KDM4D receptor
ConclusionHerb cake-partitioned moxibustion regulated abnormally expressed KDM4D in CAC rats, activated APC and Axin, the upstream molecules of Wnt/ β-catenin pathway, inhibited abnormally activated downstream molecules of Wnt/β-catenin pathway. This may be a key mechanism of herb cake-partitioned moxibustion in inhibiting CAC tumor growth. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - February 1, 2024 Category: Complementary Medicine Source Type: research

Efficacy observation of long-time needle retaining at Baihui (GV20) combined with multidirectional point-toward-point needle insertion with needle shaking at Fengchi (GB20) for cervical vertigo
ConclusionLong-time needle retaining at Baihui (GV20) combined with multidirectional point-toward-point needle insertion with needle shaking at Fengchi (GB20) can significantly reduce the clinical symptoms of CV and regulate the blood flow rate of vertebrobasilar arteries bidirectionally, and thus is an effective therapy for CV. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - December 29, 2023 Category: Complementary Medicine Source Type: research

Effects of vibrating the abdomen on peripheral blood gastrointestinal hormones and gastrointestinal motility of young anorexia model rats
ConclusionVibrating the abdomen increases the food intake and body mass of anorexia model rats, reduces the residue of gastric contents, improves the small intestine propulsion rate, and therefore has a good therapeutic effect on anorexia. The mechanism may be related to inhibiting the secretion of CCK-8 and NT in plasma and promoting the release of MTL and GAS in serum. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - December 29, 2023 Category: Complementary Medicine Source Type: research

Clinical observation of kidney-tonifying and mind-calming acupuncture therapy in the treatment of perimenopausal insomnia
ConclusionKidney-tonifying and mind-calming acupuncture therapy can improve sleep quality, relieve anxiety and depression, delay the decrease of serum E2 level, and improve related TCM symptoms in patients with PMI. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - December 29, 2023 Category: Complementary Medicine Source Type: research

Efficacy of electroacupuncture on the recovery of gastrointestinal function after laparoscopic cholecystectomy: a systematic review
ConclusionEA treatments can promote the recovery of gastrointestinal function after LC. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - December 29, 2023 Category: Complementary Medicine Source Type: research

Effects of acupuncture and moxibustion on UHRF1 and DNMT1 in ectopic endometrium of rats with endometriosis
ConclusionAcupuncture and moxibustion may up-regulate the levels of UHRF1 mRNA and UHRF1 and DNMT1 proteins in the ectopic endometrium to the normal level so as to reduce the volume of ectopic cysts and cure endometriosis in rats. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - December 29, 2023 Category: Complementary Medicine Source Type: research

Effect mechanism investigation of herb-partitioned moxibustion on relieving colon inflammation in Crohn disease rats based on neutrophil extracellular traps
ConclusionHerb-partitioned moxibustion reduced the serum NETs complex and inhibited the protein and mRNA expression of NETs complex in the colon tissue, which may be one mechanism of herb-partitioned moxibustion in relieving colon mucosal inflammation in CD. (Source: Journal of Acupuncture and Tuina Science)
Source: Journal of Acupuncture and Tuina Science - December 29, 2023 Category: Complementary Medicine Source Type: research