New Glires materials from the East Mesa, Erlian Basin (Nei Mongol, China)
Anat Rec (Hoboken). 2024 May 1. doi: 10.1002/ar.25462. Online ahead of print.ABSTRACTEast Mesa, an Eocene locality situated east of the Shara Murun River in the Erlian Basin, is characterized by basal lower red mudstones. However, a distinct depositional hiatus has been observed in these red mudstones, leading to their division into layers 1 and 2. Excitingly, recent discoveries respectively in layers 1 and 2 of the lower red mudstones at the East Mesa include new Glires (Gomphos sp.) and rodents such as Asiomys dawsoni, Gobiocylindrodon cf. G. ulausuensis, and Yuomys sp., marking their first occurrences within these horiz...
Source: Anatomical Record - May 1, 2024 Category: Anatomy Authors: Qian Li Source Type: research
Deciphering the Pancreatic Cancer Microbiome in Mainland China: Impact of Exiguobacterium/Bacillus ratio on Tumor Progression and Prognostic Significance
Pharmacol Res. 2024 Apr 29:107197. doi: 10.1016/j.phrs.2024.107197. Online ahead of print.ABSTRACTThe existing body of research underscores the critical impact of intratumoral microbiomes on the progression of pancreatic ductal adenocarcinoma (PDAC), particularly in reshaping the tumor microenvironment and influencing gemcitabine resistance. However, peritumoral tissues' microbiome, distinct from PDAC tumors, remain understudied, and Western-centric analyses overlooking potential variations in dietary-influenced microbiomes. Our study addresses this gap by 16S rRNA sequencing of PDAC tumors and matched peritumoral tissues ...
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Zhengyan Zhang Ting Wang Ming Xu Zhihan Zhang Huaizhi Wang Jing Xue Wei Wang Source Type: research
Distributions of candidate vaccine Targets, virulence Factors, and resistance features of invasive group B Streptococcus using Whole-Genome Sequencing: A Multicenter, population-based surveillance study
CONCLUSIONS: The findings from this large whole-genome sequence of GBS isolates establish important baseline data required for further surveillance and evaluating the impact of future vaccine candidates.PMID:38692955 | DOI:10.1016/j.vaccine.2024.04.062 (Source: Vaccine)
Source: Vaccine - May 1, 2024 Category: Allergy & Immunology Authors: Wenjing Ji Haijian Zhou Jie Li Carl D Britto Zheliang Liu Wen Zhang Jiaxi Du Shabir A Madhi Gaurav Kwatra Ziyaad Dangor Zhengjiang Jin Hang Zhao Yifei Zhao Yu Fang Juan Li Source Type: research
Left bundle branch pacing set to outshine biventricular pacing for cardiac resynchronization therapy?
World J Cardiol. 2024 Apr 26;16(4):186-190. doi: 10.4330/wjc.v16.i4.186.ABSTRACTThe deleterious effects of long-term right ventricular pacing necessitated the search for alternative pacing sites which could prevent or alleviate pacing-induced cardiomyopathy. Until recently, biventricular pacing (BiVP) was the only modality which could mitigate or prevent pacing induced dysfunction. Further, BiVP could resynchronize the baseline electromechanical dssynchrony in heart failure and improve outcomes. However, the high non-response rate of around 20%-30% remains a major limitation. This non-response has been largely attributable...
Source: World Journal of Cardiology - May 1, 2024 Category: Cardiology Authors: Akash Batta Juniali Hatwal Source Type: research
Analysis of tissue tropism of GCRV-II infection in grass carp using a VP35 monoclonal antibody
In this study, monoclonal antibodies against recombinant VP35 protein were generated in mice and characterized. The antibodies exhibited specific binding to the N terminal region (1-155 aa) of the recombinant VP35 protein expressed in the HEK293 cells, and native VP35 protein in the GCRV-II infected CIK cells. Immunofluorescent staining revealed that viruses aggregated in the cytoplasm of infected cells. In vivo challenge experiments showed that high levels of GCRV-II viruses were present in the gills, intestine, spleen and liver, indicating that they are the major sites for virus infection. Our study showed that the VP35 ...
Source: Developmental and Comparative Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Yanan Lu Weihua Zhao Ning Ji Dan Xu Yaoguo Li Tiaoyi Xiao Junya Wang Jun Zou Source Type: research
Unlocking renal Restoration: Mesaconine from Aconitum plants restore mitochondrial function to halt cell apoptosis in acute kidney injury
This study explored mesaconine, derived from processed Fuzi, as a promising low-toxicity alternative for AKI treatment. In this study, we assessed the protective effects of mesaconine in gentamicin (GM)-induced NRK-52E cells and AKI rat models in vitro and in vivo, respectively. Mesaconine promotes the proliferation of damaged NRK-52E cells and down-regulates intracellular transforming growth factor β1 (TGF-β1) and kidney injury molecule 1 (KIM-1) to promote renal cell repair. Concurrently, mesaconine restored mitochondrial morphology and permeability transition pores, reversed the decrease in mitochondrial membrane pote...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Yixin Rui Xiumeng Zhang Xinran Min Hongxiao Xie Xiuying Ma Funeng Geng Rong Liu Source Type: research
The impact of Chinese foreign direct investment and environmental tax revenues on air degradation in Europe: a spatial regression approach, 2000-2020
This study analyzes air pollution through the effects of China's FDI in 27 European countries over a 20-year period, with a focus on the impact of environmental tax revenues (ETRs) and the environmental context in China. The relationship is estimated through spatial regressions that account for the presence of air pollutants in neighboring countries. The findings suggest that China's FDI in Europe does not contribute to air pollution but rather has a positive impact. The presence of environmental charges filters out non-polluting investments, which has a non-linear relationship with PM2.5 pollution rates. The study also co...
Source: Environmental Science and Pollution Research International - May 1, 2024 Category: Environmental Health Authors: Gonzalo Hern ández Soto Source Type: research
Illuminating sustainable household well-being and natural resource dependence in the case of disaster resettlement in rural China
This article assesses sustainable household well-being (SHWB) and natural resource dependence using a quantitative survey of rural China. It identifies four classes of relationship between SHWB and natural resource dependence and explores the impact of disaster resettlement on these classes. The result shows that rural households that participate in disaster resettlement as well as in voluntary relocation, centralized relocation, and new-stage relocation are more likely to achieve "high well-being and low dependence." However, the overall SHWB level of the relocated households is lower than that of the non-relocated househ...
Source: Environmental Science and Pollution Research International - May 1, 2024 Category: Environmental Health Authors: Wei Liu Liyuan He Jie Li Marcus Feldman Source Type: research
Jeotgalibacillus haloalkalitolerans sp. nov., a novel alkalitolerant and halotolerant bacterium, isolated from the confluence of the Fenhe River and the Yellow River
Antonie Van Leeuwenhoek. 2024 May 1;117(1):74. doi: 10.1007/s10482-024-01968-8.ABSTRACTA Gram-stain positive, aerobic, alkalitolerant and halotolerant bacterium, designated HH7-29 T, was isolated from the confluence of the Fenhe River and the Yellow River in Shanxi Province, PR China. Growth occurred at pH 6.0-12.0 (optimum, pH 8.0-8.5) and 15-40℃ (optimum, 32℃) with 0.5-24% NaCl (optimum, 2-9%). The predominant fatty acids (> 10.0%) were iso-C15:0 and anteiso-C15:0. The major menaquinones were MK-7 and MK-8. The polar lipids were phosphatidylglycerol, diphosphatidylglycerol and two unidentified phospholipids. Phylo...
Source: Antonie van Leeuwenhoek - May 1, 2024 Category: Microbiology Authors: Ya-Fei Zhang Yun-Lin Peng Yong-Hui Xiao Bing Yu Ming-Yue Cao Zhi-Ling Zhang Le-Qun Huang Yi Li Source Type: research
Progress of mitochondrial and endoplasmic reticulum-associated signaling and its regulation of chronic liver disease by Chinese medicine
World J Hepatol. 2024 Apr 27;16(4):494-505. doi: 10.4254/wjh.v16.i4.494.ABSTRACTThe endoplasmic reticulum (ER) is connected to mitochondria through mitochondria-associated ER membranes (MAMs). MAMs provide a framework for crosstalk between the ER and mitochondria, playing a crucial role in regulating cellular calcium balance, lipid metabolism, and cell death. Dysregulation of MAMs is involved in the development of chronic liver disease (CLD). In CLD, changes in MAMs structure and function occur due to factors such as cellular stress, inflammation, and oxidative stress, leading to abnormal interactions between mitochondria ...
Source: World Journal of Hepatology - May 1, 2024 Category: Gastroenterology Authors: Yang Zheng Yi-Hui Zheng Jia-Hui Wang Tie-Jian Zhao Lei Wang Tian-Jian Liang Source Type: research
Clinical and histopathological factors for recurrence and metastasis in lacrimal gland adenoid cystic carcinoma in Chinese patients
CONCLUSIONS: For LGACC, ≥T3 category, basaloid subtype, and bone erosion were high-risk predictors. ASCT2(-) was an independent risk factor for distant metastasis, which suggested that it could be a potential biomarker for LGACC.PMID:38689460 | DOI:10.1177/11206721241249503 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - May 1, 2024 Category: Opthalmology Authors: Xiaowen Zhou Yiyi Feng Yidi Yang Chunyan Zong Yilin Yu Tianyu Zhu Jiahao Shi Renbing Jia Huifang Chen Yimin Li Xin Song Source Type: research
Population pharmacokinetic analysis for dose regimen optimization of vancomycin in Southern Chinese children
This study set out to characterize the disposition of vancomycin, quantify the exposure target and establish an optimal dosage regimen among the Southern Chinese pediatric population. Routine therapeutic drug monitoring data of 453 patients were available. We performed a retrospective population pharmacokinetic analysis of hospitalized children prescribed intravenous vancomycin using NONMEM® software. A one-compartment PPK model of vancomycin with body weight and renal functions as covariates based on a cutoff of 2 years old children was proposed in this study. Both internal and external validation showing acceptable a...
Source: CPT: Pharmacometrics and Systems Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Xianhuan Shen,
Xuejuan Li,
Jieluan Lu,
Jiahao Zhu,
Yaodong He,
Zhou Zhang,
Zebin Chen,
Jianping Zhang,
Xiaomei Fan,
Wenzhou Li Tags: ARTICLE Source Type: research
Chinese guidelines for the diagnosis and management of atrial fibrillation
AbstractAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia, significantly impacting patients' quality of life and increasing the risk of death, stroke, heart failure, and dementia. Over the past two decades, there have been significant breakthroughs in AF risk prediction and screening, stroke prevention, rhythm control, catheter ablation, and integrated management. During this period, the scale, quality, and experience of AF management in China have greatly improved, providing a solid foundation for the development of the guidelines for the diagnosis and management of AF. To further promote standardiz...
Source: Pacing and Clinical Electrophysiology : PACE - May 1, 2024 Category: Cardiology Authors: Changsheng Ma,
Shulin Wu,
Shaowen Liu,
Yaling Han Tags: ELECTROPHYSIOLOGY Source Type: research
Potential Effects of Traditional Chinese Medicine in Anti-Aging and Aging-Related Diseases: Current Evidence and Perspectives
(Source: Clinical Interventions in Aging)
Source: Clinical Interventions in Aging - May 1, 2024 Category: Geriatrics Tags: Clinical Interventions in Aging Source Type: research
Hyperuricemia Increases the Risk of Postoperative Recurrence in Chinese Patients with Chronic Rhinosinusitis
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - May 1, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
