Frog slime could protect us against future flu epidemic

Conclusion This study has identified a substance in the mucus secreted by a south Indian frog which can kill certain types of flu virus. Researchers often turn to natural substances with known health-giving properties to find potential new drugs for humans. For example, aspirin was developed based on a compound found in willow bark – which had been used in traditional medicine for hundreds of years. Some other drugs – such as some chemotherapy and anticlotting drugs – have also been developed from chemicals found in plants. By isolating the substances that have an effect the researchers can make sure they are pure and adapt and them to make them as safe and effective as possible for human use. This is another example of this process, using an animal's natural defences to identify substances that could help protect humans. It also offers yet another compelling reason why we should make an effort to prevent different species, both animal and plants, from becoming extinct. Potential treatments for human disease could be lost forever if a species disappears. As yet, tests on urumin are in the early stages. So far it has only been shown to be effective at killing some types of flu viruses in the lab but not others, and researchers will want to test it against a wider range of flu viruses. The path to developing new drugs is long, and it will be a while before we know if urumin is suitable for testing in humans, and whether it will be successful in these tes...
Source: NHS News Feed - Category: Consumer Health News Tags: Heart/lungs Medication Medical practice Source Type: news

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Authors: Wang S, Peng D Abstract Emery-Dreifuss muscular dystrophy (EDMD) is a group of hereditary muscular dystrophy syndrome caused by deficiency of genes encoding nuclear envelope proteins. Patients having EDMD show the triad of muscle dystrophy, joint contracture, and cardiac disease. In almost all patients, cardiac involvement is prevalent and is the most severe aspect of EDMD. Cardiac disease is predominantly shown by conduction defects, atrial fibrillation/flutter, and atrial standstill. Sudden death and heart failure because of left ventricular dysfunction are important causes of mortality, particularly in ...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Authors: Riera-Mestre A, Ribas J, Castellote J Abstract Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant inherited Rare Disease that causes a systemic anomalous vascular overgrowth. The approach and follow-up of these patients should be from multidisciplinary units. Its diagnosis is carried out according to Curaçao clinical Criteria. Telangiectasia in the nasal mucosa cause recurrent epistaxis, the main symptom of HHT and difficult to control. The three types of hepatic shunting, hepatic artery to hepatic vein, hepatic artery to portal vein or to portal vein to hepatic vein, can cause hi...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Authors: Rodríguez-García J, Fernández-Santos R, García-Erce JA PMID: 30502295 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Publication date: 1 March 2019Source: Inorganica Chimica Acta, Volume 487Author(s): Sami El Deeb, Benjamin N. Ma, Daniel Baecker, Ronald GustAbstractMetal complexes of substituted N,N′-bis(salicylidene)ethylenediamine ligands are interesting metallo drugs for chemotherapy. Our lead [N,N′-bis(salicylidene)-1,2-phenylenediamine]chloridoiron(III) [Fe(III)salopheneCl] showed excellent in vitro activity against tumor cells sensitive but also resistant to common antitumor drugs. For the analysis of the biological results, information about the stability in various solvents at defined biological pH values is necessary...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 8 December 2018Source: Respiratory Medicine Case ReportsAuthor(s): Iwao Shimomura, Yoshihiro Miki, Eiko Suzuki, Mineo Katsumata, Dai Hashimoto, Yoshifumi Arai, Yoshiro Otsuki, Hidenori NakamuraAbstractA 61-year-old woman with a history of palpebral conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma, treated with rituximab, was referred to the authors' hospital after follow-up positron emission tomography/computed tomography revealed 18F-fluoro-2-deoxy-D-glucose uptake in a tumor located in the left main bronchus. The diagnosis of MALT lymphoma was made by pathological and immu...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
ConclusionThis study has experimentally demonstrated that high daily intake of sugar in healthy pregnancies causes adverse effects on the mother and offspring.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
NOROVIRUS symptoms include feeling sick and having diarrhoea, and the virus is known as the ‘winter vomiting bug’. An outbreak of norovirus has spread across the UK, and Public Health England is urging the public to follow good hygiene practices. These are the signs and symptoms of norovirus to look out for.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 8 December 2018Source: American Heart JournalAuthor(s): Christophe Leclercq, Haran Burri, Antonio Curnis, Peter Paul Delnoy, Christopher A Rinaldi, Johannes Sperzel, Kwangdeok Lee, Clay Cohorn, Bernard Thibault, on behalf of the MORE-CRT MPP InvestigatorsBackgroundAlthough cardiac resynchronization therapy (CRT) is beneficial in most heart failure patients, up to 40% do not respond to CRT. Data from the MultiPointTM Pacing (MPP) IDE trial and MORE-CRT MPP PHASE I study suggest improved response in subjects in the MPP arm –programmed with wide LV electrode anatomical separation (≥...
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 8 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Mark Ballow, Tiffany Henderson, Christopher Scalchunes, R. Michael Blaese
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
At the University of Zürich, Vincent speaks with virologists Cornel Fraeful, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology aav adenovirus adenovirus-associated virus genome wide screen helper virus influenza virus viral virus entry viruses Source Type: blogs
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