Experts Discuss Unique Side Effects of Immunotherapy

If you have mesothelioma and you’ve already received standard-of-care therapies, you may be considering an immunotherapy clinical trial. If you’re considering this option, a free immunotherapy teleconference is a great place to learn more. CancerCare recently hosted two one-hour education workshops featuring panels of immunotherapy experts. Part I of the teleconference presented an overview of immunotherapy. Part II of the teleconference, which is available online for free, focused exclusively on immunotherapy side effects. Understanding these issues and the role each patient plays in managing their own side effects is critical to successful clinical trial participation. Side Effects: Immunotherapy Vs. Chemotherapy Dr. Susan Slovin, panelist and attending physician of genitourinary oncology at Memorial Sloan Kettering Cancer Center (MSK), explained the basics of chemotherapy and immunotherapy side effects. “Chemotherapy gets at the DNA, or the reproductive site, of cancer cells. It also affects normal cell function and reproduction. These actions on normal cells drive general side effects like nausea and fatigue,” Slovin explained. Immunotherapy’s mechanism of action is very different, so the side effect profile is different as well. Unlike chemotherapy, immunotherapy does not destroy cancer directly. The goal of immunotherapy is to manipulate the immune system to kill cancer without destroying normal tissue. “With normal immunity, our bodi...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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CONCLUSIONS Our results demonstrated a regulation loop among MATAL1, miR-194, and YAP1, which dynamically regulates the progression of AP, providing a new therapeutic target for treatment of this disease. PMID: 31518341 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS The findings supported that hsa_circ_0079993 acts as an oncogene in CRC through the miRNA-203a-3p.1/CREB1 axis. PMID: 31515467 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: January 2020Source: Materials Science and Engineering: C, Volume 106Author(s): Sandeep Kumar, Monika Nehra, Deepak Kedia, Neeraj Dilbaghi, K. Tankeshwar, Ki-Hyun KimAbstractBioimplant engineering aims to mature biological alternatives to restore, retain, or modify damaged tissues and/or the functionality of organs. Remarkable advancements in modern material technology have helped the diversity of materials for orthopaedic implant application. As such, nanomaterials can simulate the surface properties of natural tissues, especially with respect to surface topography, surface chemistry, surface energy, and ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: January 2020Source: Materials Science and Engineering: C, Volume 106Author(s): Kai Zhao, Guogang Cheng, Baozhen Zhang, Dan Li, Jinyu Han, Jie Chen, Baobei Wang, Mengxia Li, Tianxia Xiao, Aiwen Le, Beini Sun, Zheng Jin, Jian Zhang, Xiujun FanAbstractTo developing a multiple cancer types targeting drug delivery carrier system, a 28 amino acids from the VAR2CSA was synthesized as the placental CSA-binding peptide (plCSA-BP). Its specific binding ability to cancer cells was tested on cancer tissue array, and the results showed that plCSA-BP could bind to multiple cancer types. Then, the plCSA-BP was used as a...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 13 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yawara Eguchi, Keigo Enomoto, Takashi Sato, Atsuya Watanabe, Takayuki Sakai, Masaki Norimoto, Masami Yoneyama, Yasuchika Aoki, Munetaka Suzuki, Hajime Yamanaka, Hiroshi Tamai, Tatsuya Kobayashi, Sumihisa Orita, Miyako Suzuki, Kazuhide Inage, Yasuhiro Shiga, Naoya Hirosawa, Masahiro Inoue, Masao Koda, Takeo FuruyaAbstractThere is no imaging modality to quantitatively evaluate compressed cervical nerve roots in cervical radiculopathy. Here we sought to evaluate the usefulness of simultaneous apparent T2 mapping and neurogra...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 13 September 2019Source: Prostaglandins, Leukotrienes and Essential Fatty AcidsAuthor(s): GQ Carvalho, M Pereira-Santos, LD Marcon, ID Louro, MCG Peluzio, DB SantosAbstractThere is a lack of studies about polymorphisms in FADS genes in pregnant women. We aimed to verify the interaction between three FADS gene polymorphisms (rs174561; rs174575; rs3834458) and dietary α-linolenic acid (ALA) or linoleic/α-linolenic acid ratio (LA/ALA) and plasma concentrations of omega-3 (n-3) PUFAs in pregnant women. Of the 250 women evaluated, the homozygous for the rs174561 and rs3834458 minor...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research
Authors: Bani Younis MK, Al-Rawashdeh A, Alnajadat RM Abstract The purpose of this study was to evaluate the effect of palliative care intervention on the quality of life among Jordanian caregivers of cancer patients. Repeated measures design was used in this study. Data were collected from 137 Jordanian caregivers of cancer patients utilizing a self-administered questionnaire. An intervention program called SHARE was implemented to the experimental groups and its effectiveness in improving the overall quality of life for caregivers of cancer patients was evaluated using repeated measure ANOVA test. The results sho...
Source: Home Health Care Services Quarterly - Category: Nursing Tags: Home Health Care Serv Q Source Type: research
Authors: Tsifi A, Papaxoinis G, Diamantopoulos P, Mantzourani M, Antoniadou V, Halioti A, Gogas H Abstract In the current report we present the case of a patient experiencing a life-threatening drug-drug interaction involving the concurrent administration of capecitabine and brivudine. A 65- year-old female with metastatic breast cancer was commenced on brivudine for Herpes Zoster, while on capecitabine treatment, by a physician unfamiliar with the potential repercussions of this drug-drug interaction. As a result, she developed skin rash, severe oral mucositis, and severe and prolonged pancytopenia. These side eff...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
The objective of the present study was to investigate the mRNA levels of important miRNA machinery components, DICER1, DROSHA, DiGeroge syndrome critical region gene 8 (DGCR8), and Argonaute 2 (AGO2), and their correlations with clinicopathological characteristics of ccRCC using mRNA expression data from The Cancer Genome Atlas kidney clear cell carcinoma (TCGA KIRC) cohort and a Korean ccRCC cohort. mRNA levels of DICER1, DROSHA, and DGCR8 were significantly decreased in both cohorts. However, AGO2 was significantly downregulated only in the Korean ccRCC cohort. Additionally, positive correlations were observed between th...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
LncRNA AWPPH participates in the metastasis of non-small cell lung cancer by upregulating TGF-β1 expression. Oncol Lett. 2019 Oct;18(4):4246-4252 Authors: Huo Y, Li A, Wang Z Abstract Long non-coding RNA (lncRNA) AWPPH is a characterized oncogenic lncRNA in hepatocellular carcinoma and bladder cancer. The aim of the present study was to investigate the potential involvement of AWPPH in non-small cell lung cancer (NSCLC). Expression of AWPPH in lung biopsy tissues and serum of both healthy controls and patients with NSCLC with different tumor sizes, and with and without distant tumor metastasis was...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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