Efficacy and safety of low-dose doxepin in depressed patients suffering from insomnia: a retrospective, naturalistic case series analysis.

Conclusion: Contrasting previous results in healthy subjects, low-dose doxepin does not seem to improve sleep onset or maintenance in patients with MDD. Further research, preferably placebo-controlled, double-blind sleep laboratory trials, is necessary to determine whether low-dose doxepin may be beneficial in this important patient subgroup. PMID: 24940524 [PubMed]

http://www.ncbi.nlm.nih.gov/pubmed/24940524?dopt=Abstract

Source: Primary Care - June 23, 2014 Category: Primary Care Authors: Mews MR, Rombold F, Quante A Tags: Prim Care Companion CNS Disord Source Type: research