RWD83 Real-World Treatment Patterns in Chronic Spontaneous Urticaria in the United States
The objective of the study was to assess real-world treatment patterns in adult patients with CSU. (Source: Value in Health)
Source: Value in Health - December 1, 2022 Category: International Medicine & Public Health Authors: MM Balp, Y Geissb ühler, A Mcconnon, J Gomme, SJ Mckenna, R Kohli, W Soong Source Type: research

Clinical efficacy and safety of low-dose doxepin in Chinese patients with generalized anxiety disorder: A before–after study
This study is a before-after study and aims to investigate the effectiveness and side effects of low-dose doxepin by evaluating Hamilton Anxiety Scale (HAMA) scores, hormones, blood glucose, serum lipids, body weight, and body mass index (BMI) in patients with GAD. Forty-nine patients (20 males and 29 females) with GAD were randomly assigned to receive low-dose doxepin (6.25 mg–12.5 mg per day) for 12 weeks between February 2015 and March 2016. HAMA scores, fasting blood glucose (FBG) body weight, BMI, and some serum biochemical indexes, such as adrenocorticotropic hormone (ACTH), free triiodothyronine (FT3), total cho...
Source: Medicine - October 21, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Reply to the Editor — Give to Caesar What Belongs to Caesar
Belhassen and Tovia-Brodie commented on our study on malignant Purkinje ectopy after ajmaline or flecainide infusion in a cohort of patients with different ventricular arrhythmias. By making reference to Julius Caesar (The Gospels), they mention the omission of a case report by Tsuchiya et  al showing polymorphic and monomorphic ventricular tachycardia induced by pilsicainide, another sodium blocker. Noteworthy, individual cases using doxepin (inhibitor of HERG channel), lidocaine (sodium blocker), atropine, isoproterenol, or electrolytic disturbance (hypokalemia) have also been repo rted earlier,1–3 and here we mention...
Source: Heart Rhythm - August 20, 2022 Category: Cardiology Authors: Michel Haissaguerre, W. Escande, J.B. Gourraud, O. Bernus, F. Sacher Tags: LETTERS TO THE EDITOR Source Type: research

Author ’s reply to ‘Give to Caesar what belongs to Caesar’
Pr B Belhassen and O Tovia-Brodie commented on our study on malignant Purkinje ectopy following ajmaline or flecainide infusion in a cohort of patients with different ventricular arrhythmias. By making reference to Julius Caesar (The Gospels), they mention the omission of a case report by Tsuchiya et al showing a polymorphic and monomorphic ventricular tachycardia induced by pilsicainide, another sodium-blocker. Noteworthy, individual cases using doxepin (inhibitor of HERG-channel), lidocaine (sodium-blocker), atropine, isoproterenol, or electrolytic disturbance (hypokaliemia) have also been reported even earlier (1-3), an...
Source: Heart Rhythm - August 20, 2022 Category: Cardiology Authors: M. Haissaguerre, W. Escande, J.B. Gourraud, O. Bernus, F. Sacher Source Type: research

Host –guest complexation between cucurbit[7]uril and doxepin induced supramolecular assembly
Org. Biomol. Chem., 2022, Advance Article DOI: 10.1039/D2OB01065H, PaperKhaleel I. Assaf Cucurbit[7]uril forms a stable host –guest complex with doxepin, an antidepressant. The complexation of doxepin leads to the formation of a large assembly in aqueous solution. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - July 14, 2022 Category: Molecular Biology Authors: Khaleel I. Assaf Source Type: research

Host-Guest Complexation between Cucurbit[7]uril and Doxepin Induced Supramolecular Assembly
Org. Biomol. Chem., 2022, Accepted Manuscript DOI: 10.1039/D2OB01065H, PaperKhaleel I. Assaf The supramolecular complexation of doxepin (DOX) by cucurbit[7]uril (CB7) was investigated in aqueous solution. Results indicated the formation of host-guest complex as verified by complexation-induced chemical shifts in the NMR... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - July 6, 2022 Category: Molecular Biology Authors: Khaleel I. Assaf Source Type: research

The Protective Effects and Mechanism of Doxepin on Radiation-Induced Lung Injury in Rats
Dose Response. 2022 Jun 7;20(2):15593258221107193. doi: 10.1177/15593258221107193. eCollection 2022 Apr-Jun.ABSTRACTRadiation-induced lung injuries (RILI) is one of the serious complications of radiotherapy posed by the damage of alveolar cells and inflammation over-reaction. We aimed to investigate the potential protective effects of doxepin on RILI (20 Gy total dose at 3 Gy/min of X-ray irradiation), as well as its underlying mechanism. For animal experiments, such parameters as Immunohistochemistry and hematoxylin and eosin (H&E) staining, WBC (white blood cell), CRP (C-reactive protein), Western blot, and q-PCR wer...
Source: Dose Response - June 13, 2022 Category: Drugs & Pharmacology Authors: Xinlong Wan Xuan Shi Mengke Li Qing Chen Chang Xue Guanghui Li Yeke Huang Jingwen Yang Chan Chen Zhiyi Wang Shumei Ma Xiaodong Liu Source Type: research

The Protective Effects and Mechanism of Doxepin on Radiation-Induced Lung Injury in Rats
Dose Response. 2022 Jun 7;20(2):15593258221107193. doi: 10.1177/15593258221107193. eCollection 2022 Apr-Jun.ABSTRACTRadiation-induced lung injuries (RILI) is one of the serious complications of radiotherapy posed by the damage of alveolar cells and inflammation over-reaction. We aimed to investigate the potential protective effects of doxepin on RILI (20 Gy total dose at 3 Gy/min of X-ray irradiation), as well as its underlying mechanism. For animal experiments, such parameters as Immunohistochemistry and hematoxylin and eosin (H&E) staining, WBC (white blood cell), CRP (C-reactive protein), Western blot, and q-PCR wer...
Source: Dose Response - June 13, 2022 Category: Drugs & Pharmacology Authors: Xinlong Wan Xuan Shi Mengke Li Qing Chen Chang Xue Guanghui Li Yeke Huang Jingwen Yang Chan Chen Zhiyi Wang Shumei Ma Xiaodong Liu Source Type: research

The Protective Effects and Mechanism of Doxepin on Radiation-Induced Lung Injury in Rats
Dose Response. 2022 Jun 7;20(2):15593258221107193. doi: 10.1177/15593258221107193. eCollection 2022 Apr-Jun.ABSTRACTRadiation-induced lung injuries (RILI) is one of the serious complications of radiotherapy posed by the damage of alveolar cells and inflammation over-reaction. We aimed to investigate the potential protective effects of doxepin on RILI (20 Gy total dose at 3 Gy/min of X-ray irradiation), as well as its underlying mechanism. For animal experiments, such parameters as Immunohistochemistry and hematoxylin and eosin (H&E) staining, WBC (white blood cell), CRP (C-reactive protein), Western blot, and q-PCR wer...
Source: Dose Response - June 13, 2022 Category: Drugs & Pharmacology Authors: Xinlong Wan Xuan Shi Mengke Li Qing Chen Chang Xue Guanghui Li Yeke Huang Jingwen Yang Chan Chen Zhiyi Wang Shumei Ma Xiaodong Liu Source Type: research

In-vitro antiviral activity of doxepin hydrochloride against group B coxsackievirus
In this study, we used a cytopathic effect-based viral inhibition assay to screen an FDA-approved drug library and found that doxepin hydrochloride had potential antiviral activity. Doxepin hydrochloride exhibited strong antiviral activity against coxsackievirus B types 1-3 with a 50% inhibitory concentration of 10.12 ± 0.85 μM. Moreover, doxepin hydrochloride did not exert antiviral activity against other enteroviruses, including enterovirus A71 (subtypes BrCr/C4) and coxsackievirus A (subtypes 6/10/16). Furthermore, doxepin hydrochloride inhibited virus replication in the early stage of the infection cycle rather than ...
Source: Virus Research - May 22, 2022 Category: Virology Authors: Yongqi Yang Ge Liu Jiaoyan Jia Jianfeng Zhong Ran Yan Xiangyi Lin Kai Zheng Qinchang Zhu Source Type: research

In-vitro antiviral activity of doxepin hydrochloride against group B coxsackievirus
In this study, we used a cytopathic effect-based viral inhibition assay to screen an FDA-approved drug library and found that doxepin hydrochloride had potential antiviral activity. Doxepin hydrochloride exhibited strong antiviral activity against coxsackievirus B types 1-3 with a 50% inhibitory concentration of 10.12 ± 0.85 μM. Moreover, doxepin hydrochloride did not exert antiviral activity against other enteroviruses, including enterovirus A71 (subtypes BrCr/C4) and coxsackievirus A (subtypes 6/10/16). Furthermore, doxepin hydrochloride inhibited virus replication in the early stage of the infection cycle rather than ...
Source: Virus Research - May 22, 2022 Category: Virology Authors: Yongqi Yang Ge Liu Jiaoyan Jia Jianfeng Zhong Ran Yan Xiangyi Lin Kai Zheng Qinchang Zhu Source Type: research

Hypnotic and Melatonin/Melatonin-Receptor Agonist Treatment in Bipolar Disorder: A Systematic Review and Meta-Analysis
ConclusionsThere is a paucity of studies examining pharmacological interventions for sleep and circadian rhythm disturbance in BD. Few studies assessed sleep-related symptoms, and none quantitatively examined endogenous melatonin patterns or other circadian rhythms. Melatonin may be a promising candidate for the adjunctive treatment of bipolar mania. However, dose-finding studies and studies with larger sample sizes are needed to confirm its efficacy. We recommend parallel monitoring of sleep and circadian rhythms in future trials. Chronobiology-informed trial designs are needed to improve the quality of future studies.Pro...
Source: CNS Drugs - March 19, 2022 Category: Neurology Source Type: research

A prospective study examining the effect of selected topical and systemic drugs on pruritus grading system score and stat 6 expression in patients of prurigo nodularis
Conclusion: A combination of selected oral and topical agents can effectively control the severity of PN within one month, and this was found to correlate with STAT 6 expression. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - January 28, 2022 Category: Dermatology Authors: Diksha Agrawal Kabir Sardana Sinu R Mathachan Minakshi Bhardwaj Arvind Ahuja Swasti Jain Source Type: research

Pharmacological management of psychoactive substance withdrawal syndrome
ConclusionsSubstitution therapy seems to be the foremost choice for the treatment of psychoactive substance withdrawal. However, other medications are available but poorly utilized. Practitioners can use the armory of other available medications to manage psychoactive substance withdrawal. Patients can broaden their medication choice. Voltage-gated ion channels are a promising niche to explore. (Source: Drugs and Therapy Perspectives)
Source: Drugs and Therapy Perspectives - October 19, 2021 Category: Drugs & Pharmacology Source Type: research

Changes in histaminergic system in neuropsychiatric disorders and the potential treatment consequences
Curr Neuropharmacol. 2021 Sep 9. doi: 10.2174/1570159X19666210909144930. Online ahead of print.ABSTRACTIn contrast to that of other monoamine neurotransmitters, the association of the histaminergic system with neuropsychiatric disorders is not well documented. In the last two decades, several clinical studies involved in the development of drugs targeting the histaminergic system have been reported. These include the H3R-antagonist/inverse agonist, pitolisant, used for the treatment of excessive sleepiness in narcolepsy, and the H1R antagonist, doxepin, used to alleviate symptoms of insomnia. The current review summarizes ...
Source: Current Neuropharmacology - September 15, 2021 Category: Drugs & Pharmacology Authors: Ling Shan Dick F Swaab Source Type: research