Disrupted odontoblast differentiation and dentin dysplasia in < em > Epiprofin < /em > -deficient mice
Int J Dev Biol. 2024;68(1):19-24. doi: 10.1387/ijdb.240029lj.ABSTRACTTooth formation is a process tightly regulated by reciprocal interactions between epithelial and mesenchymal tissues. These epithelial-mesenchyme interactions regulate the expression of target genes via transcription factors. Among the regulatory elements governing this process, Epiprofin/Sp6 is a zinc finger transcription factor which is expressed in the embryonic dental epithelium and in differentiating pre-odontoblasts. Epiprofin knockout (Epfn-/-) mice present severe dental abnormalities, such as supernumerary teeth and enamel hypoplasia. Here, we des...
Source: International Journal of Developmental Biology - April 9, 2024 Category: Biology Authors: Lucia Jim énez-Rojo Susana de Vega Gaskon Ibarretxe Takashi Nakamura Fernando J Unda Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression
COPD. 2024 Dec;21(1):2322605. doi: 10.1080/15412555.2024.2322605. Epub 2024 Apr 9.ABSTRACTChronic obstructive pulmonary disease (COPD) is a chronic respiratory condition characterized by persistent inflammation and oxidative stress, which ultimately leads to progressive restriction of airflow. Extensive research findings have cogently suggested that the dysregulation of essential transition metal ions, notably iron, copper, and zinc, stands as a critical nexus in the perpetuation of inflammatory processes and oxidative damage within the lungs of COPD patients. Unraveling the intricate interplay between metal homeostasis, o...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 9, 2024 Category: Respiratory Medicine Authors: Ye Cui Xinqian Du Yunqi Li Dan Wang Zhe Lv Huihui Yuan Yan Chen Jie Liu Ying Sun Wei Wang Source Type: research
Disrupted odontoblast differentiation and dentin dysplasia in < em > Epiprofin < /em > -deficient mice
Int J Dev Biol. 2024;68(1):19-24. doi: 10.1387/ijdb.240029lj.ABSTRACTTooth formation is a process tightly regulated by reciprocal interactions between epithelial and mesenchymal tissues. These epithelial-mesenchyme interactions regulate the expression of target genes via transcription factors. Among the regulatory elements governing this process, Epiprofin/Sp6 is a zinc finger transcription factor which is expressed in the embryonic dental epithelium and in differentiating pre-odontoblasts. Epiprofin knockout (Epfn-/-) mice present severe dental abnormalities, such as supernumerary teeth and enamel hypoplasia. Here, we des...
Source: International Journal of Developmental Biology - April 9, 2024 Category: Biology Authors: Lucia Jim énez-Rojo Susana de Vega Gaskon Ibarretxe Takashi Nakamura Fernando J Unda Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression
COPD. 2024 Dec;21(1):2322605. doi: 10.1080/15412555.2024.2322605. Epub 2024 Apr 9.ABSTRACTChronic obstructive pulmonary disease (COPD) is a chronic respiratory condition characterized by persistent inflammation and oxidative stress, which ultimately leads to progressive restriction of airflow. Extensive research findings have cogently suggested that the dysregulation of essential transition metal ions, notably iron, copper, and zinc, stands as a critical nexus in the perpetuation of inflammatory processes and oxidative damage within the lungs of COPD patients. Unraveling the intricate interplay between metal homeostasis, o...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 9, 2024 Category: Respiratory Medicine Authors: Ye Cui Xinqian Du Yunqi Li Dan Wang Zhe Lv Huihui Yuan Yan Chen Jie Liu Ying Sun Wei Wang Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
Disrupted odontoblast differentiation and dentin dysplasia in < em > Epiprofin < /em > -deficient mice
Int J Dev Biol. 2024;68(1):19-24. doi: 10.1387/ijdb.240029lj.ABSTRACTTooth formation is a process tightly regulated by reciprocal interactions between epithelial and mesenchymal tissues. These epithelial-mesenchyme interactions regulate the expression of target genes via transcription factors. Among the regulatory elements governing this process, Epiprofin/Sp6 is a zinc finger transcription factor which is expressed in the embryonic dental epithelium and in differentiating pre-odontoblasts. Epiprofin knockout (Epfn-/-) mice present severe dental abnormalities, such as supernumerary teeth and enamel hypoplasia. Here, we des...
Source: International Journal of Developmental Biology - April 9, 2024 Category: Biology Authors: Lucia Jim énez-Rojo Susana de Vega Gaskon Ibarretxe Takashi Nakamura Fernando J Unda Source Type: research
Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression
COPD. 2024 Dec;21(1):2322605. doi: 10.1080/15412555.2024.2322605. Epub 2024 Apr 9.ABSTRACTChronic obstructive pulmonary disease (COPD) is a chronic respiratory condition characterized by persistent inflammation and oxidative stress, which ultimately leads to progressive restriction of airflow. Extensive research findings have cogently suggested that the dysregulation of essential transition metal ions, notably iron, copper, and zinc, stands as a critical nexus in the perpetuation of inflammatory processes and oxidative damage within the lungs of COPD patients. Unraveling the intricate interplay between metal homeostasis, o...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 9, 2024 Category: Respiratory Medicine Authors: Ye Cui Xinqian Du Yunqi Li Dan Wang Zhe Lv Huihui Yuan Yan Chen Jie Liu Ying Sun Wei Wang Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
Disrupted odontoblast differentiation and dentin dysplasia in < em > Epiprofin < /em > -deficient mice
Int J Dev Biol. 2024;68(1):19-24. doi: 10.1387/ijdb.240029lj.ABSTRACTTooth formation is a process tightly regulated by reciprocal interactions between epithelial and mesenchymal tissues. These epithelial-mesenchyme interactions regulate the expression of target genes via transcription factors. Among the regulatory elements governing this process, Epiprofin/Sp6 is a zinc finger transcription factor which is expressed in the embryonic dental epithelium and in differentiating pre-odontoblasts. Epiprofin knockout (Epfn-/-) mice present severe dental abnormalities, such as supernumerary teeth and enamel hypoplasia. Here, we des...
Source: International Journal of Developmental Biology - April 9, 2024 Category: Biology Authors: Lucia Jim énez-Rojo Susana de Vega Gaskon Ibarretxe Takashi Nakamura Fernando J Unda Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
Disrupted odontoblast differentiation and dentin dysplasia in < em > Epiprofin < /em > -deficient mice
Int J Dev Biol. 2024;68(1):19-24. doi: 10.1387/ijdb.240029lj.ABSTRACTTooth formation is a process tightly regulated by reciprocal interactions between epithelial and mesenchymal tissues. These epithelial-mesenchyme interactions regulate the expression of target genes via transcription factors. Among the regulatory elements governing this process, Epiprofin/Sp6 is a zinc finger transcription factor which is expressed in the embryonic dental epithelium and in differentiating pre-odontoblasts. Epiprofin knockout (Epfn-/-) mice present severe dental abnormalities, such as supernumerary teeth and enamel hypoplasia. Here, we des...
Source: International Journal of Developmental Biology - April 9, 2024 Category: Biology Authors: Lucia Jim énez-Rojo Susana de Vega Gaskon Ibarretxe Takashi Nakamura Fernando J Unda Source Type: research
