An orchestra of machine learning methods reveals landmarks in single-cell data exemplified with aging fibroblasts
by Lauritz Rasbach, Aylin Caliskan, Fatemeh Saderi, Thomas Dandekar, Tim Breitenbach
In this work, a Python framework for characteristic feature extraction is developed and applied to gene expression data of human fibroblasts. Unlabeled feature selection objectively determines groups and minimal gene sets separating groups. ML explainability methods transform the features correlat ing with phenotypic differences into causal reasoning, supported by further pipeline and visualization tools, allowing user knowledge to boost causal reasoning. The purpose of the framework is to identify characteristic features that are causall...
Source: PLoS One - April 17, 2024 Category: Biomedical Science Authors: Lauritz Rasbach Source Type: research
Piperidine and piperazine analogs in action: zinc(II)-mediated formation of amidines
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Nina Podjed, Janez Ko šmrlj, Barbara Modec The catalytic activity of zinc(II) compounds was exploited in the nucleophilic addition of amines to nitriles to form amidines. The reaction systems comprised a Zn(II) starting material [Zn(quin)2(H2O)] (quin– =... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 16, 2024 Category: Chemistry Authors: Nina Podjed Source Type: research
Thyroid dysfunction due to trace element deficiency-not only selenium but also zinc
CONCLUSION: It is important to consider Se and Zn deficiencies when TSH and FT4 levels are elevated. It should also be noted that transient TSH elevation may be observed with Se supplementation.PMID:38625626 | DOI:10.1007/s42000-024-00550-1 (Source: Hormones)
Source: Hormones - April 16, 2024 Category: Endocrinology Authors: Kohei Nagano Yuma Motomura Hironori Bando Masaaki Yamamoto Keitaro Kanie Kei Yoshino Yushi Hirota Tomoko Yamada Michiko Takahashi Hidenori Fukuoka Wataru Ogawa Source Type: research
Exploring the Constituents and Mechanisms of < em > Polygonum multiflorum < /em > Thunb. in Mitigating Ischemic Stroke: A Network Pharmacology and Molecular Docking Study
This study contributes new insights into the potential development of PMT for stroke prevention and treatment.PMID:38623977 | DOI:10.2174/0113862073285988240229081558 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 16, 2024 Category: Chemistry Authors: Lingyu Ruan Mengyun Zheng Xinru Xia Chaofan Pang Yating Wang Zhiwei Fan Jingtian Yang Qing Qing Hongyan Lin Yuheng Tao Junsong Wang Liqun Wang Source Type: research
Dipeptidase 1 promotes ferroptosis in renal tubular epithelial cells in diabetic nephropathy via inhibition of the GSH/GPX4 axis
Int Immunopharmacol. 2024 Apr 15;133:111955. doi: 10.1016/j.intimp.2024.111955. Online ahead of print.ABSTRACTRenal tubular injury is an important pathological change associated with diabetic nephropathy (DN), in which ferroptosis of renal tubular epithelial cells is critical to its pathogenesis. Inhibition of the glutathione/glutathione peroxidase 4 (GSH/GPX4) axis is the most important mechanism in DN tubular epithelial cell ferroptosis, but the underlying reason for this is unclear. Our biogenic analysis showed that a zinc-dependent metalloproteinase, dipeptidase 1 (DPEP1), is associated with DN ferroptosis. Here, we in...
Source: International Immunopharmacology - April 16, 2024 Category: Allergy & Immunology Authors: Yan Li Xueqi Wang Qidong Zhang Dongli Tian Yu Bai Yiduo Feng Wenhu Liu Zongli Diao Source Type: research
Exploring the Constituents and Mechanisms of < em > Polygonum multiflorum < /em > Thunb. in Mitigating Ischemic Stroke: A Network Pharmacology and Molecular Docking Study
This study contributes new insights into the potential development of PMT for stroke prevention and treatment.PMID:38623977 | DOI:10.2174/0113862073285988240229081558 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 16, 2024 Category: Chemistry Authors: Lingyu Ruan Mengyun Zheng Xinru Xia Chaofan Pang Yating Wang Zhiwei Fan Jingtian Yang Qing Qing Hongyan Lin Yuheng Tao Junsong Wang Liqun Wang Source Type: research
Thyroid dysfunction due to trace element deficiency-not only selenium but also zinc
CONCLUSION: It is important to consider Se and Zn deficiencies when TSH and FT4 levels are elevated. It should also be noted that transient TSH elevation may be observed with Se supplementation.PMID:38625626 | DOI:10.1007/s42000-024-00550-1 (Source: Hormones)
Source: Hormones - April 16, 2024 Category: Endocrinology Authors: Kohei Nagano Yuma Motomura Hironori Bando Masaaki Yamamoto Keitaro Kanie Kei Yoshino Yushi Hirota Tomoko Yamada Michiko Takahashi Hidenori Fukuoka Wataru Ogawa Source Type: research
Exploring the Constituents and Mechanisms of < em > Polygonum multiflorum < /em > Thunb. in Mitigating Ischemic Stroke: A Network Pharmacology and Molecular Docking Study
This study contributes new insights into the potential development of PMT for stroke prevention and treatment.PMID:38623977 | DOI:10.2174/0113862073285988240229081558 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 16, 2024 Category: Chemistry Authors: Lingyu Ruan Mengyun Zheng Xinru Xia Chaofan Pang Yating Wang Zhiwei Fan Jingtian Yang Qing Qing Hongyan Lin Yuheng Tao Junsong Wang Liqun Wang Source Type: research
The HIV-1 reservoir landscape in persistent elite controllers and transient elite controllers
CONCLUSIONS These results suggest the need for, and can give guidance to, the design of future research to identify a distinct proviral landscape that may be associated with the persistent control of HIV-1 without ART.FUNDING Instituto de Salud Carlos III (FI17/00186, FI19/00083, MV20/00057, PI18/01532, PI19/01127 and PI22/01796), Gilead Fellowships (GLD22/00147). NIH grants AI155171, AI116228, AI078799, HL134539, DA047034, MH134823, amfAR ARCHE and the Bill and Melinda Gates Foundation. (Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Carmen Gasca-Capote, Xiaodong Lian, Ce Gao, Isabelle C. Roseto, María Reyes Jiménez-León, Gregory Gladkov, María Inés Camacho-Sojo, Alberto Pérez-Gómez, Isabel Gallego, Luis E. Lopez-Cortes, Sara Bachiller, Joana Vitalle, Mohamed Rafii-El-Idrissi B Source Type: research
Regulation of Solvation Structure and Electrode Interface by Succinic Acid Additive for Highly Stable Aqueous Zn Batteries
J. Mater. Chem. A, 2024, Accepted Manuscript DOI: 10.1039/D4TA01107D, PaperYuanjun Zhang, fangfang Yu, Haoxuan Liu, Nana Wang, Xianzhong Yang, Shunjian Xu, Chao Wu, Huakun Liu, Shi Xue Dou Metallic zinc shows great promise as an anode material in aqueous rechargeable batteries owing to its high theoretical capacity, excellent safety, and low cost. However, the practical utilization of zinc... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - April 15, 2024 Category: Chemistry Authors: Yuanjun Zhang Source Type: research
Sorption capacity of Eichhornia crassipes (Mart.) Solms for zinc removal from electroplating industry wastewater
This study used Eichhornia crassipes (Mart.) Solms to remove zinc from wastewater from the electroplating industry in a constructed wetland. Experimental investigations were conducted for removing zinc ions from electroplating industry wastewater using various process parameters such as nutrient dosages, dilution ratios, potential of hydrogen ions, biomasses, and contact times. The outcome of this study revealed that the maximum zinc removal percentage in electroplating industrial wastewater was found for the optimum nutrient dosages of 60 g, dilution ratios of 10, potential hydrogen ion levels of 8, and biomass amounts of...
Source: Environmental Science and Pollution Research International - April 15, 2024 Category: Environmental Health Authors: Sivakumar Durairaj Source Type: research
The activation of HAMP promotes colorectal cancer cell proliferation through zinc-mediated upregulation of SMAD4 expression
CONCLUSIONS: HAMP stands out as an independent prognostic factor in CRC, representing a potential therapeutic target. Its intricate regulation by zinc, particularly through the modulation of SMAD4, unveils a novel avenue for understanding CRC biology. This study provides valuable insights into the interplay between zinc metabolism, HAMP, and CRC, offering promising clinical indicators for CRC patients. The findings present a compelling case for further exploration and development of targeted therapeutic strategies in CRC management.PMID:38617511 | PMC:PMC11009800 | DOI:10.21037/tcr-23-1292 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Fei Pan Mengting Hu Tao Ye Jiaqi Gan Meirong Ling Mei Liu Source Type: research
PVDF/ZnO piezoelectric nanofibers designed for monitoring of internal micro-pressure
In this study, we present a breakthrough in the fabrication of soft poly(vinylidene fluoride) (PVDF) organic electrospun piezoelectric nanofibers (OEPNs) with exceptional piezoelectric performance achieved through the incorporation of zinc oxide nanorods (ZnO NR). The inclusion of ZnO NR proved instrumental in augmenting the nanocrystallization of PVDF organic electrospun piezoelectric nanofibers (OEPNs), leading to a highly efficient crystal phase transformation from the α phase to the β/γ phase, serving as superior piezoelectric working dipoles. The resulting PVDF/ZnO NR OEPNs exhibited unparalleled piezoelectric outp...
Source: Atherosclerosis - April 15, 2024 Category: Cardiology Authors: Geng Chang Xuchao Pan Yu Hao Wei Du Siwei Wang Yu Zhou Jie Yang Yong He Source Type: research
Continuous and Scalable Synthesis of Prussian Blue Analogues with Tunable Structure and Composition in Surfactant-Free Microreactor for Stable Zinc-Ion Storage
ChemSusChem. 2024 Apr 15:e202400552. doi: 10.1002/cssc.202400552. Online ahead of print.ABSTRACTWe represent a segmented flow surfactant-free microfluidic strategy for continuous synthesis of Prussian blue analogues (PBAs) with high dispersity and high crystallization. Representative zinc hexacyanoferrate (ZnHCF) nanocubes were successfully synthesized in a microfluidic reactor within a few minutes via the cooperation method and possessed lower contents of crystal water and Fe(CN)63- vacancies than that of synthesis in bulk solution. The nucleation and particle growth process can be precisely controlled by the exploration ...
Source: ChemSusChem - April 15, 2024 Category: Chemistry Authors: Mingli Wang Jingkang Ma Ke Lu Songtao Lu Hong Zhang Source Type: research
EIF4A3 modulated circ_000999 promotes epithelial-mesenchymal transition in cadmium-induced malignant transformation through the miR-205-5p/ZEB1 axis
Environ Int. 2024 Apr 14;186:108656. doi: 10.1016/j.envint.2024.108656. Online ahead of print.ABSTRACTCadmium (Cd) is an accumulative toxic metal which poses a serious threat to human health, even in trace amounts. One of the most important steps in the pathophysiology of lung cancer (LC) is the epithelial-mesenchymal transition (EMT). In this investigation, a cell malignant transformation model was established by exposing human bronchial epithelial cells (16HBE) to a low dose of Cd for 30 weeks, after which a highly expressed circular RNA (circ_000999) was identified. Cd-induced EMT was clearly observed in rat lungs and 1...
Source: Environment International - April 15, 2024 Category: Environmental Health Authors: Donglei Wang Shijie Chen Yueqing Shao Yang Deng Lihua Huang Source Type: research
