CDKN2B-AS1: An indispensable long non-coding RNA in multiple diseases.

CONCLUSIONS: Long non-coding RNA CDKN2B-AS1 likely serves as a promising therapeutic target or prognosis biomarker in multiple human diseases. PMID: 32767927 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research

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AbstractChronic thromboembolic pulmonary hypertension is an underdiagnosed condition. Patients typically present with the symptoms of right heart failure. Diagnosis is usually done by radionuclide ventilation/perfusion (VQ) scan, high-quality multidetector computed tomography (CT) or pulmonary angiography at expert centers. Pulmonary endarterectomy remains the corner stone in management of chronic thromboembolic pulmonary hypertension. Deep hypothermic circulatory arrest is commonly used for the operation at most centers. In-hospital mortality ranges from 1.7 to 14.2%. Pulmonary hemorrhage, reperfusion lung injury, and rig...
Source: Indian Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
New J. Chem., 2021, Accepted Manuscript DOI: 10.1039/D1NJ01303C, PaperYonghao Liu, Jie Zang, Mengying Lv, Rui Xue, Xuetao Liu, Yuting Hu, Yu wei, Xinjun Wang, Bo Han Ulcerative colitis (UC) is a chronic, relapsing but nonspecific inflammatory bowel disease (IBD) that poses clinical challenges, as the fabrication of a safe, effective, and economical drug delivery system is... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
ConclusionsWe established the feasibility of initiating and managing patients in a monthly text-based symptom-monitoring program. The provision of smartphones and patient navigation were unique and vital components of this program.
Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionPatients recovering at home following major cancer surgery regarded electronic symptom-monitoring and feedback as acceptable and beneficial. Patients perceived that the system enhanced information provision and provided a direct link to their care team. Patients felt that the system provided reassurance at a time of uncertainty and isolation, enabling them to feel in control of their symptoms and recovery.
Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionElectronic patient-reported outcomes are perceived as valuable for variable reasons by Black and White cancer populations, with greater perceived value for communicating with clinicians reported among Blacks. To optimize equitable uptake of ePROs, oncology practices should offer several ePRO options (e.g., web-based, phone-based), as well as paper-based options, and consider the e-health literacy needs of patients during implementation.
Source: Quality of Life Research - Category: Health Management Source Type: research
I don’t do Twitter cause social media is cancer so I will post here instead: 1. Social justice - we need more diversity in the specialty and need to stop the white male micro aggressions and unconscious biases. 2. Burnout - this needs to improve. What better way to do this than academic expansion and consolidation? As we all know physicians in academic satellites are deliriously happy, content and have a major say in what their RN/MBA overlords wish to do. 3. Jobs - Potters tweeted... Read more
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
Our United Council of Neurological Subspecialties (UCNS)-accredited program is offering a one- or two-year fellowship position beginning immediately. Our fellowship goal is to train exceptional and well-rounded neurointensivists who excel in patient care, research, and education. Fellows gain clinical experience though rotating in our busy contemporary neurocritical ICU and the neurocritical care consult service in our certified Comprehensive Stroke and Level 1 Trauma Center... Read more
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Internship, Residency and Fellowship Positions Source Type: forums
Suicide risk significantly elevated for survivors alive beyond the age of 28 years; risk was lower for women than men
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Family Medicine, Internal Medicine, Oncology, Pediatrics, Psychiatry, Journal, Source Type: news
In this study we evaluated the clinical and the histopathology of ocular and extraocular SC to confirm the difference between them. We performed a retrospective review of SC in which we studied the clinical and histomorphologic features of 106 cases, including 39 cases of ocular SC and 67 cases of extraocular SC. Only 2/67 cases of extraocular SC had multiple recurrences and none of them metastasized as opposed to our cases of ocular SC wherein 21/39 cases were locally aggressive with multiple recurrences and 5 cases metastasized. Histologically, both neoplasms showed major distinct morphologic features including poor diff...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: CME Article Source Type: research
This study sought to confirm the diagnostic utility of cytokeratin 19, c-KIT, BerEP4, GATA3, and NUTM1 immunohistochemistry in distinguishing porocarcinoma from SCC. Immunohistochemical analysis of cytokeratin 19, c-KIT, BerEP4, GATA3, and NUTM1 in 14 porocarcinomas and 22 SCCs was performed; the extents and intensities of expression of these markers were recorded. The statistical associations of the immunoexpression between porocarcinoma and SCC were analyzed using the Pearson χ2 test. Cytokeratin 19 was positive in 13 (92.9%) of 14 porocarcinomas, and for all the positive cases, staining was strong and evident in>...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Original Study Source Type: research
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