Alkaloids from < em > Zanthoxylum nitidum < /em > and their anti-proliferative activity against A549 cells by regulating the EGFR/AKT/mTOR pathway
Nat Prod Res. 2024 Apr 29:1-7. doi: 10.1080/14786419.2024.2347463. Online ahead of print.ABSTRACTZanthoxylum nitidum is frequently used as a traditional Chinese medicine and food supplement. Our previous study revealed that its constituent compounds were able to inhibit cancer cell proliferation. In our continuous exploration of bioactive compounds in Z. nitidum, we isolated ten alkaloids (1-10), including one new natural compound (1), and nine known alkaloids (2-10), from an ethanolic extract of the whole plant. The chemical structures were elucidated based on a combination of comprehensive NMR and HRESIMS analyses. Compo...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Fan-Fan Wang Ping-Fang Tao Yu-Jun Zhong Yun-Qiong Gu Cai Yi Wang Feng Qin Source Type: research
Glycosides constituents from < em > Codonopsis pilosula < /em >
Nat Prod Res. 2024 Apr 29:1-4. doi: 10.1080/14786419.2024.2344738. Online ahead of print.ABSTRACTA new glycoside (1) along with six known analogues (1-7) were isolated from Codonopsis pilosula collected at Shanxi in China. The structure of 1 was established based on comprehensive spectroscopic data and literature comparison. The anti-inflammatory effects of isolated compounds were further investigated in LPS-induced RAW264.7 macrophage.PMID:38684008 | DOI:10.1080/14786419.2024.2344738 (Source: Natural Product Research)
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Yan-Gang Cheng Si-Qi Yang Pei Li Yan Wang Hui-Feng Li Xiang-Peng Kong Jin-Yan Tan Ying-Li Wang Source Type: research
Current status of liver transplantation for human immunodeficiency virus-infected patients in mainland China
This study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation (LT) in mainland China. To date, our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV, and all but one, who died two months postoperatively due to sepsis and progressive multi-organ failure, have survived. Comparative analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions, cytomegalovirus infection, bacteremia, pulmonary infections, acute kidney injury, new-onset can...
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Jian-Xin Tang Dong Zhao Source Type: research
Current status of liver transplantation for human immunodeficiency virus-infected patients in mainland China
This study provides an overview of the current landscape of HIV-positive patients receiving liver transplantation (LT) in mainland China. To date, our transplant center has conducted LT for eight end-stage liver disease patients co-infected with HIV, and all but one, who died two months postoperatively due to sepsis and progressive multi-organ failure, have survived. Comparative analysis with hepatitis B virus-infected patients during the same period revealed no statistically significant differences in acute rejection reactions, cytomegalovirus infection, bacteremia, pulmonary infections, acute kidney injury, new-onset can...
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Jian-Xin Tang Dong Zhao Source Type: research
Antifibrotic Effect of Baicalin on Arecoline Induced Human Oral Fibroblast: An In-Vitro Study
CONCLUSION: Baicalin can be used as an antifibrotic herb to treat OSMF.PMID:38679996 | DOI:10.31557/APJCP.2024.25.4.1349 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Pallavi Channe Mahesh Chavan Ramesh Bhonde Supriya M Kheur Source Type: research
Women's Knowledge, Attitudes, and Perception on Personalized Risk-Stratified Breast Cancer Screening: A Cross-Sectional Study in Malaysia
CONCLUSION: General population's awareness of individualized risk-stratified breast cancer screening was insufficient despite their favourable attitude towards the disease. A multimodal strategy may be used to improve women's knowledge, attitude, and perception of individualized risk-stratified breast cancer screening.PMID:38679982 | DOI:10.31557/APJCP.2024.25.4.1231 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Jayshree Ap Segar Teo Rong Xuan Alahakoon Mudiyanselage Gayali Nuwanya Alahakoon Harwinthra Al Ravi Soe Moe Murali Uthamalingam Mila Nu Nu Htay Source Type: research
A Comprehensive Integration of Data Regarding the Correlation of TNF- α rs1800629 Polymorphism with Susceptibility to Cervical Cancer
CONCLUSIONS: The findings from this meta-analysis suggest that the TNF-α rs1800629 polymorphism is a risk factor for cervical cancer in the general population, particularly in Caucasian and African women. However, further well-designed studies are warranted to validate these findings.PMID:38679974 | DOI:10.31557/APJCP.2024.25.4.1155 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Zahra Marzbanrad Mojgan Karimi-Zarchi Somayeyeh Noei-Teymoordash Maryam Motamedinasab Sepideh Azizi Shahla Noori-Ardebili Maedeh Barahman Maryam Yeganegi Ali Masoudi Kamran Alijanpour Maryam Aghasipour Kazem Aghili Hossein Neamatzadeh Source Type: research
Epidemiology of Uterine Cancer in Sarawak, Borneo, A 20-Year Review
CONCLUSION: The incidence of primary uterine cancer in Sarawak, Malaysia, has increased over the past 20 years, with higher incidence rates observed in older age groups and among Chinese women. The findings suggest the need for continued efforts to improve the prevention, early detection, and treatment of uterine cancer in Sarawak.PMID:38679973 | DOI:10.31557/APJCP.2024.25.4.1143 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Diana Jawa Kung Yee Wong Mastulu Binti Wahab Azizah Azhar Emmanuel Joseph Foong Eunice Melissa Joseph Johnny Pangkas Choo Huck Ooi Source Type: research
Exploring the effective compounds and potential mechanisms of Shengxian Decoction against coronary heart disease by UPLC-Q-TOF/MS and network pharmacology analysis
Heliyon. 2024 Apr 16;10(8):e29558. doi: 10.1016/j.heliyon.2024.e29558. eCollection 2024 Apr 30.ABSTRACTAs a well-known classical Chinese medicine prescription, Shengxian Decoction (SXD) has been applied for a century to treat cardiovascular diseases, especially coronary heart disease (CHD), but the potentially effective compounds and underlying mechanisms remain unclear. With ultra-performance liquid chromatography-quadrupole-time of flight-mass spectrometry (UPLC-Q-TOF/MS) and network pharmacology analysis, the potential effective compounds of SXD and their pharmacological mechanisms against CHD were identified and reveal...
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Hao-Ming Zhou Shi-Jun Yue Wen-Xiao Wang Qiao Zhang Ding-Qiao Xu Jia-Jia Li Yu-Ping Tang Xin-Yu Yang Source Type: research
Zooming in and Out of Programmed Cell Death in Osteoarthritis: A Scientometric and Visualized Analysis
This study aimed to collect articles and reviews focusing on PCD in OA, extracting data from January 1st, 2013, to October 31st, 2023, using the Web of Science. Various tools, including VOSviewer, CiteSpace, Pajek, Scimago Graphica, and the R package, were employed for scientometric and visualization analyses. Notably, China, the USA, and South Korea emerged as major contributors, collectively responsible for more than 85% of published papers and significantly influencing research in this field. Among different institutions, Shanghai Jiao Tong University, Xi'an Jiao Tong University, and Zhejiang University exhibited the hi...
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Siyang Cao Yihao Wei Yaohang Yue Ao Xiong Hui Zeng Source Type: research
Research trends and hotspots of circular RNA in cardiovascular disease: A bibliometric analysis
Noncoding RNA Res. 2024 Apr 16;9(3):930-944. doi: 10.1016/j.ncrna.2024.04.002. eCollection 2024 Sep.ABSTRACTFrom a global perspective, cardiovascular diseases (CVDs), the leading factor accounting for population mortality, and circRNAs, RNA molecules with stable closed-loop structures, have been proven to be closely related. The latent clinical value and the potential role of circRNAs in CVDs have been attracting increasing, active research interest, but bibliometric studies in this field are still lacking. Thus, in this study, we conducted a bibliometric analysis by using software such as VOSviewer, CiteSpace, Microsoft E...
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Zehui Xu Chong Guan Ziji Cheng Houle Zhou Wanting Qin Jiaming Feng Melisandre Wan Yihan Zhang Chengyao Jia Shuijin Shao Haidong Guo Shaoling Li Baonian Liu Source Type: research
Carbapenem-Resistant Enterobacter cloacae Complex in Southwest China: Molecular Characteristics and Risk Factors Caused by NDM Producers
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - April 29, 2024 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Can neurocognition, brain neurotrophic factor, triglyceride, and total cholesterol predict suicidal ideation in first ‐episode Han Chinese patients with schizophrenia?
ConclusionSerum BDNF level, PANSS score, and MCCB score can be used as auxiliary predictors of suicidal ideation in schizophrenic patients. Combining these three indicators can effectively predict suicidal ideation in schizophrenic patients. (Source: Brain and Behavior)
Source: Brain and Behavior - April 29, 2024 Category: Neurology Authors: Li Dongxia,
Ma Li,
Feng Yingying Tags: ORIGINAL ARTICLE Source Type: research
Rising Incidence of Acute Epiglottitis in Eastern China: An Eight-Year Retrospective Study and Its Association with the 24 Solar Terms
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - April 29, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
Diabetes and vascular mild cognitive impairment among Chinese ≥50 years: A cross‐sectional study with 2020 participants
ConclusionIn our study, we found that diabetes had a positive correlation with VaMCI, and high education had a negative correlation with VaMCI. Therefore, early identification and timely intervention of diabetes may reduce the risk of VaMCI and achieve early prevention of VaMCI. (Source: Brain and Behavior)
Source: Brain and Behavior - April 29, 2024 Category: Neurology Authors: Yu Zhang,
Wenna Liu,
Chen Fu,
Xuemei Liu,
Xiaobing Hou,
Huanmin Niu,
Tao Li,
Chunyan Guo,
Aixun Li,
Baoxin Chen,
Xianglan Jin Tags: ORIGINAL ARTICLE Source Type: research
