Deep-ultraviolet n-ZnGa_2O_4/p-GaN heterojunction photodetector fabricated by pulsed laser deposition
Zinc gallium oxide (ZnGa_2O_4) has attracted considerable interest in deep-ultraviolet photodetectors, due to the ultrawide bandgap, high ... (Source: Optics Letters)
Source: Optics Letters - April 19, 2024 Category: Physics Authors: Ning Cao Lichun Zhang Xin Li Xianling Meng Doudou Liang Yadan Zhu Fengzhou Zhao Source Type: research
Genome-wide identification, characterization and expression of C2H2 zinc finger gene family in Opisthopappus species under salt stress
The C2H2 zinc finger protein family plays important roles in plants. However, precisely how C2H2s function in Opisthopappus (Opisthopappus taihangensis and Opisthopappus longilobus) remains unclear. (Source: BMC Genomics)
Source: BMC Genomics - April 19, 2024 Category: Genetics & Stem Cells Authors: Xiaojuan Zhou, Ting Gao, Yimeng Zhang, Mian Han, Yuexin Shen, Yu Su, Xiaolong Feng, Qi Wu, Genlou Sun and Yiling Wang Tags: Research Source Type: research
Bi-intercalated vanadium pentoxide synthesized via hydrogen peroxide-induced phase transition for highly stable cathode in aqueous zinc ion batteries
J. Mater. Chem. A, 2024, Advance Article DOI: 10.1039/D3TA07984H, PaperJian-an Chen, Xuejun Hou, Xueli Wang, Chunxia Wang, Jiawei Wen, Yongjie Bu, Guoyong Huang, Tiantian Cao, Shengming Xu Operating principle of aqueous zinc-ion batteries (ZIBs). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - April 18, 2024 Category: Chemistry Authors: Jian-an Chen Source Type: research
Simple distance-based thread analytical device integrated with ion imprinted polymer for Zn2+ quantification in human urine samples
Analyst, 2024, Advance Article DOI: 10.1039/D4AN00076E, PaperLita Chheang, Kawin Khachornsakkul, Ruben Del-Rio-Ruiz, Wenxin Zeng, Nisakorn Thongkon, Sudtida Pliankarom Thanasupsin, Sameer Sonkusale An IIP was synthesized and immobilized into a distance-based thread substrate for zinc quantification. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - April 18, 2024 Category: Chemistry Authors: Lita Chheang Source Type: research
Corrigendum: Fast Reaction Kinetics and Commendable Low-Temperature Adaptability of Zinc Batteries Enabled by Aprotic Water-Acetamide Symbiotic Solvation Sheath
Angew Chem Int Ed Engl. 2024 Apr 18:e202406762. doi: 10.1002/anie.202406762. Online ahead of print.NO ABSTRACTPMID:38634524 | DOI:10.1002/anie.202406762 (Source: Angewandte Chemie)
Source: Angewandte Chemie - April 18, 2024 Category: Chemistry Source Type: research
Same-day post-therapy imaging with a new generation whole-body digital SPECT/CT in assessing treatment response to [ < sup > 177 < /sup > Lu]Lu-PSMA-617 in metastatic castration-resistant prostate cancer
CONCLUSION: We successfully implemented same-day post-therapy SPECT/CT after [177Lu]Lu-PSMA-617 infusions. Quantitation of 1-2 h post-therapy SPECT/CT images is a promising method for assessing treatment response. However, the approach is currently limited by its suboptimal detection of small tumor lesions and the necessity of incorporating a third-cycle SPECT/CT to mitigate the effects of any potential treatment-related flare-up. Further investigation in a larger patient cohort and prospective validation is essential to confirm these findings and to explore the role of SPECT/CT as a potential adjunct to PSMA PET/CT in man...
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Hong Song Maria Isabel Leonio Valentina Ferri Heying Duan Carina Mari Aparici Guido Davidzon Benjamin L Franc Farshad Moradi Jagruti Shah Colin P Bergstrom Alice C Fan Sumit Shah Ali Raza Khaki Sandy Srinivas Andrei Iagaru Source Type: research
A robust computational quest: Discovering potential hits to improve the treatment of pyrazinamide-resistant Mycobacterium tuberculosis
This study utilizes a novel integration of computational techniques, including multiscale biomolecular and molecular dynamics simulations, physicochemical and medicinal chemistry predictions, quantum computations and virtual screening from the ZINC and Chembridge databases, to elucidate the resistance mechanism and identify lead compounds that have the potential to improve treatment outcomes for PZA-resistant MTB, namely ZINC15913786, ZINC20735155, Chem10269711, Chem10279789 and Chem10295790. These computational methods offer a cost-effective, rapid alternative to traditional drug trials by bypassing the need for organic s...
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Muhammad Shahab Gabriel Christian de Farias Morais Shopnil Akash Umberto Laino Fulco Jonas Ivan Nobre Oliveira Guojun Zheng Shahina Akter Source Type: research
Gram-negative bacteria recognition and photodynamic elimination by Zn-DPA based sensitizers
Biomaterials. 2024 Apr 15;308:122571. doi: 10.1016/j.biomaterials.2024.122571. Online ahead of print.ABSTRACTThe abuse and overuse of antibiotics let drug-resistant bacteria emerges. Antibacterial photodynamic therapy (APDT) has shown outstanding merits to eliminate the drug-resistant bacteria via cytotoxic reactive oxygen species produced by irradiating photosensitizer. However, most of photosensitizers are not effective for Gram-negative bacteria elimination. Herein conjugates of NBS, a photosensitizer, linked with one (NBS-DPA-Zn) or two (NBS-2DPA-Zn) equivalents of zinc-dipicolylamine (Zn-DPA) have been designed to ach...
Source: Biomaterials - April 18, 2024 Category: Materials Science Authors: Zuokai Wang Shuang Zeng Yifu Hao Wenlin Cai Wen Sun Jianjun Du Saran Long Jiangli Fan Jingyun Wang Xiaoqiang Chen Xiaojun Peng Source Type: research
KLF13 promotes VSMCs phenotypic dedifferentiation by directly binding to the SM22 α promoter
In this study, we investigated the relationship between KLF13 and SM22α expression in normal and atherosclerotic plaques by bioanalysis, and observed a significant increase in KLF13 levels in the atherosclerotic plaques of both human patients and ApoE-/- mice. Knockdown of KLF13 was found to ameliorate intimal hyperplasia following carotid artery injury. Furthermore, we discovered that KLF13 directly binds to the SM22α promoter, leading to the phenotypic dedifferentiation of VSMCs. Remarkably, we observed a significant inhibition of platelet-derived growth factor BB-induced VSMCs dedifferentiation, proliferation, and mig...
Source: Atherosclerosis - April 18, 2024 Category: Cardiology Authors: Xiaofan Yuan Chuan Jiang Yuzhou Xue Fuqiang Guo Minghao Luo Lei Guo Yang Gao Tongling Yuan Hui Xu Hong Chen Source Type: research
Gram-negative bacteria recognition and photodynamic elimination by Zn-DPA based sensitizers
Biomaterials. 2024 Apr 15;308:122571. doi: 10.1016/j.biomaterials.2024.122571. Online ahead of print.ABSTRACTThe abuse and overuse of antibiotics let drug-resistant bacteria emerges. Antibacterial photodynamic therapy (APDT) has shown outstanding merits to eliminate the drug-resistant bacteria via cytotoxic reactive oxygen species produced by irradiating photosensitizer. However, most of photosensitizers are not effective for Gram-negative bacteria elimination. Herein conjugates of NBS, a photosensitizer, linked with one (NBS-DPA-Zn) or two (NBS-2DPA-Zn) equivalents of zinc-dipicolylamine (Zn-DPA) have been designed to ach...
Source: Biomaterials - April 18, 2024 Category: Materials Science Authors: Zuokai Wang Shuang Zeng Yifu Hao Wenlin Cai Wen Sun Jianjun Du Saran Long Jiangli Fan Jingyun Wang Xiaoqiang Chen Xiaojun Peng Source Type: research
A robust computational quest: Discovering potential hits to improve the treatment of pyrazinamide-resistant Mycobacterium tuberculosis
This study utilizes a novel integration of computational techniques, including multiscale biomolecular and molecular dynamics simulations, physicochemical and medicinal chemistry predictions, quantum computations and virtual screening from the ZINC and Chembridge databases, to elucidate the resistance mechanism and identify lead compounds that have the potential to improve treatment outcomes for PZA-resistant MTB, namely ZINC15913786, ZINC20735155, Chem10269711, Chem10279789 and Chem10295790. These computational methods offer a cost-effective, rapid alternative to traditional drug trials by bypassing the need for organic s...
Source: J Cell Mol Med - April 18, 2024 Category: Molecular Biology Authors: Muhammad Shahab Gabriel Christian de Farias Morais Shopnil Akash Umberto Laino Fulco Jonas Ivan Nobre Oliveira Guojun Zheng Shahina Akter Source Type: research
Molecules, Vol. 29, Pages 1845: Self-Assembled Matrine-PROTAC Encapsulating Zinc(II) Phthalocyanine with GSH-Depletion-Enhanced ROS Generation for Cancer Therapy
Lisheng Wang
The integration of a multidimensional treatment dominated by active ingredients of traditional Chinese medicine (TCM), including enhanced chemotherapy and synergistically amplification of oxidative damage, into a nanoplatform would be of great significance for furthering accurate and effective cancer treatment with the active ingredients of TCM. Herein, in this study, we designed and synthesized four matrine-proteolysis-targeting chimeras (PROTACs) (depending on different lengths of the chains named LST-1, LST-2, LST-3, and LST-4) based on PROTAC technology to overcome the limitations of matrine. LST-4,...
Source: Molecules - April 18, 2024 Category: Chemistry Authors: Sitong Lai Bing Wang Kunhui Sun Fan Li Qian Liu Xie-An Yu Lihe Jiang Lisheng Wang Tags: Article Source Type: research
Same-day post-therapy imaging with a new generation whole-body digital SPECT/CT in assessing treatment response to [177Lu]Lu-PSMA-617 in metastatic castration-resistant prostate cancer
ConclusionWe successfully implemented same-day post-therapy SPECT/CT after [177Lu]Lu-PSMA-617 infusions. Quantitation of 1 –2 h post-therapy SPECT/CT images is a promising method for assessing treatment response. However, the approach is currently limited by its suboptimal detection of small tumor lesions and the necessity of incorporating a third-cycle SPECT/CT to mitigate the effects of any potential treatment-rela ted flare-up. Further investigation in a larger patient cohort and prospective validation is essential to confirm these findings and to explore the role of SPECT/CT as a potential adjunct to PSMA PET/CT in ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 18, 2024 Category: Nuclear Medicine Source Type: research
Cancers, Vol. 16, Pages 1548: Oral Mucositis Management in Children under Cancer Treatment: A Systematic Review
ilva
Children undergoing antineoplastic treatment often present severe side effects due to the dosage and duration of treatments, with oral mucositis emerging as one of the most prevalent and painful inflammatory conditions. There is a growing body of evidence on therapeutic interventions such as cryotherapy, low-level laser therapy, and natural compounds for this condition. The aim of this systematic review was to identify and compare therapies for the management of cancer treatment-induced oral mucositis in pediatric patients. From 2655 articles obtained in initial searches, 39 articles were considered in this system...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Ricardo Bragu ês Maria Francisca Marv ão Patr ícia Correia Raquel M. Silva Tags: Systematic Review Source Type: research
