Bilastine vs. Hydroxyzine: Occupation of Brain Histamine H1 Receptors Evaluated by Positron Emission Tomography in Healthy Volunteers

ConclusionsA single oral dose of bilastine 20 mg had minimal H1RO, was not linked with subjective sedation or objective impairment of psychomotor performance, and was devoid of treatment‐related sedative AEs, thus satisfying relevant subjective, objective, and PET criteria as a nonsedating antihistamine.

Source: British Journal of Clinical Pharmacology - May 15, 2014 Category: Drugs & Pharmacology Authors: Magí Farré, Clara Pérez‐Mañá, Esther Papaseit, Esther Menoyo, Marta Pérez, Soraya Martin, Santiago Bullich, Santiago Rojas, José‐Raúl Herance, Carlos Trampal, Luis Labeaga, Román Valiente Tags: Main Paper Source Type: research