Suicidal thoughts and behaviour among South African adolescents living with HIV: can social support buffer the impact of stigma?
Adolescents living with HIV (ALHIV) are a high-risk population for suicidal ideation and attempts. Worldwide, suicide accounts for an estimated 6% of all deaths among young people, representing the second leading cause of mortality among females and the third among males aged 10 –24 years (McKinnon et al., 2016; Patton et al., 2009). Youth suicide is therefore a major global public health concern, especially in low and middle income countries (LMICs), which are home to around 90% of the world's youth and account for over 75% of global suicide deaths (McKinnon et al., 201 6; UNFPA, 2014). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 13, 2018 Category: Neurology Authors: Marisa Casale, Mark Boyes, Marija Pantelic, Elona Toska, Lucie Cluver Tags: Research paper Source Type: research

Post-stroke depression and cognitive impairment: study design and preliminary findings in a Brazilian prospective stroke cohort (EMMA study)
Stroke, as well as, dementia and depression are conditions associated with high burden of disability (Feigin et al., 2017). Particularly after a stroke, depressive, symptoms and cognitive impairment are very often conditions (Almeida et al., 2007; Mirza et al., 2016; Tatemichi et al., 1994), that either separately or concomitantly, might affect stroke survivors interfering in their short and even long-term recovery (Kauhanen et al., 1999; Parikh et al., 1987; Robinson et al., 1984). PSD occurs in around one-third of stroke patients. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 11, 2018 Category: Neurology Authors: Alessandra Baccaro, Yuan-Pang Wang, Miriam Candido, Adriana Bastos Conforto, Andr é Russowsky Brunoni, Claudia da Costa Leite, Geraldo Busatto Filho, Paulo A Lotufo, Isabela M Benseñor, Alessandra C Goulart Tags: Research report/Research paper Source Type: research

Stigma, grief and depressive symptoms in help-seeking people bereaved through suicide
The suicide of a significant other is considered to be a destructive experience causing great psychological pain in those left behind. Exposure to the suicide of a family member or friend can be a powerful, life-changing event for the person exposed. Each suicide directly affects at least six significant others, referred to as “Suicide Survivors” ( Shneidman et al., 1969). Overall, there are estimated to be 800,000 suicides per year throughout the world. Previous-year and lifetime prevalence of exposure to suicide is high - 4.31% and 21.83%, respectively (Andriessen et al., 2017). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 11, 2018 Category: Neurology Authors: P Scocco, A Preti, S Totaro, PW Corrigan, C Castriotta, The SOPROXI Team Source Type: research

Genetic and Environmental Effects on the Development of Depressive Symptoms from Adolescence to Adulthood in a Nationally Representative Sample
Depression is a mental disorder with substantial negative implications on the quality of life throughout the lifespan (Hannigan, McAdams,& Eley, 2017). The presence of depressive symptoms can be already discerned in childhood (Horowitz& Garber, 2006); however, the rate of depression sharply increases during adolescence, with a one-year prevalence of 4-5% among adolescents aged 13-18 (Thapar, Collishaw, Pine,& Thapar, 2012), matching that of adults. Depressive symptoms in adolescence place individuals at risk for developing depression in adulthood (Horowitz& Garber, 2006). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 11, 2018 Category: Neurology Authors: Albert J. Ksinan, Alexander T. Vazsonyi Tags: Research paper Source Type: research

Childhood Narcissism: A Call for Interventions
The past decades have seen a global shift toward greater individualism, with cultures increasingly valuing separateness and uniqueness over connectedness and similarity (Santos, Varnum& Grossmann, 2017). Such values may underlie narcissism, an everyday personality trait that exists throughout the population. Narcissistic children feel superior to others, believe they are entitled to privileges, and crave admiration (for an overview of its consequences, see Thomaes& Brummelman, 2016). When they receive the admiration they crave, they feel on top of the world; but when they do not, they feel like sinking into the gro...
Source: Journal of Affective Disorders - October 11, 2018 Category: Neurology Authors: Eddie Brummelman, Çisem Gürel Source Type: research

Editorial Board
(Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 10, 2018 Category: Neurology Source Type: research

Clinical characteristics of obstructive sleep apnea in bipolar disorders.
Worldwide, approximately 1% to 4% of people suffer from bipolar disorder (BD). BD is a severe mental disorder ranking as the fourth most important contributor to the global disease burden among psychiatric, neurological and substance-use disorders (Collins et al., 2011; Merikangas et al., 2007). Whereas BD has traditionally been defined by recurrences of manic and depressive episodes, it is now recognized that BD patients also present with persistent abnormalities between mood episodes (such as cognitive deficits, cardio-vascular diseases, altered sleep homeostasis and circadian dysregulation), leading to conceptualization...
Source: Journal of Affective Disorders - October 9, 2018 Category: Neurology Authors: Pierre A. Geoffroy, Jean-Arthur Micoulaud Franchi, Julia Maruani, Pierre Philip, Carole Boudebesse, Chlo é Benizri, Sunthavy Yeim, Victoire Benard, Helena Brochard, Marion Leboyer, Frank Bellivier, Bruno Etain Tags: Research paper Source Type: research

Childhood sexual abuse, poly-victimization and internalizing disorders across adulthood and older age: Findings from a 25-year longitudinal study
There is robust evidence that childhood maltreatment is associated with an increased risk of mental disorder in early and middle adulthood (Clark et al., 2010; Cougle et al., 2010; Fergusson et al., 2013; Kessler et al., 1997; Kessler et al., 2010b; Lee et al., 2010; Lindert et al., 2014; Scott et al., 2010). Furthermore, cross-sectional research indicates that associations between childhood maltreatment and mental disorder persist into late adulthood (Chou, 2012; Draper et al., 2008a; Easton et al., 2017; Ege et al., 2015; Kamiya et al., 2016; Raposo et al., 2014). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 9, 2018 Category: Neurology Authors: Charlene M. Rapsey, Kate M. Scott, Tess Patterson Tags: Research paper Source Type: research

Alterations in Patients with Major Depressive Disorder Before and After Electroconvulsive Therapy Measured by Fractional Amplitude of Low-Frequency Fluctuations (fALFF)
Major depressive disorder (MDD) is an increasingly common mental disease and is of great concern. To some extent, several common treatments such as cognitive behavioral therapy (Ritchey et al., 2011, Siegle et al., 2006) and antidepressant medication (Sheline et al., 2012) are effective for depressive patients. However, electroconvulsive therapy (ECT) is regarded as the most effective and rapid treatment for depression (Bouckaert et al., 2016, Husain et al., 2004, Kellner et al., 2016, Kellner et al., 2016), and it is a vital antidepressant treatment selection for most patients with MDD. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 9, 2018 Category: Neurology Authors: Haitang Qiu, Xinke Li, Qinghua Luo, Yongming Li, Xichuan Zhou, Hailin Cao, Yuanhong Zhong, Mingui Sun Tags: Research paper Source Type: research

Borderline Personality Disorder Traits and Suicide Risk: The Mediating Role of Insomnia and Nightmares
Borderline Personality Disorder (BPD) is characterized by affect dysregulation, self-disturbances, and behavioral and interpersonal dysregulation (American Psychiatric Association, 2013; Keng et al., 2018). The prevalence rates of BPD are estimated to be about 20% of all psychiatric inpatients, 10% of outpatients, and 2% of the general population (American Psychiatric Association, 2013; Frances and Widiger, 1986; Gunderson, 1984; Park and Park, 1997; Swartz et al., 1989). Individuals with BPD or subclinical BPD often report engaging in a wide variety of maladaptive behaviors, such as nonsuicidal self-injury (NSSI; Brown et...
Source: Journal of Affective Disorders - October 9, 2018 Category: Neurology Authors: Hilary L. DeShong, Raymond P. Tucker Tags: Research paper Source Type: research

Light up ADHD: II. Neuropharmacological effects measured by Near Infrared Spectroscopy: is there a biomarker?
Attention-deficit/hyperactivity disorder (ADHD) is one of the most frequently diagnosed neurodevelopmental disorders in childhood, and its worldwide prevalence among children and adolescents is about 5% (Faraone et al., 2015). ADHD's heterogeneous phenotypes are characterized by inattention, excessive motor activity, and high levels of impulsivity (American Psychiatric Association, 2013); these symptoms seem to arise from neurotransmission dysregulation or insufficient production of catecholamines within the prefrontal cortex (PFC) and subcortical regions (Arnsten, 2006; Del Campo et al., 2011). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 9, 2018 Category: Neurology Authors: Grazioli Silvia, Mauri Maddalena, Crippa Alessandro, Maggioni Eleonora, Molteni Massimo, Brambilla Paolo, Nobile Maria Source Type: research

Diverse Pathophysiological Processes Converge on Network Disruption in Mania
Bipolar disorders are common and severe but their pathophysiology is poorly understood and existing treatments are only partially effective and provoke significant side effects(Chen and Dilsaver, 1996; Kessler et al., 1999; Leverich et al., 2003; Perlis et al., 2006; Slama et al., 2004). Many previous studies have used functional magnetic resonance imaging (fMRI) in humans to understand bipolar pathophysiology at the network and circuit level. Fewer studies, however, have compared bipolar participants across different symptomatic states. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 9, 2018 Category: Neurology Authors: Ms Ivy Lee, Ms Ivy Lee Tags: Research paper Source Type: research

Adult Outcomes of Childhood Disruptive Disorders in Offspring of Depressed and Healthy Parents
Disruptive disorders (DD) in childhood are associated with poor mental health and social outcomes in later life (Erskine et al., 2016; Sayal et al., 2015). The most common DDs are attention deficit hyperactivity disorder (ADHD), conduct disorder (CD), and oppositional defiant disorder (ODD). Although unique diagnoses (American Psychiatric Association, 2013), they share traits such as irritability and distractibility (Krieger et al., 2013), have quite high comorbidity (Moffitt et al., 2015), and commonly predict adulthood outcomes such as depression (Meinzer et al., 2013; Stringaris et al., 2014) and substance use (Copeland...
Source: Journal of Affective Disorders - October 9, 2018 Category: Neurology Authors: Alexandre Paim Diaz, Connie Svob, Ruixin Zhao, Baxter DiFabrizio, Virginia Warner, Marc J. Gameroff, Jamie Skipper, Jay Gingrich, Jonathan Posner, Priya J. Wickramaratne, Myrna M. Weissman, Ardesheer Talati Tags: Research paper Source Type: research

Lithium monotherapy-induced tardive dyskinesia
Tardive dyskinesia is a movement disorder that develops during the course of long-term treatment with neuroleptic agents and is characterized primarily by choreiform, athetotic or rhythmic involuntary movements of mouth, face, trunk and limbs (Kane, 1995, Fountoulakis et al., 2006). Its onset is typically delayed, with symptoms first appearing only after years of treatment. It is reportedly affecting about 20-30% of patients treated with long-term neuroleptic medications, with 5% of them developing TD each year they remain on these drugs. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 9, 2018 Category: Neurology Authors: Konstantinos N. Fountoulakis, Thomas Tegos, Vasilios Kimiskidis Source Type: research

Oligopeptidases activity in bipolar disorder: ndel1 and angiotensin i converting enzyme
Abnormal activity of two enzymes relevant to neurodevelopment, namely nuclear-distribution element-like 1 (Ndel1) and angiotensin I-converting enzyme (ACE), was reported in individuals with schizophrenia; to our knowledge, these oligopeptidases were never measured in bipolar disorder (BD). Aims: Evaluate the enzyme activity of Ndel1 and ACE in euthymic individuals with BD type 1 which was compare to healthy control (HC) group. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 6, 2018 Category: Neurology Authors: Caroline Dal Mas, Michelle S. Carvalho, Lucas A. Marins, Camila M. Yonamine, Quirino Cordeiro, Roger S. McIntyre, Rodrigo B. Mansur, Elisa Brietzke, Mirian A.F. Hayashi Source Type: research

Imagery-based Treatment for Test Anxiety: A Multiple-baseline Open Trial
Test anxiety (TA), a condition which affects as many as 20% of students (see Hill& Wigfield, 1984; Holm-Hadulla et al., 2009), involves excessive negative thoughts about poor performance or failure in exams or other situations characterized by evaluation, as well as about the possible consequences of such performance. Students with high TA are more likely to be female, and have perfectionistic tendencies, which are maladaptive or unhelpful (Eum& Rice, 2011). TA is manifested in phenomenological, physiological, and behavioral responses (Zeidner, 1998; Zeidner& Matthews, 2011). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 6, 2018 Category: Neurology Authors: Jessica N. Prinz, Eran Bar-Kalifa, Eshkol Rafaeli, Haran Sened, Wolfgang Lutz Tags: Research paper Source Type: research

Effect of Self-Monitoring Through Experience Sampling on Emotion Differentiation in Depression
People can experience a vast range of emotions and oftentimes even feel multiple emotions at the same time. As some of these emotions can be quite similar, it can sometimes be difficult to discriminate between them. The ability to make nuanced distinctions and differentiate between emotions is called emotion differentiation (e.g. Barrett et al., 2001). Emotions can influence cognitive processes, which then help to regulate and shape behaviors (Baumeister et al., 2007). Barrett and colleagues (2001) showed that participants who were better in differentiating their negative emotions more often employed adaptive emotion regul...
Source: Journal of Affective Disorders - October 6, 2018 Category: Neurology Authors: Raf L.A. Widdershoven, Marieke Wichers, Peter Kuppens, Jessica A. Hartmann, Claudia Menne-Lothmann, Claudia J.P. Simons, Jojanneke A. Bastiaansen Source Type: research

Inflammation associated with volume reduction in the gray matter and hippocampus of older patients with bipolar disorder
Studies on bipolar disorder (BD) have suggested the involvement of immune system dysfunctions in the disease activity of BD (Goldsmith et al., 2016). Furthermore, progressive neuropathological processes (Berk et al., 2011) and various mood phases (Tsai et al., 1999; 2012; 2014) in BD may be linked to alterations in inflammatory cytokines. Microglia, the concentration of which is particularly high in the hippocampus, primarily mediate innate immunity and are involved in most inflammatory processes in the central nervous system (CNS) (Badoer, 2010; Perry et al., 1993). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 6, 2018 Category: Neurology Authors: Shang-Ying Tsai, Ariel G. Gildengers, Jung-Lung Hsu, Kuo-Hsuan Chung, Pao-Huan Chen, Yu-Jui Huang Tags: Research paper Source Type: research

The efficacy of adjunctive N-acetylcysteine in acute bipolar depression: a randomized placebo-controlled study
Bipolar depression is challenging to treat, partly due to few available treatments (Grunze et al., 2013). Therefore, search for new treatment options are warranted, and over the recent years, N-acetylcysteine (NAC) has been examined in bipolar disorder (BD) and other mental and neuropsychiatric disorders (Berk et al., 2013; Dean et al., 2011; Deepmala et al., 2016; Minarini et al., 2017). Additionally, NAC has been used in other areas of medicine for almost four decades (D. and Conner, 1978) and is currently used for treating paracetamol overdose (Dringen and Hirrlinger, 2003), chronic obstructive pulmonary disease (Atkuri...
Source: Journal of Affective Disorders - October 6, 2018 Category: Neurology Authors: Pernille Kempel Ellegaard, Rasmus Wentzer Licht, Ren é Ernst Nielsen, Olivia May Dean, Michael Berk, Henrik Enghusen Poulsen, Mohammadreza Mohebbi, Connie Thuroee Nielsen Tags: Research paper Source Type: research

Predictors of depressive symptoms in college students: A systematic review and meta-analysis of cohort studies
Depressive symptoms are extremely prevalent in college students nowadays which is typically characterized by sad, loss of interest, hopeless, nervous or anxious feelings and even suicidal ideation (Kessler et al., 2003; Ceyhan et al., 2009; Tomoda eta al., 2000; Wang et al., 2017). According to the results of different meta-analyses, the prevalence of depressive symptoms is higher among college students compared to the general population or non-college students (Ibrahim et al., 2013; Mikolajczyk et al., 2008; Blanco et al., 2008; Rotenstein et al., 2016; Lei et al., 2016; Ovuga et al., 2006). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 6, 2018 Category: Neurology Authors: Yan Liu, Ning Zhang, Guangyi Bao, Yubei Huang, Bingyuan Ji, Yili Wu, Chuanxin Liu, Gongying Li Tags: Research paper Source Type: research

Effects of childhood trauma on adult moral decision-making: clinical correlates and insights from bipolar disorder
Empirical investigations of moral psychology in the past 15 years have made substantial use of the theoretical framework known as the “dual process theory (DPT)”, proposed by Greene and colleagues (2004). DPT introduced a method to tease apart emotional and cognitive component processes in moral decision-making, known as the “moral dilemmas” paradigm. Moral dilemmas are short vignette-type scenarios which face the study pa rticipant with a difficult yes/no decision, in which both answers generally involve harm being caused to a person (or people). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 5, 2018 Category: Neurology Authors: Emmett M. Larsen, Luz H. Ospina, Armando Cuesta-Diaz, Antonio Vian-Lains, George C. Nitzburg, Sandra Mulaimovic, Asya Latifoglu, Rosarito Clari, Katherine E. Burdick Tags: Research paper Source Type: research

Cortical Thickness and Volume Reductions in Young Adults with Current Suicidal Ideation
Research in brain structural abnormalities of young adults with suicidal ideation may inform clinical interventions to prevent suicide. 36,000 individuals die from suicide annually (Nature, 2014),  it is the 2nd leading cause of death among individuals ages 15-24 (Centers for Disease Control and Prevention, 2013), and is associated with major depressive disorder (MDD) (Bridge et al., 2006). Risk of attempting suicide among depressed individuals may be related to cortical structural abnormal ities (Peng et al., 2016). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 5, 2018 Category: Neurology Authors: Anna Maria Segreti, Henry W Chase, Marcel Just, David Brent, Lisa Pan Tags: Research paper Source Type: research

Diagnostic consequences of a new category of anxious depression and a reduced duration requirement for anxiety symptoms in the ICD-11 PHC
The World Health Organization (WHO) Department of Mental Health and Substance Abuse is coordinating the development of the Mental, Behavioural, and Neurodevelopmental Disorders chapter of the Eleventh Revision of the International Classifications of Diseases and Related Health Problems (ICD-11), including a version of the mental disorders classification for use in primary care settings, the ICD-11 PHC (Goldberg, 2011; Goldberg, Prisciandaro and Williams, 2012). For the previous version of the classification, the ICD-10, WHO had also produced a classification of mental disorders intended for primary care settings, the ICD-1...
Source: Journal of Affective Disorders - October 5, 2018 Category: Neurology Authors: Carolina Ziebold, Jair J. Mari, David P. Goldberg, Fareed Minhas, Bushra Razzaque, Sandra Fortes, Rebeca Robles, Tai Pong Lam, Julio Bobes, Celso Iglesias, Jos é Ángel García, Geoffrey M. Reed Tags: Research paper Source Type: research

Subjective and physiological response to emotions in temporal lobe epilepsy and psychogenic non-epileptic seizures
In both epilepsy and psychogenic non-epileptic seizures (PNES) there is a high prevalence of comorbid mood disorders which are often described as the main factor contributing to poorer quality of life (Garcia, Garcia-Morales,& Gil-Nagel, 2015; Szaflarski et al., 2003). PNES are involuntary episodes of alteration of consciousness and disturbance of sensory, motor, autonomic or cognitive functions that can be misdiagnosed as epileptic seizures. They are not caused by abnormal electrical discharges in the brain and are thought to be mainly triggered by emotional distress (Brown, Syed, Benbadis, LaFrance,& Reuber, 2011...
Source: Journal of Affective Disorders - October 5, 2018 Category: Neurology Authors: Iliana Kotwas, Jean-Arthur Micoulaud-Franchi, St éphanie Khalfa, Aileen McGonigal, Mireille Bastien-Toniazzo, Fabrice Bartolomei Tags: Research paper Source Type: research

Eating pattern and psychological symptoms: a cross-sectional study based on a national large sample of Chinese adolescents
The mental health of adolescents is a pressing issue in global public health. The Global Burden of Disease Study shows that mental disorders were the main cause of disability adjusted of life years (DALY) of 10-24 year-old adolescents from 1990 to 2013 (Mokdad et al., 2016). Mental disorders such as depression, anxiety, and conduct disorder increased in ranking global age standardized DALY rates from 1990 to 2015 (Kassebaum et al., 2017). The epidemiological data shows that the prevalence of anxiety was 31.9%, behavioral disorders were 19.1%, emotional disorders were 14.3%, and substance use disorders were 11.4% in America...
Source: Journal of Affective Disorders - October 5, 2018 Category: Neurology Authors: Honglv Xu, Ying Sun, Yuhui Wan, Shichen Zhang, Huiqiong Xu, Rong Yang, Wei Wang, Hanjun Zeng, Shaojun Xu, Jiahu Hao, Fangbiao Tao Tags: Research paper Source Type: research

Disentangling the Association of Depression on the Anti-fatigue Effects of Ketamine
Fatigue and depression are complex constructs, but their association is well documented (Bakshi et al., 2000; Jacobsen et al., 2003; Brown& Kroenke, 2009). Both significantly influence the capacity to perform everyday actions and endorse greater functional disability (Lin et al., 2013; Milanovic et al., 2018). They have been strongly correlated in multiple reports (Bakshi et al., 2000; Jacobsen et al., 2003; Brown& Kroenke, 2009). However, some evidence suggests that depression and fatigue are distinct constructs, for example, it was observed that fatigue symptoms persist even after the remission of depression (Fer...
Source: Journal of Affective Disorders - October 5, 2018 Category: Neurology Authors: Leorey N. Saligan, Cristan Farmer, Elizabeth D. Ballard, Bashkim Kadriu, Carlos A. Zarate Tags: Research paper Source Type: research

Changes in levels of cortical metabotropic glutamate 2 receptors with gender and suicide but not psychiatric diagnoses
We have reported that, compared to controls, there are lower levels of [3H]LY341495 binding in Brodmann's area (BA) 24, but not BA 17 or 46, from subjects with major depressive disorders (MDD) (McOmish et al., 2016). [3H]LY341495 binding was not altered in those three cortical regions from subjects with bipolar disorders (BD) or schizophrenia. As [3H]LY341495 binds to the mammalian metabotropic glutamate receptors (GRM) 2 and 3 (Johnson et al., 1999; Wright et al., 2001), our data is consistent with the notion that there is a decrease in the total number of GRM2 plus GRM3 in BA 24 from subjects with MDD. (Source: Journal o...
Source: Journal of Affective Disorders - October 5, 2018 Category: Neurology Authors: Brian Dean, Clare Duncan, Andrew Gibbons Source Type: research

Diet and physical activity in the association between depression and metabolic syndrome: Constances study
Depression is associated with an increased risk of metabolic syndrome that contributes to the poor cardiovascular health of depressed individuals. A meta-analysis showed that individuals with depression had a 1.5 times higher odds of having a metabolic syndrome (Vancampfort et al., 2014). Although the exact mechanisms underlying this association are poorly known, several hypotheses have been proposed. Depression and metabolic syndrome may share some common alterations of the stress system which could lead to a low grade inflammatory state and to oxidative stress which damages the neurons as well as the pancreatic cells and...
Source: Journal of Affective Disorders - September 27, 2018 Category: Neurology Authors: Joane Matta, Nicolas Hoertel, Emmanuelle Kesse-Guyot, Marie Plesz, Emmanuel Wiernik, Claire Carette, S ébastien Czernichow, Frédéric Limosin, Marcel Goldberg, Marie Zins, Cédric Lemogne Tags: Research paper Source Type: research

The relationship between alcohol abuse and suicide risk according to smoking status: A cross-sectional study
Suicide is a common cause of death in most developed countries (Bae et al., 2015). In Korea, it was the fourth leading cause of death (28.1 per 100,000) in 2012 (Statistics Korea, 2013). Additionally, Korea is ranked first among the Organization for Economic Cooperation and Development (OECD) countries in suicide mortality (OECD, 2013). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - September 22, 2018 Category: Neurology Authors: Myoungjee Jung Tags: Research paper Source Type: research

Symptoms of social anxiety disorder and major depressive disorder: A network perspective
Social anxiety disorder (SAD) and major depressive disorder (MDD) are among the most prevalent disorders worldwide (Kessler  et al., 2005), and investigators have documented their high rate of comorbidity (Beesdo et al., 2007; Brown et al., 2001; Kessler et al., 2005; Ohayon and Schatzberg, 2010; Stein et al., 2001).4 Further, these disorders have been found to be associated with greater impairment when they co-occ ur than when either occurs alone (Norton et al., 2008). Despite these findings, however, we have only a limited understanding of the nature of the comorbidity of these dis...
Source: Journal of Affective Disorders - September 21, 2018 Category: Neurology Authors: Julia K. Langer, Natasha A. Tonge, Marilyn Piccirillo, Thomas L. Rodebaugh, Renee J. Thompson, Ian H. Gotlib Tags: Research paper Source Type: research

The burden of depression in systemic sclerosis patients: a nationwide population-based study
Systemic sclerosis (SSc) is an autoimmune connective-tissue disorder characterized by micro-vascular damage, immunologic impairments and tissue fibrosis, due to a massive deposition of collagen and other matrix substances within the skin and internal organs (Elhai  et al., 2015). According to a large, population-wide assessment of two claim databases, in the USA, SSc has a prevalence of 0.05% (Robinson et al., 2008). Immune-mediated inflammatory diseases including SSc have a substantial societal burden, owing to the impacts of chronicity, acute exacerbati ons and progressive disability (Enns et&nbs...
Source: Journal of Affective Disorders - September 21, 2018 Category: Neurology Authors: Nicola L. Bragazzi, Abdulla Watad, Alex Gizunterman, Dennis McGonagle, Hussein Mahagna, Doron Comaneshter, Howard Amital, Arnon D. Cohen, Daniela Amital Tags: Research paper Source Type: research

The association of vision loss and dimensions of depression over 12 years in older adults: findings from the Three City Study
Vision impairment (VI) is common in older adults, with an estimated prevalence of 25% in those aged over 70 (Stevens et al., 2013); and VI substantially contributes to burden of disease in Europe (Mathers& Loncar, 2006). An association between VI and depression in the elderly population is well established (Carriere et al., 2013; Court, McLean, Guthrie, Mercer,& Smith, 2014; Hong et al., 2015), with prevalence of comorbid depression in older adults with VI estimated to be around 30% (Hayman et al., 2007; Hong et al., 2015). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - September 21, 2018 Category: Neurology Authors: S Cosh, I Carriere, V Nael, C Tzourio, C Delcourt, C Helmer, the Sense-Cog Consortium ¥ Tags: Research paper Source Type: research

nSymptoms of Social Anxiety Disorder and Major Depressive Disorder: A Network Perspective
Social anxiety disorder (SAD) and major depressive disorder (MDD) are among the most prevalent disorders worldwide (Kessler, Berglund, et al., 2005), and investigators have documented their high rate of comorbidity (Beesdo et al., 2007; Brown et al., 2001; Kessler, Chiu et al., 2005; Ohayon& Schatzberg, 2010; Stein et al., 2001)1. Further, these disorders have been found to be associated with greater impairment when they co-occur than when either occurs alone (Norton et al., 2008). Despite these findings, however, we have only a limited understanding of the nature of the comorbidity of these disorders (Langer& Rode...
Source: Journal of Affective Disorders - September 21, 2018 Category: Neurology Authors: Julia K. Langer, Natasha A. Tonge, Marilyn Piccirillo, Thomas L. Rodebaugh, Renee J. Thompson Source Type: research

GxE effects of FKBP5 and traumatic life events on PTSD: A meta-analysis
Recent findings from the World Mental Health Survey Consortium confirm that traumatic events are common, with over 70% of individuals endorsing at least one lifetime traumatic event and approximately one third endorsing four or more traumatic events (Benjet et al., 2016). Among a national sample of U.S. adults, 89.7% were exposed to at least one traumatic event, with 8.3% of exposed individuals reporting posttraumatic stress disorder (PTSD) during their lifetime (Kilpatrick et al., 2013). PTSD increases risk for a number of significant deleterious psychological (e.g., depression, substance use disorders, anxiety; Sareen et...
Source: Journal of Affective Disorders - September 21, 2018 Category: Neurology Authors: Sage E. Hawn, Christina M. Sheerin, Mackenzie J. Lind, Terrell A. Hicks, Marisa E. Marraccini, Kaitlin Bountress, Silviu-Alin Bacanu, Nicole R. Nugent, Ananda B. Amstadter Source Type: research

Abnormal cerebellum-DMN regions connectivity in unmedicated bipolar II disorder
Bipolar disorder (BD), a severe, chronic psychiatric disease, is a leading cause of disability, morbidity, and mortality from suicide, and is associated with several medical conditions, such as cardiovascular disease, diabetes mellitus, and neurovascular disease (Merikangas et al., 2007; Prieto et al., 2014). It is characterized by episodes of depression, mania (BD I), and hypomania (BD II) that seriously affect the social functioning and quality of life of patients (Dean et al., 2004; Merikangas et al., 2007). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - September 21, 2018 Category: Neurology Authors: Guanmao Chen, Lianping Zhao, Yanbin Jia, Shuming Zhong, Feng Chen, Xiaomei Luo, Shaojuan Qiu, Shunkai Lai, Zhangzhang Qi, Li Huang, Ying Wang Tags: Research paper Source Type: research

A randomized controlled trial of ‘MUMentum Pregnancy’: Internet-delivered cognitive behavioral therapy program for antenatal anxiety and depression
During pregnancy, approximately one in five women experience clinically significant symptoms of anxiety and depression, and one in six meet diagnostic criteria for an anxiety and/or major depressive disorder (MDD; Becker, Weinberger, Chandy and Schmukler, 2016; Dennis, Falah-Hassani and Shiri, 2017). Antenatal anxiety and depression are robust predictors of postpartum depression (Austin, Tully and Parker, 2007; Milgrom et al., 2008), and if left untreated, are associated with a range of adverse outcomes for both the mother and infant (e.g., reduced antenatal care; increased risk of preterm birth, low birth weight, and late...
Source: Journal of Affective Disorders - September 21, 2018 Category: Neurology Authors: Siobhan A. Loughnan, Amanda Sie, Megan J. Hobbs, Amy E. Joubert, Jessica Smith, Hila Haskelberg, Alison E.J. Mahoney, Natalie Kladnitski, Christopher J. Holt, Jeannette Milgrom, Marie-Paule Austin, Gavin Andrews, Jill M Newby Tags: Research paper Source Type: research

The burden of depression in systemic sclerosis patients: insights from a real-world big data-based analysis
Systemic sclerosis (SSc) is an autoimmune connective-tissue disorder characterized by micro-vascular damage, immunologic impairments and tissue fibrosis, due to a massive deposition of collagen and other matrix substances within the skin and internal organs (Elhai et al., 2015). According to a large, population-wide assessment of two claim databases, in the USA, SSc has a prevalence of 0.05% (Robinson et al., 2008). Immune-mediated inflammatory diseases including SSc have a substantial societal burden, owing to the impacts of chronicity, acute exacerbations and progressive disability (Enns et al., 2018). (Source: Journal o...
Source: Journal of Affective Disorders - September 21, 2018 Category: Neurology Authors: Nicola L. Bragazzi, Abdulla Watad, Alexander Gizunterman, Dennis McGonagle, Hussein Mahagna, Doron Comaneshter, Howard Amital, Arnon D. Cohen, Daniela Amital Tags: Research paper Source Type: research

Editorial Board
(Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - September 20, 2018 Category: Neurology Source Type: research

Relations between Trait Anxiety and Depression: A Mediated Moderation Model
Trait anxiety reflects an individual's predisposition to worry and anxiety when facing dangerous or uncertain situations. In recent years, studies in cognitive neuroscience have suggested that high trait anxiety is an important vulnerable phenotype for stress-induced depression (Weger and Sandi, 2018). Individuals with high anxiety traits not only are more susceptible to stress but also have specific neurocognitive characteristics (Sandi and Richter-Levin, 2009). In the management of threats or ambiguous situations, people with high trait anxiety have a unique cognitive style. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - September 20, 2018 Category: Neurology Authors: Tao Wang, Min Li, Song Xu, Botao Liu, Tong Wu, Fang Lu, Junpeng Xie, Li Peng, Jia Wang Tags: Research paper Source Type: research

Seasonality in Bipolar Disorder: Effect of Sex and Age
Mood episodes in bipolar disorder (BD) are found to exhibit a seasonal pattern (SP), with peaks for manic episodes in spring-summer and peaks for depressive episodes in early winter (Geoffroy et al., 2014; Lee et al., 2007; Volpe et al., 2010; Medici et al., 2016; Parker et al., 2017). Mixed episodes are most often described to peak in early spring and summer (Cassidy and Carroll, 2002; Lee et al., 2007; Whitney et al., 1999; Yang et al., 2013). These patterns have been observed in countries of the northern as well as the southern hemisphere, however, rarely in equatorial regions (Medici et al., 2016). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - September 20, 2018 Category: Neurology Authors: Matth äus Fellinger, Thomas Waldhoer, Daniel König, Barbara Hinterbuchinger, Nathalie Pruckner, Josef Baumgartner, Sandra Vyssoki, Benjamin Vyssoki Tags: Research paper Source Type: research

Quality of life across domains among individuals with treatment-resistant depression
Depression is a common, debilitating illness that often fails to respond to first- and second-line treatments. For example, about one-third of patients did not reach remission after multiple optimized pharmacologic trials during the STAR-D study (Rush et al., 2006). Recent estimates for treatment resistant depression (TRD), often defined by two or more treatment failures, indicate a 12-month prevalence rate of approximately 2% in the US (Nemeroff, 2007). Furthermore, long-term outcomes of TRD are typically very poor. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - September 19, 2018 Category: Neurology Authors: Heidemarie Lex, Yarden Ginsburg, Adam F. Sitzmann, Clara Grayhack, Daniel F. Maixner, Brian J. Mickey Tags: Research paper Source Type: research

Associations between broader autism phenotype (BAP) and maternal attachment are moderated by maternal postpartum depression when infants are one month old: A prospective study of the Japan Environment & Children's Study
Recently, broader autism phenotype (BAP) has been the focus of research studies. BAP refers to the expression of behavioral and cognitive dispositions similar to autism spectrum disorders, but at subthreshold levels (Asano et al., 2014; Dawson et al., 2007). Previous studies revealed that individuals with BAP had deficits in social motivation and communication; impairments in facial processing and executive functioning; and lower levels of motor imitation and language (Asano et al., 2014; Dawson et al., 2002; 2005; Piven et al., 1997; Sucksmith, et al., 2011). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - September 19, 2018 Category: Neurology Authors: Kumi Hirokawa, Takashi Kimura, Satoyo Ikehara, Kaori Honjo, Takuyo Sato, Kimiko Ueda, Hiroyasu Iso, Japan Environment & Children's Study Group Tags: Research paper Source Type: research

The prevalence of depressive symptoms in ‘left-behind children’ in China: a meta-analysis of comparative studies and epidemiological surveys
Due to the unprecedented increase in internal migration of workers in China, a unique and widespread social phenomenon of the so-called ‘left-behind children’ (LBC) has emerged (He et al., 2012). The phenomenon of LBC refers to children who are left at home for at least 6 months while one or both parents move elsewhere to work (Duan& Zhou,  2005). The rapid economic development in China has shifted a massive workforce from rural to urban areas in recent decades (Wen& Lin,  2012). Due to the financial and social welfare constraints in urban settings, it is common for migrant workers t...
Source: Journal of Affective Disorders - September 18, 2018 Category: Neurology Authors: Yuan-Yuan Wang, Le Xiao, Wen-Wang Rao, Jing-Xin Chai, Shu-Fang Zhang, Chee H. Ng, Gabor S. Ungvari, Huiping Zhu, Yu-Tao Xiang Tags: Research paper Source Type: research

Bipolar Disorder and Psychotropic Medication: Impact on Pregnancy and Neonatal Outcomes
Bipolar disorder (BD) is a serious psychiatric condition that affects 1% to 2% of people in the United States. Inclusion of the more broadly defined bipolar spectrum disorders raises the prevalence to between 3% and 6.5% (Angst,  1998). The median age of onset of BD is during late adolescence (19.4 years in the Stanley Foundation Bipolar Network) (Post et al., 2003); therefore, women are at risk for episodes during their childbearing years. Forty to 70% of women with BD will suffer recurrent episodes post-birth (Reich an d Winokur, 1970, van Gent and Verhoeven, 1992, Wisner et al., 2004). (Source: Journ...
Source: Journal of Affective Disorders - September 18, 2018 Category: Neurology Authors: Katherine L. Wisner, Dorothy Sit, Kelly O'Shea, Debra L. Bogen, Crystal T. Clark, Emily Pinheiro, Amy Yang, Jody D. Ciolino Tags: Research paper Source Type: research

Nonlinear dynamics of mood regulation in unaffected first-degree relatives of bipolar disorder patients
Evidence from family, twin and adoption studies indicates a heritable component to bipolar disorder (Craddock  and Jones, 1999). Because unaffected relatives share a proportion of the genetic material with the patient, abnormalities found in unaffected relatives may reflect trait-related neurobiological markers of the illness. In this sense, similar structural (Chaddock et al., 2009; McDonald et al., 20 04; van der Schot et al., 2009) and functional (Antila et al., 2007; Drapier et al., 2008; Schulze et al., 2011; Surguladze et al., 2010; Thermenos et al., 2010; Zalla et&nb...
Source: Journal of Affective Disorders - September 18, 2018 Category: Neurology Authors: Ortiz A, Bradler K, Garnham J, Slaney C, McLean S, Alda M Tags: Research paper Source Type: research

Sleep and circadian rhythms as possible trait markers of suicide attempt in bipolar disorders: an actigraphy study
Bipolar Disorders (BD) are severe and frequent psychiatric disorders affecting 1 to 4% of the general population when considering the narrow definition of the disorder (e.g BD type 1 and 2) (Merikangas  et al., 2007). According to the Worldwide Healthcare Organization's data, BD are among the tenth disabling pathologies with a ten years decrease in life expectancy (Collins et al., 2011; Phillips and Kupfer, 2013). The poor prognosis of BD is closely linked to deaths by suicide (Maurizio Pompili  et al., 2013). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - September 18, 2018 Category: Neurology Authors: Victoire BENARD, Bruno ETAIN, Guillaume VAIVA, Carole BOUDEBESSE, Sunthavy YEIM, Chlo é BENIZRI, Héléna BROCHARD, Frank BELLIVIER, Pierre A. GEOFFROY Tags: Research paper Source Type: research

Stematic Comparison of Recommendations for Safe Messaging about Suicide in Public Communications
Organizations involved in suicide prevention often produce communications for the general public using various media, with several objectives. Some message are produced to inform people about suicide, others to have an impact in preventing suicide, raise awareness of the topic, persuade suicidal individuals to seek help, etc. However, organizations that create messages for public communications are generally aware of research indicates that exposure to suicide content is sometimes associated with suicide clusters and imitation self-destructive behaviours or “contagion” (Cheng et al., 2014; Haw et al., 2013). (S...
Source: Journal of Affective Disorders - September 18, 2018 Category: Neurology Authors: Brian Mishara Tags: Review article Source Type: research

Impulsive suicide attempts among young people –A prospective multicentre cohort study in Sweden
Self-harm and suicidal behaviour are common in young people; hence, prevention of fatal and non-fatal suicidal events is a target for mental health improvement strategies. When performing risk assessments, clinicians often focus on the presence of suicidal planning where the suicidal act is considered to be the end of a pathway, through a continuum of suicidal feelings (Paykel  et al., 1974; O'Connell et al., 2004). However, many suicidal acts have not been planned, and should be considered as impulsive acts (Rimkeviciene et al., 2015). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - September 17, 2018 Category: Neurology Authors: K. Beckman, A.U. Lindh, M. Waern, L. Stromsten, E.S. Renberg, B. Runeson, M. Dahlin Tags: Research paper Source Type: research

The relationship between visceral adiposity and depressive symptoms in the general Korean population
In Korea, depressive symptoms or depression are prevalent psychiatric diseases. For depression, an annual point prevalence rate and a lifetime prevalence rate are 2.5% and 5.6% (Cho et al., 2010). Subsequently, the increasing prevalence of depression will raise the problem of disease burden over time (Cho et al. 2010; L épine and Briley, 2011). Many investigators consider depression or depressive symptoms as an output of another disease (Kim et al., 2015; Morrison et al., 2015; Phillips, 2011). The need for a more comprehensive analysis of depression has led investigators to record the evidences of associations be t...
Source: Journal of Affective Disorders - September 17, 2018 Category: Neurology Authors: Sung Joon Cho, Hyun Jeong Lee, Sang Jin Rhee, Eun Young Kim, Kyoung-Nam Kim, Dae Hyun Yoon, Yong Min Ahn Source Type: research

Self-disgust as a potential mechanism explaining the association between loneliness and depression
Depression is the leading cause of disability and one of the most common mental health problems worldwide (World  Health Organization [WHO], 2017). More than 300 million people of all ages are currently living with depression, with a sharp increase in prevalence of over 18% from 2005 to 2015. At its worst, depression can become lethal, particularly in young adults (15-29 years) as more than 800.000 people die each year from suicidal depression, and from depression-related cardiovascular disease (Nemeroff& Goldschmidt, 2012; WHO, 2017). (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - September 17, 2018 Category: Neurology Authors: Antonia Ypsilanti, Lambros Lazuras, Phillip Powell, Paul Overton Tags: Research paper Source Type: research