Gram-negative bacteria recognition and photodynamic elimination by Zn-DPA based sensitizers
Biomaterials. 2024 Apr 15;308:122571. doi: 10.1016/j.biomaterials.2024.122571. Online ahead of print.ABSTRACTThe abuse and overuse of antibiotics let drug-resistant bacteria emerges. Antibacterial photodynamic therapy (APDT) has shown outstanding merits to eliminate the drug-resistant bacteria via cytotoxic reactive oxygen species produced by irradiating photosensitizer. However, most of photosensitizers are not effective for Gram-negative bacteria elimination. Herein conjugates of NBS, a photosensitizer, linked with one (NBS-DPA-Zn) or two (NBS-2DPA-Zn) equivalents of zinc-dipicolylamine (Zn-DPA) have been designed to ach...
Source: Biomaterials - April 18, 2024 Category: Materials Science Authors: Zuokai Wang Shuang Zeng Yifu Hao Wenlin Cai Wen Sun Jianjun Du Saran Long Jiangli Fan Jingyun Wang Xiaoqiang Chen Xiaojun Peng Source Type: research
A robust computational quest: Discovering potential hits to improve the treatment of pyrazinamide-resistant Mycobacterium tuberculosis
This study utilizes a novel integration of computational techniques, including multiscale biomolecular and molecular dynamics simulations, physicochemical and medicinal chemistry predictions, quantum computations and virtual screening from the ZINC and Chembridge databases, to elucidate the resistance mechanism and identify lead compounds that have the potential to improve treatment outcomes for PZA-resistant MTB, namely ZINC15913786, ZINC20735155, Chem10269711, Chem10279789 and Chem10295790. These computational methods offer a cost-effective, rapid alternative to traditional drug trials by bypassing the need for organic s...
Source: J Cell Mol Med - April 18, 2024 Category: Molecular Biology Authors: Muhammad Shahab Gabriel Christian de Farias Morais Shopnil Akash Umberto Laino Fulco Jonas Ivan Nobre Oliveira Guojun Zheng Shahina Akter Source Type: research
Molecules, Vol. 29, Pages 1845: Self-Assembled Matrine-PROTAC Encapsulating Zinc(II) Phthalocyanine with GSH-Depletion-Enhanced ROS Generation for Cancer Therapy
Lisheng Wang
The integration of a multidimensional treatment dominated by active ingredients of traditional Chinese medicine (TCM), including enhanced chemotherapy and synergistically amplification of oxidative damage, into a nanoplatform would be of great significance for furthering accurate and effective cancer treatment with the active ingredients of TCM. Herein, in this study, we designed and synthesized four matrine-proteolysis-targeting chimeras (PROTACs) (depending on different lengths of the chains named LST-1, LST-2, LST-3, and LST-4) based on PROTAC technology to overcome the limitations of matrine. LST-4,...
Source: Molecules - April 18, 2024 Category: Chemistry Authors: Sitong Lai Bing Wang Kunhui Sun Fan Li Qian Liu Xie-An Yu Lihe Jiang Lisheng Wang Tags: Article Source Type: research
Same-day post-therapy imaging with a new generation whole-body digital SPECT/CT in assessing treatment response to [177Lu]Lu-PSMA-617 in metastatic castration-resistant prostate cancer
ConclusionWe successfully implemented same-day post-therapy SPECT/CT after [177Lu]Lu-PSMA-617 infusions. Quantitation of 1 –2 h post-therapy SPECT/CT images is a promising method for assessing treatment response. However, the approach is currently limited by its suboptimal detection of small tumor lesions and the necessity of incorporating a third-cycle SPECT/CT to mitigate the effects of any potential treatment-rela ted flare-up. Further investigation in a larger patient cohort and prospective validation is essential to confirm these findings and to explore the role of SPECT/CT as a potential adjunct to PSMA PET/CT in ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 18, 2024 Category: Nuclear Medicine Source Type: research
Cancers, Vol. 16, Pages 1548: Oral Mucositis Management in Children under Cancer Treatment: A Systematic Review
ilva
Children undergoing antineoplastic treatment often present severe side effects due to the dosage and duration of treatments, with oral mucositis emerging as one of the most prevalent and painful inflammatory conditions. There is a growing body of evidence on therapeutic interventions such as cryotherapy, low-level laser therapy, and natural compounds for this condition. The aim of this systematic review was to identify and compare therapies for the management of cancer treatment-induced oral mucositis in pediatric patients. From 2655 articles obtained in initial searches, 39 articles were considered in this system...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Ricardo Bragu ês Maria Francisca Marv ão Patr ícia Correia Raquel M. Silva Tags: Systematic Review Source Type: research
Effect of cement type on vertical marginal discrepancy and residual excess cement in screwmentable and cementable implant-supported monolithic zirconia crowns
AbstractThe purpose of this study was to investigate the vertical marginal discrepancy (VMD) and residual excess cement (REC) of cementable and screwmentable monolithic zirconia crowns cemented with different types of cement. Abutments were attached to 40 implant analogues. Crowns were created using computer-aided design/computer-aided manufacturing technology from monolithic zirconia blocks, either with or without a screw access hole (SAC). Crowns created both ways were split into two groups and cemented with resin and zinc polycarboxylate cement under a 5-kg weight. VMD and REC values were evaluated using an X20 zoom ste...
Source: Odontology - April 18, 2024 Category: Dentistry Source Type: research
Vitamin D3 and zinc supplements augment the antimanic efficacy of lithium and olanzapine treatments in an animal model of mania
. (Source: Nutritional Neuroscience)
Source: Nutritional Neuroscience - April 18, 2024 Category: Nutrition Authors: Aya A. S. HuzayyinMichael K. IbrahimNahed M. A. HassaneinHelmy M. S. Ahmeda Central Administration of Drug Control, Egyptian Drug Authority (EDA), Giza, Egyptb Central Administration of Biological and Innovative Products and Clinical Studies, Egyptian Dru Source Type: research
Same-day post-therapy imaging with a new generation whole-body digital SPECT/CT in assessing treatment response to [177Lu]Lu-PSMA-617 in metastatic castration-resistant prostate cancer
ConclusionWe successfully implemented same-day post-therapy SPECT/CT after [177Lu]Lu-PSMA-617 infusions. Quantitation of 1 –2 h post-therapy SPECT/CT images is a promising method for assessing treatment response. However, the approach is currently limited by its suboptimal detection of small tumor lesions and the necessity of incorporating a third-cycle SPECT/CT to mitigate the effects of any potential treatment-rela ted flare-up. Further investigation in a larger patient cohort and prospective validation is essential to confirm these findings and to explore the role of SPECT/CT as a potential adjunct to PSMA PET/CT in ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 18, 2024 Category: Nuclear Medicine Source Type: research
Electric field distribution regulation of zinc anode toward long cycle life zinc metal battery
J. Mater. Chem. A, 2024, Accepted Manuscript DOI: 10.1039/D4TA00629A, PaperXintao Long, Yizhou Liu, Dongxin Wang, Yihang Nie, Xiaoyong Lai, Dan Luo, Xin Wang Zinc ion batteries are expected to be the next generation of rechargeable aqueous metal ion batteries, but their application is limited by its severe dendrite growth caused by inhomogeneous plating... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - April 17, 2024 Category: Chemistry Authors: Xintao Long Source Type: research
Porous layered ZnV2O4@C synthesized based on bimetallic MOF as a stable cathode material for aqueous zinc ion batteries
Dalton Trans., 2024, Accepted Manuscript DOI: 10.1039/D4DT01062K, PaperBingbing Dai, Xixun Shen, Tiantian Chen, Jian Li, Qunjie Xu Vanadium-based oxides are considered to be as a potential cathode material for aqueous zinc ion batteries (AZIBs) due to their special layered (or tunnel) structure suitable for zinc ion storage.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - April 17, 2024 Category: Chemistry Authors: Bingbing Dai Source Type: research
α-Zirconium hydrogenophosphate as a nano-container of 2-aminobenzimidazole for the corrosion protection of zinc in NaCl medium
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.I. Bouali, E. Rocca, D. Veys-Renaux, B. Rhouta, A. Khalil α-Zirconium hydrogenophosphate constitutes an efficient nanocontainer which releases the corrosion inhibitor 2-aminobenzimidazole upon contact with Na+ and buffers the local pH. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - April 17, 2024 Category: Chemistry Authors: I. Bouali Source Type: research
Comparison of trace elements in peripheral blood and bone marrow of newly diagnosed multiple myeloma patients
In this study, we aimed to evaluate alterations in trace elements in the blood and bone marrow serum of patients with newly diagnosed multiple myeloma (NMM). The levels of zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), magnesium (Mg), selenium (Se), arsenic (As), boron (B), nickel (Ni), silicon (Si) and chromium (Cr) were analyzed in the venous blood samples of the patient group comprising 70 patients with NMM (41 males and 29 females) and compared to those in the control group comprising 30 individuals (18 males and 12 females). In addition, trace element levels were analyzed in bone marrow samples from the patient gr...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Ayse Nilgun Kul Bahar Ozturk Kurt Source Type: research
Materials analysis in three paintings of Thomas Gainsborough (1727-1788) by portable X-ray fluorescence
Appl Radiat Isot. 2024 Apr 16;209:111324. doi: 10.1016/j.apradiso.2024.111324. Online ahead of print.ABSTRACTThree paintings of Thomas Gainsborough (1727-1788), one of the most influential English portrait painters of the late 18th century, from the collection of the Museu de Arte de São Paulo (MASP) - "Francis Rawdon" (1783-1784), "Portrait of Mrs. John Bolton" (1770), and "Drinkstone Park" (1747) - were investigated using portable X-ray fluorescence (pXRF), employing a W tube anode and an XR-100CR detector. These artworks represent the only paintings by Thomas Gainsborough located in the southern hemisphere. Through an ...
Source: Applied Radiation and Isotopes - April 17, 2024 Category: Radiology Authors: Let ícia Martins Birelo Carlos Roberto Appoloni Source Type: research
Caveolin-2 palmitoylation turnover facilitates insulin receptor substrate-1-directed lipid metabolism by insulin receptor tyrosine kinase
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167173. doi: 10.1016/j.bbadis.2024.167173. Online ahead of print.ABSTRACTHere, we show that insulin induces palmitoylation turnover of Caveolin-2 (Cav-2) in adipocytes. Acyl protein thioesterases-1 (APT1) catalyzes Cav-2 depalmitoylation, and zinc finger DHHC domain-containing protein palmitoyltransferase 21 (ZDHHC21) repalmitoylation of the depalmitoylated Cav-2 for the turnover, thereby controlling insulin receptor (IR)-Cav-2-insulin receptor substrate-1 (IRS-1)-Akt-driven signaling. Insulin-induced palmitoylation turnover of Cav-2 facilitated glucose uptake and fat storage...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Moonjeong Choi Jaewoong Lee Kyuho Jeong Yunbae Pak Source Type: research
Zinc ameliorates acrylamide-induced oxidative stress and apoptosis in testicular cells via Nrf2/HO-1/NfkB and Bax/Bcl2 signaling pathway
CONCLUSION: In conclusion, zinc may protect against acrylamide-induced testicular toxicity, mediated by its antioxidant, anti-inflammatory, and antiapoptotic effects.PMID:38629506 | DOI:10.1080/13510002.2024.2341537 (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - April 17, 2024 Category: Biochemistry Authors: Ayodeji Johnson Ajibare Adeyemi Fatai Odetayo Olabode Oluwadare Akintoye Luqman Aribidesi Olayaki Source Type: research
