Doxepin Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Perinatal Depression: A Guide to Detection and Management in Primary Care
Conclusions: These clinically relevant data can support the delivery of high-quality care by PCCs. Risks and benefits of PD treatments and the consequences of untreated PD should be discussed with patients to support informed decision making. (Source: Journal of the American Board of Family Medicine)
Source: Journal of the American Board of Family Medicine - January 5, 2024 Category: Primary Care Authors: Dama, M. H., Van Lieshout, R. J. Tags: Clinical Review Source Type: research

Improved Pharmacokinetic and Pharmacodynamic Profile of Deuterium-Reinforced Tricyclic Antidepressants Doxepin, Dosulepin, and Clomipramine in Animal Models
ConclusionsDeuterated TCAs can prove to be potentially better molecules in the treatment of neuropsychiatric disorders as compared with nondeuterated compounds. In addition, we have demonstrated a concept that metabolically active, site-selective deuteration can be beneficial for improving the pharmacokinetic and pharmacodynamic profiles of TCAs. A further toxicological study of these compounds is needed to validate their future clinical use. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - January 3, 2024 Category: Drugs & Pharmacology Source Type: research

Doxepin is more effective than zolpidem in improving executive function in patients with insomnia disorder
CONCLUSIONS: Both doxepin and zolpidem were found to be effective in improving sleep quality, but the effects exhibited different patterns. Doxepin improved executive function more effectively than zolpidem in patients with insomnia disorder.PMID:38123719 | DOI:10.1007/s11325-023-02972-4 (Source: Sleep and Breathing)
Source: Sleep and Breathing - December 20, 2023 Category: Sleep Medicine Authors: Zhenghe Yu Li Han Pan Yan Wenjuan Liu Lishan Ren You Xu Lili Yang Lisha Ma Yi Liu Shengdong Wang Source Type: research

Doxepin is more effective than zolpidem in improving executive function in patients with insomnia disorder
ConclusionsBoth doxepin and zolpidem were found to be effective in improving sleep quality, but the effects exhibited different patterns. Doxepin improved executive function more effectively than zolpidem in patients with insomnia disorder. (Source: Sleep and Breathing)
Source: Sleep and Breathing - December 20, 2023 Category: Respiratory Medicine Source Type: research

Unlocking the secrets of doxepin hydrochloride's crystal structure: insights from high-quality powder diffraction analysis
Ann Pharm Fr. 2023 Oct 24:S0003-4509(23)00132-3. doi: 10.1016/j.pharma.2023.10.007. Online ahead of print.ABSTRACTDoxepin hydrochloride, a versatile pharmaceutical compound, has been the subject of extensive research aimed at elucidating its crystal structure and solid-state characteristics. In this manuscript, we explore the significance of high-quality powder diffraction data in unveiling the intricate details of doxepin hydrochloride's crystal lattice. By examining the refined atom coordinates, density functional theory (DFT) optimization, and intermolecular interactions, we gain valuable insights into its structural co...
Source: Annales Pharmaceutiques Francaises - October 26, 2023 Category: Drugs & Pharmacology Authors: Renan Marcel Bonilha Dezena Paulo C ésar Pires Rosa Source Type: research

Utilizing a Microfluidic Platform to Investigate Drug-Eluting Beads: Binding and Release of Amphiphilic Antidepressants
Int J Pharm. 2023 Oct 21:123517. doi: 10.1016/j.ijpharm.2023.123517. Online ahead of print.ABSTRACTDrug-eluting beads made of responsive polyelectrolyte networks are used in the treatment of liver cancer. Aggregates of loaded drugs in complex with the networks dissolve upon release, causing swelling of the network. According to a recent mechanism the release and swelling rates are controlled by the mass transport of drug through a depletion layer created in the microgel. We hypothesise that the mechanism, in which the stability of the drug aggregates and the swelling properties of the network play crucial roles, offers mea...
Source: Cancer Control - October 23, 2023 Category: Cancer & Oncology Authors: Marcus Wanselius Yassir Al-Tikriti Per Hansson Source Type: research

Untargeted Metabolomic Analyses of Body Fluids to Differentiate TBI DOC and NTBI DOC
CONCLUSION: CSF, serum and urine metabolomic analyses could differentiate TBI DOC from NTBI DOC and functional analyses showed a metabolic change difference between TBI DOC and NTBI DOC.PMID:37817528 | DOI:10.2174/0115665240249826230928104512 (Source: Current Molecular Medicine)
Source: Current Molecular Medicine - October 11, 2023 Category: Molecular Biology Authors: Xiaoping Xiao Long Xu Hezhen Lu Xiaoyan Liu Haidan Sun Zhengguang Guo Jiameng Sun Feng Qi Xia Niu Aiwei Wang Qianqian Ge Yutong Zhuang Xiaoli Geng Xueling Chen Ying Lan Jianghong He Wei Sun Source Type: research

Untargeted Metabolomic Analyses of Body Fluids to Differentiate TBI DOC and NTBI DOC
CONCLUSION: CSF, serum and urine metabolomic analyses could differentiate TBI DOC from NTBI DOC and functional analyses showed a metabolic change difference between TBI DOC and NTBI DOC.PMID:37817528 | DOI:10.2174/0115665240249826230928104512 (Source: Molecular Medicine)
Source: Molecular Medicine - October 11, 2023 Category: Molecular Biology Authors: Xiaoping Xiao Long Xu Hezhen Lu Xiaoyan Liu Haidan Sun Zhengguang Guo Jiameng Sun Feng Qi Xia Niu Aiwei Wang Qianqian Ge Yutong Zhuang Xiaoli Geng Xueling Chen Ying Lan Jianghong He Wei Sun Source Type: research