Formulation analysis of functional fragrance via polar-gradient extraction method and chemometrics pattern recognition
In this study, characteristic components of 15 natural flavors was analyzed by the polar-gradient extraction (PGE) technique in combination with GC-MS and chemometrics pattern recognition. The obtained results were utilized for the traceability of 4 functional fragrance formulations. The optimal PGE system consisting of 5 different polar solvents, was developed based on similarity-intermiscibility theory. Four chemometrics pattern recognition models including PCA, HCA, PLS-DA, and OPLS-DA were constructed based on the characteristic component database constituting 15 natural flavors. These models were used to trace 4 funct...
Source: Talanta - April 30, 2024 Category: Chemistry Authors: Meijin Wang Wanru Wang Xiaohua Zhang Guilin Dai Kewen Tang Source Type: research
Fangchinoline inhibits growth and biofilm of Candida albicans by inducing ROS overproduction
J Cell Mol Med. 2024 May;28(9):e18354. doi: 10.1111/jcmm.18354.ABSTRACTInfections caused by Candida species, especially Candida albicans, threaten the public health and create economic burden. Shortage of antifungals and emergence of drug resistance call for new antifungal therapies while natural products were attractive sources for developing new drugs. In our study, fangchinoline, a bis-benzylisoquinoline alkaloid from Chinese herb Stephania tetrandra S. Moore, exerted antifungal effects on planktonic growth of several Candida species including C. albicans, with MIC no more than 50 μg/mL. In addition, results from micro...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Longfei Yang Xiaonan Wang Zhiming Ma Yujie Sui Xin Liu Source Type: research
Screening of the effective sites of Cichorium glandulosum against hyperuricemia combined with hyperlipidemia and its network pharmacology analysis
This study aims to explore the pharmacological effects and mechanisms of Cichorium glandulosum on this comorbidity through a combination of animal experiments, network pharmacology, and molecular docking techniques. A rat model of hyperuricaemia combined with hyperlipidaemia was established through a high-fat and high-purine diet, and the effective parts of the aqueous extract of Cichorium glandulosum to reduce uric acid and lipid levels were screened and the components of the parts were analysed by LC-MS/MS. The active components, core targets, and key pathways were analysed using network pharmacology and validated by mol...
Source: Computational Biology and Chemistry - April 30, 2024 Category: Bioinformatics Authors: Zhiguo Yang Bo Lyu Bin Ma Yuefeng Gao Dongmei Qin Source Type: research
Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis
Curr Top Med Chem. 2024 Apr 29. doi: 10.2174/0115680266289292240420062705. Online ahead of print.ABSTRACTBerbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of medicine. Numerous in-vitro and in-vivo studies revealed the apoptotic and cytotoxic potential of Ber against different cell lines (SMMC-7721, A549, MDA-MB-231, and K562) by upregulating pro-apoptotic (Bax, p53) and downregulating anti-apoptotic (Bcl-2, survivin) proteins. O...
Source: Current Topics in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Gulzar Muhammad Muhammad Ajaz Hussain Zahid Shafiq Adnan Ashraf Umer Shafique Ajmal Khan Asaad Khalid Javid Hussain Ahmed Al-Harrasi Source Type: research
Fangchinoline inhibits growth and biofilm of Candida albicans by inducing ROS overproduction
J Cell Mol Med. 2024 May;28(9):e18354. doi: 10.1111/jcmm.18354.ABSTRACTInfections caused by Candida species, especially Candida albicans, threaten the public health and create economic burden. Shortage of antifungals and emergence of drug resistance call for new antifungal therapies while natural products were attractive sources for developing new drugs. In our study, fangchinoline, a bis-benzylisoquinoline alkaloid from Chinese herb Stephania tetrandra S. Moore, exerted antifungal effects on planktonic growth of several Candida species including C. albicans, with MIC no more than 50 μg/mL. In addition, results from micro...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Longfei Yang Xiaonan Wang Zhiming Ma Yujie Sui Xin Liu Source Type: research
Acidification induce chemical and microbial variation in tea plantation soils and bacterial degradation of the key acidifying phenolic acids
Arch Microbiol. 2024 Apr 30;206(5):239. doi: 10.1007/s00203-024-03858-z.ABSTRACTCamellia sinensis is an important economic plant grown in southern subtropical hilly areas, especially in China, mainly for the production of tea. Soil acidification is a significant cause of the reduction of yield and quality and continuous cropping obstacles in tea plants. Therefore, chemical and microbial properties of tea growing soils were investigated and phenolic acid-degrading bacteria were isolated from a tea plantation. Chemical and ICP-AES investigations showed that the soils tested were acidic, with pH values of 4.05-5.08, and the p...
Source: Archives of Microbiology - April 30, 2024 Category: Microbiology Authors: Yuhan Zhang Binjie Wang Guiwei Wang Zhisheng Zheng Ying Chen Ou Li Yulong Peng Xiufang Hu Source Type: research
Fever-induced acute sleep terrors in children and adolescents following SARS-CoV-2 infection
CONCLUSION: SARS-CoV-2 infection may precipitate acute sleep terrors in children and adolescents. The course of these sleep terrors is generally benign, with all patients achieving spontaneous complete remission over time.PMID:38689200 | DOI:10.1007/s11325-024-03038-9 (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 30, 2024 Category: Sleep Medicine Authors: Xiaoli Wang Na Yuan Jiang Zhu Bi Wang Wenjuan Zhang Yonghong Liu Source Type: research
Expression of Concern: Effects of salinity and moisture on sediment net nitrogen mineralization in salt marshes of a Chinese estuary
Chemosphere. 2024 May;356:142012. doi: 10.1016/j.chemosphere.2024.142012. Epub 2024 Apr 11.NO ABSTRACTPMID:38685652 | DOI:10.1016/j.chemosphere.2024.142012 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Source Type: research
Expression of Concern: The prospective effects of long-term exposure to ambient PM2.5 and constituents on mortality in rural East China
Chemosphere. 2024 May;356:141997. doi: 10.1016/j.chemosphere.2024.141997. Epub 2024 Apr 11.NO ABSTRACTPMID:38685640 | DOI:10.1016/j.chemosphere.2024.141997 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Source Type: research
Concentrations, sources and health risk of bisphenols in red swamp crayfish (Procambarus clarkii) from South-Eastern China
Chemosphere. 2024 Apr 27:142187. doi: 10.1016/j.chemosphere.2024.142187. Online ahead of print.ABSTRACTBisphenol analogs (BPs) are extensively employed in commercial and industrial products and they have been found in a variety of environmental matrices and human samples. The red swamp crayfish (Procambarus clarkii) has been a trendy food in China in recent decades. However, the levels of BPs in Chinese crayfish and the associated hazards of human exposure remain unknown. Thus, in this study, the levels of eight BPs in crayfish gathered from five major provinces engaged in crayfish within the Yangtze River Basin were analy...
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Xinjie Li Jiayi Xu Zhuochang Bi Junye Bian Jiayin Huang Zhihui Guo Qinru Xiao Yujie Sha Jiajia Ji Tingting Zhu Shaoyou Lu Source Type: research
Effects of dextran molecular weight on starch retrogradation and technological properties of Chinese steamed bread: Based on the rubber/glass transition
Int J Biol Macromol. 2024 Apr 27:131887. doi: 10.1016/j.ijbiomac.2024.131887. Online ahead of print.ABSTRACTFrom the perspective of rubber/glass transition, this study clarified that the impact of dextran on retarding hardening behavior and slowing starch retrogradation of Chinese Steamed Bread (CSB) depended on its molecular weight and concentration level. Guggenheim-Anderson-de Boer (GAB) model was fitted to explore critical behavior changes in rubber/glass transition of CSB. Incorporation of high molecular weight dextran enhanced the elasticity of dough and porosity of CSB, reduced the aging and hardening degree of CSB ...
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Shunqin Li Ronghao Sun Ying Gong Jiayi Cui Wenjie Sui Tao Wu Rui Liu Min Zhang Source Type: research
Structural clarification of mannoglucan GSBP-2 from Ganoderma sinense and its effects on triple-negative breast cancer migration and invasion
In conclusion, GSBP-2 could inhibit the proliferation, migration, and invasion of MDA-MB-231 cells and showed significant anti-angiogenic ability. These findings indicate that GSBP-2 is a promising therapeutic adjuvant for TNBC.PMID:38688342 | DOI:10.1016/j.ijbiomac.2024.131903 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Yikun Xie Yifan Su Yurong Wang Dawei Zhang Qian Yu Chunyan Yan Source Type: research
Expression of Concern: Effects of salinity and moisture on sediment net nitrogen mineralization in salt marshes of a Chinese estuary
Chemosphere. 2024 May;356:142012. doi: 10.1016/j.chemosphere.2024.142012. Epub 2024 Apr 11.NO ABSTRACTPMID:38685652 | DOI:10.1016/j.chemosphere.2024.142012 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Source Type: research
Expression of Concern: The prospective effects of long-term exposure to ambient PM2.5 and constituents on mortality in rural East China
Chemosphere. 2024 May;356:141997. doi: 10.1016/j.chemosphere.2024.141997. Epub 2024 Apr 11.NO ABSTRACTPMID:38685640 | DOI:10.1016/j.chemosphere.2024.141997 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Source Type: research
Concentrations, sources and health risk of bisphenols in red swamp crayfish (Procambarus clarkii) from South-Eastern China
Chemosphere. 2024 Apr 27:142187. doi: 10.1016/j.chemosphere.2024.142187. Online ahead of print.ABSTRACTBisphenol analogs (BPs) are extensively employed in commercial and industrial products and they have been found in a variety of environmental matrices and human samples. The red swamp crayfish (Procambarus clarkii) has been a trendy food in China in recent decades. However, the levels of BPs in Chinese crayfish and the associated hazards of human exposure remain unknown. Thus, in this study, the levels of eight BPs in crayfish gathered from five major provinces engaged in crayfish within the Yangtze River Basin were analy...
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Xinjie Li Jiayi Xu Zhuochang Bi Junye Bian Jiayin Huang Zhihui Guo Qinru Xiao Yujie Sha Jiajia Ji Tingting Zhu Shaoyou Lu Source Type: research
