Detectives and helpers: Natural products as resources for chemical probes and compound libraries
Publication date: Available online 25 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Anutthaman Parthasarathy, Pavan K. Mantravadi, Karunakaran Kalesh (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 26, 2020 Category: Drugs & Pharmacology Source Type: research

Target identification and validation of natural products with label-free methodology: A critical review from 2005 to 2020
Publication date: Available online 25 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Lingyun Dai, Zhijie Li, Dan Chen, Lin Jia, Jinan Guo, Tianyun Zhao, Pär Nordlund (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 26, 2020 Category: Drugs & Pharmacology Source Type: research

Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms
Publication date: Available online 25 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Mu-Yang Huang, Xiao-Ming Jiang, Bing-Lin Wang, Yang Sun, Jin-Jian Lu (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 26, 2020 Category: Drugs & Pharmacology Source Type: research

Evidence-based strategies for the characterisation of human drug and chemical glucuronidation in vitro and UDP-glucuronosyltransferase reaction phenotyping
Publication date: Available online 25 September 2020Source: Pharmacology & TherapeuticsAuthor(s): John O. Miners, Andrew Rowland, Jonathan J. Novak, Kimberly Lapham, Theunis C. Goosen (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 26, 2020 Category: Drugs & Pharmacology Source Type: research

Nicotine’ actions on energy balance: Friend or foe?
Publication date: Available online 26 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Patricia Seoane-Collazo, Carlos Diéguez, Rubén Nogueiras, Kamal Rahmouni, José Manuel Fernández-Real, Miguel López (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 26, 2020 Category: Drugs & Pharmacology Source Type: research

Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression
Publication date: Available online 24 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Kristen Fousek, Lucas A. Horn, Claudia Palena (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 26, 2020 Category: Drugs & Pharmacology Source Type: research

Therapeutic potential of sulfur-containing natural products in inflammatory diseases
Publication date: Available online 20 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Xu Cao, Lei Cao, Wencan Zhang, Rongzhu Lu, Jin-Song Bian, Xiaowei Nie (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 22, 2020 Category: Drugs & Pharmacology Source Type: research

The strategies and techniques of drug discovery from natural products
Publication date: Available online 19 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Li Zhang, Junke Song, Linglei Kong, Tianyi Yuan, Wan Li, Wen Zhang, Biyu Hou, Yang Lu, Guanhua Du (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 20, 2020 Category: Drugs & Pharmacology Source Type: research

Tubulin modifying enzymes as target for the treatment of tau-related diseases
Publication date: Available online 19 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Krzysztof Rogowski, Khaled Hached, Carole Crozet, Siem Van Der Laan (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 20, 2020 Category: Drugs & Pharmacology Source Type: research

Extracellular vesicles in hepatology: Physiological role, involvement in pathogenesis, and therapeutic opportunities
Publication date: Available online 19 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Maria Azparren-Angulo, Felix Royo, Esperanza Gonzalez, Marc Liebana, Bruno Brotons, Jesús Berganza, Felipe Goñi-de-Cerio, Nicoló Manicardi, Laia Abad-Jordà, Jordi Gracia-Sancho, Juan M. Falcon-Perez (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 20, 2020 Category: Drugs & Pharmacology Source Type: research

Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines
Publication date: Available online 18 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Ying Han, Hui Sun, Aihua Zhang, Guangli Yan, Xi-jun Wang (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 20, 2020 Category: Drugs & Pharmacology Source Type: research

The role of the brain renin-angiotensin system (RAS) in mild traumatic brain injury (TBI)
Publication date: Available online 18 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Jason D. Vadhan, Robert C. Speth (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 20, 2020 Category: Drugs & Pharmacology Source Type: research

Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases
Publication date: Available online 19 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Michael J. Davies (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 20, 2020 Category: Drugs & Pharmacology Source Type: research

RANKL as a key figure in bridging between the bone and immune system: Its physiological functions and potential as a pharmacological target
Publication date: Available online 19 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Masashi Honma, Yuki Ikebuchi, Hiroshi Suzuki (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 20, 2020 Category: Drugs & Pharmacology Source Type: research

A novel rationale for targeting FXI: Insights from the hemostatic microRNA targetome for emerging anticoagulant strategies
Publication date: Available online 6 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Jamie Nourse, Sven Danckwardt (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 19, 2020 Category: Drugs & Pharmacology Source Type: research

A natural product solution to aging and aging-associated diseases
Publication date: Available online 11 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Chuanbin Yang, Wei Zhang, Xiaoduo Dong, Chunjin Fu, Jimin Yuan, Menglong Xu, Zhen Liang, Chen Qiu, Chengchao Xu (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 13, 2020 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: October 2020Source: Pharmacology & Therapeutics, Volume 214Author(s): (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 12, 2020 Category: Drugs & Pharmacology Source Type: research

Chloroquine and Hydroxychloroquine in the Treatment of Malaria and Repurposing in Treating COVID-19
Publication date: Available online 8 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Zi-Ning Lei, Zhuo-Xun Wu, Shaowei Dong, Dong-Hua Yang, Litu Zhang, Zunfu Ke, Chang Zou, Zhe-Sheng Chen (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 8, 2020 Category: Drugs & Pharmacology Source Type: research

Efficacy and mechanism of actions of natural antimicrobial drugs
Publication date: Available online 8 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Ling Ye, Jiaxing Zhang, Wei Xiao, Shuwen Liu (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 8, 2020 Category: Drugs & Pharmacology Source Type: research

Insights into glucocorticoid responses derived from omics studies
Publication date: Available online 8 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Mengyuan Kan, Blanca E. Himes (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 8, 2020 Category: Drugs & Pharmacology Source Type: research

The roles of non-coding RNAs in vascular calcification and opportunities as therapeutic targets
Publication date: Available online 8 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Juhee Ryu, Youngkeun Ahn, Hyun Kook, Young-Kook Kim (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 8, 2020 Category: Drugs & Pharmacology Source Type: research

A novel rationale for targeting FXI: Insights from the hemostatic miRNA targetome for emerging anticoagulant strategies
Publication date: Available online 6 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Jamie Nourse, Sven Danckwardt (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 8, 2020 Category: Drugs & Pharmacology Source Type: research

The root cause of drug resistance in HER2-positive breast cancer and the therapeutic approaches to overcoming the resistance
Publication date: Available online 6 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Yuesheng Zhang (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 8, 2020 Category: Drugs & Pharmacology Source Type: research

Carcinogenesis: Failure of resolution of inflammation?
Publication date: Available online 3 September 2020Source: Pharmacology & TherapeuticsAuthor(s): Anna Fishbein, Bruce D. Hammock, Charles N. Serhan, Dipak Panigrahy (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - September 5, 2020 Category: Drugs & Pharmacology Source Type: research

Pharmacological treatment of eating disorders, comorbid mental health problems, malnutrition and physical health consequences
Publication date: Available online 25 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Hubertus Himmerich, Carol Kan, Katie Au, Janet Treasure (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 26, 2020 Category: Drugs & Pharmacology Source Type: research

Tumor organoid models in precision medicine and investigating cancer-stromal interactions
Publication date: Available online 24 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Ren Xu, Xiaotao Zhou, Shike Wang, Christine Trinkle (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 26, 2020 Category: Drugs & Pharmacology Source Type: research

The opioid-P2Y12 inhibitor interaction: Potential strategies to mitigate the interaction and consideration of alternative analgesic agents in myocardial infarction
Publication date: Available online 21 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Himawan Fernando, James A. Shaw, Paul S. Myles, Karlheinz Peter, Dion Stub (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 23, 2020 Category: Drugs & Pharmacology Source Type: research

TGFβ-Directed Therapeutics: 2020
Publication date: Available online 21 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Beverly A. Teicher (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 23, 2020 Category: Drugs & Pharmacology Source Type: research

An update on human T-cell leukemia virus type I (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) focusing on clinical and laboratory biomarkers
Publication date: Available online 21 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Junji Yamauchi, Natsumi Araya, Naoko Yagishita, Tomoo Sato, Yoshihisa Yamano (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 23, 2020 Category: Drugs & Pharmacology Source Type: research

NRF2 in human neoplasm: Cancer biology and potential therapeutic target
Publication date: Available online 15 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Yang Liu, Fengchao Lang, Chunzhang Yang (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 16, 2020 Category: Drugs & Pharmacology Source Type: research

Updates on community acquired pneumonia management in the ICU
Publication date: Available online 15 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Girish B. Nair, Michael S. Niederman (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 16, 2020 Category: Drugs & Pharmacology Source Type: research

Good cops turn bad: The contribution of neutrophils to immune-checkpoint inhibitor treatment failures in cancer
Publication date: Available online 15 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Huajia Zhang, A. McGarry Houghton (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 16, 2020 Category: Drugs & Pharmacology Source Type: research

Molecular mechanisms and therapeutic implications of tetrandrine and cepharanthine in T cell acute lymphoblastic leukemia and autoimmune diseases
Publication date: Available online 12 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 13, 2020 Category: Drugs & Pharmacology Source Type: research

G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects
Publication date: Available online 7 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Claudia Riccardi, Ettore Napolitano, Chiara Platella, Domenica Musumeci, Daniela Montesarchio (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 13, 2020 Category: Drugs & Pharmacology Source Type: research

The birth of artemisinin
Publication date: Available online 8 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Nan Ma, Ziyue Zhang, Fulong Liao, Tingliang Jiang, Youyou Tu (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 13, 2020 Category: Drugs & Pharmacology Source Type: research

Traditional application and modern pharmacological research of Artemisia annua L.
Publication date: Available online 3 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Xinchi Feng, Shijie Cao, Feng Qiu, Boli Zhang (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 4, 2020 Category: Drugs & Pharmacology Source Type: research

Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination
Publication date: Available online 3 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Jinghui Zhang, Haoxun Wang, Yunzhou Fan, Zhou Yu, Guofeng You (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 4, 2020 Category: Drugs & Pharmacology Source Type: research

TSLP as druggable target – a silver-lining for atopic diseases?
Publication date: Available online 3 August 2020Source: Pharmacology & TherapeuticsAuthor(s): Partho Protim Adhikary, Zheng Tan, Brent D.G. Page, Sarah Hedtrich (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - August 4, 2020 Category: Drugs & Pharmacology Source Type: research

Phytocannabinoid drug-drug interactions and their clinical implications
Publication date: November 2020Source: Pharmacology & Therapeutics, Volume 215Author(s): Daniela Amaral Silva, David W. Pate, Robert D. Clark, Neal M. Davies, Ayman O.S. El-Kadi, Raimar Löbenberg (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - July 21, 2020 Category: Drugs & Pharmacology Source Type: research

Transcription factor GLIS3: Critical roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes
Publication date: Available online 18 July 2020Source: Pharmacology & TherapeuticsAuthor(s): David W. Scoville, Hong Soon Kang, Anton M. Jetten (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - July 19, 2020 Category: Drugs & Pharmacology Source Type: research

Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy
Publication date: Available online 18 July 2020Source: Pharmacology & TherapeuticsAuthor(s): Miaomiao Ye, Yizuo Song, Shuya Pan, Man Chu, Zhi-Wei Wang, Xueqiong Zhu (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - July 19, 2020 Category: Drugs & Pharmacology Source Type: research

Targeting BET bromodomain proteins in cancer: The example of lymphomas
Publication date: Available online 18 July 2020Source: Pharmacology & TherapeuticsAuthor(s): Filippo Spriano, Anastasios Stathis, Francesco Bertoni (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - July 19, 2020 Category: Drugs & Pharmacology Source Type: research

How precise is quantitative prediction of pharmacokinetic effects due to drug-drug interactions and genotype from in vitro data? A comprehensive analysis on the example CYP2D6 and CYP2C19 substrates
Publication date: Available online 17 July 2020Source: Pharmacology & TherapeuticsAuthor(s): Christof Dücker, Jürgen Brockmöller (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - July 18, 2020 Category: Drugs & Pharmacology Source Type: research

Glycoprotein VI - Novel target in antiplatelet medication
Publication date: Available online 16 July 2020Source: Pharmacology & TherapeuticsAuthor(s): Oliver Borst, Meinrad Gawaz (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - July 17, 2020 Category: Drugs & Pharmacology Source Type: research

Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment
Publication date: Available online 11 July 2020Source: Pharmacology & TherapeuticsAuthor(s): Françoise Stanke-Labesque, Elodie Gautier-Veyret, Stephanie Chhun, Romain Guilhaumou, on behalf of the French Society of Pharmacology and Therapeutics (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - July 11, 2020 Category: Drugs & Pharmacology Source Type: research

Novel therapeutics for portal hypertension and fibrosis in chronic liver disease
Publication date: Available online 11 July 2020Source: Pharmacology & TherapeuticsAuthor(s): Sergi Guixé-Muntet, Chang-Peng Zhu, Wei-Fen Xie, Jordi Gracia-Sancho (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - July 11, 2020 Category: Drugs & Pharmacology Source Type: research

Statins in the treatment of depression: Hype or hope?
Publication date: Available online 8 July 2020Source: Pharmacology & TherapeuticsAuthor(s): Ole Köhler-Forsberg, Christian Otte, Stefan M. Gold, Søren Dinesen Østergaard (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - July 9, 2020 Category: Drugs & Pharmacology Source Type: research

Good or bad: Application of RAAS inhibitors in COVID-19 patients with cardiovascular comorbidities
Publication date: Available online 9 July 2020Source: Pharmacology & TherapeuticsAuthor(s): James Jiqi Wang, Matthew L. Edin, Darryl C. Zeldin, Chenze Li, Dao Wen Wang, Chen Chen (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - July 9, 2020 Category: Drugs & Pharmacology Source Type: research

Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors
Publication date: Available online 7 July 2020Source: Pharmacology & TherapeuticsAuthor(s): Rui Kamada, Fuki Kudoh, Shogo Ito, Itsumi Tani, Jose Isagani B. Janairo, James G. Omichinski, Kazuyasu Sakaguchi (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - July 9, 2020 Category: Drugs & Pharmacology Source Type: research

Cyclooxygenases and the cardiovascular system
Publication date: Available online 5 July 2020Source: Pharmacology & TherapeuticsAuthor(s): Jane A. Mitchell, Nicholas S. Kirkby, Blerina Ahmetaj-Shala, Paul Armstrong, Marilena Crescente, Plinio Ferreira, Maria Elisa Lopes Pires, Ricky K. Vaja, Timothy D. Warner (Source: Pharmacology and Therapeutics)
Source: Pharmacology and Therapeutics - July 6, 2020 Category: Drugs & Pharmacology Source Type: research