Non-psoriatic uses of calcipotriol: a concise updated review
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361422.ABSTRACTCalcipotriol (calcipotriene) is a synthetic vitamin D3 derivative that is a standard treatment option for psoriasis. It is generally well tolerated with minimal side effects. Due to its ability to reduce keratinocyte proliferation and induce keratinocyte differentiation as well as its immunomodulatory effects, calcipotriol has been used to treat a variety of skin disorders such as atopic dermatitis, actinic keratoses, lichen planus, seborrheic keratoses, and vitiligo . We surveyed the literature examining the use of calcipotriol for non-psoriatic derm...
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Riya T Patel Jane J Gay Kiley K Fagan Joshua D Eikenberg Source Type: research
Biosimilars in dermatology: identifying myths and knowledge gaps
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361423.ABSTRACTBiosimilars are beginning to gain regulatory approval in the United States. Biosimilars are structurally near identical to the innovator and must demonstrate identical pharmacokinetics via the same binding affinity and biological function on assays. However, biologics are so complex that even the innovator company cannot produce exact duplicates; there is batch-to-batch variation. The International Psoriasis Council has outlined a biosimilarity index, which aims to standardize preclinical definitions of biosimilarity. Such an index, paired with post-appr...
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Palak V Patel Caitlin G Purvis Ramiz N Hamid Steven R Feldman Source Type: research
Workforce requirements for keratinous cysts: clinicians expend 1200 full-time effort years annually
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361424.ABSTRACTKeratinous cysts are amongst the 10 most common dermatologic ambulatory diagnoses. Thus, we aimed to estimate the time and cost spent annually on management of keratinous cysts. We conducted a cross-sectional study using the National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey between 2007 and 2018 (most recent years available). Conservatively, $2.1 billion per year was spent on healthcare for keratinous cysts. On average, the full-time work of 1200 (840-1800) physicians and non-physician providers are required...
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Gabrielle M Rivin Alan B Fleischer Source Type: research
A national survey comparing practice patterns and residency training satisfaction for categorical dermatology versus combined internal medicine and dermatology trained physicians
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361425.ABSTRACTCombined internal medicine and dermatology (med-derm) training programs were created to advance complex medical dermatology and inpatient dermatology care. A prior study demonstrated that compared to categorical dermatology residents, med-derm residents had less program satisfaction, yet indicated a stronger desire to pursue careers in academia. No follow-up data on practice patterns after training has been reported. We aimed to characterize differences in residency program satisfaction and practice patterns between physicians trained in categorical derm...
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Joohee Han Sanna D Ronkainen Audrey Jacobsen Kimberly A Bohjanen Joseph F Merola Maria L Colavincenzo Christine A DeWitt Nicole M Fett Anna Haemel Misha Rosenbach Victoria P Werth Scott Lunos Noah Goldfarb Source Type: research
Diffuse skin findings secondary to lymph node tularemia in a patient with chronic rheumatoid arthritis on methotrexate
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361426.ABSTRACTTularemia has many atypical presentations which can represent a diagnostic challenge. The history is essential in the investigation of this disease. Bite-induced primary skin lesions should be distinguished from the infrequent immune-mediated secondary skin lesions. Herein, we present an atypical pseudovesicular rash secondary to Francisella tularensis.PMID:37591266 | DOI:10.5070/D329361426 (Source: Dermatol Online J)
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: S Kandemir F Dezoteux C Loiez T Hubiche S Laurent S Darras Source Type: research
Usefulness of immunohistochemical staining in diagnosing a challenging case of oral primary syphilis
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361427.ABSTRACTClinicians involved in the diagnosis of mucocutaneous diseases should be aware that syphilis is still prevalent among humans and its accurate diagnosis may require substantial clinical evaluation. Herein, we report a case of primary syphilis presenting as an isolated ulcer on the upper left labial oral mucosa. The lesion exhibited no specific features and could have been easily mishandled. An important clinical observation was the presence of a satellite-enlarged lymph node in the left submandibular area, which was highly indicative of primary syphilis. ...
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Norberto Sugaya Marilia Trierveiler Dante Migliari Source Type: research
Cytokeratin-20 negative nodal Merkel cell carcinoma with regressed primary: a potential pitfall in interpretation of nodal metastasis
We report a case of nodal MCC with an atypical immunohistochemistry pattern presented as bilateral axillary lymphadenopathy in a 90-year-old man with a remote history of a skin lesion that healed spontaneously leaving a scar.PMID:37591268 | DOI:10.5070/D329361428 (Source: Dermatol Online J)
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Nada Mohamed Debby Rampisela Alan C Gowan Source Type: research
Cutaneous rhabdomyoma in an 82-year-old White man
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361429.ABSTRACTThis case highlights a primary cutaneous rhabdomyoma presenting as a slowly enlarging subcutaneous nodule on the mentum of an 82-year-old White man with a medical history of two intracranial rhabdomyomas. Although they are rarely syndromic, it is important to note that the most common demographic for presentation of rhabdomyomas includes older males presenting as a subcutaneous nodule on the head, neck, or oral cavity. They are most often seen in isolation but can be multifocal in up to 25% of all cases. Being a rare entity, there is no generally recogni...
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Jarett Casale Sabiha Uddin Britton Upchurch Muammar Arida Adam Ingraffea Source Type: research
Smokeless tobacco keratosis
We present a 50-year-old man with an extensive history of smokeless tobacco use and development of the characteristic lesion. Shave biopsy showed typical changes of this benign condition and tobacco cessation was recommended.PMID:37591270 | DOI:10.5070/D329361430 (Source: Dermatol Online J)
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Curtis J Petruzzelli Alison Varano Andrew Desrosiers Eric W Hossler Christen M Mowad Source Type: research
Multiple keratotic projections on the palms and soles
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361431.ABSTRACTSpiny keratoderma (SKD) is a rare palmoplantar keratoderma that presents with few to numerous millimetric hyperkeratotic projections on the palms and soles. It has been described with both hereditary and acquired variants. The acquired form, which presents in older adults, has been associated with a variety of systemic diseases and malignant conditions. In patients suspected of having acquired spiny keratoderma, an evaluation for malignant conditions may be warranted. Treatment with topical keratolytics or topical and oral retinoids is usually insufficie...
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Joana Barbosa Miguel Coelho Alexandre Joao Source Type: research
Localized alopecic myxedema of the scalp
This report showcases a rare presentation of localized myxedema of the scalp, highlighting the diverse cutaneous manifestations of autoimmune thyroid diseases.PMID:37591272 | DOI:10.5070/D329361432 (Source: Dermatol Online J)
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Mohammad Saffari Doost Nick R Love Maxwell A Fung Danielle M Tartar Source Type: research
Successful radical surgical resection of a giant neurofibroma
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361433.ABSTRACTLarge neurofibromas often cause significant patient morbidity and present a unique challenge to dermatologists and surgeons. Radical resection offers the lowest rate of recurrence but is not often pursued due to the high risk of intraoperative hemorrhage and difficulty in repairing large defects. Subtotal resection and debulking are more frequently performed, leading to higher rates of recurrence. This case highlights a particularly large neurofibroma and demonstrates how surgical techniques like preoperative embolization and advancement flaps can improv...
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Eric L Bean Daniel J Lewis James Abbott Angela J Jiang John P Fischer Taine Tv Pechet Roman Bronfenbrener Source Type: research
Paclitaxel-induced dorsal hand-foot syndrome
We present an unusual case of paclitaxel-induced HFS localized to the dorsal hands of a 66-year-old man with metastatic angiosarcoma. Early identification and management of HFS is critical to allow for continuation of chemotherapy while improving patient quality of life.PMID:37591274 | DOI:10.5070/D329361434 (Source: Dermatol Online J)
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Eugenie Y Quan Casey Engel Patrick S Rush Joshua D Eikenberg Source Type: research
Macrolides for the treatment of bullous pemphigoid
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361435.NO ABSTRACTPMID:37591275 | DOI:10.5070/D329361435 (Source: Dermatol Online J)
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Henry Zou Steven Daveluy Source Type: research
Patient satisfaction with dermatologists, resident physicians, and physician assistants: a multi-year cross-sectional study in an academic medical center
Dermatol Online J. 2023 Jun 15;29(3). doi: 10.5070/D329361436.NO ABSTRACTPMID:37591276 | DOI:10.5070/D329361436 (Source: Dermatol Online J)
Source: Dermatol Online J - August 17, 2023 Category: Dermatology Authors: Cynthia F Griffith Peter A Young Richard L Froman Rebecca Vasquez Melissa M Mauskar Source Type: research