[News] 58th ASTRO annual meeting
Rick C Miller (Mayo Clinic, Jacksonville, FL, USA) and colleagues reported the results of their randomised phase 3 trial (NCT02229539) comparing doxepin mouthwash or so-called magic mouthwash (consisting of a diphenhydramine, lidocaine, and antacid solution) with placebo, to treat pain from oral mucositis in patients receiving radiotherapy to the head and neck. The primary endpoint was the reduction in pain from oral mucositis relative to baseline pain scores. Miller reported that both doxepin and magic mouthwash improved pain relative to placebo (mean area under the curve [AUC] reduction for doxepin was 11 ·9 vs placebo ...
Source: The Lancet Oncology - October 5, 2016 Category: Cancer & Oncology Authors: Isabel Lokody Tags: News Source Type: research
Itch in Psoriasis Management.
Authors: Szepietowski JC, Reich A
Abstract
Psoriasis is a common chronic inflammatory skin disease observed in about 1-3% of the general population. About 60-90% of patients with psoriasis suffer from itching. Interestingly, in the past itch was not considered as an important symptom of psoriasis. Despite the high frequency of itch in psoriasis, the pathogenesis of this symptom is still not fully elucidated. Although most studies indicate neurogenic inflammation and the role of neuropeptides, other mediators may be important as well. The majority of psoriatic patients consider itch as the most bothersome s...
Source: Current Problems in Dermatology - September 1, 2016 Category: Dermatology Tags: Curr Probl Dermatol Source Type: research
Neurologic Itch Management.
Authors: Şavk E
Abstract
Neurologic itch is defined as pruritus resulting from any dysfunction of the nervous system. Itch arising due to a neuroanatomic pathology is seen to be neuropathic. Causes of neuropathic itch range from localized entrapment of a peripheral nerve to generalized degeneration of small nerve fibers. Antipruritic medications commonly used for other types of itch such as antihistamines and corticosteroids lack efficacy in neuropathic itch. Currently there are no therapeutic options that offer relief in all types of neuropathic pruritus, and treatment strategies vary according to etiolo...
Source: Current Problems in Dermatology - September 1, 2016 Category: Dermatology Tags: Curr Probl Dermatol Source Type: research
Psychogenic Itch Management.
Authors: Szepietowski JC, Reszke R
Abstract
Pruritus is a bothersome and prevalent symptom reported by patients suffering from both cutaneous and extracutaneous diseases. Psychogenic pruritus, also referred to as functional itch disorder, is a distinct clinical entity. According to the definition proposed by the French Psychodermatology Group (FPDG) in 2007, the disorder is characterized by pruritus which is the chief complaint and psychologic factors that contribute to eliciting, worsening, and sustaining the symptoms. Specific diagnostic criteria were proposed, including 3 compulsory and 7 optional, of w...
Source: Current Problems in Dermatology - September 1, 2016 Category: Dermatology Tags: Curr Probl Dermatol Source Type: research
[Pruritus in psoriasis : Profile and therapy].
Authors: Tsianakas A, Mrowietz U
Abstract
Psoriasis is a common chronic inflammatory disease with an incidence of about 0.5-3 %. Previously psoriasis was not primarily regarded to be associated with pruritus; however, this perception has changed in recent years. Meanwhile data conclusively show that between 64 and 97 % of patients report about pruritus that can be severe in a number of cases. Apart from suffering from psoriasis, the presence of pruritus causes additional stress and leads to a significant impairment of health-related quality of life. Neurogenic inflammation at least in part contribut...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - July 7, 2016 Category: Dermatology Tags: Hautarzt Source Type: research
Comparison of pregabalin with doxepin in the management of uremic pruritus: a randomized single blind clinical trial
Discussion Pregabalin was more effective than doxepin in reducing the severity of uremic pruritus and improving the quality of life of patients in this study, so we suggest that clinician can consider pregabalin prior to using antihistamine drugs in the management of severe itch in hemodialysis patients. (Source: Hemodialysis International)
Source: Hemodialysis International - June 30, 2016 Category: Hematology Authors: Nazanin Foroutan, Abbas Etminan, Naemeh Nikvarz, Mohadese Shojai Shahrokh Abadi Tags: Original Article Source Type: research
Topically applied mesoridazine exhibits the strongest cutaneous analgesia and minimized skin disruption among tricyclic antidepressants: the skin absorption assessment.
Abstract
Tricyclic antidepressants (TCAs) are found to have an analgesic action for relieving cutaneous pain associated with neuropathies. The aim of this study was to assess cutaneous absorption and analgesia of topically applied TCAs. Percutaneous delivery was investigated using nude mouse and pig skin models at both infinite and saturated doses. We evaluated the cutaneous analgesia in nude mice using the pinprick scores. Among five antidepressants tested in the in vitro experiment, mesoridazine, promazine and doxepin showed a superior total absorption percentage. The drug with the lowest total absorptio...
Source: European Journal of Pharmaceutics and Biopharmaceutics - May 30, 2016 Category: Drugs & Pharmacology Authors: Liu KS, Chen YW, Aljuffali IA, Chang CW, Wang JJ, Fang JY Tags: Eur J Pharm Biopharm Source Type: research
Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans.
Abstract
A frequent empirical observation is that cold-induced counter-irritation may attenuate itch. The aim of this randomized, single-blinded, exploratory study was to evaluate the counter-irritation effects of cold-stimulation and topical application of transient receptor potential TRPA1/M8-agonists (trans-cinnamaldehyde/L-menthol, respectively), on histamine-induced itch, wheal and neurogenic inflammation in 13 healthy volunteers. Histamine 1% was applied to the volar forearms using skin prick-testing lancets. Recorded outcome-parameters were itch intensity, wheal reactions and neurogenic inflammation...
Source: Acta Derm Venereol A... - May 2, 2016 Category: Dermatology Authors: Andersen HH, Melholt C, Hilborg SD, Jerwiarz A, Randers A, Simoni A, Elberling J, Arendt-Nielsen L Tags: Acta Derm Venereol Source Type: research
Trap and release of bisphenol-A, 2-naphthol, and doxepin using a 1-hexadecylamine-copper(II)-amine functionalized indium-tin-oxide electrode
Publication date: 1 July 2016 Source:Chemical Engineering Journal, Volume 295 Author(s): Guo-Rong Lin, John Biechele-Speziale, Elijah Ernst, Stuart Burris, Eric D. Conte, Wei-Ping Dow, Rong-Ho Lee, Shing-Yi Suen An electrically controlled and renewable hydrophobic surface used to trap and release three test pollutants on an indium-tin-oxide (ITO) electrode is presented. Oxygen plasma was used to maximize the activated hydroxyl groups on the ITO surface, which were reacted with (3-aminopropyl) triethoxysilane (APTES) to create a 3-amino propyl layer. Copper(II) ions were introduced and attached to the te...
Source: Chemical Engineering Journal - March 22, 2016 Category: Chemistry Source Type: research
Fatal toxicity index of medicinal drugs based on a comprehensive toxicology database
In this study, we assessed the FTI of medicinal drugs in 3 years (2005, 2009, and 2013) in Finland. As the measure of drug consumption, we used the number of defined daily doses (DDD) per population in each year. There were 70 medicinal drugs in Finland for which the mean FTI expressed as the number of deaths per million DDD over the three study years was higher or equal to 0.1. The Anatomical Therapeutic Chemical (ATC) classification system was used for the classification of the active ingredients of medicinal drugs according to the organ or system which they act on. Of these 70 drugs, 55 drugs (78.6 %) acted on the ner...
Source: International Journal of Legal Medicine - March 17, 2016 Category: Medical Law Source Type: research
Lowering the High Cost of Cancer Drugs—IV
The astonishing cost of selected drugs to treat cancer1 also extends to medications used in the supportive care of patients with cancer. A recent phase 3 placebo-controlled study of liquid doxepin (a tricyclic antidepressant drug) for painful stomatitis related to cancer treatment found a highly significant benefit for doxepin.2 After the results of this study became available, I started to prescribe doxepin regularly for this indication. Initially, my patients had some problems with insurance denial because treatment of stomatitis with doxepin is not a US Food and Drug Administration–approved indication. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - March 1, 2016 Category: Internal Medicine Authors: James A. Martenson Tags: Letter to the Editor Source Type: research
Emerging role of orexin antagonists in insomnia therapeutics: An update on SORAs and DORAs.
Abstract
The pharmacological management of insomnia has lately become a challenge for researchers worldwide. As per the third International Classification of Sleep disorders (ICSD-3) insomnia can be defined as a state with repeated difficulty in sleep initiation, duration, consolidation, or quality that occurs despite adequate opportunity and circumstances for sleep, and results in some form of daytime impairment. The conventional treatments approved for management of insomnia were benzodiazepines (BZDs) (estazolam, quazepam, triazolam, flurazepam and temazepam) and non-BZDs, also known as z-drugs (zaleplo...
Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Kumar A, Chanana P, Choudhary S Tags: Pharmacol Rep Source Type: research
Post-herpetic Neuralgia: a Review.
Abstract
Post-herpetic neuralgia (PHN) is a chronic neuropathic pain condition that persists 3 months or more following an outbreak of shingles. Shingles, also known as acute herpes zoster, is associated with the reactivation of the dormant varicella zoster virus in an individual who has experienced chicken pox. PHN is associated with persistent and often refractory neuropathic pain. Patients may experience multiple types of pain including a constant deep, aching, or burning pain; a paroxysmal, lancinating pain; hyperalgesia (painful stimuli are more painful than expected); and allodynia (pain associated ...
Source: Herpes - February 18, 2016 Category: Infectious Diseases Authors: Hadley GR, Gayle JA, Ripoll J, Jones MR, Argoff CE, Kaye RJ, Kaye AD Tags: Curr Pain Headache Rep Source Type: research
Post-herpetic Neuralgia: a Review
Abstract
Post-herpetic neuralgia (PHN) is a chronic neuropathic pain condition that persists 3 months or more following an outbreak of shingles. Shingles, also known as acute herpes zoster, is associated with the reactivation of the dormant varicella zoster virus in an individual who has experienced chicken pox. PHN is associated with persistent and often refractory neuropathic pain. Patients may experience multiple types of pain including a constant deep, aching, or burning pain; a paroxysmal, lancinating pain; hyperalgesia (painful stimuli are more painful than expected); and allodynia (pain associat...
Source: Current Pain and Headache Reports - February 15, 2016 Category: Neurology Source Type: research
The effect of histamine on changes in mental energy and fatigue after a single bout of exercise
Publication date: 1 January 2016 Source:Physiology & Behavior, Volume 153 Author(s): Bryan D. Loy, Patrick J. O'Connor The purpose of this research was to determine if histamine, acting on brain H1 receptors, influences changes in feelings of energy and fatigue or cognitive test performance after acute exercise. Women (n=20) with low vigor and high fatigue were administered the H1 antagonist drug doxepin hydrocholoride (6mg) in tomato juice and tomato juice alone (placebo) in a randomized, double-blinded, cross-over experiment before performing 30min of light intensity cycling exercise and completing energy...
Source: Physiology and Behavior - October 31, 2015 Category: Physiology Source Type: research
