Bilastine vs. hydroxyzine: occupation of brain histamine H1‐receptors evaluated by positron emission tomography in healthy volunteers
ConclusionsA single oral dose of bilastine 20 mg had minimal H1RO, was not associated with subjective sedation or objective impairment of psychomotor performance and was devoid of treatment‐related sedative AEs, thus satisfying relevant subjective, objective and PET criteria as a non‐sedating antihistamine. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - October 20, 2014 Category: Drugs & Pharmacology Authors: Magí Farré, Clara Pérez‐Mañá, Esther Papaseit, Esther Menoyo, Marta Pérez, Soraya Martin, Santiago Bullich, Santiago Rojas, José‐Raúl Herance, Carlos Trampal, Luis Labeaga, Román Valiente Tags: Pharmacodynamics Source Type: research
Drug Treatment of Primary Insomnia: A Meta-Analysis of Polysomnographic Randomized Controlled Trials
Conclusions
Future studies should use objective and subjective assessment. Focusing on efficacy, clinicians should favor benzodiazepine receptor agonists and classical benzodiazepines over antidepressants (including low-dose doxepin) for primary insomnia treatment, but the additional consideration of different side effect profiles can lead to alternative treatment decisions. (Source: CNS Drugs)
Source: CNS Drugs - September 1, 2014 Category: Neurology Source Type: research
Topical treatments of skin pain: a general review with a focus on hidradenitis suppurativa with topical agents.
Abstract
Hidradenitis Supprurativa (HS) is a painful chronic follicular disease. Few papers have addressed pain control for this debilitating condition. Possible topical agents include tricyclic antidepressants, opioids, anticonvulsants, NSAIDs, NMDA receptor antagonists, local anesthetics and other agents. The first line agents for the topical treatment of the cutaneous pain of HS are diclonefac gel 1% and liposomal xylocaine 4% and 5% cream or 5% ointment. The chief advantage of topical xylocaine is that is quick acting i.e. immediate however with a limited duration of effect 1-2 hours. The use of topica...
Source: Dermatol Online J - July 23, 2014 Category: Dermatology Authors: Scheinfeld N Tags: Dermatol Online J Source Type: research
Formulation and evaluation of thermosensitive biogels for nose to brain delivery of doxepin.
The objective of this study was to use chitosan and glycerophosphate based thermoreversible systems for delivery of doxepin to brain through intranasal administration. Formulations were prepared by admixture of suitable dilutions of chitosan and glycerophosphate with or without polyethylene glycol, followed by addition of the antidepressant doxepin hydrochloride. Both systems were evaluated for gelling characteristics, rheology, mucoadhesion, in vitro release, and ex vivo permeation through sheep nasal mucosa. In vivo efficacy was evaluated in Swiss albino mice through the forced swim test. Nasal tissues of mice subjected ...
Source: Biomed Res - July 19, 2014 Category: Research Authors: Naik A, Nair H Tags: Biomed Res Int Source Type: research
Eosinophilic folliculitis occurring after stem cell transplant for acute lymphoblastic leukemia: a case report and review
ConclusionsA fourth proposed subtype of EF is associated with HIV‐negative hematologic disease. This subtype is distinguished by a predictable timeframe to presentation and a relatively rapid response to therapy. Although EF is an important consideration in all patients with hematologic malignancy, clinically heightened suspicion is warranted during the 2–3 months after transplant. (Source: International Journal of Dermatology)
Source: International Journal of Dermatology - July 11, 2014 Category: Dermatology Authors: Kristine Zitelli, Neil Fernandes, Brian B. Adams Tags: Report Source Type: research
Efficacy and safety of low-dose doxepin in depressed patients suffering from insomnia: a retrospective, naturalistic case series analysis.
Conclusion: Contrasting previous results in healthy subjects, low-dose doxepin does not seem to improve sleep onset or maintenance in patients with MDD. Further research, preferably placebo-controlled, double-blind sleep laboratory trials, is necessary to determine whether low-dose doxepin may be beneficial in this important patient subgroup.
PMID: 24940524 [PubMed] (Source: Primary Care)
Source: Primary Care - June 23, 2014 Category: Primary Care Authors: Mews MR, Rombold F, Quante A Tags: Prim Care Companion CNS Disord Source Type: research
Doxepin for insomnia: A systematic review of randomized placebo-controlled trials
The objective of this systematic review was to obtain a precise summary of the efficacy and safety of doxepin as a hypnotic. We searched key databases and trial registers up to March 2014 and contacted pharmaceutical companies and the FDA for unpublished data. A total of nine randomized placebo-controlled trials were analyzed. Six studies were on doxepin 1–6 mg/d, two on doxepin 25–300 mg/d, and one on ramelteon 8 mg and doxepin 3 mg combined. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - June 18, 2014 Category: Sleep Medicine Authors: Wing-Fai Yeung, Ka-Fai Chung, Kam-Ping Yung, Tommy Ho-Yee Ng Tags: Clinical review Source Type: research
Doxepin for Insomnia: A Systematic Review of Randomized Placebo-controlled Trials
(Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - June 18, 2014 Category: Sleep Medicine Authors: Wing-Fai Yeung, Ka-Fai Chung, Kam-Ping Yung, Tommy Ho-Yee Ng Source Type: research
Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain.
CONCLUSIONS: In summary, the results suggest that when amitriptyline (but not doxepin or venlafaxine) is locally co-administered with morphine the effectiveness under neuropathic pain is enhanced, although additional studies are necessary to explain differential mechanisms of interaction of antidepressant drugs with morphine after local administration.
PMID: 24905524 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - June 1, 2014 Category: Drugs & Pharmacology Authors: Jagla G, Mika J, Makuch W, Obara I, Wordliczek J, Przewlocka B Tags: Pharmacol Rep Source Type: research
Doxepin Rinse Versus Placebo in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Head and Neck Radiotherapy With or Without Chemotherapy: A Phase III, Randomized, Double-Blind Trial (NCCTG-N09C6 [Alliance]) [Head and Neck Cancer]
Conclusion
A doxepin rinse diminishes OM pain. Further studies are warranted to determine its role in the management of OM. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 16, 2014 Category: Cancer & Oncology Authors: Leenstra, Miller, Qin, Martenson, Dornfeld, Bearden, Puri, Stella, Mazurczak, Klish, Novotny, Foote, Loprinzi Tags: Pain Control, Supportive Care, Radiation, Pain Control, Supportive Care, Radiation Oncology Head and Neck Cancer Source Type: research
Bilastine vs. Hydroxyzine: Occupation of Brain Histamine H1 Receptors Evaluated by Positron Emission Tomography in Healthy Volunteers
ConclusionsA single oral dose of bilastine 20 mg had minimal H1RO, was not linked with subjective sedation or objective impairment of psychomotor performance, and was devoid of treatment‐related sedative AEs, thus satisfying relevant subjective, objective, and PET criteria as a nonsedating antihistamine. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - May 15, 2014 Category: Drugs & Pharmacology Authors: Magí Farré, Clara Pérez‐Mañá, Esther Papaseit, Esther Menoyo, Marta Pérez, Soraya Martin, Santiago Bullich, Santiago Rojas, José‐Raúl Herance, Carlos Trampal, Luis Labeaga, Román Valiente Tags: Main Paper Source Type: research
Design, development and characterization of buccal bioadhesive films of Doxepin for treatment of odontalgia
Drug Delivery, Ahead of Print. (Source: Drug Delivery)
Source: Drug Delivery - March 27, 2014 Category: Drugs & Pharmacology Tags: article Source Type: research
Contact allergens in oral antihistamines.
CONCLUSIONS: Ingestion of antihistamines could precipitate a systemic contact dermatitis in a patient sensitized to an allergen present as an excipient in the medicine.
PMID: 24603514 [PubMed - in process] (Source: Dermatitis)
Source: Dermatitis - March 1, 2014 Category: Dermatology Authors: McEnery-Stonelake M, Silvestri DL Tags: Dermatitis Source Type: research
National Use of Prescription Medications for Insomnia: NHANES 1999-2010
Conclusion:In this nationally representative sample, reported use of prescription medications commonly used for insomnia (MCUFIs) within the preceding month was common, particularly among older adults and those seeing a mental health provider, with high use of sedative polypharmacy among MCUFI users.Citation:Bertisch SM; Herzig SJ; Winkelman JW; Buettner C. National use of prescription medications for insomnia: NHANES 1999-2010. SLEEP 2014;37(2):343-349. (Source: Sleep)
Source: Sleep - February 3, 2014 Category: Sleep Medicine Source Type: research
Antidepressants for smoking cessation.
CONCLUSIONS: The antidepressants bupropion and nortriptyline aid long-term smoking cessation. Adverse events with either medication appear to rarely be serious or lead to stopping medication. Evidence suggests that the mode of action of bupropion and nortriptyline is independent of their antidepressant effect and that they are of similar efficacy to nicotine replacement. Evidence also suggests that bupropion is less effective than varenicline, but further research is needed to confirm this finding. Evidence suggests that neither selective serotonin reuptake inhibitors (e.g. fluoxetine) nor monoamine oxidase inhibitors aid ...
Source: Cochrane Database of Systematic Reviews - January 8, 2014 Category: Journals (General) Authors: Hughes JR, Stead LF, Hartmann-Boyce J, Cahill K, Lancaster T Tags: Cochrane Database Syst Rev Source Type: research
