A New Safety Scoring System for the Use of Psychotropic Drugs During Lactation
Conclusions:
Most psychotropic drugs examined in this article have “moderate” or “low” safety profile. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - December 31, 2020 Category: Drugs & Pharmacology Tags: Therapeutic Opinion Source Type: research
Efficacy of uremic pruritus treatment in patients undergoing hemodialysis, a network meta-analysis for randomized clinical trials.
CONCLUSIONS: So we conclude that gabapentin, pregabalin and anti-histamine has a similar efficacy on pruritus control.
PMID: 33203613 [PubMed - as supplied by publisher] (Source: Nephrologie and Therapeutique)
Source: Nephrologie and Therapeutique - November 14, 2020 Category: Urology & Nephrology Authors: Feng WW, Yuan B, Shen FY, Fan WY, Mei DS, Bao BY, Chen QJ Tags: Nephrol Ther Source Type: research
Chronic inducible urticaria: classification and prominent features of physical and non-physical types.
Authors: Pozderac I, Lugović-Mihić L, Artuković M, Stipić-Marković A, Kuna M, Ferček I
Abstract
Chronic inducible urticaria (CIndU) is a common inflammatory skin condition characterized by the recurrence of itchy wheals and/or angioedema that lasts more than 6 weeks and is induced by specific physical or environmental stimuli (cold, heat, exercise, pressure, sunlight, vibration, water, etc.). According to the current international classification, it includes physical urticarias (dermographism, delayed-pressure urticaria, exercise-induced urticaria, cold urticaria, heat urticaria, solar urticaria, and...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - September 26, 2020 Category: Dermatology Tags: Acta Dermatovenerol Alp Pannonica Adriat Source Type: research
Wide QRS Complex Tachycardia With a Dominant R-Wave in Lead aVR
A woman in her 50s presented to the emergency department in a comatose condition 1 hour after she had consumed 50 tablets each of doxepin and amitriptyline as a suicide attempt due to depression. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - September 21, 2020 Category: Internal Medicine Source Type: research
Elucidation of Degradation Behavior of Tricyclic Antidepressant Amoxapine in Artificial Gastric Juice.
Abstract
The degradation behavior of eight tricyclic antidepressants (TCAs; amitriptyline, amoxapine (AMX), imipramine, clomipramine, desipramine, doxepin, dothiepin, and nortriptyline) in artificial gastric juice was investigated to estimate their pharmacokinetics in the stomach. As a result, among the eight TCAs, only AMX was degraded in artificial gastric juice. The degradation was a pseudo first-order reaction; activation energy (Ea) was 88.70 kJ/mol and activation entropy (ΔS) was -80.73 J/K·mol. On the other hand, the recovery experiment revealed that the degradation product did not revert to A...
Source: Chemical and Pharmaceutical Bulletin - September 5, 2020 Category: Drugs & Pharmacology Authors: Saito K, Hagiwara N, Sakamoto M, Wakana D, Ito R, Hosoe T Tags: Chem Pharm Bull (Tokyo) Source Type: research
Use of antidepressants with pharmacogenetic prescribing guidelines in a 10-year depression cohort of adult primary care patients
Conclusion
One-quarter of primary care patients used an antidepressant that was not recommended for them based on CYP2D6- and CYP2C19-based prescribing guidelines and switching medications tended to be more common in this group. Studies to determine the impact of CYP2D6 and CYP2C19 genotyping on reducing gene-antidepressant mismatches are warranted. (Source: Pharmacogenetics and Genomics)
Source: Pharmacogenetics and Genomics - August 13, 2020 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research
Roles of Lys191 and Lys179 in regulating thermodynamic binding forces of ligands to determine their binding affinity for human histamine H1 receptors.
In this study, we evaluated the roles of Lys1915.39 and Lys179ECL2 in regulating the thermodynamic binding forces of non-carboxylated and carboxylated antihistamines that determine their binding affinity for human H1 receptors. The binding enthalpy and entropy of the 3 sets of non-carboxylated and corresponding carboxylated antihistamines (doxepin and olopatadine, desloratadine and loratadine, and terfenadine and fexofenadine, respectively) were estimated using the van't Hoff equation with the dissociation constants obtained from the displacement curves of the non-carboxylated and carboxylated antihistamines against the bi...
Source: Biochemical Pharmacology - July 28, 2020 Category: Drugs & Pharmacology Authors: Kobayashi C, Tanaka A, Yasuda T, Hishinuma S Tags: Biochem Pharmacol Source Type: research
Lemborexant (Dayvigo) for Insomnia
Date: June 29, 2020
Issue #:
1601Summary:
The FDA has approved lemborexant (Dayvigo– Eisai),
an orexin receptor antagonist, for treatment of sleep-onset
and/or sleep-maintenance insomnia in adults. It
is the second orexin receptor antagonist to be approved
for this indication; suvorexant (Belsomra) was the first. (Source: The Medical Letter)
Source: The Medical Letter - June 22, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Ambien Antihistamines Ativan Belsomra bromazepam Dayvigo Doral Doxepin Edluar estazolam Eszopiclone Flurazepam Halcion Imovane insomnia lemborexant Lorazepam Lunesta melatonin Mogadon nitrazepam Oxazepam Quazepa Source Type: research
Doxepin in children and adolescents with symptoms of insomnia: a single-center experience
Journal of Clinical Sleep Medicine,<a href="https://jcsm.aasm.org/toc/jcsm/16/5">Volume 16, Issue 5</a>, Page 743-747, May 2020. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - May 14, 2020 Category: Sleep Medicine Authors: Yash D. ShahVirginia StringelIvan PavkovicSanjeev V. KothareDivision of Child Neurology, Department of Pediatrics, Cohen Children ’s Medical Center, New Hyde Park, New York Source Type: research
Optimizing doxepin therapy in dermatology: Introducing blood level monitoring and genotype testing.
Authors: Myers B, Reddy V, Chan S, Thibodeaux Q, Brownstone N, Koo J
Abstract
Doxepin, a tricyclic antidepressant, is the most efficacious antipruritic available to dermatologists, however its use is often suboptimal because of significant interindividual variability in doxepin plasma levels and clinical response between patients taking the same dose. As result, the Food and Drug Administration approves a maximum dose of 300 mg of doxepin per day and a 10 mg per cc liquid doxepin concentrate. These allow patients to significantly increase or decrease their dose, due to either a lack of clinical efficac...
Source: Journal of Dermatological Treatment - April 30, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Antidepressant Prescribing in England: Patterns and Costs.
Conclusions: Broadly, the findings are in keeping with National Institute for Health and Care Excellence guidance in that the bulk of prescriptions were for SSRIs. Regular audit of patient treatment at a general practice level will ensure appropriate targeted use of licensed medications as supported by the evidence base.
PMID: 32302071 [PubMed - as supplied by publisher] (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - April 19, 2020 Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Identifying and responding to fatigue and apathy in Parkinson's disease: a review of current practice.
Authors: Lazcano Ocampo C, Wan YM, van Wamelen DJ, Batzu L, Boura I, Titova N, Leta V, Qamar M, Martinez-Martin P, Ray Chaudhuri K
Abstract
Introduction: Fatigue and apathy are two key non-motor symptoms in Parkinson's disease (PD), with documented negative impact on Quality of life (QoL) and a frequent burden for caregivers.Areas covered: In this invited review, researchers from the Parkinson Foundation Centre of Excellence in non-motor research at King's College Hospital and King's College London comment on the latest pathophysiology, clinical phenomenology, the most frequently used scales for fatigue and apathy...
Source: Expert Review of Neurotherapeutics - April 16, 2020 Category: Neurology Tags: Expert Rev Neurother Source Type: research
High-throughput protein precipitation method with 96-well plate for determination of Doxepin and Nordoxepin in human plasma by LC-MS/MS.
Abstract
The aim of this study was to establish high-throughput and sensitive liquid chromatography tandem mass spectrometry method for the determination of Doxepin and its major active metabolite Nordoxepin in human plasma. It has been designed for bioequivalence study for formulations containing 25 mg of Doxepin. Doxepin and Nordoxepin were extracted from human plasma samples by protein precipitation (PPT) with acetonitrile by using PPT 96-well plates. Analyte separation was done using Phenomenex Kinetex™ Biphenyl (100 x 2.1 mm, 2.6 μm) column using isocratic elution with a mobile phase of 20 mM ammon...
Source: Biomedical Chromatography : BMC - April 5, 2020 Category: Biomedical Science Authors: Margaryan T, Sargsyan M, Gevorgyan A, Zakaryan H, Aleksanyan A, Harutyunyan A, Armoudjian Y, Mikayelyan A Tags: Biomed Chromatogr Source Type: research
Selecting a pharmacotherapy regimen for patients with chronic insomnia.
Authors: Hassinger AB, Bletnisky N, Dudekula R, El-Solh AA
Abstract
Introduction: Chronic insomnia, whether it is primary or in combination with another medical or psychiatric disorder, is a prevalent condition associated with significant morbidity, reduced productivity, increased risk of accidents, and poor quality of life. Pharmacologic and behavioral treatments have equivalent efficacy with each having its own advantages and limitations.Areas covered: The purpose of this perspective is to delineate the limitations encountered in implementing cognitive behavioral therapy (CBT) and to review the pharmacol...
Source: Expert Opinion on Pharmacotherapy - March 24, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Supramolecular microextraction combined with paper spray ionization mass spectrometry for sensitive determination of tricyclic antidepressants in urine.
Abstract
This work describes a novel methodology to analyze four tricyclic antidepressants (amitriptyline, doxepin, imipramine and, nortriptyline) in urine samples by combining supramolecular microextraction and paper spray ionization mass spectrometry (PS-MS). The proposed method uses a supramolecular solvent in which reverse micelles of 1-decanol are dispersed in tetrahydrofuran (THF)/water. The extraction of the tricyclic antidepressants at pH 9.0 requires a sample volume of 10.0 mL, short extraction time (1.0 min of extraction and 5 min of centrifugation), low amounts of organic solvent (50 μL of ...
Source: Analytica Chimica Acta - March 10, 2020 Category: Chemistry Authors: Oliveira FM, Scheel GL, Augusti R, Tarley CRT, Nascentes CC Tags: Anal Chim Acta Source Type: research
