Cocaine-induced behavioral sensitization is greater in adolescent than in adult mice and heightens cocaine-induced conditioned place preference in adolescents
Publication date: Available online 18 April 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Rosana Camarini, Lucas Barbosa Hoffmann, Andrea Suarez, Mariana Rae, Tania Marcourakis, Ricardo Marcos PautassiAbstractAdolescents are more sensitive than adults to the neural and behavioral effects of psychostimulants, and exhibit greater vulnerability to drug abuse, dependence or relapse into these conditions. We have reported that cocaine pretreatment during adolescence promotes the expression of behavioral sensitization to a greater extent than when the pretreatment occurs at adulthood. Behavioral sensitization has ...
Source: Pharmacology Biochemistry and Behavior - April 19, 2019 Category: Biochemistry Source Type: research

The adrenergic receptor antagonist carvedilol interacts with serotonin 2A receptors both in vitro and in vivo
Publication date: Available online 15 April 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Kevin Sean Murnane, Osman F. Guner, J. Phillip Bowen, Kalyn M. Rambacher, Nader H. Moniri, Tyler J. Murphy, Cedrick Maceo Daphney, Aboagyewaah Oppong-Damoah, Kenner C. RiceAbstractThere is increasing support for the potential clinical use of compounds that interact with serotonin 2A (5-HT2A) receptors. It is therefore of interest to discover novel compounds that interact with 5-HT2A receptors. In the present study, we used computational chemistry to identify critical ligand structural features of 5-HT2A receptor binding...
Source: Pharmacology Biochemistry and Behavior - April 16, 2019 Category: Biochemistry Source Type: research

Sex differences in the effect of bupropion and naltrexone combination on alcohol drinking in mice
Publication date: Available online 13 April 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Yan Zhou, Francesco Leri, Malcolm J. Low, Mary Jeanne KreekAbstractA fixed dose combination of bupropion (BPP) and naltrexone (NTX), Contrave®, is an FDA approved pharmacotherapy for the treatment of obesity. A recent study found that combining BPP with low-dose NTX reduced alcohol drinking in alcohol-preferring male rats. To explore potential pharmacological effects of the BPP + NTX combination on alcohol drinking, both male and female C57Bl/6J mice were tested on one-week drinking-in-the dark (DID) and three-w...
Source: Pharmacology Biochemistry and Behavior - April 14, 2019 Category: Biochemistry Source Type: research

Exploring the interoceptive stimulus effects of nicotine and varenicline
Publication date: June 2019Source: Pharmacology Biochemistry and Behavior, Volume 181Author(s): Brady M. Thompson, Scott T. Barrett, Rick A. BevinsAbstractLearning processes associated with nicotine influence the development of addiction to tobacco products. In the present report, we are interested in the interoceptive stimulus effects of nicotine acquiring control over appetitive behaviors – specifically, reward seeking. Also of interest is the current smoking cessation drug, varenicline (Chantix®). Varenicline, with its nicotine-like stimulus effects, can decrease withdrawal and cravings for a subset of individ...
Source: Pharmacology Biochemistry and Behavior - April 11, 2019 Category: Biochemistry Source Type: research

The neonatal treatment with clomipramine decreases sexual motivation and increases estrogen receptors expression in the septum of male rats: Effects of the apomorphine
The objective of this study was to analyze the effect of a non-selective dopamine agonist (apomorphine) on sexual incentive motivation in rats exposed to clomipramine (CMI) in the neonatal period. In addition, we evaluated the expression of mRNA ERα and ERβ in nucleus accumbens (NAcc) and septum of CMI rats. We found that only a few rats subjected to neonatal CMI treatment performed mounts, intromissions and ejaculations. Also, those rats spent less time exploring the sexual incentive zone and had lower preference scores; this effect was reverted by administering 0.1 mg/kg of apomorphine. Finally, the CMI rats...
Source: Pharmacology Biochemistry and Behavior - April 11, 2019 Category: Biochemistry Source Type: research

Comparison of the effects of 1MeTIQ and olanzapine on performance in the elevated plus maze test and monoamine metabolism in the brain after ketamine treatment
Publication date: Available online 6 April 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Agnieszka Wąsik, Magdalena Białoń, Marcelina Żarnowska, Lucyna Antkiewicz-MichalukAbstractAnxiety is a common symptom of schizophrenia. Ketamine, which acts as a noncompetitive antagonist of glutamatergic NMDA receptors by binding to the phencyclidine site, may induce schizophrenia-like symptoms and promote anxiogenic-like behaviour. The symptoms of anxiety in rodents can be measured by the elevated plus maze (EPM) test. 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), as a neuroprotective and antiaddictive substanc...
Source: Pharmacology Biochemistry and Behavior - April 7, 2019 Category: Biochemistry Source Type: research

Exploring the interoceptive-stimulus effects of nicotine and varenicline
Publication date: Available online 4 April 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Brady M. Thompson, Scott T. Barrett, Rick A. BevinsAbstractLearning processes associated with nicotine influence the development of addiction to tobacco products. In the present report, we are interested in the interoceptive stimulus effects of nicotine acquiring control over appetitive behaviors – specifically, reward seeking. Also of interest is the current smoking cessation drug, varenicline (Chantix®). Varenicline, with its nicotine-like stimulus effects, can decrease withdrawal and cravings for a subset of...
Source: Pharmacology Biochemistry and Behavior - April 5, 2019 Category: Biochemistry Source Type: research

Interoceptive awareness is associated with acute alcohol-induced changes in subjective effects
Publication date: Available online 1 April 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Mateo Leganes-Fonteneau, Yun Cheang, Yan Lam, Sarah Garfinkel, Theodora DukaAbstractInteroception, the sensing of bodily signals, is related to emotional reactivity and may contribute to the pathophysiology of addiction. Evidence is accumulating that individuals with alcohol use disorders and other substance-dependences show altered interoceptive processing, however little is known about the acute effects of alcohol on interoception and how this may influence the perception of drug induced effects.In a double-blind desig...
Source: Pharmacology Biochemistry and Behavior - April 2, 2019 Category: Biochemistry Source Type: research

Prolonged exposure of rats to varenicline increases anxiety and alters serotonergic system, but has no effect on memory
In conclusion, compilation of the data indicates that prolonged exposure of rats to varenicline promoted anxiogenic effects and alteration in serotonergic system, which corroborated behavioral findings. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - April 2, 2019 Category: Biochemistry Source Type: research

Single nucleotide polymorphisms, variable number tandem repeats and allele influence on serotonergic enzyme modulators for aggressive and suicidal behaviors: A review
This article mainly reviews studies on the relationship between 5-HT transmissions and genetic variations involved in aggression (particularly impulsive aggression) or suicide in people with different ethnicities and psychiatric disorders. We found that most SNPs, VNTRs, and alleles exerted influences on aggression or suicide. Only A128C in TPH1, A138G in 5-HT2A, and L type in the VNTR of monoamine oxidase A (MAOA) affected both aggression and suicide. The associations between some genetic variations and aggression/suicide may be influenced by gender, age, ethnicity, psychiatric disease, and even parenting or prenatal stre...
Source: Pharmacology Biochemistry and Behavior - March 28, 2019 Category: Biochemistry Source Type: research

Cannabinoids, interoception, and anxiety
Publication date: Available online 25 March 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Allyson K. Andrade, Briana Renda, Jennifer E. MurrayAbstractThe use of cannabis is rapidly gaining legal status across North America. Such dramatic legislative shifts have prompted an urgency in elucidating the stimulus effects of cannabis consumption. Cannabis use, though relatively safe compared to other drugs of abuse, has been associated with greater risk of mental health disorders, possibly via its primary psychoactive constituent, Δ-9-tetrahydrocannabinol (THC). In this review, we discuss endocannabinoid act...
Source: Pharmacology Biochemistry and Behavior - March 26, 2019 Category: Biochemistry Source Type: research

Editorial Board
Publication date: April 2019Source: Pharmacology Biochemistry and Behavior, Volume 179Author(s): (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - March 25, 2019 Category: Biochemistry Source Type: research

The neonatal treatment with clomipramina decreases sexual motivation and increases estrogen receptors expression in the septum of male rats: Effects of the apomorphine
Publication date: Available online 22 March 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Tania Molina-Jiménez, Martín Jiménez-Tlapa, Malinalli Brianza-Padilla, Rossana Citlali Zepeda, Marisela Hernández-González, Herlinda Bonilla-JaimeAbstractAdministering clomipramine during the early days of life induced several behavioral and neurochemical alterations in adult male rats, which resemble major depression disorder. The alterations affected sexual performance, which is considered a reward-seeking behavior regulated by the dopaminergic system. Given that estrogen receptors a...
Source: Pharmacology Biochemistry and Behavior - March 22, 2019 Category: Biochemistry Source Type: research

Reversal effect of Riparin IV in depression and anxiety caused by corticosterone chronic administration in mice
Publication date: Available online 20 March 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Raquell de Castro Chaves, Auriana Serra Vasconcelos Mallmann, Natália Ferreira Oliveira, Iris Cristina Maia Oliveira, Victor Celso Cavalcanti Capibaribe, Daniel Moreira Alves da Silva, Iardja Stéfane Lopes, José Tiago Valentim, Alyne Mara Rodrigues de Carvalho, Danielle Silveira Macêdo, Silvânia Maria Mendes Vasconcelos, Stanley Juan Chaves Gutierrez, José Maria Barbosa Filho, Francisca Cléa Florenço de SousaAbstractMental disorders have a multifactorial etiology and...
Source: Pharmacology Biochemistry and Behavior - March 21, 2019 Category: Biochemistry Source Type: research

5-HT2A receptors modulate dopamine D2-mediated maternal effects
Publication date: Available online 21 March 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Jun Gao, Leilei Chen, Ming LiAbstractSerotonin 5-HT2A receptors are expressed throughout the mesolimbic and mesocortical dopamine pathways, and manipulation of this receptor system has a profound impact on dopamine functions and dopamine-mediated behaviors. It is highly likely that 5-HT2A receptors may also modulate the D2-mediated maternal effects. The present study investigated this issue and also explored the possible behavioral mechanisms. We tested the effects of two D2 drugs (an agonist quinpirole: 0.5, 1.0 mg/k...
Source: Pharmacology Biochemistry and Behavior - March 21, 2019 Category: Biochemistry Source Type: research

Simvastatin exerts antidepressant-like activity in mouse forced swimming test: Role of NO-cGMP-KATP channels pathway and PPAR-gamma receptors
Publication date: Available online 8 March 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Reza Naserzadeh, Niloofar Abad, Behnam Ghorbanzadeh, Mojtaba Dolatshahi, Mohammad Taghi MansouriAbstractSimvastatin, one of the lipophilic statins, has been shown to be effective in reducing depression in rodents. The present study aimed to investigate the potential antidepressant-like activity of simvastatin and the possible involvement of NO-cGMP-KATP channels pathway and PPARγ using forced swimming test (FST) in mice. In addition, the interaction between simvastatin and fluoxetine as a reference drug was examine...
Source: Pharmacology Biochemistry and Behavior - March 8, 2019 Category: Biochemistry Source Type: research

GABAB receptors modulate morphine antinociception: Pharmacological and genetic approaches
Publication date: Available online 6 March 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Valeria T. Pedrón, Andrés P. Varani, Bernhard Bettler, Graciela N. BalerioAbstractPrevious studies in our laboratory showed an interaction between the GABAergic and opioid systems involved in the analgesic effect of baclofen (BAC). Furthermore, it is known that sex differences exist regarding various pharmacological responses of morphine (MOR) and they are related to an increased sensitivity to MOR effects in males. The aims of the present study were to evaluate the possible involvement of the GABAB recepto...
Source: Pharmacology Biochemistry and Behavior - March 8, 2019 Category: Biochemistry Source Type: research

Multivariate pattern analysis of the neural correlates of smoking cue attentional bias
Publication date: Available online 5 March 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Amanda Elton, Vicki W. Chanon, Charlotte A. BoettigerAbstractThe automatic capture of attention by drug cues, or attentional bias, is associated with craving and predicts future drug use. Despite its clinical significance, the neural bases of attentional bias to drug cues is not well understood. To address this gap, we undertook a neuroimaging investigation of the neural correlates of attentional bias towards smoking cues. Twenty-nine adults, including 14 active smokers and 15 non-smokers, completed a spatial cuing task ...
Source: Pharmacology Biochemistry and Behavior - March 5, 2019 Category: Biochemistry Source Type: research

The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats
Publication date: Available online 27 February 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): J.M. Witkin, R. Cerne, P.G. Davis, K.B. Freeman, J.M. do Carmo, J.K. Rowlett, K.R. Methuku, A. Okun, S.D. Gleason, X. Li, M.J. Krambis, M. Poe, G. Li, J.M. Schkeryantz, R. Jahan, L. Yang, W. Guo, L.K. Golani, W.H. Anderson, J.T. CatlowAbstractClinical evidence indicates that positive allosteric modulators (PAMs) of GABAA receptors have analgesic benefit in addition to efficacy in anxiety disorders. However, the utility of GABAA receptor PAMs as analgesics is compromised by the central nervous system side effects of n...
Source: Pharmacology Biochemistry and Behavior - February 28, 2019 Category: Biochemistry Source Type: research

Morphine administered post-trial can induce potent conditioned morphine effects
Publication date: Available online 27 February 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Lucas Rangel de Oliveira, Breno Garone dos Santos, João Marcos de Mello Bastos, Richard Ian Samuels, Robert J. Carey, Marinete Pinheiro CarreraAbstractMorphine has substantial pro-dopamine effects and in rodents, this is expressed in behavior as increased locomotor activation. Here we administered post-trial 3 dose levels of morphine (3.0, 5.0 and 10.0 mg/kg) or vehicle either immediately or after a 15 min delay to different groups of rats following a brief (5 min) exposure to a novel test environment. T...
Source: Pharmacology Biochemistry and Behavior - February 27, 2019 Category: Biochemistry Source Type: research

Acute effect of vaporized Cannabis on sleep and electrocortical activity
In conclusion, administration of low doses of THC by vaporization of a specific type of Cannabis produced a small increment of NREM sleep, but only during the light (resting) phase. This was accompanied by subtle modifications of high frequency bands power (during the light phase) and spindle coherence (during the dark phase), which are associated with cognitive processing. Our results reassure the importance of exploring the sleep-promoting properties of Cannabis. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - February 26, 2019 Category: Biochemistry Source Type: research

Dose dependent behavioral effects of acute alcohol administration in zebrafish fry
Publication date: Available online 23 February 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Benjamin Tsang, Rida Ansari, Robert GerlaiAbstractThe zebrafish is becoming increasingly utilized in behavioral neuroscience as it appears to strike a good compromise between practical simplicity and system complexity. Particularly in alcohol (ethanol) research, the zebrafish has been employed as a translationally relevant model organism. However, the majority of studies investigating the effects of alcohol on brain function and behavior has used adult zebrafish. In the current study, we utilize 6–8 post-fertil...
Source: Pharmacology Biochemistry and Behavior - February 25, 2019 Category: Biochemistry Source Type: research

The serotonin-2C agonist Lorcaserin delays intravenous choice and modifies the subjective and cardiovascular effects of cocaine: A randomized, controlled human laboratory study
ConclusionsCombined treatment with cocaine and lorcaserin was safe in a limited number of subjects, but did not diminish cocaine-motivated behavior or drug-induced ‘high’. Some positive subjective effects of cocaine were enhanced by lorcaserin, and it delayed intravenous choices and decreased craving under some conditions. Effects on heart rate depended on the type of reinforcer being self-administered.Trial registrationclinicaltrials.gov Identifier, NCT02680288. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - February 25, 2019 Category: Biochemistry Source Type: research

Examination of the Gateway Hypothesis in a rat model
Publication date: Available online 21 February 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Kathryn E. Eklund, Kevin S. Nishida, Erin S. Barry, Kwang H. Choi, Neil E. GrunbergAbstractThe Gateway Hypothesis is based on epidemiological data and states there is a progression of drug use from use of a softer drug (e.g., nicotine) to use of a harder drug (e.g., morphine). It has been suggested that this sequence is causal and is relevant to drug prevention policies and programs. The present experiment used an animal model to investigate whether the Gateway Hypothesis involves a causal progression. Subjects were ...
Source: Pharmacology Biochemistry and Behavior - February 22, 2019 Category: Biochemistry Source Type: research

Compulsive methamphetamine taking and abstinence in the presence of adverse consequences: Epigenetic and transcriptional consequences in the rat brain
Publication date: Available online 21 February 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Jean Lud Cadet, Ravish Patel, Subramaniam JayanthiAbstractMethamphetamine addiction is characterized by compulsive binges of drug intake despite adverse life consequences. A model of methamphetamine self-administration that includes contingent footshocks to constitute adverse consequences has helped to segregate rats that reduce or stop lever pressing for methamphetamine (sensitive) from those that continue to lever press for the drug (resistant) in the presence of negative outcomes.We have observed differential DNA ...
Source: Pharmacology Biochemistry and Behavior - February 22, 2019 Category: Biochemistry Source Type: research

Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats
Publication date: Available online 19 February 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Amir H. Rezvani, Corinne Wells, Susan Slade, Yingxian Xiao, Kenneth J. Kellar, Edward D. LevinAbstractSazetidine-A selectively desensitizes α4β2 nicotinic receptors and also has partial agonist effects. We have shown that subcutaneous acute and repeated injections as well as chronic infusions of sazetidine-A significantly reduce intravenous (IV) nicotine self-administration in rats. To further investigate the promise of sazetidine-A as a smoking cessation aid, it is important to determine sazetidine-A effe...
Source: Pharmacology Biochemistry and Behavior - February 20, 2019 Category: Biochemistry Source Type: research

Enrichment-induced differences in methamphetamine drug discrimination in male rats
Publication date: Available online 20 February 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Nicole M. Chacho, Emily Adams, Dustin J. StairsAbstractRats raised in an enriched environment show a decrease in sensitivity to the subjective effects of the psychostimulant d-amphetamine. The purpose of the present study was to determine if environmental enrichment during development alters the subjective effects of the more commonly abused drug methamphetamine. Male Sprague-Dawley rats were raised in either an enriched (EC) or an isolated condition (IC). EC and IC rats were trained on a two-lever operant procedure ...
Source: Pharmacology Biochemistry and Behavior - February 20, 2019 Category: Biochemistry Source Type: research

Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities
Publication date: Available online 17 February 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Ana Lúcia Bertarello Zeni, Anderson Camargo, Ana Paula DalmagroAbstractDepression is a neuropsychiatry medical condition with high prevalence, in which the hypothalamic-pituitary-adrenal axis dysfunction has been postulated as the main cause. The glucocorticoids can be harmful to the brain, particularly by induction of oxidative stress and glutamatergic damage, therefore antioxidants or neuroprotective agents could have beneficial effects. Lutein (LUT) is a dietary xanthophyll able to arrive in the brain that ...
Source: Pharmacology Biochemistry and Behavior - February 18, 2019 Category: Biochemistry Source Type: research

Editorial Board
Publication date: March 2019Source: Pharmacology Biochemistry and Behavior, Volume 178Author(s): (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - February 17, 2019 Category: Biochemistry Source Type: research

The importance and depth of reproducibility in rodent models of psychiatric diseases
Publication date: March 2019Source: Pharmacology Biochemistry and Behavior, Volume 178Author(s): Jared W. Young, Haim Einat (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - February 17, 2019 Category: Biochemistry Source Type: research

Anxiogenic-like behavior and deficient attention/working memory in rats expressing the human DISC1 gene
Publication date: Available online 16 February 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): An-Li Wang, Owen Y. Chao, Yi-Mei Yang, Svenja V. Trossbach, Christian P. Müller, Carsten Korth, Joseph P. Huston, Maria Angelica de Souza SilvaAbstractIn humans, mutations in the Disrupted-in-schizophrenia 1 (DISC1) gene have been related to psychiatric disorders, including symptoms of abnormal cognitive and emotional behaviors. In our previous studies, overexpression of the human DISC1 gene in rats resulted in schizophrenia-like phenotypes showing deficits in motor learning, impaired cognitive function and dysf...
Source: Pharmacology Biochemistry and Behavior - February 16, 2019 Category: Biochemistry Source Type: research

Evaluation of SYA16263 as a new potential antipsychotic agent without catalepsy
Publication date: Available online 12 February 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Barbara A. Bricker, Kwame Peprah, Hye J. Kang, S.Y. AblordeppeyAbstractSYA16263 exhibited moderate radioligand binding affinity at the D2 receptor and produced inhibition of apomorphine-induced climbing behavior in mice with an ED50 value of 3.88 mg/kg IP, predicting potential antipsychotic effects in humans.Analysis of plasma and brains from rats injected IP with SYA16263 over the course of 24 h revealed a log [brain]/[plasma] (log BB) at Cmax observed equal to 1.08, indicating that SYA16263 enters the brain and...
Source: Pharmacology Biochemistry and Behavior - February 12, 2019 Category: Biochemistry Source Type: research

Discriminative stimulus effects of mecamylamine and nicotine in rhesus monkeys: Central and peripheral mechanisms
Publication date: Available online 6 February 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Colin S. Cunningham, Megan J. Moerke, Lance R. McMahonAbstractMecamylamine is a non-competitive nicotinic acetylcholine receptor (nAChR) antagonist that has been prescribed for hypertension and as an off-label smoking cessation aid. Here, we examined pharmacological mechanisms underlying the interoceptive effects (i.e., discriminative stimulus effects) of mecamylamine (5.6 mg/kg s.c.) and compared the effects of nAChR antagonists in this discrimination assay to their capacity to block a nicotine discriminative stimu...
Source: Pharmacology Biochemistry and Behavior - February 7, 2019 Category: Biochemistry Source Type: research

Responses to positive and aversive stimuli in estrous female rats housed in a seminatural environment: Effects of yohimbine and chlordiazepoxide
Publication date: Available online 5 February 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Olivia Le Moëne, Anders ÅgmoAbstractThe behavioral effects of putative anxiolytic and anxiogenic drugs are usually evaluated in highly standardized tests. Here, we determined the effects of such drugs in rats housed in mixed sex groups in a seminatural environment. Sexually receptive female Wistar rats were treated with either the anxiolytic drug chlordiazepoxide (2 mg/kg), the anxiogenic drug yohimbine (1 mg/kg), or saline (1 ml/kg). Different emotional challenges eliciting purportedly positive affec...
Source: Pharmacology Biochemistry and Behavior - February 6, 2019 Category: Biochemistry Source Type: research

Exogenous progesterone for cannabis withdrawal in women: Feasibility trial of a novel multimodal methodology
Publication date: Available online 31 January 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Brian J. Sherman, Margaret A. Caruso, Aimee L. McRae-ClarkAbstractBackgroundSex differences in cannabis use disorder (CUD) and its treatment have been identified. Women report more severe withdrawal and have shown worse treatment outcomes. Ovarian hormones are implicated in these differences and research suggests that exogenous progesterone may be an effective pharmacotherapy.MethodsThe current randomized, placebo-controlled, feasibility trial tested a novel multimodal methodology for administering exogenous progester...
Source: Pharmacology Biochemistry and Behavior - February 1, 2019 Category: Biochemistry Source Type: research

The light-dark task in zebrafish confuses two distinct factors: Interaction between background shade and illumination level preference
Publication date: Available online 27 January 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Amanda Facciol, Mahrukh Iqbal, Aishwarya Eada, Steven Tran, Robert GerlaiAbstractThe light-dark preference task has been commonly used in rodents to screen for anxiogenic and anxiolytic drugs. However, recent adaptations of the light-dark preference test for zebrafish have produced inconsistent results. Several studies have reported that zebrafish exhibit a preference for light, while others have found a preference for black. We suggest the inconsistencies may be the result of confusing certain parameters of the test ...
Source: Pharmacology Biochemistry and Behavior - January 27, 2019 Category: Biochemistry Source Type: research

Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies
Publication date: Available online 26 January 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Milky Kohno, Jeanne Link, Laura E. Dennis, Holly McCready, Marilyn Huckans, William F. Hoffman, Jennifer M. LoftisAbstractAddiction is a worldwide public health problem and this article reviews scientific advances in identifying the role of neuroinflammation in the genesis, maintenance, and treatment of substance use disorders. With an emphasis on neuroimaging techniques, this review examines human studies of addiction using positron emission tomography to identify binding of translocator protein (TSPO), which is upre...
Source: Pharmacology Biochemistry and Behavior - January 26, 2019 Category: Biochemistry Source Type: research

Effects of nicotine conditioning history on alcohol and methamphetamine self-administration in rats
ConclusionsIn female, but not male rats, an appetitive conditioning history with nicotine decreases methamphetamine, but not alcohol, self-administration. This dissociation suggests that the effects may be due to a specific increase in the reinforcing value of methamphetamine. This may have implications for better understanding the progression of drug use from nicotine to methamphetamine. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - January 20, 2019 Category: Biochemistry Source Type: research

Editorial Board
Publication date: February 2019Source: Pharmacology Biochemistry and Behavior, Volume 177Author(s): (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - January 18, 2019 Category: Biochemistry Source Type: research

Chronic unpredictable mild stress accelerates lipopolysaccharide- induced microglia activation and damage of dopaminergic neurons in rats
In this study, in vivo experiments are used to evaluate the effects of CUMS on lipopolysaccharide (LPS)-induced microglia activation and NLRP3 inflammasome activation. The results showed that CUMS pretreatment for 14 days significantly aggravated the behavioral dysfunction of PD rats, increased the activation of microglia. Pretreatment with CUMS for 14 days increased the levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-a (TNF-a) in the serum, and increased the expression of NLRP-3, ASC, Casepase-1 in the substantia nigra of PD rats. Our data showed that pretreatment with CUMS ...
Source: Pharmacology Biochemistry and Behavior - January 16, 2019 Category: Biochemistry Source Type: research

Effects of chronic lithium exposure in a modified rodent ketamine-induced hyperactivity model of mania
Publication date: Available online 16 January 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Jacob T. Krug, Adam K. Klein, Erin M. Purvis, Kathy Ayala, Matthew S. Mayes, Lisette Collins, Matthew P.A. Fisher, Aaron EttenbergAbstractBipolar illness is characterized by periods of “mania” — high energy, irritability, and increased psychomotor activation. While the neurobiological investigation of mania has been limited by the lack of reliable animal models, researchers have recently reported that daily subanesthetic doses of ketamine produce a lithium-reversible increase in rodent locomotor acti...
Source: Pharmacology Biochemistry and Behavior - January 16, 2019 Category: Biochemistry Source Type: research

Increased BDNF-TrkB signaling in the nucleus accumbens plays a role in the risk for psychosis after cannabis exposure during adolescence
In this study, we examined whether brain-derived neurotrophic factor (BDNF) and its receptor TrkB signaling plays a role in the risk for psychosis after exposure of cannabinoid (CB) receptor agonist during adolescence. Repeated administration of the CB receptor agonist WIN55,212-2 (2 mg/kg/day) during adolescence (P35 – P45) significantly increased methamphetamine (METH: 1 mg/kg)-induced hyperlocomotion in adulthood (P70 – P74) compared with vehicle-treated mice. Western blot analysis showed that BDNF-TrkB signaling in the nucleus accumbens (NAc) of WIN55,212-2-treated mice were significantly higher than th...
Source: Pharmacology Biochemistry and Behavior - January 15, 2019 Category: Biochemistry Source Type: research

Amantadine enhances nigrostriatal and mesolimbic dopamine function in the rat brain in relation to motor and exploratory activity
ConclusionsResults showed reductions of D2/3R binding in regions of the nigrostriatal and mesolimbic system after challenge with AMA, which reflect an increased availability of dopamine. Thereby, an inverse relationship between nigrostriatal and mesolimbic dopamine and motor/exploratory activity can be inferred. Findings may be relevant for the treatment of neurological and psychiatric conditions such as Parkinson's disease, Huntington's disease or schizophrenia, which are characterized by both dopaminergic and glutamatergic dysfunction. (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - January 11, 2019 Category: Biochemistry Source Type: research

BDNF-TrkB signaling in the nucleus accumbens plays a role in the risk for psychosis after cannabis exposure during adolescence
In this study, we examined whether brain-derived neurotrophic factor (BDNF) and its receptor TrkB signaling plays a role in the risk for psychosis after exposure of cannabinoid (CB) receptor agonist during adolescence. Repeated administration of the CB receptor agonist WIN55,212-2 (2 mg/kg/day) during adolescence (P35 – P45) significantly increased methamphetamine (METH: 1 mg/kg)-induced hyperlocomotion in adulthood (P70 – P74) compared with vehicle-treated mice. Western blot analysis showed that BDNF-TrkB signaling in the nucleus accumbens (NAc) of WIN55,212-2-treated mice were significantly higher than th...
Source: Pharmacology Biochemistry and Behavior - January 9, 2019 Category: Biochemistry Source Type: research

Editorial Board
Publication date: January 2019Source: Pharmacology Biochemistry and Behavior, Volume 176Author(s): (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - January 6, 2019 Category: Biochemistry Source Type: research

Retraction notice to “Dopamine Ds3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors” [Pharmacology, Biochemistry and Behavior 171 (2018) 46–53]
Publication date: January 2019Source: Pharmacology Biochemistry and Behavior, Volume 176Author(s): Gregory L. Powell, John Paul Bonadonna, Annika Vannan, Kuiying Xu, Robert H. Mach, Robert R. Luedtke, Janet L. Neisewander (Source: Pharmacology Biochemistry and Behavior)
Source: Pharmacology Biochemistry and Behavior - January 6, 2019 Category: Biochemistry Source Type: research

Effects of caffeine ingestion on the diurnal variation of cognitive and repeated high-intensity performances
Publication date: Available online 3 January 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Youssef Souissi, Makram Souissi, Hamdi ChtourouAbstractThe purpose of this study was to evaluate the effects of caffeine ingestion on the daily variation of cognitive (i.e., reaction time (RT), attention) and repeated high-intensity exercise performances.Fifteen active males (age: 20 ± 1 years, height: 174.3 ± 4.3 cm, body-mass: 70.8 ± 3.5 kg) performed cognitive and physical tasks under two different circumstances [after a placebo or caffeine ingestion (6 mg/kg of body-mass)] a...
Source: Pharmacology Biochemistry and Behavior - January 4, 2019 Category: Biochemistry Source Type: research

CB1 positive allosteric modulation attenuates Δ9-THC withdrawal and NSAID-induced gastric inflammation
Publication date: Available online 28 December 2018Source: Pharmacology Biochemistry and BehaviorAuthor(s): K.R. Trexler, M.L. Eckard, S.G. KinseyAbstractRecently, multiple compounds have been synthesized that target the allosteric binding site(s) of CB1. These CB1 positive allosteric modulators, may capture the benefits of cannabinoid receptor activation without unwanted psychoactive effects, such as sedation. For example, ZCZ011 blocks neuropathic pain, absent the catalepsy, sedation, and hypothermia caused by CB1 orthosteric modulators, including Δ9-tetrahydrocannabinol (THC). The primary goal of the present study...
Source: Pharmacology Biochemistry and Behavior - December 29, 2018 Category: Biochemistry Source Type: research

Revisiting inflammation in bipolar disorder
Publication date: Available online 24 December 2018Source: Pharmacology Biochemistry and BehaviorAuthor(s): Gabriel R. Fries, Consuelo Walss-Bass, Moises E. Bauer, Antonio L. TeixeiraAbstractBipolar disorder (BD) has been associated with immune changes, and yet their underlying mechanisms are still not fully understood. Here, we review the current state of the field, concerning the inflammatory alterations observed in the periphery and in the central nervous system, followed by a discussion of potential underlying mechanisms. We focus mainly on recently proposed mechanisms including the role of the gut-brain axis, the rele...
Source: Pharmacology Biochemistry and Behavior - December 24, 2018 Category: Biochemistry Source Type: research

Neuroimmune signaling in alcohol use disorder
Publication date: Available online 24 December 2018Source: Pharmacology Biochemistry and BehaviorAuthor(s): Emma K. Erickson, Emily K. Grantham, Anna S. Warden, R. Adron HarrisAbstractAlcohol use disorder (AUD) is a widespread disease with limited treatment options. Targeting the neuroimmune system is a new avenue for developing or repurposing effective pharmacotherapies. Alcohol modulates innate immune signaling in different cell types in the brain by altering gene expression and the molecular pathways that regulate neuroinflammation. Chronic alcohol abuse may cause an imbalance in neuroimmune function, resulting in prolo...
Source: Pharmacology Biochemistry and Behavior - December 24, 2018 Category: Biochemistry Source Type: research