A novel neurological function of rice bran: a standardized rice bran supplement promotes non ‐rapid eye movement sleep in mice through histamine H1 receptors
Conclusions: RBS decreases sleep latency and promotes NREMS through the inhibition of H1R, suggesting that it could be a promising therapeutic agent for insomnia.This article is protected by copyright. All rights reserved (Source: Nahrung / Food)
Source: Nahrung / Food - July 19, 2017 Category: Nutrition Authors: Min Young Um, Sojin Kim, Young ‐Ho Jin, Minseok Yoon, Hyejin Yang, Jaekwang Lee, Jonghoon Jung, Yoshihiro Urade, Zhi‐Li Huang, Sangoh Kwon, Suengmok Cho Tags: Research Article Source Type: research
Insomnia: Pharmacologic Therapy.
Abstract
Insomnia accounts for more than 5.5 million visits to family physicians each year. Although behavioral interventions are the mainstay of treatment, pharmacologic therapy may be necessary for some patients. Understanding the risks and benefits of insomnia medications is critical. Controlled-release melatonin and doxepin are recommended as first-line agents in older adults; the so-called z-drugs (zolpidem, eszopiclone, and zaleplon) should be reserved for use if the first-line agents are ineffective. For the general population with difficulty falling asleep, controlled-release melatonin and the z-dr...
Source: American Family Physician - July 1, 2017 Category: Primary Care Authors: Matheson E, Hainer BL Tags: Am Fam Physician Source Type: research
Highly sensitive LC-MS/MS method to estimate doxepin and its metabolite nordoxepin in human plasma for a bioequivalence study
Publication date: Available online 16 June 2017 Source:Journal of Pharmaceutical Analysis Author(s): Nirav P. Patel, Mallika Sanyal, Naveen Sharma, Dinesh S. Patel, Pranav S. Shrivastav, Bhavin N. Patel A selective, sensitive and rugged liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay has been developed for the simultaneous determination of doxepin (Dox) and its pharmacologically active metabolite, nordoxepin (NDox) in human plasma. The analytes and their internal standards (IS) were extracted from 500µL of human plasma by liquid-liquid extraction using methyl tert-butyl ether. Chromatographic separ...
Source: Journal of Pharmaceutical Analysis - June 17, 2017 Category: Drugs & Pharmacology Source Type: research
Doxepin inhibits GPVI-dependent platelet Ca2+ signaling and collagen-dependent thrombus formation
In conclusion, doxepin is a powerful inhibitor of GPVI-dependent platelet Ca2+ signaling, platelet activation, and thrombus formation. (Source: AJP: Cell Physiology)
Source: AJP: Cell Physiology - June 7, 2017 Category: Cytology Authors: Geue, S., Walker-Allgaier, B., Eissler, D., Tegtmeyer, R., Schaub, M., Lang, F., Gawaz, M., Borst, O., Münzer, P. Tags: RESEARCH ARTICLE Source Type: research
Can human allergy drug fexofenadine, an antagonist of histamine (H1) receptor, be used to treat dog and cat? Homology modeling, docking and molecular dynamic Simulation of three H1 receptors in complex with fexofenadine
Publication date: Available online 17 May 2017 Source:Journal of Molecular Graphics and Modelling Author(s): Safaa Sader, Jun Cai, Anna C.G. Muller, Chun Wu Fexofenadine, a potent antagonist to human histamine 1 (H1) receptor, is a non-sedative third generation antihistamine that is widely used to treat various human allergic conditions such as allergic rhinitis, conjunctivitis and atopic dermatitis. Encouragingly, it’s been successfully used to treat canine atopic dermatitis, this supports the notion that it might have a great potential for treating other canine allergic conditions and other mammal pets such as do...
Source: Journal of Molecular Graphics and Modelling - May 18, 2017 Category: Molecular Biology Source Type: research
Baseline Sleep Efficiency and Arousal Index Do Not Predict Who Will Benefit From Sedatives in Improving Positive Airway Pressure Adherence in Sleep Apnea to 90.
Abstract
Positive airway pressure (PAP) is the preferred treatment for obstructive sleep apnea (OSA), but adherence is low. Educational or ongoing supportive intervention improves the number of PAP adherent patients from the 50% to the 70% range. A common side effect of PAP is increased awakenings. This prospective trial examined baseline polysomnographically derived sleep efficiency and arousal index in PAP adherent and nonadherent patients, and in patients needing sedating medicines to attain PAP adherence versus those who did not need such medicines. Patients with OSA were titrated on PAP during a polys...
Source: Clinical EEG and Neuroscience - May 1, 2017 Category: Neuroscience Authors: Sangal RB Tags: Clin EEG Neurosci Source Type: research
The Clinical Pharmacology of Non-sedating Antihistamines
Publication date: Available online 27 April 2017 Source:Pharmacology & Therapeutics Author(s): Kazuhiko Yanai, Takeo Yoshikawa, Ai Yanai, Tadaho Nakamura, Tomomitsu Iida, Rob Leurs, Manabu Tashiro We previously reported on brain H1 receptor occupancy measurements of antihistamines in human brain using [11C]doxepin and positron emission tomography (PET). We proposed the use of brain H1 receptor occupancy to classify antihistamines objectively into three categories of sedating, less-sedating, and non-sedating antihistamines according to their sedative effects. Non-sedating antihistamines are recommended for ...
Source: Pharmacology and Therapeutics - April 28, 2017 Category: Drugs & Pharmacology Source Type: research
Development of a buccal doxepin platform for pain in oral mucositis derived from head and neck cancer treatment.
This study describes the development of semisolid formulations containing doxepin (DOX) for pain relief in oral mucositis, frequently related to chemotherapy and/or radiotherapy treatments in patients with head and neck cancer. Chemical permeation enhancers were evaluated and selected according to the results obtained from rheological studies, drug release, permeation and retention through buccal mucosa. Finally, the selected formulation was compared in vivo, with a reference DOX mouthwash, whose clinical efficacy had been previously reported. The obtained findings showed that an orabase(®) platform loading transcutol(®)...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 21, 2017 Category: Drugs & Pharmacology Authors: Sanz R, Calpena AC, Mallandrich M, Gimeno Á, Halbaut L, Clares B Tags: Eur J Pharm Biopharm Source Type: research
Doxepin inhibits GPVI-dependent platelet Ca(2+) signaling and collagen-dependent thrombus formation.
In conclusion, doxepin is a powerful inhibitor of GPVI-dependent platelet Ca(2+) signaling, platelet activation and thrombus formation.
PMID: 28404545 [PubMed - as supplied by publisher] (Source: Am J Physiol Cell Ph...)
Source: Am J Physiol Cell Ph... - April 12, 2017 Category: Cytology Authors: Geue S, Walker-Allgaier B, Eißler D, Tegtmeyer R, Schaub M, Lang F, Gawaz M, Borst O, Münzer P Tags: Am J Physiol Cell Physiol Source Type: research
Topical Treatments for Localized Neuropathic Pain
AbstractPurpose of ReviewTopical therapeutic approaches in localized neuropathic pain (LNP) syndromes are increasingly used by both specialists and general practitioners, with a potentially promising effect on pain reduction. In this narrative review, we describe the available compounds for topical use in LNP syndromes and address their potential efficacy according to the literature.Recent FindingsLocal anaesthetics (e.g., lidocaine, bupivacaine and mepivacaine), as well as general anaesthetic agents (e.g., ketamine), muscle relaxants (e.g., baclofen), capsaicin, anti-inflammatory drugs (e.g., diclofenac), salicylates, ant...
Source: Current Pain and Headache Reports - March 6, 2017 Category: Neurology Source Type: research
Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline
Introduction:The purpose of this guideline is to establish clinical practice recommendations for the pharmacologic treatment of chronic insomnia in adults, when such treatment is clinically indicated. Unlike previous meta-analyses, which focused on broad classes of drugs, this guideline focuses on individual drugs commonly used to treat insomnia. It includes drugs that are FDA-approved for the treatment of insomnia, as well as several drugs commonly used to treat insomnia without an FDA indication for this condition. This guideline should be used in conjunction with other AASM guidelines on the evaluation and treatment of ...
Source: Journal of Clinical Sleep Medicine : JCSM - February 15, 2017 Category: Sleep Medicine Source Type: research
Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans.
Abstract
A frequent empirical observation is that cold-induced counter-irritation may attenuate itch. The aim of this randomized, single-blinded, exploratory study was to evaluate the counter-irritation effects of cold-stimulation and topical application of transient receptor potential TRPA1/M8-agonists (trans-cinnamaldehyde/L-menthol, respectively), on histamine-induced itch, wheals and neurogenic inflammation in 13 healthy volunteers. Histamine 1% was applied to the volar forearms using skin prick-test lancets. Recorded outcome-parameters were itch intensity, wheal reactions, and neurogenic inflammation ...
Source: Acta Derm Venereol A... - January 3, 2017 Category: Dermatology Authors: Andersen HH, Melholt C, Hilborg SD, Jerwiarz A, Randers A, Simoni A, Elberling J, Arendt-Nielsen L Tags: Acta Derm Venereol Source Type: research
An update of management of insomnia in patients with chronic orofacial pain
This article is protected by copyright. All rights reserved. (Source: Oral Diseases)
Source: Oral Diseases - December 31, 2016 Category: ENT & OMF Authors: Galit Almoznino, Yaron Haviv, Yair Sharav, Rafael Benoliel Tags: Review Article Source Type: research
Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC ®) for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants: 2016 Update.
This article is protected by copyright. All rights reserved.
PMID: 27997040 [PubMed - as supplied by publisher] (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - December 19, 2016 Category: Drugs & Pharmacology Authors: Kevin Hicks J, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC Tags: Clin Pharmacol Ther Source Type: research
A Phase III, Randomized Double-Blind Study of Doxepin Rinse versus Magic Mouthwash versus Placebo in the Treatment of Acute Oral Mucositis Pain in Patients Receiving Head and Neck Radiotherapy with or without Chemotherapy (Alliance A221304)
Oral mucositis (OM) is a major cause of morbidity during radiotherapy (RT) of the head and neck (H&N). “Magic Mouthwash,” a term encompassing a variety of lidocaine-based rinses, is widely used for OM but no large randomized controlled trials (RCT's) have shown it to be beneficial. In 2012, Doxepin oral rinse (DOX) was shown to reduce OM pain, compared to placebo, in a large RCT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 16, 2016 Category: Radiology Authors: R.C. Miller, J. Le-Rademacher, T.T.W. Sio, J.L. Leenstra, G.P. Rine, A. Curtis, A.K. Singh, J.A. Martenson, R.J. Novotny, A.D. Tan, P. Reiter, C.L. Loprinzi Source Type: research
