Anti-laminin 332 antibodies in graft-versus-host disease-associated bullous pemphigoid after allogeneic peripheral blood stem cell transplantation
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses. A combination regimen of topical corticosteroids (clobetasol ...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Yasutoshi Hida Riho Kageji Hirofumi Bekku Norito Ishii Source Type: research
Secondary syphilis presenting as leukocytoclastic vasculitis in a 61-year-old man
We report a case of secondary syphilis presenting with an acute, rapidly progressive purpuric eruption mimicking leukocytoclastic vasculitis. A 61-year-old man presented with a 6-day history of nonpruritic rash on his chest and lower extremities associated with fatigue, sore throat, and night sweats. Examination revealed purpuric papules, extending from the dorsal feet to the hips; mucosal surfaces were not involved. A diagnosis of cutaneous small-vessel vasculitis was favored with possible triggers of IgA vasculitis. Initial work-up showed acute kidney injury and microscopic hematuria. Renal biopsy showed IgA nephropathy ...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Nada Mohamed Nicole N Dacy Lisa M Lopez Lindsay M Bicknell Source Type: research
Two congenital cases of pigmented epithelioid melanocytoma with unique clinical and genetic features
We report two unique cases of congenital PEM with PRKCA fusion transcripts: a multifocal PEM with an aggressive incompletely resectable scalp tumor and a solitary palmar PEM with newly reported ITGB5-PRKCA fusion. Through these case reports and a summary of previously reported cases, we outline the spectrum of disease of PEM and highlight the key clinical and histopathologic features associated with PEM with PRKCA fusion transcripts. We also discuss the treatment options and suggest that surgical excision without further adjuvant systemic treatment is reasonable first-line therapy given the favorable prognosis.PMID:3847863...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Hiba Zaaroura Benoit Cyrenne Gino R Somers Karen Wy Wong Kristen M Davidge Evan J Propst Abhaya V Kulkarni Winnie Lo Anita Villani Irene Lara-Corrales Rebecca Levy Source Type: research
Generalized perforating granuloma annulare associated with latent tuberculosis successfully treated with isoniazid: case report and review
We report a 66-year-old woman who presented with a 7-month history of mostly asymptomatic generalized infiltrated, flesh-colored to red-brown umbilicated or crusted papules. Histopathological findings were compatible with perforating granuloma annulare. Diagnostic workup revealed latent tuberculosis. To the best of our knowledge, this is the second published case of GPGA associated with latent tuberculosis and the first one that was successfully treated by isoniazid monotherapy. From our case we can speculate and support the theory that GPGA is a phenotypic granulomatous response to multiple etiologies and/or antigenic sti...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Igor Kapetanovic Martina Bosic Branislav Lekic Dubravka Zivanovic Source Type: research
Exacerbation of Darier disease with lithium therapy
Dermatol Online J. 2023 Oct 15;29(5). doi: 10.5070/D329562405.ABSTRACTDarier disease is an autosomal dominant blistering disorder linked to mutation of the endoplasmic reticulum calcium pump, SERCA2, which compromises keratinocyte adhesion and differentiation. Beyond the typical keratotic and eroded skin lesions, patients with Darier disease often present with psychiatric co-morbidities. Herein, we present a biopsy-confirmed case of Darier disease in a patient with bipolar disorder, whose cutaneous disease dramatically worsened upon initiation of lithium therapy. In consultation with the patient's psychiatrist, lithium was...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Shant Tamazian Cory L Simpson Source Type: research
A case of monkeypox and cytomegalovirus coinfection manifesting with crusted lesions mimicking rupiod syphilis
We present a 41-year-old man patient with untreated HIV with generalized rupioid crusted ulcerated plaques with perineal ulceration that were found to represent monkeypox and cytomegalovirus infections.PMID:38478642 | DOI:10.5070/D329562406 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Jean Zevallos Jhoann Aurich Jose Quiroz Source Type: research
A case series of hydroxychloroquine exacerbating the dermatomyositis rash
Dermatol Online J. 2023 Oct 15;29(5). doi: 10.5070/D329562407.ABSTRACTHydroxychloroquine (HCQ) is an antimalarial agent that is commonly used in the management of rheumatic skin disease. Few reports exist documenting exacerbation of dermatomyositis (DM) related to HCQ. Herein, we describe three adult patients with worsening DM cutaneous disease after starting HCQ and resolution or improvement with cessation. The time to exacerbation ranged from two weeks to nine months after the initiation of HCQ 400mg/day. Two of the three patients had antibodies to transcription intermediary factor 1γ (TIF1γ) and the other had antibodi...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Katelyn Rypka Michele Buonomo Connor Buechler Molly Benolken Adam Swigost Nikifor Konstantinov Kevin Gaddis Noah Goldfarb Source Type: research
Erythema elevatum diutinum in a patient with rheumatoid arthritis
We report a 65-year-old woman with painful and itchy lesions on her elbows, hands, knees, and foot for a year. Histopathologic examination confirmed the diagnosis of erythema elevatum diutinum and treatment with dapsone produced significant clinical improvement within few weeks. Erythema elevatum diutinum is a rare disease that should be considered in patients with violaceous nodular plaques located over the extensor regions of the limbs. Knowledge of this unusual pathology and its association helps to avoid misdiagnosis and late treatment.PMID:38478644 | DOI:10.5070/D329562408 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Maraya Semblano Bittencourt Tally Serruya Luana De Oliveira Loureiro Aline Dias Coelho De Souza Camilla Correa Neri Ana Thais Machado Moutinho Caren Dos Santos Lima Source Type: research
Cutaneous metastasis as a first sign of adenocarcinoma of the cervix
We present a patient whose cutaneous signs led to the diagnosis of metastatic adenocarcinoma of the cervix.PMID:38478645 | DOI:10.5070/D329562409 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Shadai Gociman Scott R Florell Jennie T Clarke Source Type: research
An unusual presentation of pigmented purpuric lichenoid dermatitis
Dermatol Online J. 2023 Oct 15;29(5). doi: 10.5070/D329562410.ABSTRACTPigmented purpuric lichenoid dermatitis (PPLD) is a rare subtype of pigmented purpuric dermatosis, which classically presents with a mixture of lichenoid papules and patches on the bilateral lower extremities. Herein, we describe an unusual case of a 47-year-old man with PPLD who presented with 1-3mm discrete papules without the presence of larger patches. The diagnosis of PPLD should be considered for patients presenting with bilateral symmetric discrete papules on the legs.PMID:38478646 | DOI:10.5070/D329562410 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Christine De Antonis Jordan T Hyde Jason B Lee Sylvia Hsu Source Type: research
Red crusty plaques in a young man
Dermatol Online J. 2023 Oct 15;29(5). doi: 10.5070/D329562411.ABSTRACTPemphigus foliaceus is a superficial blistering disorder characterized by erosions and scaling in a seborrheic distribution. The condition typically occurs in healthy individuals but issues arise from delayed diagnosis. Many cases remain undiagnosed or misdiagnosed due to the lack of awareness of the condition. With use of common diagnostic tools, pemphigus foliaceus can be easily identified and monitored. Histological analysis exhibits "chicken wire" patterning along keratinocytes in the upper epidermis, whereas immunofluorescence study displays subcorn...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Mishma Farsi Cassandra M Johnson Kelly Segars Jonathan Rhim Source Type: research
Erythematous scaly plaques and nodules on scalp
We describe a 45-year-old man who presented with erythematous scaly plaques and nodules on his scalp. In previously reported cases, there were only descriptions of nodules as well as tumors. However, in our case, the patient presented with plaques and nodules on his scalp that quickly resolved with treatment for syphilis. It is important to recognize and treat syphilis at an early stage.PMID:38478648 | DOI:10.5070/D329562412 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Peiying Audrey Ho Yee Yen Gwee Choon Chiat Oh Source Type: research
Ficus carica L photodermatitis: a report of five cases with histopathologic study and review of the literature
We present five cases of photodermatitis caused by contact with Ficus carica L and subsequent exposure to sunlight. A histopathologic study and review of the literature are included.PMID:38478649 | DOI:10.5070/D329562413 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Stefano Veraldi Luisa Carlotta Rossi Gianluca Nazzaro Source Type: research
Livedoid vasculopathy
Dermatol Online J. 2023 Oct 15;29(5). doi: 10.5070/D329562414.ABSTRACTLivedoid vasculopathy is a painful thrombo-occlusive vascular disorder characterized by spontaneous thrombosis in medium-size arterioles, which causes localized hypoxia and skin ulceration. As livedoid vasculopathy is rare, case reports are the primary means of expanding collective knowledge about its presentation and response to various therapies.PMID:38478650 | DOI:10.5070/D329562414 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Melissa C Leeolou Kerri E Rieger Jennifer E Yeh Source Type: research
Assessment and quality improvement of the Community Care Network: Veterans Administration (VA) patient access to community Mohs micrographic surgery
Dermatol Online J. 2023 Oct 15;29(5). doi: 10.5070/D329562415.NO ABSTRACTPMID:38478651 | DOI:10.5070/D329562415 (Source: Dermatol Online J)
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Aheli Chattopadhyay Drew Saylor Amanda Twigg Source Type: research
