Cochrane January-March 2019: highlights from Q1

' Cochrane exists so that healthcare decisions get better. ’ That is the first sentence of our Strategy to 2020 that aims to put Cochrane evidence at the heart of health decision-making all over the world. Here ’s a look back at some key highlights of our work in the first quarter of 2019, from January to March.Cochrane began preparations for its annual flagship event,Cochrane ’s Colloquium in Santiago, Chile 22-25 October, 2019. During this time, many Cochrane contributors submitted abstracts as part of the scientific programme, this year ‘embracing diversity’. We also opened the call for hosts for the second Global Evidence Summit in 2021, a multi-disciplinary and cross-cultural event to exchange ideas about how we best produce, summarize and disseminate evidence to inform policy and practice, and using that evidence to improve people ’s lives across the world.  In Q1 2019, we saw the many ways people are using and accessing our health evidence. An international group of researchers found Cochrane Database of Systematic Reviews to be the  most referenced health-related journal on Wikipedia. The World Health Organization published  guidelines for malaria vector control, drawing on seven Cochrane reviews specially prepared for them by the Cochrane Infectious Diseases Group. We also started  a new online series that collects stories about how Cochrane evidence is being used - from in the work...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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CONCLUSION: In the outpatient clinic specializing in oral anticoagulation, patients add more specific beliefs about the interference of vitamin K-rich diet on coagulation, when compared to those in the general cardiology outpatient clinic. PMID: 31618372 [PubMed - in process]
Source: Revista gaucha de enfermagem EENFUFRGS - Category: Nursing Tags: Rev Gaucha Enferm Source Type: research
Publication date: Available online 16 October 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Nicole E. Breuner, Shelby L. Ford, Andrias Hojgaard, Lynn M. Osikowicz, Christina M. Parise, Maria F. Rosales Rizzo, Ying Bai, Michael L. Levin, Rebecca J. Eisen, Lars EisenAbstractThe invasive, human-biting Asian longhorned tick, Haemaphysalis longicornis, was detected in New Jersey in the eastern United States in August of 2017 and by November of 2018 this tick had been recorded from 45 counties across 9 states, primarily along the Eastern Seaboard. The establishment of H. longicornis in the United States has raised the ques...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 16 October 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): V. Arpudhamary, S. Priya, Muhammed A.P. Manzoor, D. Mubarakali, S. HemalathaAbstractCancer is a group of diseases characterized by the rapid creation of abnormal cells. Cancer is one of the leading causes of death in humans, affecting millions of people per year. Cembranoids are carbocyclic diterpenes composed of 14-membered ring, mainly present in the genera Nicotiana and Pinus in plants, and soft coral and other organisms. Cembranoids are cytotoxic and inhibit phospholipid metabolism. The present study is focus...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
In this study, 3D Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) were employed to construct quantitative structure-activity relationship (QSAR) models of a series of niacinamide analogues as antiandrogens. The obtained models have good reliability and predictivity. In addition, the contour maps from the models can intuitively aid to understand the vital structural characteristics of niacinamides related with the AR antagonistic activities. Our study provides important guidance for the rational design and screening of highly potential active antiandrogens.
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
CONCLUSION: The results of the Keynote-048 study have already led to the approval of pembrolizumab in the first line for platin-sensitive HNSCC in the USA and the expected approval in Europe will presumably change the therapeutic landscape in the long term. In the future, effective therapies for patients without a response to programmed cell death 1 (PD-1)/PD-L1 inhibition will be needed. PMID: 31612261 [PubMed - as supplied by publisher]
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
We report the results from a study evaluating a commercially available artificial pelleted diet for bass and live feed (fathead minnows). Following a six-month diet-acclimation period, age-0 smallmouth bass were assessed using morphometric measures, histologic and immune-function end points using conventional methods, miniaturized cell isolation and assay methods as well as imaging flow cytometry. Fish on the two diets did not significantly differ in length, weight, or condition factor, indicating that growth was similar in the two groups. Histologic examination revealed relatively higher levels of macrophage aggregates an...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 17 October 2019Source: Journal of Bioscience and BioengineeringAuthor(s): Hui-Suan Ng, Tze-Cheng Ng, Phei Er Kee, Joo Shun Tan, Hip Seng Yim, John Chi-Wei LanAqueous biphasic flotation (ABF) integrates aqueous biphasic system (ABS) and solvent sublation for recovery of target biomolecules. The feasibility of the alcohol/salt ABF for exclusive partition of cytochrome c to one specific phase of the system was investigated. Aliphatic alcohols of different carbon chain length (ethanol, 1-propanol and 2-propanol) and salts (sulfate, phosphate and citrate) were used for the phase formation. The...
Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research
In this study, the gel bead was characterized using FTIR, XPS, SEM, EDS, and 13C NMR. The experimental data shows that there is a strong correlation between adsorption capacity. The adsorption data fitted well with the Freundlich isotherm model and the pseudo-second-order model. The results of thermodynamics show that the adsorption process is spontaneous, endothermic, and increases entropy. The maximum adsorption capacity for DS was calculated as 493.81 mg/g at pH 5 (308 K). The adsorbent still exhibited excellent adsorption capacity after recycling five times, showing it has excellent potential for practica...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 16 October 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Mark B. Meyer, J. Wesley PikeAbstractCyp27b1 and Cyp24a1 are reciprocally regulated in the kidney by the key hormones PTH, FGF23, and 1,25(OH)2D3. Our recent genomic studies in mice identified a complex kidney-specific enhancer module located within the introns of adjacent Mettl1 (M1) and Mettl21b (M21) genes that mediate basal and PTH induction of Cyp27b1 as well as suppression by FGF23 and 1,25(OH)2D3. Gross deletion of these segments in mice has severe consequences on skeletal health, and directl...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 16 October 2019Source: Chemico-Biological InteractionsAuthor(s): Yasmeen M. Attia, Dina M. El-Kersh, Reham A. Ammar, Aliaa Adel, Aya Khalil, Hoda Walid, Kirullos Eskander, Mohamed Hamdy, Nada Reda, Nour Elhoda Mohsen, Ghada M. Al-Toukhy, Mohamed Tarek Mansour, Mohamed M. ElmazarAbstractTreatment of breast cancer by paclitaxel (PAX) often encounters therapeutic failure most likely caused by innate/acquired resistance. Cancer stem cells (CSCs) and multidrug resistance complex (MDR-1 or P-glycoprotein) overexpression are main mechanisms implicated in chemoresistance. Increased aldehyde dehro...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
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