Frog slime could protect us against future flu epidemic

Conclusion This study has identified a substance in the mucus secreted by a south Indian frog which can kill certain types of flu virus. Researchers often turn to natural substances with known health-giving properties to find potential new drugs for humans. For example, aspirin was developed based on a compound found in willow bark – which had been used in traditional medicine for hundreds of years. Some other drugs – such as some chemotherapy and anticlotting drugs – have also been developed from chemicals found in plants. By isolating the substances that have an effect the researchers can make sure they are pure and adapt and them to make them as safe and effective as possible for human use. This is another example of this process, using an animal's natural defences to identify substances that could help protect humans. It also offers yet another compelling reason why we should make an effort to prevent different species, both animal and plants, from becoming extinct. Potential treatments for human disease could be lost forever if a species disappears. As yet, tests on urumin are in the early stages. So far it has only been shown to be effective at killing some types of flu viruses in the lab but not others, and researchers will want to test it against a wider range of flu viruses. The path to developing new drugs is long, and it will be a while before we know if urumin is suitable for testing in humans, and whether it will be successful in these tes...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medication Medical practice Source Type: news

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ConclusionThis systematic review highlighted the potential of a goal setting technique in the asthma self-management education. However, due to the limitations of the quality and quantity of the included literature, more rigorous studies are needed. In the future, better effective study protocol combining with goal setting approach and other behavior technique is needed to further investigate.
Source: International Journal of Nursing Sciences - Category: Nursing Source Type: research
Authors: Nafiu OO, Owusu-Bediako K, Chimbira WT Abstract BACKGROUND: Recent data among pediatric otolaryngology patients showed unexplained higher rates of serious perioperative respiratory adverse events (PRAE) in black children compared to their white peers. We evaluated whether preoperative respiratory comorbidity (PRC) burden contributes to racial disparity in serious PRAE in children undergoing non-otolaryngologic procedures. METHODS: Rates of serious PRAE (laryngospasm and/or bronchospasm) were compared across racial groups in a retrospective cohort of black and white children (N = 18538; black ...
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
Publication date: Available online 30 March 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Young-Woo Jeon, Seugyun Yoon, Gi June Min, Sung-Soo Park, Silvia Park, Jae-Ho Yoon, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Hee-Je Kim, Seok Lee, Chang-Ki Min, Jong Wook Lee, Seok-Goo ChoAbstractIntroductionAllogeneic hematopoietic stem cell transplant with reduced-intensity conditioning is an effective therapeutic option for patients with refractory or relapsed aggressive non-Hodgkin lymphoma (NHL).Patients and MethodsWe retrospectively evaluated survival outcomes and the efficacy of our fludarabine/mel...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
This study evaluates NLR in a large cohort of HCC patients. Methods: We retrospectively reviewed 789 HCC cases (1993-2017) for demographics, tumor characteristics, treatment, and survival. NLR was stratified into NLR ≥1.5 and NLR ≥3 and analyzed for correlation with American Joint Committee on Cancer (AJCC) and Barcelona Clinic Liver Cancer (BCLC) stages. In 235 patients who underwent liver resection, survival and recurrence were evaluated by NLR. Results: In 789 HCC cases, mean NLR was increased with advanced AJCC and BCLC stages. Hepatitis C patients were less likely to have NLR ≥1.5 and ≥3. Non-alcoh...
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
Publication date: Available online 20 April 2019Source: Clinica Chimica ActaAuthor(s): K. Dalal, B. Dalal, S. Bhatia, A. Shukla, A. ShankarkumarAbstractBackgroundHepatocellular carcinoma (HCC) due to Hepatitis B viral (HBV) infection is major cause in Asia-Pacific countries. Its early detection is of paramount importance using a marker having both sensitivity and specificity. The present study promises diagnostic and prognostic markers by the identification of site specific glycoforms on Haptoglobin (Hp) using LC-MS/MS and lectin ELISA in liver diseased conditions in HBV infection.MethodsThree groups of patients: chronic, ...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
ConclusionsAmbulating patients supported with VA-ECMO, despite femoral arterial cannulation, appears feasible and safe in carefully selected patients.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: May 2019Source: The Annals of Thoracic Surgery, Volume 107, Issue 5Author(s): Amitabh M. Chopra, Victor A. Ferraris
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
GIDEON what’s new summary: April 19 to April 21, 2019 Infectious Diseases – Outbreaks (7 updates) 7 DiseasesMap Infectious Diseases – Diseases (87 updates) 34 Diseases53 Country notesMap Infectious Diseases – Drugs (1 updates) 1 Drug Microbiology – Bacteria (1 updates) 1 Bacteria Microbiology – Mycobacteria (1 updates) 1 Mycobacteria The post Update: April 21, 2019 appeared first on GIDEON - Global Infectious Diseases and Epidemiology Online Network.
Source: GIDEON blog - Category: Databases & Libraries Authors: Tags: What's New Source Type: blogs
Publication date: Available online 20 April 2019Source: BiologicalsAuthor(s): Mozhdeh Namvarpour, Majid Tebianian, Reza Mansouri, Seyyed Mahmoud Ebrahimi, Shiva KashkooliAbstractAccording to some difficulties against tuberculosis (TB) vaccination, development of new TB vaccines has been noted in recent years. Selection of proper route for vaccination is one of the most important factors for induction of good immune responses. Hence, in this study, the effects of different administration routes, including intranasal (I.N), subcutaneous (S.C) and intramuscular (I.M) on immune responses against Mycobacterium tuberculosis ESAT...
Source: Biologicals - Category: Biology Source Type: research
CONCLUSION: emergency nurses perceive their practice during the management of an epidemic expanded in that they shouldered a greater responsibility in the control of infectious diseases. This expansion led to role ambiguity among them. PMID: 31002559 [PubMed - in process]
Source: British Journal of Nursing - Category: Nursing Authors: Tags: Br J Nurs Source Type: research
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