Factors Influencing Iatrogenic Skin Injury in Neonates and Nursing Strategies
CONCLUSION: Length of stay, orotracheal intubation use, and gastric tube use are independent risk factors for iatrogenic skin injury in neonates. Hospital stays and unnecessary use of orotracheal intubation and gastric tube should be reduced in future clinical management. Attention should be paid to strengthening skin observation and care, keeping skin dry and clean, and preventing iatrogenic skin injury.PMID:38687850 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Huifang Deng Chunhua Li Nuo Yu Source Type: research
Associations of combined phenotypic aging and genetic risk with incident cancer: A prospective cohort study
CONCLUSIONS: Within and across genetic risk groups, older PhenoAge was consistently related to an increased risk of incident cancer with adjustment for chronological age and the aging process could be retarded by adherence to a healthy lifestyle.FUNDING: This work was supported by the National Natural Science Foundation of China (82230110, 82125033, 82388102 to GJ; 82273714 to MZ); and the Excellent Youth Foundation of Jiangsu Province (BK20220100 to MZ).PMID:38687190 | DOI:10.7554/eLife.91101 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Lijun Bian Zhimin Ma Xiangjin Fu Chen Ji Tianpei Wang Caiwang Yan Juncheng Dai Hongxia Ma Zhibin Hu Hongbing Shen Lu Wang Meng Zhu Guangfu Jin Source Type: research
Pharmacokinetic, Pharmacodynamic, and Safety Profiles of Proline Henagliflozin in Chinese Subjects with Varying Degrees of Liver Dysfunction
J Clin Pharmacol. 2024 Apr 30. doi: 10.1002/jcph.2437. Online ahead of print.ABSTRACTProline henagliflozin, a novel selective inhibitor of sodium glucose cotransporter 2, is a treatment for type 2 diabetes mellitus. We designed a parallel-group, open-label, and multicenter study to evaluate the pharmacokinetic (PK), pharmacodynamic (PD), and safety profiles of henagliflozin in Chinese subjects with varying degrees of liver dysfunction. Thirty-two subjects were enrolled and divided into four groups based on liver function (normal liver function, mild, moderate, or severe liver dysfunction). The area under the plasma concent...
Source: The Journal of Clinical Pharmacology - April 30, 2024 Category: Drugs & Pharmacology Authors: Likun Ding Lin Yang Danjun Ren Xiaohua Gao Juanli Zhang Meiyou Liu Li Sun Qingbo Diao Sheng Feng Aidong Wen Jingwen Wang Source Type: research
Ayurvedic and Chinese Herbs against Coronaviruses
Curr Pharm Des. 2024 Apr 29. doi: 10.2174/0113816128269864231112094917. Online ahead of print.ABSTRACTCOVID-19 is a viral disease that infects the lower airways, causing severe acute respiratory syndrome (SARS) and fatal pneumonia. The ripple effect of the COVID-19 outbreak has created serious problems in the healthcare systems of many countries and had far-reaching consequences for the global economy. Thus, effective control measures should be implemented for this coronavirus infection in the future. The ongoing episode of the SARS-CoV-2 sickness, COVID-19, in China, and the subsequent irregular spread of contamination to...
Source: Current Pharmaceutical Design - April 30, 2024 Category: Drugs & Pharmacology Authors: Amin Gasmi Sonia Kanwal Petro Oliinyk Roman Lysiuk Mariia Shanaida Asma Gasmi Benahmed Walallawita Kankanamge Tharindu Dushmantha Maria Arshad Ivanna Kernychna Larysa Lenchyk Taras Upyr Volodymyr Shanaida Geir Bj ørklund Source Type: research
Systematic Chemical Analysis of Crude Glycan Isolates from the Seven‑herb Decoction Quanzhenyiqitang with Anti-COPD Activity
Chem Biodivers. 2024 Apr 30:e202400277. doi: 10.1002/cbdv.202400277. Online ahead of print.ABSTRACTThe classical Chinese Medicine prescription, Quanzhenyiqitang (QZYQT), containing seven tonic herbs (Shudi, Dangshen, Maidong, Baizhu, Niuxi, Fuzi, and Wuweizi) is clinically used to treat chronic obstructive pulmonary disease (COPD). Although there are studies on the pharmacological effects of QZYQT, little attention has been paid to its active carbohydrate ingredients. We performed a systematic chemical analysis of the crude glycan isolates from the seven-herb decoction (GI-QZYQT) after confirming its anti-COPD activity. GI...
Source: Chemistry and Biodiversity - April 30, 2024 Category: Biochemistry Authors: Lingchong Wang Xiaoxian Yu Shiting Dai Longchao Dai Ran Ao Dapeng Zhang Source Type: research
Tumor-targeted gypenoside nanodrug delivery system with double protective layers
CONCLUSIONS: We have established a tumor-targeted nanodrug delivery system that can target and kill liver cancer cells and may provide a strategy for preparing new nanodrug-loaded preparations of traditional Chinese medicine.PMID:38687941 | DOI:10.4103/jcrt.jcrt_134_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Zongqiang Lai Facheng Bai Tao Pu Jun Li Lining Wu Zhou Zhou Nuo Yang Source Type: research
The Role of Attentional Control in Mindfulness Intervention for Emotional Distress: A Randomized Controlled Trial With Longitudinal Mediation Analyses
CONCLUSIONS: The present trial provides evidence suggesting that mindfulness interventions may alleviate emotional distress through the enhancement of attentional control.TRIAL REGISTRATION: Chinese Clinical Trial Registry number: ChiCTR2200064140.PMID:38687203 | DOI:10.1002/cpp.2981 (Source: Clinical Psychology and Psychotherapy)
Source: Clinical Psychology and Psychotherapy - April 30, 2024 Category: Psychiatry Authors: Zhenzhen Wang Kaerqika Shalihaer Stefan G Hofmann Shixing Feng Xinghua Liu Source Type: research
Fangchinoline inhibits growth and biofilm of Candida albicans by inducing ROS overproduction
J Cell Mol Med. 2024 May;28(9):e18354. doi: 10.1111/jcmm.18354.ABSTRACTInfections caused by Candida species, especially Candida albicans, threaten the public health and create economic burden. Shortage of antifungals and emergence of drug resistance call for new antifungal therapies while natural products were attractive sources for developing new drugs. In our study, fangchinoline, a bis-benzylisoquinoline alkaloid from Chinese herb Stephania tetrandra S. Moore, exerted antifungal effects on planktonic growth of several Candida species including C. albicans, with MIC no more than 50 μg/mL. In addition, results from micro...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Longfei Yang Xiaonan Wang Zhiming Ma Yujie Sui Xin Liu Source Type: research
Screening of the effective sites of Cichorium glandulosum against hyperuricemia combined with hyperlipidemia and its network pharmacology analysis
This study aims to explore the pharmacological effects and mechanisms of Cichorium glandulosum on this comorbidity through a combination of animal experiments, network pharmacology, and molecular docking techniques. A rat model of hyperuricaemia combined with hyperlipidaemia was established through a high-fat and high-purine diet, and the effective parts of the aqueous extract of Cichorium glandulosum to reduce uric acid and lipid levels were screened and the components of the parts were analysed by LC-MS/MS. The active components, core targets, and key pathways were analysed using network pharmacology and validated by mol...
Source: Computational Biology and Chemistry - April 30, 2024 Category: Bioinformatics Authors: Zhiguo Yang Bo Lyu Bin Ma Yuefeng Gao Dongmei Qin Source Type: research
Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis
Curr Top Med Chem. 2024 Apr 29. doi: 10.2174/0115680266289292240420062705. Online ahead of print.ABSTRACTBerbamine (Ber) is an active medicinal bisbenzylisoquinoline alkaloid, which is usually obtained from different plants of the genus Berberis (family Berberidaceae) and is used to cure various disorders in traditional Chinese and Ayurvedic systems of medicine. Numerous in-vitro and in-vivo studies revealed the apoptotic and cytotoxic potential of Ber against different cell lines (SMMC-7721, A549, MDA-MB-231, and K562) by upregulating pro-apoptotic (Bax, p53) and downregulating anti-apoptotic (Bcl-2, survivin) proteins. O...
Source: Current Topics in Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Gulzar Muhammad Muhammad Ajaz Hussain Zahid Shafiq Adnan Ashraf Umer Shafique Ajmal Khan Asaad Khalid Javid Hussain Ahmed Al-Harrasi Source Type: research
Fangchinoline inhibits growth and biofilm of Candida albicans by inducing ROS overproduction
J Cell Mol Med. 2024 May;28(9):e18354. doi: 10.1111/jcmm.18354.ABSTRACTInfections caused by Candida species, especially Candida albicans, threaten the public health and create economic burden. Shortage of antifungals and emergence of drug resistance call for new antifungal therapies while natural products were attractive sources for developing new drugs. In our study, fangchinoline, a bis-benzylisoquinoline alkaloid from Chinese herb Stephania tetrandra S. Moore, exerted antifungal effects on planktonic growth of several Candida species including C. albicans, with MIC no more than 50 μg/mL. In addition, results from micro...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Longfei Yang Xiaonan Wang Zhiming Ma Yujie Sui Xin Liu Source Type: research
Expression of Concern: The prospective effects of long-term exposure to ambient PM2.5 and constituents on mortality in rural East China
Chemosphere. 2024 May;356:141997. doi: 10.1016/j.chemosphere.2024.141997. Epub 2024 Apr 11.NO ABSTRACTPMID:38685640 | DOI:10.1016/j.chemosphere.2024.141997 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Source Type: research
Expression of Concern: Effects of salinity and moisture on sediment net nitrogen mineralization in salt marshes of a Chinese estuary
Chemosphere. 2024 May;356:142012. doi: 10.1016/j.chemosphere.2024.142012. Epub 2024 Apr 11.NO ABSTRACTPMID:38685652 | DOI:10.1016/j.chemosphere.2024.142012 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Source Type: research
Concentrations, sources and health risk of bisphenols in red swamp crayfish (Procambarus clarkii) from South-Eastern China
Chemosphere. 2024 Apr 27:142187. doi: 10.1016/j.chemosphere.2024.142187. Online ahead of print.ABSTRACTBisphenol analogs (BPs) are extensively employed in commercial and industrial products and they have been found in a variety of environmental matrices and human samples. The red swamp crayfish (Procambarus clarkii) has been a trendy food in China in recent decades. However, the levels of BPs in Chinese crayfish and the associated hazards of human exposure remain unknown. Thus, in this study, the levels of eight BPs in crayfish gathered from five major provinces engaged in crayfish within the Yangtze River Basin were analy...
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Xinjie Li Jiayi Xu Zhuochang Bi Junye Bian Jiayin Huang Zhihui Guo Qinru Xiao Yujie Sha Jiajia Ji Tingting Zhu Shaoyou Lu Source Type: research
Expression of Concern: Effects of salinity and moisture on sediment net nitrogen mineralization in salt marshes of a Chinese estuary
Chemosphere. 2024 May;356:142012. doi: 10.1016/j.chemosphere.2024.142012. Epub 2024 Apr 11.NO ABSTRACTPMID:38685652 | DOI:10.1016/j.chemosphere.2024.142012 (Source: Chemosphere)
Source: Chemosphere - April 30, 2024 Category: Chemistry Source Type: research
