Molecular mechanism of dissolvable metal nanoparticles-enhanced CO < sub > 2 < /sub > fixation by algae: Metal-chlorophyll synthesis
This study selected six representative metal NPs (Fe3O4, ZnO, CuO, NiO, MgO, and Ag) to investigate their impacts on CO2 fixation by algae (Chlorella vulgaris). We discovered an intriguing phenomenon that bivalent metal ions released from the metal NPs, especially from ZnO NPs, substituted Mg2+ within the porphyrin ring. This interaction led to 81.8% and 76.1% increases in Zinc-chlorophyll and Magnesium-chlorophyll contents within algal cells at 0.01 mM ZnO NPs, respectively. Integrating metabolomics and transcriptomics analyses revealed that ZnO NPs mainly promoted the photosynthesis-antenna protein pathway, porphyrin and...
Source: Environmental Pollution - April 15, 2024 Category: Environmental Health Authors: Ruohua Qu Na Liu Qiong Wen Jingyi Guo Fei Ge Source Type: research
Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types
We report the synthesis of a novel, Zn2+-chelating derivative of the pan-BETi (+)-JQ1, (+)-JQ1-DPA, in which (+)-JQ1 was conjugated to dipicolyl amine (DPA). As controls, we synthesized (+)-JQ1-DBA, a non-Zn2+-chelating derivative, and (-)-JQ1-DPA, an inactive enantiomer that chelates Zn2+. Molecular modeling and biophysical assays showed that (+)-JQ1-DPA and (+)-JQ1-DBA retain potent binding to BET bromodomains in vitro. Cellular assays demonstrated (+)-JQ1-DPA attenuated NF-ĸB target gene expression in β-cells stimulated with the pro-inflammatory cytokine interleukin 1β. To assess β-cell selectivity, we isolated isle...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 15, 2024 Category: Physiology Authors: Rachel A Jones Lipinski Jennifer S Stancill Raymundo Nu ñez Sarah L Wynia-Smith Daniel J Sprague Joshua A Nord Amir Bird John A Corbett Brian C Smith Source Type: research
Sorption capacity of Eichhornia crassipes (Mart.) Solms for zinc removal from electroplating industry wastewater
This study used Eichhornia crassipes (Mart.) Solms to remove zinc from wastewater from the electroplating industry in a constructed wetland. Experimental investigations were conducted for removing zinc ions from electroplating industry wastewater using various process parameters such as nutrient dosages, dilution ratios, potential of hydrogen ions, biomasses, and contact times. The outcome of this study revealed that the maximum zinc removal percentage in electroplating industrial wastewater was found for the optimum nutrient dosages of 60 g, dilution ratios of 10, potential hydrogen ion levels of 8, and biomass amounts of...
Source: Environmental Science and Pollution Research International - April 15, 2024 Category: Environmental Health Authors: Sivakumar Durairaj Source Type: research
Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types
We report the synthesis of a novel, Zn2+-chelating derivative of the pan-BETi (+)-JQ1, (+)-JQ1-DPA, in which (+)-JQ1 was conjugated to dipicolyl amine (DPA). As controls, we synthesized (+)-JQ1-DBA, a non-Zn2+-chelating derivative, and (-)-JQ1-DPA, an inactive enantiomer that chelates Zn2+. Molecular modeling and biophysical assays showed that (+)-JQ1-DPA and (+)-JQ1-DBA retain potent binding to BET bromodomains in vitro. Cellular assays demonstrated (+)-JQ1-DPA attenuated NF-ĸB target gene expression in β-cells stimulated with the pro-inflammatory cytokine interleukin 1β. To assess β-cell selectivity, we isolated isle...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 15, 2024 Category: Physiology Authors: Rachel A Jones Lipinski Jennifer S Stancill Raymundo Nu ñez Sarah L Wynia-Smith Daniel J Sprague Joshua A Nord Amir Bird John A Corbett Brian C Smith Source Type: research
Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types
We report the synthesis of a novel, Zn2+-chelating derivative of the pan-BETi (+)-JQ1, (+)-JQ1-DPA, in which (+)-JQ1 was conjugated to dipicolyl amine (DPA). As controls, we synthesized (+)-JQ1-DBA, a non-Zn2+-chelating derivative, and (-)-JQ1-DPA, an inactive enantiomer that chelates Zn2+. Molecular modeling and biophysical assays showed that (+)-JQ1-DPA and (+)-JQ1-DBA retain potent binding to BET bromodomains in vitro. Cellular assays demonstrated (+)-JQ1-DPA attenuated NF-ĸB target gene expression in β-cells stimulated with the pro-inflammatory cytokine interleukin 1β. To assess β-cell selectivity, we isolated isle...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 15, 2024 Category: Physiology Authors: Rachel A Jones Lipinski Jennifer S Stancill Raymundo Nu ñez Sarah L Wynia-Smith Daniel J Sprague Joshua A Nord Amir Bird John A Corbett Brian C Smith Source Type: research
Phytic Acid Customized Hydrogel Polymer Electrolyte and Prussian Blue Analogue Cathode Material for Rechargeable Zinc Metal Hydrogel Batteries
A novel phytic acid (PA) modulated zinc hydrogel polymer electrolyte (ZHPE) as an efficient electrolyte and separator for rechargeable Zn-metal hydrogel batteries (ZMHB) is designed. The zincophilic, and hydrogen bonding characteristics of ZHPE help in regulating uniform dendrite-free Zn-deposition over the Zn anode surface. ZHPE in combination with the developed high-voltage zinc hexacyanoferrate (ZHF) cathode performs as an efficient ZMHB. AbstractZinc anode deterioration in aqueous electrolytes, and Zn dendrite growth is a major concern in the operation of aqueous rechargeable Zn metal batteries (AZMBs). To tackle this,...
Source: Small - April 15, 2024 Category: Nanotechnology Authors: Swati Dilwale,
Priyanka Pandinhare Puthiyaveetil,
Athira Babu,
Sreekumar Kurungot Tags: Research Article Source Type: research
Boosting Spatial Charge Storage in Ion ‐Compatible Pores of Carbon Superstructures for Advanced Zinc‐Ion Capacitors
Flower-shaped heterodiatomic carbon superstructures with compatible pore dimensions for Zn(H2O)62+ ions are designed through the supramolecular self-assembly of 1,3,5-triazine-2,4,6-triamine and cyanuric acid via in-plane H-bonding and out-of-planeπ–π stacking. A high-kinetics anion −cation hybrid charge storage mechanism of carbon superstructures is proposed, contributing to excellent energy density, rate capacity, and cyclic life for Zn-ion capacitors. AbstractCapacitive carbon cathodes deliver great potential for zinc-ion hybrid capacitors (ZHCs) due to their resource abundance and structural versatility. However,...
Source: Small - April 15, 2024 Category: Nanotechnology Authors: Pingxuan Liu,
Ziyang Song,
Ling Miao,
Yaokang Lv,
Lihua Gan,
Mingxian Liu Tags: Research Article Source Type: research
The RNA ‐binding protein RBMS3 inhibits the progression of colon cancer by regulating the stability of LIMS1 mRNA
ConclusionsThe discernments delineate RBMS3 as a novel suppressor of cancer via LIMS1, thereby bestowing fresh therapeutic possibilities and illuminating the intricacies of colon cancer. (Source: Cancer Medicine)
Source: Cancer Medicine - April 15, 2024 Category: Cancer & Oncology Authors: Yafei Li,
Shuoshuo Wang,
Guoli Li,
Chunyang Gao,
Zihan Cui,
Mingqi Cong,
Jie Hu,
Minghui Zhang,
Xiaoming Jin,
Haiying Sun,
Dan Kong Tags: RESEARCH ARTICLE Source Type: research
ZNF554 Inhibits Endometrial Cancer Progression via Regulating RBM5 and Inactivating WNT/ β-Catenin Signaling Pathway
ConclusionZNF554 functions as a tumor suppressor in UCEC. Furthermore, ZNF554 regulates UCEC progression through the RBM5/WNT/ β-catenin signaling pathway. ZNF554 shows a promise as both a prognostic biomarker and a therapeutic target for UCEC. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - April 15, 2024 Category: Research Source Type: research
The Role of the Polymer Matrix on the Energy Band Gap of Nanocomposites of Aluminium, Silver and Zinc Oxide
AbstractAchieving optimal optical properties for polymers matrix with Al, Ag and ZnO nano composites has received considerable attention due to their broad applications in advanced optical devices. Employing three unique polymers PS, PMMA, and PVA further compounded the outcomes. Energy dispersive X-ray imaging showed integrity for samples with different filler concentrations of Al, Ag, and ZnO nanoparticles. Furthermore, our UV visible transmittance spectrums showed low transmittance in the UV range but demonstrated an opposing correlation with nanoparticle concentrations. During the calculation of the energy band gap, it...
Source: Plasmonics - April 15, 2024 Category: Biomedical Science Source Type: research
Molecules, Vol. 29, Pages 1795: The Fast Quantification of Vitamin B12 in Milk Powder by High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry
This study presents a new technique for determining vitamin B12 in milk powder using high-performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS). We used ultrasonics with potassium ferrocyanide and zinc acetate solutions to extract the samples. 59Co was employed as the analytical target for cyanocobalamin. It was separated using a Phenomenex Luna 5 &mu;m C18 (250 &times; 4.6 mm) chromatographic column with a mobile phase consisting of 1.6 mmol/L EDTA and 0.4 mmol/L KH2PO4 in a 60% v/v methanol solution (pH = 4.0). The sample has an excellent separating degree for free c...
Source: Molecules - April 15, 2024 Category: Chemistry Authors: Yang Zhou Zheng Tags: Article Source Type: research
Monitoring the utilization and effectiveness of Iron and Vitamin D supplementations program and its predictive factors in high schools ’ girls in Qom, Iran
Conclusion:The inadequate and incomplete rate of IVDSP in Qom was high and more than 60% of distributed supplementations have been wasted. Our results showed that students who were participated in educational orientation classes were more successful and eager in iron and vitamin D3 consumption. Therefore, it is recommended to increase interventions at individual, interpersonal, intra-organizational and inter-organizational levels in order to fully support the program and ultimately increase the efficiency of the program. (Source: Journal of Preventive Medicine and Hygiene)
Source: Journal of Preventive Medicine and Hygiene - April 15, 2024 Category: International Medicine & Public Health Authors: Abolfazl Mohammadbeigi, Dr Source Type: research
Exposure to hull cleaning wastewater induces mortality through oxidative stress and cholinergic disturbance in the marine polychaete Perinereis aibuhitensis
In this study, we provide evidence on acute harmful effects of hull cleaning wastewater in marine polychaete Perinereis aibuhitensis by analyzing physiological and biochemical parameters such as survival, burrowing activity, and oxidative status. Raw wastewater samples were collected during ship hull cleaning processes in the field. Two wastewater samples for the exposure experiment were prepared in the laboratory: 1) mechanically filtered in the in-water cleaning system (MF) and 2) additionally filtered with a 0.45 μm filter in the laboratory (LF). These wastewater samples contained high concentrations of metals (zinc an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: Somyeong Lee Jaehee Kim Jee-Hyun Jung Moonkoo Kim Hyun Park Jae-Sung Rhee Source Type: research
Exposure to hull cleaning wastewater induces mortality through oxidative stress and cholinergic disturbance in the marine polychaete Perinereis aibuhitensis
In this study, we provide evidence on acute harmful effects of hull cleaning wastewater in marine polychaete Perinereis aibuhitensis by analyzing physiological and biochemical parameters such as survival, burrowing activity, and oxidative status. Raw wastewater samples were collected during ship hull cleaning processes in the field. Two wastewater samples for the exposure experiment were prepared in the laboratory: 1) mechanically filtered in the in-water cleaning system (MF) and 2) additionally filtered with a 0.45 μm filter in the laboratory (LF). These wastewater samples contained high concentrations of metals (zinc an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: Somyeong Lee Jaehee Kim Jee-Hyun Jung Moonkoo Kim Hyun Park Jae-Sung Rhee Source Type: research
Exposure to hull cleaning wastewater induces mortality through oxidative stress and cholinergic disturbance in the marine polychaete Perinereis aibuhitensis
In this study, we provide evidence on acute harmful effects of hull cleaning wastewater in marine polychaete Perinereis aibuhitensis by analyzing physiological and biochemical parameters such as survival, burrowing activity, and oxidative status. Raw wastewater samples were collected during ship hull cleaning processes in the field. Two wastewater samples for the exposure experiment were prepared in the laboratory: 1) mechanically filtered in the in-water cleaning system (MF) and 2) additionally filtered with a 0.45 μm filter in the laboratory (LF). These wastewater samples contained high concentrations of metals (zinc an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: Somyeong Lee Jaehee Kim Jee-Hyun Jung Moonkoo Kim Hyun Park Jae-Sung Rhee Source Type: research
