Synthetic psychoactive cathinones: Hypothermia and reduced lethality compared to methamphetamine and methylenedioxymethamphetamine
ConclusionsThese data indicate that, under the conditions studied here: (1) SPCs exhibit less lethality than MA and MDMA; (2) SPCs impair thermoregulation; (3) effects of SPCs on temperature appear to be independent of effects on lethality. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - February 13, 2020 Category: Biochemistry Source Type: research

A historical review of antidepressant effects of ketamine and its enantiomers
Publication date: Available online 5 February 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Yan Wei, Lijia Chang, Kenji HashimotoAbstractThe robust antidepressant effects of (R,S)-ketamine are among the most important discoveries in mood research over the last half century. Off-label use of (R,S)-ketamine, which is an equal mixture of (R)-ketamine and (S)-ketamine, has become especially popular in the United States (US) for treatment-resistant depression. On March 5, 2019, the US Food and Drug Administration approved an (S)-ketamine nasal spray for use in treatment-resistant depression, though its use has be...
Source: Pharmacology Biochemistry and Behavior - February 7, 2020 Category: Biochemistry Source Type: research

Editorial Board
Publication date: February 2020Source: Pharmacology Biochemistry and Behavior, Volume 189Author(s): (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - January 30, 2020 Category: Biochemistry Source Type: research

Serotonin 5-HT1A and 5-HT1B receptors co-mediate the RU 24969-induced locomotor activity of male and female preweanling rats
Publication date: February 2020Source: Pharmacology Biochemistry and Behavior, Volume 189Author(s): Sanders A. McDougall, Jasmine A.M. Robinson, Esperanza Larios Ramirez, Henry A. DiazAbstractThe serotonin (5-HT) 1A/1B agonist RU 24969 robustly increases the locomotor activity of adult male rats and mice; however, studies using selective antagonists alternately report that 5-HT1A, 5-HT1B, or both receptor types mediate RU 24969's locomotor activating effects. The purpose of the present study was to extend these past findings by administering a selective 5-HT1 agonist and/or antagonists to male and female preweanling rats. ...
Source: Pharmacology Biochemistry and Behavior - January 26, 2020 Category: Biochemistry Source Type: research

5-aminoisoquinolinone attenuates social behavior deficits and immune abnormalities in the BTBR T+ Itpr3tf/J mouse model for autism
In this study, we investigated the effect of 5-AIQ on sociability tests, self-grooming, marble burying, and locomotor activities in BTBR T+ Itpr3tf/J (BTBR) mice, which serve as an ASD animal model. We further investigated the possible molecular mechanism of 5-AIQ administration on CXCR4-, CXCR6-, IFN-γ-, IL-22-, NOS2-, STAT1-, T-bet-, and RORγT-producing CD3+ T cells isolated from the spleens of treated mice. We also explored its effects on mRNA expression in brain tissue. Our results showed that in BTBR mice, 5-AIQ treatment significantly prevented self-grooming and marble burying behaviors and enhanced socia...
Source: Pharmacology Biochemistry and Behavior - January 24, 2020 Category: Biochemistry Source Type: research

Antiamnesic effects of tofisopam against scopolamine-induced cognitive impairments in rats
In this study, we investigated the potential therapeutic effects of tofisopam, a 2,3-benzodiazepine derivative anxiolytic, on cognitive deficits in rats with scopolamine-induced amnesia. Cognitive performance of the rats was investigated by using the Morris water maze and passive avoidance tests. Changes in motor activity were assessed by using the activity cage and Rota-rod tests and then morphological changes in the hippocampus were assessed via immunohistochemical stainings. The results indicated that scopolamine impaired learning and memory parameters in rats. Worsened cognitive performance, neuronal loss, and decrease...
Source: Pharmacology Biochemistry and Behavior - January 23, 2020 Category: Biochemistry Source Type: research

Electrophysiological biomarkers of antidepressant response to ketamine in treatment-resistant depression: Gamma power and long-term potentiation
This study reviews electrophysiological studies of ketamine's effects in individuals with depression as well as healthy controls, with a focus on two putative markers of synaptic potentiation: gamma oscillations and long-term potentiation. The review focuses on: 1) measures of gamma oscillations and power and their relationship to both acute, psychotomimetic drug effects as well as delayed antidepressant response in mood disorders; 2) changes in long-term potentiation as a promising measure of synaptic potentiation following ketamine administration; and 3) recent efforts to model antidepressant response to ketamine using n...
Source: Pharmacology Biochemistry and Behavior - January 18, 2020 Category: Biochemistry Source Type: research

Serotonin 5-HT1A and 5-HT1B receptors co-mediate the RU 24629-induced locomotor activity of male and female preweanling rats
Publication date: Available online 17 January 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Sanders A. McDougall, Jasmine A.M. Robinson, Esperanza Larios Ramirez, Henry A. DiazAbstractThe serotonin (5-HT) 1A/1B agonist RU 24969 robustly increases the locomotor activity of adult male rats and mice; however, studies using selective antagonists alternately report that 5-HT1A, 5-HT1B, or both receptor types mediate RU 24969's locomotor activating effects. The purpose of the present study was to extend these past findings by administering a selective 5-HT1 agonist and/or antagonists to male and female preweanling...
Source: Pharmacology Biochemistry and Behavior - January 18, 2020 Category: Biochemistry Source Type: research

mGlu2/3 receptor antagonism: A mechanism to induce rapid antidepressant effects without ketamine-associated side-effects
Publication date: Available online 16 January 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Jeffrey M. WitkinAbstractThe consensus that ketamine can produce rapid-onset antidepressant effects in patients combined with the recent approval of S(+)-ketamine (Esketamine) as an antidepressant, has fueled the search for other compounds that might recapitulate the remarkable therapeutic benefits of ketamine. At the same time, discovery efforts have been additionally directed toward minimization of the tolerability, side-effect, and safety issues associated with ketamine. The history of thought on the viability of m...
Source: Pharmacology Biochemistry and Behavior - January 17, 2020 Category: Biochemistry Source Type: research

Behavioral responses of mGluR3-KO mice to the lipopolysaccharide-induced innate inflammatory reaction
Publication date: Available online 15 January 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Lainiola Mira, Linden Anni-Maija, Aitta-aho TeemuAbstractAcute lipopolysaccharide (LPS) administration induces innate inflammatory signalling and produces sickness reaction characterized by reduced drinking, eating and reduced locomotor exploration, as well as emotional changes indicating increased helplessness/despair. LPS administration has been used to model behavioral and emotional responses to inflammatory reactions. Our aim was to find out whether the lack of metabotropic glutamate receptor 3 (mGluR3) in the kno...
Source: Pharmacology Biochemistry and Behavior - January 15, 2020 Category: Biochemistry Source Type: research

Memory deterioration based on the tobacco smoke exposure and methylazoxymethanol acetate administration vs. aripiprazole, olanzapine and enrichment environment conditions
Publication date: Available online 15 January 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Ratajczak Piotr, Kus Krzysztof, Murawiecka Patrycja, Słodzińska Iwona, Zaprutko Tomasz, Kopciuch Dorota, Paczkowska Anna, Nowakowska ElżbietaAbstractEnrichment environment conditions, as well as tobacco smoke exposure, may affect cognitive function (e.g. spatial memory) in an animal model of schizophrenia and schizophrenic patients.The aim of this study was to find whether spatial memory function impairment is found in methylazoxymethanol acetate treated rats (an animal model of schizophrenia) and whether aripipraz...
Source: Pharmacology Biochemistry and Behavior - January 15, 2020 Category: Biochemistry Source Type: research

Chronic oral treatment with risperidone impairs recognition memory and alters brain-derived neurotrophic factor and related signaling molecules in rats
Publication date: Available online 13 January 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Indrani Poddar, Patrick M. Callahan, Caterina M. Hernandez, Anilkumar Pillai, Xiangkun Yang, Michael G. Bartlett, Alvin V. TerryAbstractAntipsychotic drugs (APDs) are essential for the treatment of schizophrenia and other neuropsychiatric illnesses such as bipolar disease. However, they are also extensively prescribed off-label for many other conditions, a practice that is controversial given their potential for long-term side effects. There is clinical and preclinical evidence that chronic treatment with some APDs ma...
Source: Pharmacology Biochemistry and Behavior - January 14, 2020 Category: Biochemistry Source Type: research

Lisdexamfetamine suppresses instrumental and consummatory behaviors supported by foods with varying degrees of palatability: Exploration of a binge-like eating model
In conclusion, lisdexamfetamine affected both food intake and food-reinforced operant behavior, with larger effects seen in the group exposed to chocolate. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - January 11, 2020 Category: Biochemistry Source Type: research

Editorial Board
Publication date: January 2020Source: Pharmacology Biochemistry and Behavior, Volume 188Author(s): (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - January 3, 2020 Category: Biochemistry Source Type: research

Duloxetine reverses the symptoms of overactive bladder co-existing with depression via the central pathways
Publication date: Available online 31 December 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Andrzej Wróbel, Anna Serefko, Andrzej Woźniak, Jacek Kociszewski, Aleksandra Szopa, Radosław Wiśniewski, Ewa PoleszakAbstractThough the association between overactive bladder (OAB) and depression was noticed years ago, the pharmaceutical market does not offer one universal drug that would cure both conditions at the same time. The main goal of our present experiments was to determine whether a 14-day administration of solifenacin (0.03 mg/kg/day), mirabegron (1 mg/kg/day), or duloxetine (1 mg/kg/day) ...
Source: Pharmacology Biochemistry and Behavior - January 1, 2020 Category: Biochemistry Source Type: research

In vivo evaluation of the CB1 allosteric modulator LDK1258 reveals CB1-receptor independent behavioral effects
Publication date: Available online 30 December 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Mohammed Mustafa, Giulia Donvito, Lauren Moncayo, Amelia Swafford, Justin Poklis, Ralph Grauer, Teresa Olszewska, Debra A. Kendall, Dai Lu, Aron H. LichtmanAbstractIn the present study, we examined whether LDK1258, which produces strong CB1 receptor allosteric effects in in vitro assays, would elicit in vivo effects consistent with allosteric activity. In initial studies, LDK1258 reduced food consumption and elicited delayed antinociceptive effects in the chronic constrictive injury of the sciatic nerve (CCI) model o...
Source: Pharmacology Biochemistry and Behavior - December 30, 2019 Category: Biochemistry Source Type: research

Aripiprazole prevents stress-induced anxiety and social impairment, but impairs antipredatory behavior in zebrafish
Publication date: Available online 29 December 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Heloísa Helena de Alcantara Barcellos, Aline Pompermaier, Suelen Mendonça Soares, Victoria Costa Maffi, Marina Fernandes, Gessi Koakoski, Karina Kirsten, Bernardo Baldisserotto, Leonardo José Gil BarcellosAbstractEnvironmental pollution caused by antipsychotic residues is a relevant ecological problem. Studies revealed that residues of these drugs are present in a wide range of different ecosystems and can have adverse effects on non-target organisms even in low environmental concentrations. Amon...
Source: Pharmacology Biochemistry and Behavior - December 29, 2019 Category: Biochemistry Source Type: research

Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent repeated intermittent administration of (R)-ketamine, but not (S)-ketamine: Role of BDNF-TrkB signaling
Publication date: Available online 19 December 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Yunfei Tan, Yuko Fujita, Youge Qu, Lijia Chang, Yaoyu Pu, Siming Wang, Xingming Wang, Kenji HashimotoAbstractThe N-methyl-d-aspartate receptor (NMDAR) antagonists including phencyclidine (PCP) and ketamine produce cognitive deficits in rodents and humans. We previously reported that (R)-ketamine produced the beneficial effects compared to (S)-ketamine in several animal models including depression. Here we compared the effects of two enantiomers of ketamine on cognitive deficits in mice after repeated administration o...
Source: Pharmacology Biochemistry and Behavior - December 20, 2019 Category: Biochemistry Source Type: research

Efficacy of infliximab in treatment-resistant depression: A systematic review and meta-analysis
ConclusionInfliximab was not efficient in reducing depressive symptoms according to the HAM-D, only when the patients already had increased inflammatory genes, including TNF and C-reactive protein (CRP). (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - December 15, 2019 Category: Biochemistry Source Type: research

The influence of nicotine metabolic rate on working memory over 6 hours of abstinence from nicotine
ConclusionsMinimal change in working memory over 6 h of nicotine abstinence was observed. Overall, NMR was not significantly associated with the change in processing speed, however Caucasian fast metabolizers displayed poorer accuracy and processing speed at discrete time points. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - December 13, 2019 Category: Biochemistry Source Type: research

Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine
Publication date: Available online 9 December 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Satoshi Deyama, Ronald S. DumanAbstractClinical and preclinical studies have demonstrated that depression, one of the most common psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), contributing to neuronal atrophy in the prefrontal cortex (PFC) and hippocampus, and reduced hippocampal adult neurogenesis. Conventional monoaminergic antidepressants can block/reverse, at least partially, these ...
Source: Pharmacology Biochemistry and Behavior - December 11, 2019 Category: Biochemistry Source Type: research

The influence of nicotine metabolic rate on working memory over 6 hours of abstinence from nicotine
ConclusionsMinimal change in working memory over 6 h of nicotine abstinence was observed. Overall, NMR was not significantly associated with the change in processing speed, however Caucasian fast metabolizers displayed poorer accuracy and processing speed at discrete time points. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - December 7, 2019 Category: Biochemistry Source Type: research

Alpha2-adrenergic dysregulation in congenic DxH recombinant inbred mice selectively bred for a high fear-sensitized (H-FSS) startle response
Publication date: Available online 2 December 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Rochelle N. Wickramasekara, Charles Bockman, Joachim Hanke, Herbert Schwegler, JoAnn McGee, Edward Walsh, Deniz Yilmazer-HankeAbstractPatients with anxiety disorders and posttraumatic stress disorder (PTSD) exhibit exaggerated fear responses and noradrenergic dysregulation. Fear-related responses to α2-adrenergic challenge were therefore studied in DxH C3H/HeJ-like recombinant inbred (C3HLRI) mice, which are a DBA/2J-congenic strain selectively bred for a high fear-sensitized startle (H-FSS). C3HLRI mice showed ...
Source: Pharmacology Biochemistry and Behavior - December 3, 2019 Category: Biochemistry Source Type: research

Decreased medial entorhinal cortical thickness in olanzapine exposed female rats is not ameliorated by exercise
Publication date: Available online 27 November 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): M.L. Woodward, A.H. Ker, A.M. Barr, C.L. Beasley, C. Hercher, H.N. Boyda, R.M. Procyshyn, W.G. Honer, D.J. LangAbstractAerobic exercise has been associated with hippocampal plasticity, both in healthy adults and in psychosis patients, but its impact on cortical regions remains unclear. The entorhinal cortex serves as a critical gateway for the hippocampus, and recent studies suggest that this region may also be impacted following an exercise regime. In order to investigate the effects of antipsychotic medications and...
Source: Pharmacology Biochemistry and Behavior - November 28, 2019 Category: Biochemistry Source Type: research

Influence of the CB1 and CB2 cannabinoid receptor ligands on the activity of atypical antidepressant drugs in the behavioural tests in mice
Publication date: Available online 27 November 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Ewa Poleszak, Sylwia Wośko, Karolina Sławińska, Elżbieta Wyska, Aleksandra Szopa, Katarzyna Świąder, Andrzej Wróbel, Urszula Doboszewska, Piotr Wlaź, Aleksandra Wlaź, Anna SerefkoAbstractAvailable data support the notion that cannabinoids, whose therapeutic value is limited due to severe adverse reactions, could be beneficial as adjunctive agents in the management of mood disorders. Polytherapy, which is superior to monotherapy in the terms of effectiveness, usually requires lower doses of the individu...
Source: Pharmacology Biochemistry and Behavior - November 28, 2019 Category: Biochemistry Source Type: research

Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model
Publication date: Available online 28 November 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Rita L. Vaz, Sara Sousa, Diana Chapela, Herma C. van der Linde, Rob Willemsen, Ana D. Correia, Tiago F. Outeiro, Nuno D. AfonsoAbstractParkinson's disease (PD) is known as a movement disorder due to characteristic motor features. Existing therapies for PD are only symptomatic, and their efficacy decreases as disease progresses. Zebrafish, a vertebrate in which parkinsonism has been modelled, offers unique features for the identification of molecules with antiparkinsonian properties. Here, we developed a screening ass...
Source: Pharmacology Biochemistry and Behavior - November 28, 2019 Category: Biochemistry Source Type: research

Therapeutic efficacy of environmental enrichment for substance use disorders
Publication date: Available online 26 November 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Ewa Galaj, Eddy D. Barrera, Robert RanaldiAbstractAddiction to drug and alcohol is regarded as a major health problem worldwide for which available treatments show limited effectiveness. The biggest challenge remains to enhance the capacities of interventions to reduce craving, prevent relapse and promote long-term recovery. New strategies to meet these challenges are being explored. Findings from preclinical work suggest that environmental enrichment (EE) holds therapeutic potential for the treatment of substance us...
Source: Pharmacology Biochemistry and Behavior - November 26, 2019 Category: Biochemistry Source Type: research

Disrupting the endocannabinoid system in early adolescence negatively impacts sociability
Publication date: Available online 25 November 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Daniela Cossio, Henry Stadler, Zoe Michas, Colin Johnston, Hassan H. LopezAbstractAnimal models suggest that the endocannabinoid system (eCS) helps regulate various aspects of social behavior, including play behavior and social reward, during adolescence. Properly tuned endocannabinoid signaling may be a critical developmental component in the emergence of normal adult sociability. In the current experiment, we attempted to pharmacologically disrupt endocannabinoid tone during early adolescence, and then measure the ...
Source: Pharmacology Biochemistry and Behavior - November 26, 2019 Category: Biochemistry Source Type: research

Sub-chronic taurine administration induces behavioral sensitization but does not influence ethanol-induced dopamine release in the nucleus accumbens
Publication date: Available online 23 November 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Lisa Ulenius, Anna Andrén, Louise Adermark, Bo Söderpalm, Mia EricsonAbstractPreclinical studies have shown that the amino acid taurine is of importance for the dopamine elevating properties of ethanol. Taurine intake has escalated over the last decade due to increased consumption of taurine-containing energy drinks and dietary supplements. Whether long-term intake of large amounts of taurine induces adaptations affecting ethanol-induced dopamine elevation is not clear. Thus the aim of the present studies...
Source: Pharmacology Biochemistry and Behavior - November 25, 2019 Category: Biochemistry Source Type: research

Intracellular mechanisms and behavioral changes in mouse model of attention deficit hyperactivity disorder: Importance of age-specific NMDA receptor blockade
Publication date: Available online 20 November 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Harish M. Kawade, Chandrashekhar D. Borkar, Ashwini S. Shambharkar, Omprakash Singh, Praful S. Singru, Nishikant K. Subhedar, Dadasaheb M. KokareAbstractExposure of NMDA receptor antagonists during developmental stages leads to behavioral consequences like attention deficit hyperactivity disorder (ADHD). However, the underlying molecular mechanisms have remained poorly understood. Herein, we studied the phosphorylated Akt (pAkt) and caspase-3, the key regulators of neuronal cell survival/death, as the probable downst...
Source: Pharmacology Biochemistry and Behavior - November 20, 2019 Category: Biochemistry Source Type: research

Rapastinel, a novel glutamatergic agent with ketamine-like antidepressant actions: Convergent mechanisms
Publication date: Available online 13 November 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Taro Kato, Ronald S. DumanAbstractConventional antidepressant medications, which act on monoaminergic systems, have significant limitations, including a time lag of weeks to months and low rates of therapeutic efficacy. Recently, clinical findings demonstrate that ketamine, a dissociative anesthetic that blocks N-methyl-d-aspartate (NMDA) receptor channel activity, causes rapid (within hours) and long-lasting (7 to 10 days) antidepressant effects. Rapastinel is a novel glutamatergic compound that acts as an NMDAR p...
Source: Pharmacology Biochemistry and Behavior - November 15, 2019 Category: Biochemistry Source Type: research

Editorial Board
Publication date: December 2019Source: Pharmacology Biochemistry and Behavior, Volume 187Author(s): (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - November 13, 2019 Category: Biochemistry Source Type: research

ANAVEX®2-73 (blarcamesine), a Sigma-1 receptor agonist, ameliorates neurologic impairments in a mouse model of Rett syndrome
Publication date: December 2019Source: Pharmacology Biochemistry and Behavior, Volume 187Author(s): Walter E. Kaufmann, Jeffrey Sprouse, Nell Rebowe, Taleen Hanania, Daniel Klamer, Christopher U. MisslingAbstractRett syndrome (RTT) is a severe neurodevelopmental disorder that is associated in most cases with mutations in the transcriptional regulator MECP2. At present, there are no effective treatments for the disorder. Despite recent advances in RTT genetics and neurobiology, most drug development programs have focused on compounds targeting the IGF-1 pathway and no pivotal trial has been completed as yet.Thus, testing no...
Source: Pharmacology Biochemistry and Behavior - November 6, 2019 Category: Biochemistry Source Type: research

Voluntary exercise and estradiol reverse ovariectomy-induced spatial learning and memory deficits and reduction in hippocampal brain-derived neurotrophic factor in rats
This study was designed to investigate the effects of voluntary exercise and estrogen replacement on learning and memory deficits and reduction of hippocampal brain derived neurotrophic factor (BDNF) levels induced by ovariectomy. Ovariectomized rats were given daily vehicle or 17 β-estradiol (20 μg/kg) and allowed to freely exercise in a running wheel over the course of 2 weeks. After this period, they were trained and tested on a water-maze spatial task for 5 consecutive days, followed by a probe test one day later. At the end of the behavioral tests, all animals were decapitated and their hippocampal levels ...
Source: Pharmacology Biochemistry and Behavior - November 6, 2019 Category: Biochemistry Source Type: research

The activity-regulated cytoskeleton-associated protein, Arc/Arg3.1, influences mouse cocaine self-administration
Publication date: Available online 1 November 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Rachel D. Penrod, Morgane Thomsen, Makoto Taniguchi, Yuhong Guo, Christopher W. Cowan, Laura N. SmithAbstractThe activity-regulated cytoskeleton-associated protein (Arc, also known as Arg3.1), an immediate early gene and synaptic regulator, is upregulated following a single cocaine exposure. However, there is not much known regarding Arc/Arg3.1's potential contribution to addiction-relevant behaviors. Despite known learning and memory deficits in contextual fear and water-maze reversal learning tasks, we find that mic...
Source: Pharmacology Biochemistry and Behavior - November 1, 2019 Category: Biochemistry Source Type: research

A single coadministration of subeffective doses of ascorbic acid and ketamine reverses the depressive-like behavior induced by chronic unpredictable stress in mice
In this study, we investigated the ability of a single coadministration of subeffective doses of ascorbic acid and ketamine to reverse the depressive-like behavior induced by chronic unpredictable stress (CUS) in mice. Moreover, we examined the effect of combined administration of ascorbic acid and ketamine on hippocampal phosphorylation of p70S6K and immunocontents of GLUA1 and PSD-95 in mice submitted to the CUS procedure. CUS procedure was applied for 21 days. Animals received a single coadministration of subeffective doses of ascorbic acid (0.1 mg/kg) and ketamine (0.1 mg/kg) and were subjected to behavioral eval...
Source: Pharmacology Biochemistry and Behavior - November 1, 2019 Category: Biochemistry Source Type: research

d-Cycloserine reverses scopolamine-induced object and place memory deficits in a spontaneous recognition paradigm in rats
Publication date: December 2019Source: Pharmacology Biochemistry and Behavior, Volume 187Author(s): Takaaki Ozawa, Kazuo Yamada, Yukio IchitaniAbstractd-Cycloserine (DCS) is a partial agonist of the glutamatergic N-methyl-d-aspartate (NMDA) receptor-associated glycine site, and it prevents the amnesic effects of the muscarinic receptor antagonist scopolamine in various memory tests in rodents. In the present study, we tested the hypothesis that DCS has anti-amnesic effects in scopolamine-induced deficits using spontaneous object recognition and place recognition tests. In both tests, scopolamine (0.5 mg/kg, i.p.) was sys...
Source: Pharmacology Biochemistry and Behavior - November 1, 2019 Category: Biochemistry Source Type: research

Rewarding and aversive doses of caffeine alter activity but not conditioned place preference induced by ethanol in DBA/2J mice
Publication date: Available online 31 October 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Alfredo Zuniga, Christopher L. CunninghamAbstractIncreases in the consumption of ethanol and caffeine have been attributed to increased subjective feelings of intoxication and pleasure from the combination. Previous studies have shown that caffeine can be rewarding at low doses and aversive at high doses, although these findings are at times inconsistent between studies using comparable doses. Similarly, studies investigating the rewarding effects of ethanol and caffeine combinations have yielded mixed results. To add...
Source: Pharmacology Biochemistry and Behavior - November 1, 2019 Category: Biochemistry Source Type: research

Conditioned taste avoidance induced by the combination of heroin and cocaine: Implications for the use of speedball
Publication date: Available online 31 October 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Anthony L. Riley, Karen A. Pescatore, Katharine H. Nelson, Madeline E. CrissmanAbstractSpeedball (heroin + cocaine) is a prevalent drug combination among intravenous drug users. Although its use is generally discussed to be a function of changes in the rewarding effects of either or both drugs, changes in the aversive effects of either drug may also be impacted (weakened) by the combination. To address this latter possibility and its potential role in the use of speedball, the present studies examined the interact...
Source: Pharmacology Biochemistry and Behavior - November 1, 2019 Category: Biochemistry Source Type: research

Differential expression of nicotine withdrawal as a function of developmental age in the rat
Publication date: Available online 24 October 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Robin J. Keeley, Tom E. Mayer, Li-Ming Hsu, Hanbing Lu, Yihong Yang, Elliot A. SteinAbstractCigarette smoking and resultant nicotine dependence remain major public health problems. Most smokers begin before the age of 18, yet preclinical models have insufficiently characterized the development of nicotine dependence in adolescence. To categorize the short-term effects of chronic nicotine administration throughout adolescence and adulthood, we exposed male Sprague Dawley rats to 14 days of continuously delivered nico...
Source: Pharmacology Biochemistry and Behavior - October 25, 2019 Category: Biochemistry Source Type: research

Energy drink constituents (caffeine and taurine) selectively potentiate ethanol-induced locomotion in mice
Publication date: December 2019Source: Pharmacology Biochemistry and Behavior, Volume 187Author(s): Lisa Ulenius, Louise Adermark, Bo Söderpalm, Mia EricsonAbstractMixing alcohol with energy drinks has emerged as a popular trend over the last decade. However, epidemiological studies have found this consumption to be associated with increased hazards, such as binge drinking, increased alcohol-related harm and risk of developing alcohol use disorder. The mechanisms underlying these effects are not clear, but much attention has been attributed to caffeine. However, taurine, another common ingredient in energy drinks, has...
Source: Pharmacology Biochemistry and Behavior - October 25, 2019 Category: Biochemistry Source Type: research

Intraperitoneal 8-OH-DPAT reduces competition from contextual but not discrete conditioning cues
Publication date: December 2019Source: Pharmacology Biochemistry and Behavior, Volume 187Author(s): H.J. Cassaday, K.E. ThurAbstractThe effects of the serotonergic (5-hydroxytryptamine, 5-HT) agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.2 and 0.4 mg/kg i.p.) were examined in trace conditioning (Experiment 1) and overshadowing (Experiment 2) procedures. Both experiments used a fear conditioning procedure conducted off-the-baseline in water deprived male Wistar rats. 8-OH-DPAT was administered during conditioning and its effects were examined drug free as the suppression of an established licking response, ...
Source: Pharmacology Biochemistry and Behavior - October 25, 2019 Category: Biochemistry Source Type: research

Dissimilar interaction between dopaminergic and cholinergic systems in the initiation of emission of 50-kHz and 22-kHz vocalizations
Publication date: Available online 23 October 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Michael Silkstone, Stefan M. BrudzynskiAbstractRats emit 22-kHz or 50-kHz ultrasonic vocalizations (USVs) to signal their emotional state to other conspecifics. The 22-kHz USVs signal a negative emotional state while 50-kHz USVs reflect a positive affective state. The initiation of 22-kHz USVs is dependent on the activity of cholinergic neurons within the laterodorsal tegmental nucleus that release acetylcholine along the medial cholinoceptive vocalization strip. Emission of 50-kHz USVs is dependent upon the activatio...
Source: Pharmacology Biochemistry and Behavior - October 25, 2019 Category: Biochemistry Source Type: research

The combination of mirtazapine plus venlafaxine reduces immobility in the forced swim test and does not inhibit female sexual behavior
ConclusionsMirtazapine and venlafaxine exerted an effect in the FST, which was also evident when sub-effective doses of both antidepressants were combined. This combination also lacked adverse effects on female sexual behavior. The results suggest that “California Rocket Fuel” could be an effective antidepressant therapy with no adverse sexual effects in women. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - October 25, 2019 Category: Biochemistry Source Type: research

TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in mice
In this study, we characterized in vitro and in vivo profiles of a novel highly selective OX2R agonist, TAK-925 [methyl (2R,3S)-3-[(methylsulfonyl)amino]-2-{[(cis-4-phenylcyclohexyl)oxy]methyl}piperidine-1-carboxylate]. TAK-925 activated human recombinant OX2R with 50% effective concentration value of 5.5 nM, and showed>5000-fold selectivity over OX1R in calcium mobilization assays. TAK-925 induced OX2R-downstream signals similar to those displayed by orexin peptides in Chinese hamster ovary cells stably expressing human OX2R. In an electrophysiological study, TAK-925 activated physiological OX2R on histaminergic neur...
Source: Pharmacology Biochemistry and Behavior - October 23, 2019 Category: Biochemistry Source Type: research

Ethanol pre-exposure does not increase delay discounting in P rats, but does impair the ability to dynamically adapt behavioral allocation to changing reinforcer contingencies
Publication date: Available online 22 October 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Steven Wesley Beckwith, Cristine Lynn CzachowskiAbstractIncreased subjective discounting of delayed rewards is associated with substance abuse, and individuals tend to discount their drug of choice at a greater rate compared to monetary rewards. While there is evidence indicating that increased delay discounting (DD) is a risk factor for substance abuse, some results suggest that exposure to drugs of abuse also increases DD, but effects are mixed. The current study examined whether ethanol pre-exposure increases DD an...
Source: Pharmacology Biochemistry and Behavior - October 23, 2019 Category: Biochemistry Source Type: research

Vaporized Cannabis differentially modulates sexual behavior of female rats according to the dose
Publication date: Available online 20 October 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Alejandra Mondino, Santiago Fernandez, Carlos Garcia-Carnelli, María José Castro, Eleuterio Umpierrez, Pablo Torterolo, Atilio Falconi, Daniella AgratiAbstractStudies exploring the effect of compounds that modulate the endocannabinoid system on sexual behavior have yielded contradictory results. However, the effect of smoked Cannabis in women has been consistently associated with an increase in sexual drive. Therefore, it can be speculated that vaporized cannabis will augment sexually motivated component...
Source: Pharmacology Biochemistry and Behavior - October 22, 2019 Category: Biochemistry Source Type: research

Age- and sex-related changes in the severity of physical and psychological dependence in morphine-dependent rats
Publication date: Available online 19 October 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Javad Mohammadian, Hossein Miladi-GorjiAbstractGender- and age-dependent effects on the severity of morphine dependence are still controversial. The aim of this study was to investigate the effects of age and sex on the severity of physical and psychological dependence in morphine-dependent rats. The young/aged male and female Wistar rats were chronically treated with bi-daily doses (10 mg/kg, at 12 h intervals) of morphine for 14 days. Then, rats were tested for the severity of physical dependence on morphine (...
Source: Pharmacology Biochemistry and Behavior - October 20, 2019 Category: Biochemistry Source Type: research

Editorial Board
Publication date: November 2019Source: Pharmacology Biochemistry and Behavior, Volume 186Author(s): (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - October 16, 2019 Category: Biochemistry Source Type: research

Strain differences in muscarinic cholinergic receptor antagonism of fat intake and acquisition and expression of fat-conditioned flavor preferences in male BALB/c, C57BL/6 and SWR mice
Publication date: Available online 5 October 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Ben Iskhakov, Petra Dohnalova, Julia Iskhakova, Tatjana Mustac, Asnat Yuabov, Jason Macanian, Emanuel Israel, Nicole Locurto, Nicole Franz, Gabriela Fazilov, Merna Shenouda, Richard J. BodnarAbstractMurine strain differences occur for both intakes of and preferences for sugars and fats. Previous studies demonstrated that the muscarinic cholinergic receptor antagonist, scopolamine (SCOP) more potently reduced sucrose and saccharin intakes in inbred C57BL/6 and BALB/c than SWR mice, sucrose-conditioned flavor preferences...
Source: Pharmacology Biochemistry and Behavior - October 6, 2019 Category: Biochemistry Source Type: research