Predictors of Hospital Mortality and the Related Burden of Disease in Severe Traumatic Brain Injury: A Prospective Multicentric Study in Brazil

Conclusions This is the first multicentric and prospective study on hospital mortality and the burden of TBI based on YLLs in Brazil. The burden of TBI determined by disability-adjusted life years (DALYs) remains to be investigated in Brazil. Older age, Marshall CT classification, presence SAH on the CT scan, lower GCS scores, and pupillary abnormalities are independent predictors of hospital mortality. The hospital mortality due to severe TBI was similar to those from other trauma centers in Brazil and Latin America and did not change significantly since the end of the 1990s. Present study findings are in agreement with the view that extrapolation from predictive TBI models in HIC to LMIC may lead to inaccurate estimation of TBI-related hospital mortality. These results have implications for further TBI multicentric trials including countries with different income levels. Ethics Statement This study was carried out in accordance with the recommendations of Comitê de Ética em Pesquisa em Seres Humanos da Universidade (Plataforma Brazil Registration 02832612.6.1001.0121). Informed consent to participate was signed by each patient's family. Author Contributions AD, JQ, KL, EK, FD, and RW: study design, literature revision, manuscript revision. RW and FD: statistical analysis and manuscript writing. FA, IR, MS, DS, CF, CR, and FD: data collection, and manuscript revision. Funding This work was supported by PRONEX Program (NENASC Project, process 56...
Source: Frontiers in Neurology - Category: Neurology Source Type: research