Safranal exerts a neuroprotective effect on Parkinson's disease with suppression of NLRP3 inflammation activation
CONCLUSIONS: Safranal played a neuroprotective effect on the Parkinson's disease and its mechanism was related to the inhibition of NLRP3 inflammasome activation.PMID:38683404 | PMC:PMC11059006 | DOI:10.1007/s11033-024-09537-y (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Wenping Yang Yongyue Wei Jin Sun Caixia Yao Fen Ai Haixia Ding Source Type: research
Glycosides constituents from < em > Codonopsis pilosula < /em >
Nat Prod Res. 2024 Apr 29:1-4. doi: 10.1080/14786419.2024.2344738. Online ahead of print.ABSTRACTA new glycoside (1) along with six known analogues (1-7) were isolated from Codonopsis pilosula collected at Shanxi in China. The structure of 1 was established based on comprehensive spectroscopic data and literature comparison. The anti-inflammatory effects of isolated compounds were further investigated in LPS-induced RAW264.7 macrophage.PMID:38684008 | DOI:10.1080/14786419.2024.2344738 (Source: Natural Product Research)
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Yan-Gang Cheng Si-Qi Yang Pei Li Yan Wang Hui-Feng Li Xiang-Peng Kong Jin-Yan Tan Ying-Li Wang Source Type: research
Alkaloids from < em > Zanthoxylum nitidum < /em > and their anti-proliferative activity against A549 cells by regulating the EGFR/AKT/mTOR pathway
Nat Prod Res. 2024 Apr 29:1-7. doi: 10.1080/14786419.2024.2347463. Online ahead of print.ABSTRACTZanthoxylum nitidum is frequently used as a traditional Chinese medicine and food supplement. Our previous study revealed that its constituent compounds were able to inhibit cancer cell proliferation. In our continuous exploration of bioactive compounds in Z. nitidum, we isolated ten alkaloids (1-10), including one new natural compound (1), and nine known alkaloids (2-10), from an ethanolic extract of the whole plant. The chemical structures were elucidated based on a combination of comprehensive NMR and HRESIMS analyses. Compo...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Fan-Fan Wang Ping-Fang Tao Yu-Jun Zhong Yun-Qiong Gu Cai Yi Wang Feng Qin Source Type: research
Lactic Acid Chemical Peeling in Skin Disorders
Clin Cosmet Investig Dermatol. 2024 Apr 23;17:901-909. doi: 10.2147/CCID.S455700. eCollection 2024.ABSTRACTLactic acid is the most widely occurring natural organic acid in nature. It not only exhibits mild and safe properties but also possesses multiple physiological activities, such as antibacterial effects, immune regulation, and promotion of wound healing, making it one of the most popular chemical peeling agents. Chemical peels are commonly used in the field of aesthetic dermatology as a non-invasive therapeutic approach. This research aims to provide valuable references for clinical dermatologists by summarizing the c...
Source: Clinical, Cosmetic and Investigational Dermatology - April 29, 2024 Category: Dermatology Authors: Xiaoyue Feng Jianli Shang Zhengping Gu Xingyi Luo Yong Chen Youting Liu Source Type: research
On the Relationship between MMA Levels in Blood Products and Donor Sex, Age, and Donation Frequency
J Nutr Sci Vitaminol (Tokyo). 2024;70(2):124-130. doi: 10.3177/jnsv.70.124.ABSTRACTAs the aging process accelerates, the age structure of blood donors turns to older and even aged groups. Methylmalonic acid (MMA), a byproduct of propionate metabolism, may be upregulated in the serum of older adults. As a mediator of chronic disease and tumor progression, the MMA content in blood products has become the focus of research. Absolute concentrations of MMA in blood products were determined based on the liquid chromatography-tandem mass spectrometry, so as to analyze how they were affected by donors' age, sex, and frequency of b...
Source: Journal of Nutritional Science and Vitaminology - April 29, 2024 Category: Nutrition Authors: Fei Li Aiwei Zhu Caixia Huang Hui Guo Lingling Zhu Hua Zhuang Suochun Cao Source Type: research
Antioxidant and anti ‑inflammatory effects of esculin and esculetin (Review)
Exp Ther Med. 2024 Apr 12;27(6):248. doi: 10.3892/etm.2024.12536. eCollection 2024 Jun.ABSTRACTFraxinus chinensis Roxb is a deciduous tree, which is distributed worldwide and has important medicinal value. In Asia, the bark of Fraxinus chinensis Roxb is a commonly used traditional Chinese medicine called Qinpi. Esculetin is a coumarin compound derived from the bark of Fraxinus chinensis Roxb and its glycoside form is called esculin. The aim of the present study was to systematically review relevant literature on the antioxidant and anti-inflammatory effects of esculetin and esculin. Esculetin and esculin can promote the ex...
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Shaohua Ju Youli Tan Qiang Wang Ling Zhou Kun Wang Chenghong Wen Mingjian Wang Source Type: research
Rapid discrimination of geographical origin of garlic (Allium sativum L.): A metabolomic approach applied to paper spray mass spectrometry data
CONCLUSION: Hence, this combined strategy holds promise not only as an effective tool for the authentication of the geographical origin of garlic but also as a powerful means for biomarker discovery.PMID:38682308 | DOI:10.1002/rcm.9743 (Source: Rapid Communications in Mass Spectrometry : RCM)
Source: Rapid Communications in Mass Spectrometry : RCM - April 29, 2024 Category: Chemistry Authors: Victor Dos Santos Azevedo Leite Brena Rodrigues Mota Ikehara Nat ália Reis de Almeida Rodinei Augusti Frederico Garcia Pinto Source Type: research
Current status of liver transplantation for human immunodeficiency virus-infected patients in mainland China
This study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation (LT) in mainland China. To date, our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV, and all but one, who died two months postoperatively due to sepsis and progressive multi-organ failure, have survived. Comparative analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions, cytomegalovirus infection, bacteremia, pulmonary infections, acute kidney injury, new-onset can...
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Jian-Xin Tang Dong Zhao Source Type: research
Effectiveness and Safety of Radiofrequency Ablation versus Liver Resection in the Treatment of Early-stage Hepatocellular Carcinoma: A Systematic Review and Meta-analysis
CONCLUSION: During the treatment of hepatocellular carcinoma, hepatectomy demonstrates superior clinical efficacy compared to radiofrequency ablation, particularly in its ability to control tumor recurrence. However, radiofrequency ablation presents with fewer complications and a higher level of safety. These findings can serve as a valuable foundation for clinicians when selecting the most suitable treatment approaches for liver cancer.PMID:38684504 | DOI:10.62713/aic.3155 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Zhifeng Xu Yiren Hu Lidong Huang Source Type: research
Sex Differences in Outcomes of Hepatobiliary and Pancreatic Surgery with Accelerated Rehabilitation
CONCLUSION: We identified sex differences in the clinical prognosis and performance of perioperative patients undergoing hepatobiliary and pancreatic surgery with accelerated rehabilitation. The perioperative pulmonary rehabilitation risk of male patients was higher than that of female patients, and the time to first defecation was longer in male than in female patients. The incidence of nausea and vomiting in women was higher than in men.PMID:38684503 | DOI:10.62713/aic.3169 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Xinxin Zhang Qian Wang Min Zhang Liguang Chen Danhong Peng Source Type: research
Current status of liver transplantation for human immunodeficiency virus-infected patients in mainland China
This study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation (LT) in mainland China. To date, our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV, and all but one, who died two months postoperatively due to sepsis and progressive multi-organ failure, have survived. Comparative analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions, cytomegalovirus infection, bacteremia, pulmonary infections, acute kidney injury, new-onset can...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Jian-Xin Tang Dong Zhao Source Type: research
Helicobacter cholecystus bacteremia in an adult with acute cholecystitis
We report the isolation of Helicobacter cholecystus from a positive blood culture from a 58-year-old man in China who had bacteremia and acute cholecystitis. The patient's condition improved after symptomatic support treatment and subtotal cholecystectomy. This finding suggests that H. cholecystus should be considered as potential human pathogens.PMID:38684428 | DOI:10.7883/yoken.JJID.2023.468 (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - April 29, 2024 Category: Infectious Diseases Authors: Jinxia Su Shunguang Li Morui Chen Zewei Huang Huijun Liu Pinghua Qu Source Type: research
Changes in liver and kidney function, red blood cell count and hemoglobin levels 1 day after ultrasound-guided percutaneous microwave ablation for uterine fibroids
CONCLUSION: Ultrasound-guided percutaneous microwave ablation for uterine fibroids can impose a higher detoxification load on the liver and cause thermal damage to and the destruction of RBCs within local circulation, potentially leading to AKI. Protein levels significantly decreased after UPMWA. Therefore, perioperative organ function protection measures and treatment should be actively integrated into clinical practice to improve prognosis and enhance recovery.PMID:38684224 | DOI:10.1080/02656736.2024.2338542 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 29, 2024 Category: Internal Medicine Authors: Xiao-Yu Huang Qin-Sheng Lu Shao-Ping Wu Han-Ming Huang Yong-Fa Zhang Source Type: research
Association of the triglyceride-glucose index with early-onset atherosclerotic cardiovascular disease events and all-cause mortality: a prospective cohort study
CONCLUSIONS: A higher TyG index is significantly associated with an increased incidence of early-onset ASCVD events and all-cause mortality in a young and middle-aged population from North China.PMID:38685099 | DOI:10.1186/s12933-024-02249-4 (Source: Atherosclerosis)
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Qiqi Hou Qi Qi Quanle Han Jie Yu Jianmei Wu Hui Yang Shuohua Chen Shouling Wu Kangbo Li Source Type: research
Exploring the effective compounds and potential mechanisms of Shengxian Decoction against coronary heart disease by UPLC-Q-TOF/MS and network pharmacology analysis
Heliyon. 2024 Apr 16;10(8):e29558. doi: 10.1016/j.heliyon.2024.e29558. eCollection 2024 Apr 30.ABSTRACTAs a well-known classical Chinese medicine prescription, Shengxian Decoction (SXD) has been applied for a century to treat cardiovascular diseases, especially coronary heart disease (CHD), but the potentially effective compounds and underlying mechanisms remain unclear. With ultra-performance liquid chromatography-quadrupole-time of flight-mass spectrometry (UPLC-Q-TOF/MS) and network pharmacology analysis, the potential effective compounds of SXD and their pharmacological mechanisms against CHD were identified and reveal...
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Hao-Ming Zhou Shi-Jun Yue Wen-Xiao Wang Qiao Zhang Ding-Qiao Xu Jia-Jia Li Yu-Ping Tang Xin-Yu Yang Source Type: research
