Thalamic Atrophy Without Whole Brain Atrophy Is Associated With Absence of 2-Year NEDA in Multiple Sclerosis
Conclusion: Patients with isolated thalamic atrophy were at a higher risk for not reaching 2-year NEDA-3 and for EDSS increase than patients with no identified brain atrophy. The groups were clinically indistinguishable. A single measurement of thalamic and whole brain atrophy could help identify patients needing most effective therapies from early on. Introduction The quantification of brain atrophy by MRI has become an increasingly important part of evaluating neurodegeneration in MS (1, 2). Atrophy measures can reflect the damage on the central nervous system (CNS) caused by the pathological processes of the disease. However, some contributors to volumetric change, such as fluid shifts, are potentially more reversible than others, e.g., axonal and/or neuronal loss. Brain atrophy occurs in all clinical stages of untreated MS patients at a rate of 0.5–1.35%/year, in comparison with 0.1–0.3%/year in healthy individuals (1). Thalamus and other deep gray matter (GM) nuclei are among the first GM structures to be affected in MS. Several studies have shown associations between GM atrophy and measures of disease progression, such as accumulation of physical disability (3, 4) and cognitive impairment (5). Thalamic atrophy occurs from early on in the disease course (6) and it has been associated with the transition from clinically isolated syndrome (CIS) to definite MS (7). Thalamic atrophy has been shown to correlate with accumulation of disability in patients w...
Conclusion: The voucher programme enhanced uptake of the complete continuum of maternal care and the benefits extended to the most vulnerable women. However, a lack of continued transition through the continuum of maternal care was identified. This insight can assist in designing effective interventions to prevent intermittent or interrupted care-seeking. Programmes that improve access to quality healthcare in pregnancy, childbirth and the postnatal period can have wide-ranging benefits. A coherent continuum-based approach to understanding maternal care-seeking behaviour is thus expected to have a greater impact on materna...
ConclusionReadability of currently available OPEM on breast density may be written at a level too difficult for the general public to comprehend, which may represent a barrier to educational goals of newly passed federal breast density legislation.
This study was designed to assess consistency of 3 existing scoring systems in patients with T2D duration
Conclusion: In conclusion, Frey's procedure appears to be a less burdensome surgical procedure. Thus, it could be the first option for management of patients with large pancreatic stone. PMID: 31824884 [PubMed]
Epithelioid trophoblastic tumor is a malignancy derived from the chorionic laeve-type intermediate trophoblast with sufficient rarity that the vast majority of literature on the topic exists in the form of case reports and small series. Classically, it is regarded as a well-circumscribed tumor with an expansile growth pattern that occurs in reproductive-aged women, usually after a normal pregnancy. However, we recently encountered a case of epithelioid trophoblastic tumor with aggressive spread throughout the abdomen and pelvis in a 68-yr-old female presenting 30 yr after her last delivery. Although to our knowledge...
[AI London] Groundbreaking ruling could have significant impact across continent
The active ingredient in psychedelic mushrooms is called psilocybin -- and a new study suggests it could safely be used as a therapeutic approach to treat depression when other drugs have failed to work.
FDA officially has a new boss. The U.S. Senate voted 72-18 on Thursday to confirmÂ Stephen Hahn, MD,Â as theÂ new FDA Commissioner. The news was largely well received by industry advocacyÂ groups like AdvaMed and professional societies like the American Heart Association. âDr. Hahn is an excellent choice to lead FDA, and we congratulate him on his swift and overwhelming bipartisan confirmation," said AdvaMed CEO Scott Whitaker. "During the confirmation process, Dr. Hahn demonstrated his deep understanding of the agencyâs mission to pr...
Conclusions: Findings suggest that veterans with mild and moderate-to-severe TBI are at increased risk of death by drug overdose and firearms, with overdose risk heightened with age. Data indicate that prevention efforts in patients with TBI include targeted means reduction. PMID: 31822136 [PubMed - as supplied by publisher]
[New Zimbabwe] Zimbabwe has recorded a decrease in the under-five mortality rate in the last five years as compared to the previous period, findings by the Multiple Indicator Cluster Survey (MISC) Findings have revealed.
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