Histamine H 1 receptor occupancy by the new-generation antipsychotics olanzapine and quetiapine: a positron emission tomography study in healthy volunteers

Conclusions Olanzapine and quetiapine have high H1RO values in the human brain under their clinical minimum doses. This study provides a foundation of the properties by which new-generation antipsychotics block the central histaminergic system in humans.

http://link.springer.com/10.1007/s00213-015-4002-2

Source: Psychopharmacology - July 7, 2015 Category: Psychiatry Source Type: research