The Relationship between Serum Vitamin E Level and Risk Factors for Arteriosclerosis in Japanese Postmenopausal Women.
Authors: Nakatsu Y, Niida S, Tanaka K, Takenaka S, Kuwabara A Abstract Since vitamin E is one of the most potent antioxidant and anti-inflammatory agents, vitamin E can play a role against arteriosclerosis through various actions. Then, we have studied the relationship between serum vitamin E status and risk factors for arteriosclerosis in Japanese postmenopausal women. One hundred and seven subjects (70.0±7.7 y) were evaluated for vitamin E status by measuring serum α- and γ-tocopherol (αT and γT) levels. The number of arteriosclerosis risk factors was defined by the existence of hig...
Source: Journal of Nutritional Science and Vitaminology - July 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Factors Associated with Nutrition of Japanese Patients with Rheumatoid Arthritis Who Underwent the Mini Nutritional Assessment (MNA), Health Assessment Questionnaire Disability Index, and Body Composition Assessment by Bioelectrical Impedance Analysis.
Authors: Mochizuki T, Yano K, Ikari K, Okazaki K Abstract The aim of this study is to identify the factors associated with nutrition in Japanese patients with rheumatoid arthritis (RA). Overall, 409 patients with RA who underwent the Mini Nutritional Assessment (MNA), bone mineral density determination, and body composition assessment by bioelectrical impedance analysis were enrolled. The analysis of factors associated with malnutrition was performed by comparing groups categorized by MNA score (≥24, 17-23.5, and
Source: Journal of Nutritional Science and Vitaminology - July 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Nutritional Status and Feeding Practice among Dysphagic Older Adult Inpatients in Vietnam.
This study aimed to investigate the nutritional status of and feeding practices for dysphagic older adult inpatients in some Vietnamese hospitals. The study was designed as a cross-sectional study and was conducted in three large hospitals in northern Vietnam. The data for 1007 older inpatients (58.3% were females, mean age was 75.5±7.3 y) about their dysphagic status, nutritional status and feeding practices were collected by dietitians. About 29% of the older adult inpatients suffered from malnutrition and 54% had a risk of malnutrition. Half of the dysphagia group had malnutrition and 42% were at risk of malnutri...
Source: Journal of Nutritional Science and Vitaminology - July 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Effects of Evening-Only Low-Carbohydrate Meal on Healthy Volunteers.
Authors: Yaegashi A, Suzuki J Abstract We performed a pre/post-interventional study with participants as self-controls to evaluate the effects of consuming an evening-only low-carbohydrate meal (LCM) at 1800 h on biochemical measures of glucose and lipid metabolism. Study participants comprised 14 healthy men (age range, 20-29 y) who, consumed standard test meals (STMs) or LCM at 1800 h. Blood samples were collected at fasting, and at 60-, 120-, and 240 min after the start of the meals. The 60-min postprandial levels and the area under the curve (AUC) 0-120 min for plasma glucose were significantly lower after the ...
Source: Journal of Nutritional Science and Vitaminology - July 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Associations between Green Tea Consumption and Coffee Consumption and the Prevalence of Coronary Artery Disease.
Authors: Kishimoto Y, Saita E, Taguchi C, Aoyama M, Ikegami Y, Ohmori R, Kondo K, Momiyama Y Abstract Green tea and coffee contain various bioactive compounds (e.g., polyphenols), and their consumption has been proposed to decrease the risk of cardiovascular diseases. Here, we investigated the associations between the consumption of green tea and that of coffee and the prevalence of coronary artery disease (CAD) in Japanese patients. The study group was 612 patients who underwent coronary angiography at Tokyo Medical Center between July 2008 and February 2017. CAD was confirmed in 388 of the patients: one-vessel di...
Source: Journal of Nutritional Science and Vitaminology - July 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Association of Dietary Change during Pregnancy with Large-for-Gestational Age Births: A Prospective Observational Study.
Authors: Minato-Inokawa S, Hayashi I, Nirengi S, Yamaguchi K, Takakura K, Sakane N, Nagai N Abstract Being born with large birthweight is considered as a risk of non-communicable diseases later in life. However, it is not fully understood what kind of maternal dietary intake during pregnancy affect large birthweight. Therefore, we examined the association of dietary intakes and its changes during pregnancy with large-for-gestational-age (LGA) births in Japanese pregnant women. In the prospective study, 245 pregnant women who visited Kyoto Medical Center were enrolled. Nutrition survey using brief-type self-administ...
Source: Journal of Nutritional Science and Vitaminology - July 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Effects of a Standardized Oligomerized-Polyphenol from Litchi chinensis Fruit Extract and Mixed Plant Extract Supplementation on Peripheral Circulation and Cold Sensitivity.
Authors: Waki H, Suzuki T, Uebaba K, Hisajima T Abstract Certain individuals tend to suffer from a cold sensation-particularly in the lower extremities-despite most people not suffering from the same sensation. In Japan, this phenomenon is called "hie-sho" and reduces quality of life for several people, particularly women. A previous study has shown that a standardized oligomerized-polyphenol from Litchi chinensis fruit extract (OPLFE) reportedly causes a significant increase in body surface temperature. The present study aimed to investigate whether supplementation with OPLFE affected peripheral circulat...
Source: Journal of Nutritional Science and Vitaminology - July 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Contribution of Katsura-uri (Japan's Heirloom Pickling Melon, Cucumis melo var. conomon) at the Completely Ripe Stage to Diabetes Control.
This study provides information regarding the health benefits of Katsura-uri and its utility in treating diabetes. The study methodology involved measuring the color and firmness of Katsura-uri fruit at five ripening stages, and quantitation of the aroma substances, proximate composition, and sugars. Significant changes were detected in the color, firmness, and level of aroma substances with ripening of Katsura-uri fruit, albeit with no major changes in proximate composition, with the exception of dietary fiber, and sugars. To determine the effects of Katsura-uri juice, the blood glucose levels of ten diabetic volunteers a...
Source: Journal of Nutritional Science and Vitaminology - July 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Development of Pretreatment Protocols for Determination of Soybean β-Conglycinin in Processed Soybean Foods Using Commercial ELISA Kits.
In this study, samples were pretreated by mixing them with rice flour powder prior to extraction of proteins. Then, we used commercially available ELISA kits for detection of allergens that could be present in any contaminating soybean residue. This enabled accurate and highly reproducible quantitation of β-conglycinin content in several processed soybean foods. PMID: 32612090 [PubMed - in process] (Source: Journal of Nutritional Science and Vitaminology)
Source: Journal of Nutritional Science and Vitaminology - July 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Nutritional Therapy with Vitamin K1 Is Effective in the Improvement of Vitamin K Status and Bone Turnover Markers in Patients with Severe Motor and Intellectual Disabilities.
Authors: Kuwabara A, Nagae A, Kitagawa M, Tozawa K, Kumode M, Tanaka K Abstract We have previously reported that patients with severe motor and intellectual disabilities (SMID) have a high prevalence of vitamin K deficiency both in the liver and bone. Thus, vitamin K therapy for SMID patients should be considered. In the present study, we have studied the efficacy of nutritional therapy with vitamin K1 for improving their vitamin K status and bone metabolism markers in patients with SMID. During the 3-mo period, 19 patients under enteral feeding received vitamin K1 treatment, the dose of which was determined to mee...
Source: Journal of Nutritional Science and Vitaminology - July 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Brain-Derived Neurotrophic Factor Up-Regulation by the Methanol Extract of Foxtail Millet in Human Peripheral Cells.
In this study, we revealed that ACHN human kidney adenocarcinoma cells secreted BDNF. In addition, we demonstrated that the methanol extract of foxtail millet up-regulated BDNF levels in ACHN cells. Our results indicate that ACHN cells could be useful in the screening for peripheral-BDNF up-regulators, and that foxtail millet may have the potential to elevate BDNF levels in peripheral tissues. PMID: 32612092 [PubMed - in process] (Source: Journal of Nutritional Science and Vitaminology)
Source: Journal of Nutritional Science and Vitaminology - July 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Sex-Specific Association between Serum Vitamin D Status and Lipid Profiles: A Cross-Sectional Study of a Middle-Aged and Elderly Chinese Population.
Authors: Huang F, Liu Q, Zhang Q, Wan Z, Hu L, Xu R, Cheng A, Lv Y, Wang L Abstract Studies have shown that vitamin D status might be associated with dyslipidaemia, but results are conflicting and there might exist sex differences. The aim of our study was to explore the sex-specific association between vitamin D status and serum lipids and atherogenic index of plasma (AIP, a predictor for atherosclerosis) among Chinese middle-aged and elderly adults. A total of 4,021 middle-aged and elderly participants from a health management centre were included in this cross-sectional study. The individuals were classified int...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Effect of a Moderate Carbohydrate-Restricted Diet on DPP-4 Inhibitor Action among Individuals with Type 2 Diabetes Mellitus: A 6-Month Intervention Study.
In this study we aimed to elucidate the effects of a moderate carbohydrate-restricted diet on glucose metabolism and renal function in patients with T2D on dipeptidyl peptidase-4 (DPP-4) inhibitors. Nineteen outpatients with T2D continued on a moderate carbohydrate-restricted diet (targeting 50% of calories) for 6 mo. Meanwhile, 10 other outpatients with T2D on DPP-4 inhibitors had the conventional calorie-restricted diet using the food exchange table. No change in prescription drugs occurred for both groups during the study period. After the intervention, the carbohydrate content in dietary intake was lowered significantl...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

A Study of Dietary and BMI Changes Over Time in Mothers of Children with Food Allergies.
We examined changes in food and BMI over time in the mothers of children with food allergies. A total of 146 mothers completed a diet survey twice, with the first conducted in 2013-2016 and the second in 2018, and the dietary changes were examined. Furthermore, among the 120 mothers who eliminated eggs from their diet in the first survey, 98 continued to eliminate eggs and 22 reintroduced eggs during the second survey, and the change over time was examined. Additionally, factors related to BMI were analyzed. We observed a change in the amount of egg intake over time within each group. As the number of children who consumed...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Easy to Swallow Rice Cake as a Carbohydrate Source during Endurance Exercise Suppressed Feelings of Thirst and Hunger without Changing Exercise Performance.
Authors: Ishihara K, Taniguchi H, Akiyama N, Asami Y Abstract The present guidelines for sports nutrition recommend relatively higher doses of carbohydrates (CHO) for endurance exercise. There is a need for novel food products that are solid but easy to swallow and supply a large dose of CHO without gastrointestinal distress (ingesting a large amount of sugar solution may cause gastrointestinal distress because of its high osmolality). We prepared a modified rice cake (SPRC, sweet potato rice cake) and assessed its properties in swallowing and mastication; we also assessed the availability of this modified rice cak...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Liver-Oriented Acute Metabolic Effects of A Low Dose of L-Carnitine under Fat-Mobilizing Conditions: Pilot Human Clinical Trial.
Authors: Odo S, Tanabe K, Yohda M, Yamauchi M Abstract The acute metabolic effect of low dosages of L-carnitine under fat-mobilizing conditions was investigated. Healthy subjects (Study 1: n=5; Study 2: n=6) were asked to fast overnight. Then, 30 min of aerobic exercise on a cycle ergometer was performed after supplementation, followed by a 3.5-h sedentary recovery phase. The following ingestion patterns were used: Study 1 (i) noningestion, (ii) 750 mg of L-carnitine (LC), and (iii) 750 mg of LC+50 g of carbohydrate (CHO); Study 2 (iv) noningestion, (v) 500 mg of LC, (vi) 30 mg of CoQ10, and (vii) 500 mg of LC+30 m...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Pre-Exercise Glucose Ingestion May Improve Endurance Capacity in East Asian Student Athletes with Lower Blood Glucose Response.
Authors: Koma R, Terasawa N Abstract The main purpose of this study was to investigate the influence of pre-exercise glucose ingestion after a 2.5-h fast on the endurance capacity and blood glucose response in East Asian athletes who is expected to have genetically low insulin response. A total of 8 Japanese student athletes ingested 1.5 g/kg body mass of glucose (G trial) or 0.5 g/kg body mass of artificial sweetener dissolved in water (P trial) 30 min before exercise test after consuming a standardized breakfast. The exercise test comprised 40 min cycling exercise at 50% maximal oxygen uptake (VO2max), immediatel...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Calcium Intake and Bone Mineral Acquisition during the Pubertal Growth Spurt: Three-Year Follow-Up of the Kitakata Kids Health Study in Japan.
Authors: Kouda K, Iki M, Fujita Y, Nakamura H, Uenishi K, Ohara K, Nishiyama T Abstract Calcium intake during a growth spurt may influence bone mineral acquisition. However, no population-based cohort studies have examined the relationship between calcium intake and whole-body bone mineral acquisition in Japanese children. The present study investigated the relationship between calcium intake and whole-body bone mineral acquisition in community-dwelling children in a northeast region of Japan using dual-energy X-ray absorptiometry. The source population for the baseline survey comprised all school children in 4th t...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Maternal Protein Restriction Increases Autophagy in the Pancreas of Newborn Rats.
Authors: Yang M, Zhang D, Li Y, Xin Y Abstract A maternal low-protein diet increases the susceptibility of offspring to type 2 diabetes by inducing alterations in β cell mass and function. However, the mechanism of this pancreas injury remains poorly understood. The present study aimed to assess whether autophagy is altered in the pancreas of intrauterine growth restriction (IUGR). In addition, the autophagy associated mammalian target of rapamycin complex 1 (mTORC1) signaling and endoplasmic reticulum (ER) stress were further evaluated in the pancreas. The maternal protein restriction IUGR rat model was estab...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Investigating Anti-Obesity Effects by Oral Administration of Aloe vera Gel Extract (AVGE): Possible Involvement in Activation of Brown Adipose Tissue (BAT).
This study was designed to assess the role of brown adipose tissue (BAT) in the anti-obesity effect of AVGE. Six-week-old male mice were divided into three groups; STD (standard diet), HFD (60% high fat diet) and AVGE (60% high fat diet with AVGE treatment). During 11 wk of AVGE administration, body weight has been monitored. Tissue samples were obtained to be measured the weight and evaluated the gene expressions. Mice treated with AVGE had suppressed body weight, and liver and fat weight gain. To investigate BAT activation, we measured the expression of mRNA related to BAT thermogenesis. Mice in the AVGE group had higher...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Possible Involvement of Lipids in the Effectiveness of Kombu in Individuals with Abnormally High Serum Triglyceride Levels.
Authors: Nishiumi S, Izumi Y, Kobayashi T, Yoshida M Abstract In Japan, Kombu (Laminaria japonica), which is a type of seaweed, is considered to be a foodstuff with health-promoting benefits, and Japanese people actively incorporate Kombu into their diets. Previously, we reported that the frequent intake of Kombu reduced the serum triglyceride levels of subjects with abnormally high serum triglyceride levels. In the current human study, we performed metabolomic analysis of serum lipids, and then the molecular species profiles of phosphatidylcholines (PC), phosphatidylethanolamines (PE), lysophosphatidylcholines (LP...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Coleus forskohlii Extract Attenuated the Beneficial Effect of Diet-Treatment on NASH in Mouse Model.
In this study, we examined the effect of CFE on the treatment of NASH. C57BL/6 mice (male, 10-wk-old) were fed a NASH diet (high-fat, low-methionine, and choline-deficient diet) for 12 wk to establish NASH. Then, we examined the effect of 0.5% (w/w) CFE in diet during diet-treatment (change to control diet) and/or treadmill-exercise (45 min at 20 m/min, 5 d/wk) to improve NASH for 3 wk. After experimental period, lipids profiles and liver functional markers in the blood, and hepatic lipid content and major CYP subtype mRNA expression and activity in liver were measured. Diet-treatment, but not exercise decreased liver weig...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Effect of High Fructose-Induced Metabolic Syndrome on Tissue Vitamin E and Lipid Peroxide Levels in Rats.
Authors: Kitagawa A, Ohta Y, Ohashi K, Yashiro K, Fukuzawa K Abstract In the present study, we examined the effect of high fructose-induced metabolic syndrome (MetS) on tissue vitamin E and lipid peroxide (LPO) levels in rats. Feeding of a diet containing 60% fructose (HFD) to Wistar rats for 2, 4, and 6 wk caused week-dependent increases in HOMA-IR score and serum insulin, triglyceride, total cholesterol, and free fatty acid concentrations. Each week HFD feeding increased serum vitamin E concentration. Six-week HFD feeding reduced vitamin E status (the serum ratio of vitamin E/triglyceride+total cholesterol). Four...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Improved Bioavailability of β-Carotene by Amorphous Solid Dispersion Technology in Rats.
Improved Bioavailability of β-Carotene by Amorphous Solid Dispersion Technology in Rats. J Nutr Sci Vitaminol (Tokyo). 2020;66(2):207-210 Authors: Otani S, Miki S, Nakamura Y, Ishimoto K, Ago Y, Nakagawa S Abstract β-Carotene (BC) is a natural lipophilic carotenoid mainly present in vegetables and fruits. Although it has various beneficial pharmacological activities, its bioavailability is low owing to its low water solubility. Recently, we reported that BC solid dispersion prepared using hot-melt technology with polyvinylpyrrolidone and sucrose fatty acid esters was in an amorphous state and...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Efficacy of Improvised Topical Zinc (1%) Ora-Base on Oral Mucositis during Cancer Chemo-Radiation-A Randomized Study.
Authors: Chaitanya N, Badam R, Aryasri AS, Pallarla S, Garlpati K, Akhila M, Soni P, Gali S, Inamdar P, Parinita B, Zaheer K, Prabhath T, Swetha A Abstract Oral mucositis refers to erythematous and ulcerative lesions of oral mucosa during chemo/radiotherapy. Treatment modalities were directed towards reduction in severity of oral mucositis. Zinc plays an important role to retard oxidative processes and is considered as the critical component in wound healing. To compare the efficacy of zinc alone with improvised zinc preparation in reducing the severity of oral mucositis. Improvised zinc was a combination of zinc o...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Vitamin D Status and Related Factors among Korean Stroke Survivors: A Nationwide Population-Based Study.
Authors: Lee JS, Kim YH Abstract The aim of this study was to investigate the vitamin D status and related factors in community-dwelling Korean stroke survivors. Data of 23,872 individuals ≥20 y who participated in the Korea National Health and Nutrition Examination Surveys (KNHANES) were analyzed. Participants who had ever been diagnosed with stroke by a doctor were defined as stroke survivors (n=431). The serum 25-hydroxyvitamin D (25(OH)D) level was measured by radioimmunoassay, and vitamin D deficiency was defined as 25(OH)D
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Dietary Factors and Eating Behaviors Affecting Diet-Induced Thermogenesis in Obese Individuals: A Systematic Review.
In conclusion, the findings suggest that in obese individuals, DIT is associated with various factors related to meal, nutrient, and dietary habits. However, because of the complexity of the relationship between DIT and obesity, it is difficult to determine the critical element underlying this association. PMID: 32115447 [PubMed - in process] (Source: Journal of Nutritional Science and Vitaminology)
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

A Flow Injection Chemiluminescence Method for the Determination of Retinol in Pharmaceutical Formulations by Using Luminol-Diperiodatoargentate(III) Reaction.
Authors: Ambar, Asghar M, Ameen F, Al-Nadhari S, Waseem A, Yaqoob M, Alarfaj AA, Nabi A Abstract In this paper, a chemiluminescence (CL) method is proposed for retinol determination by combining flow injection (FI) methodology. The CL reaction is based on the oxidation of luminol by diperiodatoargentate(III) (DPA) in the presence of retinol. Under the optimum conditions, the relative CL intensity was linear to the concentration of retinol over the range 5.0×10-3-14 mg L-1 (y=347.26x+2.5944, R2=0.9999, n=8) with limit of detection (LOD) of 1.5×10-3 mg L-1 (S/N=3) and limit of quantification (LOQ) of 5.0&...
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Gut Microbiota Is Not Involved in the Induction of Acute Phase Protein Expression Caused by Vitamin C Deficiency.
In this study, we investigated the possibility that changes in gut microbiota are involved in the induction of APP gene expression by vitamin C deficiency. ODS rats that cannot genetically synthesize vitamin C were divided into 4 groups based on the presence or absence of vitamin C or antibiotics and were raised for 15 d. Neomycin, vancomycin, and ampicillin were used as antibiotics, and 300 mg L-ascorbic acid/kg was added to the AIN93G diet. Vitamin C deficiency affected neither the wet tissue weights nor relative abundance of bacteria in the cecal contents. Antibiotic administration increased wet weights of the cecum, ce...
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Dose Effect of Bovine Lactoferrin Fortification on Iron Metabolism of Anemic Infants.
Authors: Chen K, Zhang G, Chen H, Cao Y, Dong X, Li H, Liu C Abstract To evaluate the effect of iron-fortified formula with different concentrations of bovine lactoferrin (bLF) on improvement of anemic status in term infants who were previously breast-fed. A randomized, controlled, open, and post-market intervention study. A total of 108 infants aged 6-9 mo who were previously breast-fed and weaned were selected. The subjects were divided into three groups with the sequence of outpatient: fortified group 1 (FG1) with a bLF concentration of 38 mg/100 g, FG2 with 76 mg/100 g bLF, FG0 with no bLF. The intervention dur...
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

The Association with Dietary Patterns and Risk of Anemia in Japanese Elderly.
This study aimed to evaluate the association between anemia and eating patterns in Japanese elderly. Our study included 6,864 elderly individuals, aged ≥65 y, whose data were obtained from the 2010-2015 National Health and Nutritional Survey, Japan. Anemia was defined as whole blood hemoglobin concentrations
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Induction of Autophagy and Changes in Cellular Metabolism in Glucose Starved C2C12 Myotubes.
Authors: Nakai N, Kitai S, Iida N, Inoue S, Nakata K, Murakami T, Higashida K Abstract Mouse myoblast C2C12 cells are commonly used as a model system for investigating the metabolic regulation of skeletal muscle. As it is therefore important to understand the metabolic features of C2C12 cells, we examined the effect of glucose starvation on autophagy in C2C12 myotubes. After culture of C2C12 myotubes with high (HG, 25.0 mM) or low (LG, 5.6 mM) glucose concentrations, the concentration of glucose in the LG group had decreased to 0 mM after 24 h of culture and was around 17 mM after 48 h of culture in the HG group. T...
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Red Clover (Trifolium pratense L.) Sprout Prevents Metabolic Syndrome.
We examined the prevention effect of red clover (Trifolium pratense L.) sprout on metabolic syndrome using a high-carbohydrate and high-fat diet (Western diet; WD)-induced male C57BL/6J obese model mouse. Red clover sprout-lyophilized powder (RC) contained 3.5 mg/g dry-weight of formononetin as a major phenolic compound, as analyzed by high performance liquid chromatography. Supplementation of 0.3% (w/w) RC in a WD (WD+RC) showed an anti-obesity effect and ameliorated lipid metabolism in the obese model mice. Additionally, fasting plasma glucose levels were significantly reduced in the WD+RC group. Administration of 0.1 mg...
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Evaluation of Protein Requirements Using the Indicator Amino Acid Oxidation Method.
Authors: Yoshikawa M, Morita S, Sonoki H, Iwamoto H, Takeda Y Abstract The indicator amino acid oxidation (IAAO) method is a novel method for determining protein requirements. Recently, the protein requirement of healthy young men was reevaluated using this method, and the currently recommended protein requirement based on nitrogen balance study was found to be deficient. Similarly, with respect to experimental animals, the protein concentration used widely in the experimental diets was assumed to be deficient. However, only a few studies have tested the IAAO method in experimental animals. In particular, there are...
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Significant Species Differences in Intestinal Phosphate Absorption between Dogs, Rats, and Monkeys.
This study revealed significant species differences in intestinal phosphate absorption. NaPi-IIb contributes to intestinal phosphate uptake in rats and dogs. However, in monkeys, phosphate is poorly absorbed due to the slight degradation of organic phosphate in the intestine. PMID: 32115455 [PubMed - in process] (Source: Journal of Nutritional Science and Vitaminology)
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Antioxidant Capacities of Plant-Derived Foods Commonly Consumed in Japan.
Authors: Takebayashi J, Oki T, Tsubota-Utsugi M, Ohkubo T, Watanabe J Abstract To provide reliable data for high quality epidemiological studies examining the relationship between health and antioxidant intake from daily foods, 107 plant-derived food items (12 rice, bread and noodles, 5 potatoes and starches, 9 pulses, 6 nuts/seeds, 29 vegetables, 22 fruits, 5 mushrooms, 7 algae, and 12 beverages) were selected as commonly consumed foods in Japan based on dietary records, and their antioxidant capacities were evaluated by validated hydrophilic- and lipophilic-oxygen radical absorbance capacity (H-ORAC and L-ORAC) m...
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

The Seed Coat Extract of Black Soybean Decreases Nicotine-Induced Vascular Fiber Degradation by Suppressing Matrix Metalloproteinase 2 Expression.
This study focuses on proanthocyanidins, well known for their potent antioxidant activity. We speculated that proanthocyanidins can suppress nicotine-induced weakening of vascular walls. To estimate the effect of black soybean seed coat extract (BSSCE), rich in proanthocyanidins, on nicotine-induced weakening of the aortic wall, mice were divided into four groups: the control diet and distilled water group (named C), BSSCE solution diet and distilled water group (named B), control diet and 0.5 mg/mL nicotine solution group (named CN), and BSSCE solution diet and 0.5 mg/mL nicotine solution group (named BN). Nicotine-induce...
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Metabolomic Analysis of Liver from Dietary Biotin Deficient Mice.
In this study, we analyzed the metabolomic profiles of liver extracts prepared from biotin-sufficient (BS) and -deficient (BD) mice. Thirteen of 126 metabolites showed significantly different concentrations between liver extracts from BD and BS mice. The concentrations of 5 essential amino acids, Met, Val, Thr, Ile, and Leu, and 2 conditionally essential amino acids, Cys and Tyr were significantly lower in BD mice than in BS mice. Among these, the concentrations of sulfur-containing amino acids, Cys and Met, were more than 1.5-fold lower in BD mice. The concentrations of Met metabolites, such as S-adenosylmethionine and S-...
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Dietary Cystine Ameliorates Defects in Spermatogenesis via Testosterone Production Induced by Protein Deficiency and Darkness in Rats.
Authors: Obata F, Yu G, Ohta H, Susuki N, Shimazaki M, Nishimura S, Hanai M Abstract Nutrition and light-dark cycle influence rat testicular development. With 9% casein diet (low protein diet) under normal 12 h-12 h lighting cycles (9P), juvenile rat testes undergo normal growth. On the other hand, a low protein diet with constant darkness (D9P) results in a growth arrest of rat testes. Supplementation of cystine to the low protein diet under constant darkness (D9PC) had a tendency to increase testes weight, suggesting an improvement in growth suppression. Whether the growth suppression of testes in D9P is associat...
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Retraction.
Authors: PMID: 32115460 [PubMed - in process] (Source: Journal of Nutritional Science and Vitaminology)
Source: Journal of Nutritional Science and Vitaminology - March 4, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Association of Intake Folate and Related Gene Polymorphisms with Breast Cancer.
Authors: Chen X, Ahamada H, Zhang T, Bai Z, Wang C Abstract Breast cancer is one of the most common malignancies in women worldwide and is associated with a variety of risk factors. Folate and vitamin B12 are key elements of the one-carbon metabolism pathway where methylenetetrahydrofolate reductase (MTHFR) plays a significant role. Though many molecular and epidemiological studies have been performed to explore the relationship between intake folate, vitamin B12, MTHFR gene polymorphism and breast cancer risk, there is no consensus to date. By reviewing the relevant literatures and summarizing the potential effect...
Source: Journal of Nutritional Science and Vitaminology - January 7, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

The Protective Effects of Myricetin against Cardiovascular Disease.
Authors: Wang L, Wu H, Yang F, Dong W Abstract Cardiovascular disease (CVD) is the leading cause of death globally, except Africa, and poses a severe health burden worldwide. Both in vitro and in vivo studies have demonstrated the protective effects of myricetin for preventing CVD. For this review, we have assessed the literature from 2009 to 2019 at home and abroad to uncover the protective roles of myricetin for preventing CVD. Myricetin exhibits cardioprotective, anti-hypertensive, anti-atherosclerotic, anti-hyperglycemic, and anti-hyperlipidemic effects. In addition, myricetin may alleviate some of the complica...
Source: Journal of Nutritional Science and Vitaminology - January 7, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Relation of Serum 25-Hydroxyvitamin D Status with Skeletal Muscle Mass and Grip Strength in Patients on Peritoneal Dialysis.
Authors: Wang L, Luo Q, Zhu B, Zhou F Abstract The aim of this study was to investigate the association of serum 25-hydroxyvitamin D (25(OH)D) with skeletal muscle mass (SMM) and grip strength in patients on peritoneal dialysis. In this single center retrospective study, a total of 113 incident peritoneal dialysis patients (65 men, 48 women) were included. Serum concentrations of 25(OH)D were measured through radioimmunoassay. Hypovitaminosis was classified when the level of serum 25(OH)D was
Source: Journal of Nutritional Science and Vitaminology - January 7, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Effects of Long-Term Calcium Supplementation on Rats Bone Mineral Density and Cardiovascular Based on Metabonomics.
In this study, metabonomics were employed to evaluate the changes of metabolism in rats with long-term calcium supplementation and further seek the potential markers of cardiovascular risk. SD rats were divided into two groups including normal control group (calcium intake, 0.50 g/kg bw) and high calcium supplement group (calcium intake, 2.50 g/kg bw). After 6 mo, the cardiovascular system and bone mineral density were observed. UPLC-MS was used to analyze serum metabonomics in rats. The results showed that the contents of total cholesterol and low-density lipoprotein cholesterol in the high calcium group were significantl...
Source: Journal of Nutritional Science and Vitaminology - January 7, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

AMPK α2 Deficiency Does Not Affect the Exercise-Induced Improvements in Glucose Tolerance and Metabolic Disorders in Mice Fed a High-Fat Diet.
AMPKα2 Deficiency Does Not Affect the Exercise-Induced Improvements in Glucose Tolerance and Metabolic Disorders in Mice Fed a High-Fat Diet. J Nutr Sci Vitaminol (Tokyo). 2019;65(6):491-497 Authors: Sun ZG, Tian G, Zheng XC, Liu WY, Luo XT, Xiao J, Song H, Xu X Abstract Exercise can improve obesity and metabolic disorders in mice fed a high-fat diet (HFD), but the role of AMPKα2 in the process remains unclear. The aim of this study was to investigate the role of AMPKα2 in the exercise-induced improvements in glucose tolerance and metabolic turnover in obesity mice. Male wild-type mic...
Source: Journal of Nutritional Science and Vitaminology - January 7, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Effects of an Enteral Formula Containing Fermented Dairy Products on Epithelial Ion Transport in Rat Intestines.
In conclusion, the consumption of FDP-F changed the total amounts and components of gut microbiota and organic acids, and resulted in inhibitory changes in mucosal luminal stimulant- and nervous system-mediated fluid secretory function. These findings suggest that FDP-F might prevent the incidence of diarrhea during EN. PMID: 31902863 [PubMed - in process] (Source: Journal of Nutritional Science and Vitaminology)
Source: Journal of Nutritional Science and Vitaminology - January 7, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Effect of Tryptophan, Vitamin B6, and Nicotinamide-Containing Supplement Loading between Meals on Mood and Autonomic Nervous System Activity in Young Adults with Subclinical Depression: A Randomized, Double-Blind, and Placebo-Controlled Study.
This study investigated the effects of TRP, vitamin B6, and nicotinamide-containing supplements loading between meals on mood and ANS activity in depressive young adults. Thirty depressive young adults were randomly allocated to receive TRP, vitamin B6, and nicotinamide-containing supplements or a placebo supplements twice daily between meals for 7 d. Mood was measured using the Center for Epidemiologic Studies Depression Scale (CES-D) and the Profile of Mood States (POMS). ANS activities were analyzed by heart rate variability power spectral analysis. Blood samples were assayed for plasma total TRP concentration. For anal...
Source: Journal of Nutritional Science and Vitaminology - January 7, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Hepatic Fat Content Is Associated with Fasting-Induced Fibroblast Growth Factor 21 Secretion in Mice Fed Soy Proteins.
Authors: Taniguchi H, Akiyama N, Ishihara K Abstract Previous studies suggest that circulating fibroblast growth factor 21 (FGF21) levels are elevated in patients with fatty liver, while fasting-induced secretion of FGF21 is lower in obese patients. It has been reported that soy protein prevents hepatic fat accumulation and induces FGF21 secretion. The present study was designed to evaluate the response of circulating FGF21 levels to feeding and fasting in mice fed soy protein-rich diets. For this, C57BL/6J mice were distributed into control, high-fat high-sucrose (HFHS)-casein protein, HFHS-soy protein, and HFHS-&...
Source: Journal of Nutritional Science and Vitaminology - January 7, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Development and Evaluation of Novel ELISA for Determination of Urinary Pentosidine.
In conclusion, this ELISA system is promising to evaluate the effect of AGE on lifestyle-related diseases. PMID: 31902866 [PubMed - in process] (Source: Journal of Nutritional Science and Vitaminology)
Source: Journal of Nutritional Science and Vitaminology - January 7, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Undernutrition in Pregnant Rats Induces Glucose Intolerance with Enhanced Expression of Inflammation-Related Genes in Peripheral Leukocytes of the Offspring.
Authors: Jin F, Honma K, Mochizuki K, Goda T Abstract Impaired glucose tolerance (IGT) induces chronic inflammation and subsequent development of complications triggered by arteriosclerosis. Moreover, undernutrition in pregnant rodents can induce IGT in their offspring. Here, we assessed whether undernutrition in pregnant rats would induce chronic inflammation in their offspring by measuring the expression levels of inflammation-related genes in peripheral blood leukocytes. Pregnant Wistar rats were divided into two groups: the control group received an American Institute of Nutrition Rodent diet (AIN-93G) ad libit...
Source: Journal of Nutritional Science and Vitaminology - January 7, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research