Extramammary Paget disease.
Abstract In 1874, Sir James Paget first described Paget disease of the nipple, also known as mammary Paget disease. In 1889, extramammary Paget disease (EMPD) of the scrotum and penis was identified. Although mammary and extramammary Paget disease are both characterized by epidermal Paget cells and share a similar clinical presentation, their uniqueness lies in anatomical location and histogenesis. EMPD presents as an erythematous plaque on apocrine gland bearing areas (i.e. vulva, perineum, perianal region, scrotum, and penis) in older men and women. It can be a focal, multifocal, or an ectopic process. Immunohis...
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: St Claire K, Hoover A, Ashack K, Khachemoune A Tags: Dermatol Online J Source Type: research

Healthcare and dermatology on WeChat.
Abstract WeChat is a closed social networking platform that allows users to connect privately, providing instant text, photo sharing, voice, and video calls. It is now the most popular mobile chat app in China. The widespread use and ease of establishing technology made WeChat an ideal platform for healthcare, in which it has many uses that include scheduling, follow up, and post-procedure monitoring. In addition, one may make payments and handle prescriptions via e-pharmacy. Dermatologists are often looking for a secure and easy way to use mobile applications to share clinical images and to obtain photographs fro...
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Maymone MB, Du T, Dellavalle RP Tags: Dermatol Online J Source Type: research

Oral lichen sclerosus: a rare case and update.
z LMG Abstract Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease that often affects the anogenital area; oral mucosal lesions are extremely rare. A 52-year-old woman presented for evaluation of an 8-year history of a persistent whitish plaque in the buccal mucosa. Intraoral examination revealed multiple elevated whitish plaques diffusely distributed in the buccal mucosa associated with an area of tissue atrophy. Although both leukoplakia and lichen planus were considered, incisional biopsy and later, full excision confirmed the histopathological diagnosis of oral LS. After 6 months of follow-up...
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Gonçalo RIC, Vargas YDCM, Medeiros HCM, Xerez MC, Santos HBP, Queiroz LMG Tags: Dermatol Online J Source Type: research

Incisional biopsy critical in obtaining definitive diagnosis in a clinically challenging case.
We present a case of a 70-year-old man with hidradenocarcinoma of the left chin, a diagnosis that was delayed owing to repeated superficial biopsies that were negative for disease. Diagnosis was ultimately obtained via an incisional biopsy. We discuss the clinical features of hidradenocarcinoma and why this diagnosis can be easily missed with superficial biopsies. It is important that dermatologists consider incisional biopsies in the workup of clinically challenging lesions for which malignancy is considered. PMID: 31046907 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Fernandez J, Ren V, Cohen D, Shimizu I Tags: Dermatol Online J Source Type: research

Darier disease with disseminated herpes simplex virus type 2 infection.
Abstract Darier disease (DD), also known as keratosis follicularis or Darier-White disease, is a rare autosomal dominant genodermatosis that presents as hyperkeratotic, warty papules affecting the seborrheic and intertriginous areas. Patients with DD are at risk of secondary infections including the rare complication of Kaposi varicelliform eruption (KVE), a widespread viral infection most commonly caused by herpes simplex virus (HSV). Darier disease with secondary KVE can lead to widespread systemic infection and death. This case report discusses an individual with DD who subsequently developed KVE due to dissemi...
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Walker K, Martini A, Philips H, Sharp L, Thomas K, Tarbox M Tags: Dermatol Online J Source Type: research

Multiple acantholytic dyskeratotic acanthomas in a liver-transplant recipient.
We present here a new case of this rare lesion that developed in a liver-transplant patient and review the salient features of this uncommon condition. PMID: 31046909 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Kanitakis J, Gouillon L, Jullien D, Ducroux E Tags: Dermatol Online J Source Type: research

Late-onset amyloidosis cutis dyschromica: an unusual case.
u G, Ekşioğlu M Abstract Amyloidosis cutis dyschromica (ACD) is a rare form of primary cutaneous amyloidosis. ACD, first described by Morishima in 1970 is characterized by (i) macular, speckled, reticular hyperpigmentation with hypopigmented spots distributed extensively over the body; (ii) little or no pruritus; (iii) prepubertal onset; and (iv) focal subepidermal amyloid deposition. A 49-year-old woman presented with a 20-year history of progressive, asymptomatic, generalized mottled hyper- and hypopigmented macules all over the body. Histopathological examination of a punch biopsy specimen showed deposition o...
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Kutlu Ö, Çetinkaya PÖ, Ünverdi H, Vahapoğlu G, Ekşioğlu M Tags: Dermatol Online J Source Type: research

Endogenous ochronosis: when clinical suspicion prevails over histopathology.
We report a new case of EO with cutaneous and joint involvement, in which a high clinical suspicion, confirmed by elevated AHG in urine was the key in the diagnosis. PMID: 31046911 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Sánchez-Martínez EM, García-Briz MI, Moneva-Léniz LM, Gegúndez-Hernández H, Pose-Lapausa P, Mateu-Puchades A Tags: Dermatol Online J Source Type: research

Molluscum contagiosum with dermoscopic features in an unusual areola and nipple location.
Abstract Molluscum contagiosum is a common, contagious viral skin disease that often affects children and adolescents. Involvement of the areola and nipple are rarely reported. Herein we report two young women with molluscum contagiosum on the areola-nipple complex and we discuss the dermoscopic features of the lesions at this unusual site. PMID: 31046912 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Demirdag HG, Ayanoglu BT, Durmus B, Bulut M, Akay BN Tags: Dermatol Online J Source Type: research

Morphea secondary to interferon beta1b injection: a case and review of the literature.
Abstract Interferon beta (IFNβ) is a drug used successfully in the treatment of multiple sclerosis (MS). Although IFNβ is a safe and well-tolerated drug, dermatological side effects are common. The most common dermatological adverse effect is a local reaction at the injection site. It may also cause inflammatory and immune-mediated dermatological side effects. However, morphea induced by IFNβ1b injection is very rare. PMID: 31046913 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Ozlu E, Karadag AS, Akdeniz N, Uzuncakmak TK, Zemheri E, Ozkanli S Tags: Dermatol Online J Source Type: research

Allergic contact dermatitis related to homemade slime: a case and review of the literature.
We present a case of a child with hand dermatitis, history of exposure to slime, and positive allergen patch testing to two ingredients found in slime. The case underscores the need for clinicians to be aware of slime as a possible cause of allergic contact dermatitis in children. Given the trend of newly-reported cases, we briefly review the current literature to date. PMID: 31046914 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Mainwaring W, Zhao J, Hunt R Tags: Dermatol Online J Source Type: research

Exogenous ochronosis: the failure of depigmenting creams.
We present a woman who developed EO on the face, upper chest, and back after prolonged use of a depigmenting cream containing hydroquinone. PMID: 31046915 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Sánchez-Martínez EM, García-Briz MI, Moneva-Léniz LM, Gegúndez-Hernández H, Pose-Lapausa P, Mateu-Puchades A Tags: Dermatol Online J Source Type: research

Melanoma patient notification and treatment timelines.
Abstract Melanoma is an extremely aggressive cancer for which the American Academy of Dermatology currently does not have formal recommendations outlining a timeline from biopsy to definitive treatment. Our dermatology department investigated our treatment timeline for melanoma. Using the database from our electronic medical record, Epic, we evaluated patients over a one-year period; in total we identified 109 melanomas. We evaluated patient demographics, tumor characteristics, and timelines regarding diagnosis and treatments. There was a statistically significant difference in patient notification of diagnosis an...
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Niehues NB, Evanson B, Smith WA, Fiore CT, Parekh P Tags: Dermatol Online J Source Type: research

Paradoxical reversed plantar involvement during ixekizumab therapy for psoriasis.
We present a patient with palmoplantar psoriasis treated with ixekizumab who achieved a favorable response that was coupled with a rare paradoxical reaction, reversed plantar involvement. The reason for this phenomenon and its clinical course are uncertain, but these new lesions are proving recalcitrant to complementary therapies. Provided the increasingly widespread use of biologic therapies, the incidence and diversity of paradoxical reactions are expected to increase. PMID: 31046917 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Martínez-Doménech Á, García-Legaz-Martínez M, Magdaleno-Tapial J, Giácaman M, Hernández-Bel P, Pérez-Ferriols A Tags: Dermatol Online J Source Type: research

Metastatic squamous cell carcinoma arising in the setting of folliculitis decalvans.
We present a patient with severe, chronic FD who developed metastatic squamous cell carcinoma of the scalp. PMID: 31046918 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Esaa F, Shah PR, Dolohanty LB Tags: Dermatol Online J Source Type: research

Corrigendum: A novel ultraviolet B home phototherapy system: Efficacy, tolerability, adherence, and satisfaction.
Abstract The original article was published on February 15, 2019 and corrected on April 15, 2019. The third pair of panes of Figure 2 were reversed, such that the pane previously depicted on the left was after phototherapy. The corrected sequence is now before phototherapy, on the left, and after, on the right. This change appears in the revised online PDF copy of this article. PMID: 31046919 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - April 15, 2019 Category: Dermatology Authors: Unrue EL, Cline A, Collins A, Nguyen VH, Pelle MT, Blake P, Feldman SR Tags: Dermatol Online J Source Type: research

Animated video consultation for reducing pre-operative anxiety in dermatologic surgery.
Abstract Pre-operative anxiety is common in patients undergoing dermatologic surgery. This pilot study aimed to evaluate whether the addition of an animated educational video to conventional in-person surgery consultation helps to reduce pre-operative anxiety related to anesthesia, surgery, wound care, and post-operative pain in patients undergoing outpatient dermatologic surgery. Patients awaiting dermatologic surgery were randomized into groups with conventional consultation, or video with consultation prior to undergoing their procedure. The conventional consultation group received conventional consultation wit...
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Platto JF, Maarouf M, Hendricks A, Kurtzman DJ, Shi VY Tags: Dermatol Online J Source Type: research

Revised Mohs surgery care guidelines for squamous cell carcinoma in-situ are overdue.
Abstract The treatment of cutaneous squamous cell carcinoma in situ by Mohs micrographic surgery is currently deemed as appropriate by the Mohs Appropriate Use Criteria. However, squamous cell carcinoma in situ is a very superficial, indolent, low-risk tumor amenable to destructive and non-surgical treatments. It is uncommon for squamous cell carcinoma in situ to have progressed to invasive malignancy subsequent to definitive management. The suggestion that squamous cell carcinoma in situ on certain anatomic locations has a poorer prognosis is widely assumed but lacks an evidence base. We recommend that most prima...
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Carley SK, Dixon A, Zachary CB, Steinman HK Tags: Dermatol Online J Source Type: research

Adherence to a novel home phototherapy system with integrated features.
CONCLUSIONS: By implementing a smartphone application and web-based portal with the home phototherapy system, patients have multiple mechanisms in place to ensure adherence. PMID: 30982300 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Cline A, Unrue EL, Collins A, Feldman SR Tags: Dermatol Online J Source Type: research

Sexual dimorphism and transgender medicine: appealing to a viewer's sense of beauty.
Abstract Sexual dimorphism - the phenotypic structural differences between male and female faces - has been shown to be an important universal component of beauty. This concept plays a key role in facial feminization surgery (FFS), which consists of contouring and reshaping features of the skull itself to alter the foundation of the face. FFS has been shown to improve quality of life among transgender women and therefore an understanding of the procedure and the concept of sexual dimorphism is key for plastic surgeons, dermatologists, and other healthcare providers. PMID: 30982301 [PubMed - in process] (...
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Rajanala S, Maymone MB, Vashi NA Tags: Dermatol Online J Source Type: research

Unilateral granuloma annulare in association with pyoderma gangrenosum and chronic lymphocytic leukemia.
We describe an unusual case of unilateral GA confined to the thigh on a previously amputated limb. A man in his 80s with a past medical history of below-knee amputation of the left leg owing to severe leg ulcers from pyoderma gangrenosum, chronic lymphocytic leukemia, and dyslipidemia developed a slowly spreading eruption on the distal stump spreading proximally. On physical examination, he had numerous non-scaly violaceous papules and annular plaques from the stump to the lateral, medial, and anterior thigh. Histology confirmed a diagnosis of GA. The extensive, chronic lesions make this presentation of GA very unusual in ...
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Borda LJ, Mervis JS, Kirsner RS Tags: Dermatol Online J Source Type: research

A novel case of TIF1 gamma autoantibody positive dermatomyositis associated with a non-functional pancreatic neuroendocrine tumor.
Abstract Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by proximal muscle weakness associated with a distinct cutaneous eruption. The association of DM with malignancy has been extensively described in the literature. Patients with DM that also have transcriptional intermediary factor 1. PMID: 30982303 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Varedi D, Frigerio A, Scaife C, Hull C Tags: Dermatol Online J Source Type: research

The nail flag sign in heart transplant recipients: case reports and review of the patients with the flag sign of the nail.
Abstract The nail plate flag sign is a distinctive nail plate change that appears as white, red, white, and red sequential transverse bands beginning at the proximal nail fold. This distinctive nail change was initially described in patients with diabetes mellitus and leprosy; indeed, it was considered to be characteristic, but not diagnostic of leprosy. Subsequently, the flag sign was observed in patients with vitiligo. The flag sign has recently been noted in two men following heart transplantation. In summary, the flag sign is a unique nail change that has occurred in patients with autoimmune disorders, infecti...
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Cohen PR Tags: Dermatol Online J Source Type: research

Ulcerated tophaceous gout.
We report the case of a 38-year-old man, undiagnosed with gout, who presented to clinic for evaluation of ulcers with chalky white granules. The wounds were determined to be ulcerated tophaceous gout. Risk factors for ulceration over tophi and reported treatments are discussed. PMID: 30982305 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Ryan MP, Monjazeb S, Goodwin BP, Group AR Tags: Dermatol Online J Source Type: research

Persistent generalized Grover disease: complete remission after treatment with oral acitretin.
We report a 56-year-old woman with recalcitrant, persistent, and generalized GD who showed complete remission after 6 weeks of treatment with oral acitretin (0.8mg/kg/day). The treatment was well-tolerated and laboratory parameters remained unchanged. The patient remains free of any recurrence at 26 months. To the best of our knowledge, this is the first report of a complete remission of the persistent form of GD as a result of oral acitretin monotherapy. PMID: 30982306 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Pasmatzi E, Kousparos G, Mytidou C, Nicolaou N, Tanteles GA, Badavanis G, Monastirli A, Tsambaos D Tags: Dermatol Online J Source Type: research

Elastosis perforans serpiginosa related to vascular Ehlers-Danlos syndrome.
We present a 26-year-old woman with EPS known to have vascular Ehlers-Danlos syndrome. PMID: 30982307 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Uldall Pallesen KA, Lindahl KH, Bygum A Tags: Dermatol Online J Source Type: research

Multiple flat-topped scaly violaceous papules.
Abstract Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis characterized by susceptibility to beta-genus human papillomavirus (HPV) infection. Owing to TMC6/EVER1 and TMC8/EVER2 mutations that lead to abnormal transmembrane channels in the endoplasmic reticulum involved in immunological pathways, keratinocytes cannot combat infection from non-pathogenic HPV strains. Mutations involving RHOH, MST-1, CORO1A, and IL-7 have also been associated with EV in patients without TMC6 or TMC8 mutations. We highlight a 27-year-old man with multiple violaceous flat-topped papules with scale and irreg...
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Girijala RL, Nyinawinyange D, Parekh PK, Grimwood RE Tags: Dermatol Online J Source Type: research

A case of cutaneous nodules in a sporotrichoid pattern.
We present a patient with a sporotrichoid cutaneous infection by Mycobacterium marinum, highlighting that even with the availability of novel microbiological detection techniques, tissue culture remains an essential tool for diagnostic confirmation. PMID: 30982309 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Esteves M, Nogueira A, Azevedo F Tags: Dermatol Online J Source Type: research

Late onset nevus comedonicus of scalp: a rare site for an uncommon condition.
We report a case of a 19-year old woman with nevus comedonicus of the scalp that appeared in adolescence. This case has been presented for its sheer rarity, atypical site, and classic appearance. PMID: 30982310 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Mathachan SR, Arora P, Ahuja A, Gautam RK Tags: Dermatol Online J Source Type: research

A diagnostic challenge: inflamed and pigmented seborrheic keratosis. Clinical, dermoscopic, and histopathological correlation.
In conclusion, pigmented and inflamed SK does not usually tend to show typical dermoscopic features of SK and may mimic other pigmented lesions, including melanoma. All skin lesions that cannot be classified as clearly benign should undergo biopsy. PMID: 30982311 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Mansur AT, Yildiz S Tags: Dermatol Online J Source Type: research

The cotton tipped applicator - a scratch for the itch and more during dermatologic surgery.
Abstract An itch during surgery can be distracting. Sterile cotton tipped applicators are inexpensive and multipurpose tools that may be used for a variety of simple surgical tasks such as scratching an itch on the surgeon or patient's face. They may also be used to adjust glasses and turn on surgical lights or the electrocautery machine. PMID: 30982312 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Siscos SM, Neill BC, Seger EW, Hocker TL Tags: Dermatol Online J Source Type: research

Medical school ranking and dermatology match results: an analysis of the 2018 match data.
This study sought to explore whether there is a difference in the percentage of graduates matching into dermatology residencies based on the rank of the medical school. Publicly available match lists from highly ranked medical schools were compared to match lists from other allopathic schools to determine the proportion of graduates matching into dermatology. The data was analyzed using a chi square test and a significant difference was found between the percentage of students matching into dermatology from top schools (5.19%) compared to control schools (1.92%), (P<0.0001). PMID: 30982313 [PubMed - in process]...
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Ryan MP, De Jong AL, Wagner RF Tags: Dermatol Online J Source Type: research

Identification of a novel mutation in the ST14 gene in an Iranian family with ichthyosis and hypotrichosis.
Abstract Inherited ichthyosis is a heterogeneous group of rare cutaneous disorders characterized by hyperkeratosis and scaly skin. So far, only a few genetic studies on ichthyosis have been performed in Iran. Herein, we reported a family with two cases of ichthyosis and hypotrichosis that were investigated by whole exome sequencing. Targeted data analysis identified a novel nonsense variant c.1243C>T (p.Gln415Ter) located at exon 11 of the ST14 gene in the proband. Sanger sequencing showed co-segregation of this mutation with the disease in this family. Further studies are needed to develop knowledge about ...
Source: Dermatol Online J - March 15, 2019 Category: Dermatology Authors: Taghavi-Basmenj M, Razipour M, Davoudi-Dehaghani E, Nasimi M, Abghari FZ, Karimipoor M Tags: Dermatol Online J Source Type: research

Diet and psoriasis.
CONCLUSIONS: Dietary changes alone do not cause a large effect in psoriasis but may become an important adjunct to current first line treatments. PMID: 30865402 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Pona A, Haidari W, Kolli SS, Feldman SR Tags: Dermatol Online J Source Type: research

Laser-assisted drug delivery for the treatment of androgenetic alopecia: ablative laser fractional photothermolysis to enhance cutaneous topical delivery of platelet-rich plasma - with or without concurrent bimatoprost and/or minoxidil.
In conclusion, to potentially maximize the stimulation of hair growth, laser assisted drug delivery of platelet-rich plasma - with or without bimatoprost and/or minoxidil - should be considered in patients with androgenetic alopecia in order to effectively deliver the agents to the dermis where the bulge area of the hair follicles is located. PMID: 30865404 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Cohen PR Tags: Dermatol Online J Source Type: research

A novel ultraviolet B home phototherapy system: Efficacy, tolerability, adherence, and satisfaction.
CONCLUSIONS: The home phototherapy system provided a safe and effective means to manage plaque psoriasis. PMID: 30865405 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Unrue EL, Cline A, Collins A, Nguyen VH, Pelle MT, Blake P, Feldman SR Tags: Dermatol Online J Source Type: research

Non-uremic calciphylaxis in a patient with multiple rheumatologic diseases.
Abstract Non-uremic calciphylaxis is a rare, life-threatening condition characterized clinically by cutaneous necrosis and histologically by calcium deposition in small vessel walls. The etiology of non-uremic calciphylaxis remains the subject of ongoing speculation and debate. Herein we present a patient with calciphylaxis who had normal kidney function and numerous rheumatologic diseases, namely systemic lupus erythematosus (SLE), Sjogren syndrome (SS), and myasthenia gravis (MG). We review the pathophysiology, possible mechanisms, and management for non-uremic calciphylaxis. PMID: 30865406 [PubMed - in pro...
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Kusari A, Cotter D, Hinds B, Paravar T Tags: Dermatol Online J Source Type: research

Cutaneous toxicity associated with enfortumab vedotin treatment of metastatic urothelial carcinoma.
We report a patient with metastatic urothelial carcinoma treated with enfortumab vedotin who developed erythematous, scaly papules and plaques on his torso and extremities with corresponding histologic features of vacuolar interface dermatitis and maturation disarray of keratinocytes. He was successfully treated with topical corticosteroids. Cutaneous toxicity appears to be a common adverse reaction in this growing class of antibody-drug conjugates. PMID: 30865407 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Wu S, Adamson AS Tags: Dermatol Online J Source Type: research

Glans penis necrosis caused by calcific uremic arteriolopathy.
We present an 81-year-old man with a history of diabetes mellitus, hypertension, and end-stage renal disease with a one-month evolution of painful necrotic ulcers on his glans penis. He was diagnosed with CUA. Owing to infection complicated by sepsis; penectomy was performed. Unfortunately, the patient died of myocardial infarction during his hospitalization. PMID: 30865408 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Villela-Segura U, Peralta-Serna J, Guerrero-Álvarez A, Estrada-Aguilar L Tags: Dermatol Online J Source Type: research

Solitary noninfiltrating angiolipoma on the finger, an unusual localization.
Abstract Angiolipoma, a subtype of lipoma, is a benign adypocytic soft tissue tumor composed of mature adipose tissue and small vascular proliferations. This entity makes up 5-17% of all lipomas. The diagnosis is made by clinical and pathological examination, ultrasonography, and/or magnetic resonance imaging (MRI). It is generally an encapsulated tumor (noninfiltrative), but rarely has an infiltrative form. Angiolipoma mostly occurs on the trunk and extremities with male predominance. The forearm is the most frequent location for angiolipomas. It is very rarely seen on the fingers. Herein, we report a patient wit...
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Karaali MG, Polat AK, Koku Aksu AE, Leblebici C, Gurel MS Tags: Dermatol Online J Source Type: research

Blastic plasmacytoid dendritic cell neoplasm: an early presentation.
arneiro FRO Abstract A blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a cutaneous lymphoma derived from a plasmacytoid dendritic precursor cell that exhibits aggressive clinical behavior. Herein, we report a 46-year-old woman with a complaint of a painless nodule on the back, associated with pruritus. The nodule grew and new growths appeared over six months of evolution. The histopathological examination of one of the left upper limb lesions showed a dense lymphoid cell infiltrate with atypia in the superficial and deep dermis. Immunohistochemistry showed positivity for CD45, S-100 protein, CD123, and TCL...
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Silveira SO, Fernandes CMA, Pinto ÉB, Einecke YS, Palheta CDSA, Brito CVB, Dias Júnior LB, Carneiro FRO Tags: Dermatol Online J Source Type: research

Mycobacterium marinum lymphocutaneous infection.
We present a 33-year-old man with no immunosuppressive history who was seen in our department with skin nodules over his hand and forearm, distributed in a sporotrichoid pattern. His hobbies included maintaining an aquarium of tropical fish. Histological examination of the patient's skin biopsy was compatible with the diagnosis of mycobacterial infection, and the Ziehl-Neelsen staining revealed acid-fast bacilli. Molecular techniques confirmed the suspicion of M. marinum infection. A necropsy was performed on one of the patient's fish, more specifically, a Poecilia reticulata, and resulted in identification of M. marinum f...
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Bouceiro-Mendes R, Ortins-Pina A, Fraga A, Marques T, Viveiros M, Machado D, Soares-de-Almeida L, Freitas JP, Filipe P Tags: Dermatol Online J Source Type: research

Neurosis and true dermatosis: a case of ossified pilomatricoma developing within a self-inflicted ulcer.
We describe a case of skin picking disorder with underlying pilomatricoma. The patient met criteria for skin picking disorder and had been prescribed numerous topical treatments without efficacy by countless physicians over 18 years. In addition, a pilomatricoma was discovered within a self-inflicted ulcer. Pilomatricomas can rarely result from trauma and develop ossification, both of which were true of this lesion. The prevalence of skin picking disorder proves more pervasive than previously realized and it has only recently been recognized by the DSM-5 as an independent diagnosis. Therefore, it is necessary to clarify th...
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Culver AL, Hernandez A, Paek SY Tags: Dermatol Online J Source Type: research

Umbilical condyloma lata.
We describe a patient with an unusual presentation of condyloma lata on the umbilicus. PMID: 30865413 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Alexanian C, Le S, Ma C, Fung M, Tartar D Tags: Dermatol Online J Source Type: research

Verrucous melanoma masquerading as a seborrheic keratosis.
We present a patient with a verrucous melanoma that could be mistaken for a benign skin tumor like an inflamed seborrheic keratosis. In our patient's case, her verrucous plaque was initially clinically suggestive of a benign seborrheic keratosis. However, given the patient's complaint of pain associated with the lesion, a biopsy was performed and revealed a verrucous-keratotic malignant melanoma, which was subsequently removed through surgical excision. It is important to remain vigilant of this diagnosis, as treatment for inflamed seborrheic keratosis often includes a trial of cryotherapy, which potentially could lead to ...
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Tran PT, Truong AK, Munday W, Alexanian S, Levins P Tags: Dermatol Online J Source Type: research

Large peri-punctal eccrine hidrocystoma.
We report a patient with a peri-punctal hidrocystoma of the eyelid. PMID: 30865415 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Desai A, Mishra DK, Ali MJ Tags: Dermatol Online J Source Type: research

Electrosurgical debulking of pretibial myxedema of the foot.
Abstract Pretibial myxedema or thyroid dermopathy constitutes dermal deposition of mucin, primarily hyaluronic acid and chondroitin sulfate. It is a manifestation of autoimmune thyroiditis, seen more in Graves disease than in Hashimoto thyroiditis. The time delay from treatment of hyperthyroidism to appearance of localized myxedema varies from one month to 16 years (mean 5.13 years). Despite a variety of therapeutic options, failure and relapse rates are high. Therapeutic options reported in the literature include compression, topical and intralesional corticosteroids, oral pentoxifylline, octreotide, rituximab, p...
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Alia E, Feit EJ, Levitt JO Tags: Dermatol Online J Source Type: research

Acrodermatitis continua of Hallopeau response to optimized biological therapy.
Abstract Acrodermatitis continua of Hallopeau, first described in 1890, is an uncommon variant of pustular psoriasis. It presents as a sterile pustular eruption of the tips of fingers and toes. The condition has a chronic, relapsing course and is often resistant to many anti-psoriatic therapies. In the following case, we present our experience of etanercept use in a 61-year-old man. Although initial therapy with high-dose etanercept achieved a rapid, sustained response and remission, the lesions relapsed a few months into a lower, maintenance dosage. This result prompted the use a second biotherapeutic agent ustek...
Source: Dermatol Online J - February 15, 2019 Category: Dermatology Authors: Adas A, Dadban A, Arnault JP, Chaby G, Lok C Tags: Dermatol Online J Source Type: research

Bioidentical hormone therapy in menopause: relevance in dermatology.
Abstract Hormone replacement therapy has been shown to be effective in alleviating menopausal symptoms. However, its use is controversial owing to potential health risks, such as thromboembolism and cancer. Bioidentical hormone therapy has recently become popular as an alternative to conventional hormone replacement therapy. These bioidentical hormones have a molecular structure identical to endogenous hormones found in a woman's body. A claimed advantage of bioidentical hormone therapy is the compounding practice in order to individualize therapy depending on patient's own hormone levels and symptoms. However, th...
Source: Dermatol Online J - January 15, 2019 Category: Dermatology Authors: Borda LJ, Wong LL, Tosti A Tags: Dermatol Online J Source Type: research

Cutaneous cytomegalovirus manifestations, diagnosis, and treatment: a review.
The objective of this study is to aid in recognition, diagnosis, and treatment of CMV according to dermatological evidence. A complete literature search was performed within PubMed, resulting in the inclusion of 58 patient cases. The most common dermatologic manifestation was perianal or oral ulcers, but the locations and types of lesions noted throughout the review were numerous. Treatment is often simple, yet incorrect diagnoses along with concurrent illnesses can often complicate management. It is imperative for CMV to be detected early in its course to prevent mortality, especially in the immunocompromised. Dermatologi...
Source: Dermatol Online J - January 15, 2019 Category: Dermatology Authors: Drozd B, Andriescu E, Suárez A, De la Garza Bravo MM Tags: Dermatol Online J Source Type: research