Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats
CONCLUSION: Asiaticoside induces thoracic aorta relaxation by mediating high-conductance calcium-activated potassium channel opening, promoting nitric oxide release from endothelial cells and regulating Ca2+ influx and outflow, thereby reducing systolic blood pressure in rats.PMID:38597444 | PMC:PMC11006695 | DOI:10.12122/j.issn.1673-4254.2024.03.14 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: G Lu H Sun Z Sun L Liu L Wang N Zhang Y Wang Y He J Ji X Li P Kang B Tang Source Type: research
Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats
CONCLUSION: Asiaticoside induces thoracic aorta relaxation by mediating high-conductance calcium-activated potassium channel opening, promoting nitric oxide release from endothelial cells and regulating Ca2+ influx and outflow, thereby reducing systolic blood pressure in rats.PMID:38597444 | PMC:PMC11006695 | DOI:10.12122/j.issn.1673-4254.2024.03.14 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: G Lu H Sun Z Sun L Liu L Wang N Zhang Y Wang Y He J Ji X Li P Kang B Tang Source Type: research
Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats
CONCLUSION: Asiaticoside induces thoracic aorta relaxation by mediating high-conductance calcium-activated potassium channel opening, promoting nitric oxide release from endothelial cells and regulating Ca2+ influx and outflow, thereby reducing systolic blood pressure in rats.PMID:38597444 | PMC:PMC11006695 | DOI:10.12122/j.issn.1673-4254.2024.03.14 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: G Lu H Sun Z Sun L Liu L Wang N Zhang Y Wang Y He J Ji X Li P Kang B Tang Source Type: research
Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats
CONCLUSION: Asiaticoside induces thoracic aorta relaxation by mediating high-conductance calcium-activated potassium channel opening, promoting nitric oxide release from endothelial cells and regulating Ca2+ influx and outflow, thereby reducing systolic blood pressure in rats.PMID:38597444 | PMC:PMC11006695 | DOI:10.12122/j.issn.1673-4254.2024.03.14 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: G Lu H Sun Z Sun L Liu L Wang N Zhang Y Wang Y He J Ji X Li P Kang B Tang Source Type: research
Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats
CONCLUSION: Asiaticoside induces thoracic aorta relaxation by mediating high-conductance calcium-activated potassium channel opening, promoting nitric oxide release from endothelial cells and regulating Ca2+ influx and outflow, thereby reducing systolic blood pressure in rats.PMID:38597444 | PMC:PMC11006695 | DOI:10.12122/j.issn.1673-4254.2024.03.14 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: G Lu H Sun Z Sun L Liu L Wang N Zhang Y Wang Y He J Ji X Li P Kang B Tang Source Type: research
Effect of asiaticoside on systolic blood pressure and relaxation of isolated thoracic aorta of rats
CONCLUSION: Asiaticoside induces thoracic aorta relaxation by mediating high-conductance calcium-activated potassium channel opening, promoting nitric oxide release from endothelial cells and regulating Ca2+ influx and outflow, thereby reducing systolic blood pressure in rats.PMID:38597444 | PMC:PMC11006695 | DOI:10.12122/j.issn.1673-4254.2024.03.14 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: G Lu H Sun Z Sun L Liu L Wang N Zhang Y Wang Y He J Ji X Li P Kang B Tang Source Type: research
Viruses, Vol. 16, Pages 583: The Inhibition of Gag-Pol Expression by the Restriction Factor Shiftless Is Dispensable for the Restriction of HIV-1 Infection
fan Pöhlmann
The interferon-induced host cell protein Shiftless (SFL) inhibits −1 programmed ribosomal frameshifting (−1PRF) required for the expression of HIV-1 Gal-Pol and the formation of infectious HIV-1 particles. However, the specific regions in SFL required for antiviral activity and the mechanism by which SFL inhibits −1PRF remain unclear. Employing alanine scanning mutagenesis, we found that basic amino acids in the predicted zinc ribbon motif of SFL are essential for the suppression of Gag-Pol expression but dispensable for anti-HIV-1 activity. We have shown that SFL...
Source: Viruses - April 10, 2024 Category: Virology Authors: Niklas J äger Shreya Ahana Ayyub Frank Peske David Liedtke Jens Bohne Markus Hoffmann Marina V. Rodnina Stefan P öhlmann Tags: Article Source Type: research
Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis
No effective therapies for pulmonary fibrosis (PF) exist because of the unclear molecular pathogenesis and the lack of effective therapeutic targets. Zinc finger protein 451 (ZNF451), a transcriptional regulat... (Source: Respiratory Research)
Source: Respiratory Research - April 10, 2024 Category: Respiratory Medicine Authors: Hong Peng, Yu Zhang, Jiali Min, Yuexin Tan and Shanshan Liu Tags: Research Source Type: research
Ultra-low diffusion barrier tetramethyl ammonium cation-intercalated layered MnO2 for high-performance aqueous zinc-ion batteries
J. Mater. Chem. A, 2024, Advance Article DOI: 10.1039/D4TA00609G, PaperZixiang Zhou, Jianbo Tong, Xiaoliang Zou, Yue Wang, Yuxuan Bai, Yifan Yang, Youyong Li, Chao Wang, Shuling Liu TMA+ pre-intercalated MnO2 displays enhanced diffusion kinetics, high capacity, and robust cycling stability as a cathode material for zinc-ion batteries. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - April 9, 2024 Category: Chemistry Authors: Zixiang Zhou Source Type: research
One ‐Pot Etching Pyrolysis to Defect‐Rich Carbon Nanosheets to Construct Multiheteroatom‐Coordinated Iron Sites for Efficient Oxygen Reduction
Regulating the carbon defects and the coordination structure shows great potential for promoting oxygen reduction reaction of single-atom catalysts. One-Pot Etching Pyrolysis strategy is proposed to construct Fe single-atom catalysts (Fe-SACs) with high specific surface area and controllable coordination structure. The Fe-SACs after structural optimization show significantly improved oxygen reduction reaction. AbstractConstructing multiheteroatom coordination structure in carbonaceous substrates demonstrates an effective method to accelerate the oxygen reduction reaction (ORR) of supported single-atom catalyst. Herein, the...
Source: Small - April 9, 2024 Category: Nanotechnology Authors: Shichao Peng,
Xilan Ma,
Jiachen Tian,
Changliang Du,
Lifen Yang,
Erchao Meng,
Youqi Zhu,
Meishuai Zou,
Chuanbao Cao Tags: Research Article Source Type: research
Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression
COPD. 2024 Dec;21(1):2322605. doi: 10.1080/15412555.2024.2322605. Epub 2024 Apr 9.ABSTRACTChronic obstructive pulmonary disease (COPD) is a chronic respiratory condition characterized by persistent inflammation and oxidative stress, which ultimately leads to progressive restriction of airflow. Extensive research findings have cogently suggested that the dysregulation of essential transition metal ions, notably iron, copper, and zinc, stands as a critical nexus in the perpetuation of inflammatory processes and oxidative damage within the lungs of COPD patients. Unraveling the intricate interplay between metal homeostasis, o...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 9, 2024 Category: Respiratory Medicine Authors: Ye Cui Xinqian Du Yunqi Li Dan Wang Zhe Lv Huihui Yuan Yan Chen Jie Liu Ying Sun Wei Wang Source Type: research
A dynamic regulatory switch for phase separation of FUS protein: Zinc ions and zinc finger domain
Biochem Biophys Res Commun. 2024 Apr 7;710:149862. doi: 10.1016/j.bbrc.2024.149862. Online ahead of print.ABSTRACTZinc is an important trace element in the human body, and its homeostasis is closely related to amyotrophic lateral sclerosis (ALS). Cytoplasmic FUS proteins from patients with ALS aggregate their important pathologic markers. Liquid-liquid phase separation (LLPS) of FUS can lead to its aggregation. However, whether and how zinc homeostasis affects the aggregation of disease-associated FUS proteins in the cytoplasm remains unclear. Here, we found that zinc ion enhances LLPS and promotes the aggregation in the c...
Source: Biochemical and Biophysical Research communications - April 9, 2024 Category: Biochemistry Authors: Yatao Chen Xiaoying Pei Long Chen Liming Chen Source Type: research
Metal nanoparticle-induced effects on green toads (Amphibia, Anura) under climate change: conservation implications
In this study, we investigated the survival, developmental, behavioral, and histological reactions of Bufotes viridis embryos and larvae exposed to different NPs for a duration of 10 days, using lethal concentrations (LC25%, LC50%, and LC75% mg/L) under both ambient (AT: 18 °C) and high (HT: 21 °C) temperatures. Based on LC, NiONPs > ZnONPs > CuONPs > Al2O3NPs > TiO2NPs > Fe3O4NPs showed the highest mortality at AT. A similar pattern was observed at HT, although mortality occurred at lower concentrations and Fe3O4NPs were more toxic than TiO2NPs. The results indicated that increasing concentrations of NPs ...
Source: Environmental Science and Pollution Research International - April 9, 2024 Category: Environmental Health Authors: Somaye Vaissi Azam Chahardoli Zahra Minoosh Siavosh Haghighi Pouria Heshmatzad Source Type: research
Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression
COPD. 2024 Dec;21(1):2322605. doi: 10.1080/15412555.2024.2322605. Epub 2024 Apr 9.ABSTRACTChronic obstructive pulmonary disease (COPD) is a chronic respiratory condition characterized by persistent inflammation and oxidative stress, which ultimately leads to progressive restriction of airflow. Extensive research findings have cogently suggested that the dysregulation of essential transition metal ions, notably iron, copper, and zinc, stands as a critical nexus in the perpetuation of inflammatory processes and oxidative damage within the lungs of COPD patients. Unraveling the intricate interplay between metal homeostasis, o...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - April 9, 2024 Category: Respiratory Medicine Authors: Ye Cui Xinqian Du Yunqi Li Dan Wang Zhe Lv Huihui Yuan Yan Chen Jie Liu Ying Sun Wei Wang Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
