Modulatory interactions of T-2 and deoxynivalenol mycotoxins on murine femoral development and osteological integrity
In this study, we conducted a systematic assessment of the effectsof Deoxynivalenol (DON) and T-2 mycotoxins on the developmental processes and structural integrity of murine femurs, considering both the isolated and synergistic effects of these toxins. To this end, we divided 72 male mice into nine groups, each subjected to varying dosages of T-2, DON, or their combinations. Over a four-week experimental period, meticulous monitoring was undertaken regarding the mice's body weight, biochemical markers of bone formation and resorption, and the activity of relevant cells. To comprehensively evaluate alterations in bone stru...
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: Cong Yao Shuichu Hao Chun Zhang Li Liu Yumeng Jia Peilin Meng Cuiyan Wu Xiong Guo Source Type: research
Sucrose esters of aryldihydronaphthalene-type lignans, and antitumor activity of extracts of < em > Moltkiopsis ciliata < /em > (Forssk.) aerial parts
Nat Prod Res. 2024 Apr 11:1-11. doi: 10.1080/14786419.2024.2341307. Online ahead of print.ABSTRACTOne new compound (3f-[(7'R,8'R)-4,4'-dihydroxy-5-methoxy-2,7'-cycloligna-7-en-9-methoxycarbonyl, 9'-carbonyl-O-] -β- D-fructofuranosyl- (2→1)-α- D-glucopyranoside) (Moltkiopsin A) (2) was isolated and identified from the extract of aerial parts of the wild Egyptian plant Moltkiopsis ciliata (Frossk.), family Boraginaceae, for the first time, along with two aryldihydronaphthalene lignans 3f→9':6f→9-[(7'R,8'R)-4,4'- dihydroxy-3,3',5-trimethoxy-2,7'-cycloligna-7-en-9,9'-dicarbonyl]-6g-acetyl-α-D-gluco pyranosyl-(1→2) -...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Amal Mahmoud Youssef Moustafa Mohamed Abdel-Moneim Mohamed E Mostafa Mamdouh Abdel-Mogib Marwa Rabee Abdel-Hak Source Type: research
Vitamin D status in children
J Pediatr (Rio J). 2024 Apr 8:S0021-7557(24)00037-8. doi: 10.1016/j.jped.2024.04.001. Online ahead of print.NO ABSTRACTPMID:38604241 | DOI:10.1016/j.jped.2024.04.001 (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - April 11, 2024 Category: Pediatrics Authors: Roger Bouillon Leen Antonio Nick Narinx Source Type: research
Modulatory interactions of T-2 and deoxynivalenol mycotoxins on murine femoral development and osteological integrity
In this study, we conducted a systematic assessment of the effectsof Deoxynivalenol (DON) and T-2 mycotoxins on the developmental processes and structural integrity of murine femurs, considering both the isolated and synergistic effects of these toxins. To this end, we divided 72 male mice into nine groups, each subjected to varying dosages of T-2, DON, or their combinations. Over a four-week experimental period, meticulous monitoring was undertaken regarding the mice's body weight, biochemical markers of bone formation and resorption, and the activity of relevant cells. To comprehensively evaluate alterations in bone stru...
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: Cong Yao Shuichu Hao Chun Zhang Li Liu Yumeng Jia Peilin Meng Cuiyan Wu Xiong Guo Source Type: research
Sucrose esters of aryldihydronaphthalene-type lignans, and antitumor activity of extracts of < em > Moltkiopsis ciliata < /em > (Forssk.) aerial parts
Nat Prod Res. 2024 Apr 11:1-11. doi: 10.1080/14786419.2024.2341307. Online ahead of print.ABSTRACTOne new compound (3f-[(7'R,8'R)-4,4'-dihydroxy-5-methoxy-2,7'-cycloligna-7-en-9-methoxycarbonyl, 9'-carbonyl-O-] -β- D-fructofuranosyl- (2→1)-α- D-glucopyranoside) (Moltkiopsin A) (2) was isolated and identified from the extract of aerial parts of the wild Egyptian plant Moltkiopsis ciliata (Frossk.), family Boraginaceae, for the first time, along with two aryldihydronaphthalene lignans 3f→9':6f→9-[(7'R,8'R)-4,4'- dihydroxy-3,3',5-trimethoxy-2,7'-cycloligna-7-en-9,9'-dicarbonyl]-6g-acetyl-α-D-gluco pyranosyl-(1→2) -...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Amal Mahmoud Youssef Moustafa Mohamed Abdel-Moneim Mohamed E Mostafa Mamdouh Abdel-Mogib Marwa Rabee Abdel-Hak Source Type: research
Antioxidants accelerate tendon-to-bone healing after rotator cuff repair surgery
This study aimed to investigate the effects of reduction of oxidative stress induced by antioxidants such as N-acetylcysteine (NAC) and vitamin C (VC) on rotator cuff repair in a rotator cuff repair model in rats. Infraspinatus tendon was ruptured in 48 rats and repaired 1 week later. Rats were divided into 3 groups: NAC group, VC group, or control group, and were administered NAC, VC, or distilled water respectively. The specimens were collected at 3, 6, and 12 weeks after repair. Histological evaluation was performed using hematoxylin/eosin and toluidine blue staining, and oxidative stress was evaluated using dihydroethi...
Source: Journal of Shoulder and Elbow Surgery - April 11, 2024 Category: Orthopaedics Authors: Hirohisa Uehara, Yoshiaki Itoigawa, Daichi Morikawa, Akihisa Koga, Hironori Tsurukami, Muneaki Ishijima Source Type: research
Vitamin D as an intervention for improving quadriceps muscle strength in patients after anterior cruciate ligament reconstruction: study protocol for a randomized double-blinded, placebo-controlled clinical trial
The goal of anterior cruciate ligament reconstruction (ACLR) is to restore the preinjury level of knee function to return to play (RTP). However, even after completing the rehabilitation programme, some patien... (Source: Trials)
Source: Trials - April 11, 2024 Category: General Medicine Authors: Michael Tim-yun Ong, Xiaomin Lu, Ben Chi-yin Choi, Siu-Wai Wan, Qianwen Wang, Gene Chi-wai Man, Pauline Po-yee Lui, Daniel Tik-Pui Fong, Daniel Kam-wah Mok and Patrick Shu-hang Yung Tags: Study protocol Source Type: research
Lower Risk of Low Bone Mineral Density in High Vitamin E Level in Older People: A Cross-Sectional Study
In this study, we investigated the relationship between serum Vitamin E levels and LBMD in the elderly. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - April 11, 2024 Category: Nutrition Authors: Ying-Long Peng, Zi-Yan Wang, Xuan-Jia Wang, Yu-Tong Ji, Yaqing Wen, Yanpei Mai Source Type: research
Ambient ultraviolet-B radiation, supplements and other factors interact to impact vitamin D status differently depending on ethnicity: a cross-sectional study
Many determinants of vitamin D status have been well-described, yet supplementation guidelines largely follow a one-size-for-all model and deficiency remains common. We hypothesised that accounting accurately for ultraviolet-B (UVB) radiation and considering interactions could advance understanding of vitamin D status. (Source: Clinical Nutrition)
Source: Clinical Nutrition - April 11, 2024 Category: Nutrition Authors: Margaret M. Brennan, Jos van Geffen, Michiel van Weele, Lina Zgaga, Rasha Shraim Source Type: research
Dilated cardiomyopathy due to hypocalcaemia: a case report
ConclusionThis adds to literature of this rare cause of reversible cardiomyopathy secondary to hypocalcemia reported from the South Asian region of the world. This case highlights the impact of proper treatment improving the heart failure in patients with hypocalcemic cardiomyopathy. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 11, 2024 Category: General Medicine Source Type: research
Molecules, Vol. 29, Pages 1732: Effect of the Drying Method and Storage Conditions on the Quality and Content of Selected Bioactive Compounds of Green Legume Vegetables
This study aimed to determine the effect of the drying method (freeze-drying, air-drying), storage period (12 months), and storage conditions (2&ndash;4 &deg;C, 18&ndash;22 &deg;C) applied to two legume species: green beans and green peas. The raw and dried materials were determined for selected physical parameters typical of dried vegetables, contents of bioactive components (vitamin C and E, total chlorophyll, total carotenoids, &beta;-carotene, and total polyphenols), antioxidative activity against the DPPH radical, and sensory attributes (overall quality and profiles of color, te...
Source: Molecules - April 11, 2024 Category: Chemistry Authors: Piotr G ębczyński Ma łgorzata Tabaszewska Katarzyna Kur Maria Zbylut-G órska Jacek S łupski Tags: Article Source Type: research
Characteristics of the oral microbiota in patients with primary Sj ögren’s syndrome
ConclusionsThe oral microbial ecology of patients with pSS is dysregulated, resulting in a decrease in overall diversity.Prevotella andVeillonella may be related to pSS, whileFusobacterium,Actinomyces, andLeptotrichia may be related to dental caries in pSS patients.Key Points•This study revealed differences in the oral microbial composition of patients with pSS compared to healthy controls.•We included a plaque group of pSS patients to identify the microbiota related to pSS and dental caries.•Prevotella and Veillonella may contribute to pSS, and Fusobacterium,Actinomyces, and Leptotrichia are associated with dental c...
Source: Clinical Rheumatology - April 11, 2024 Category: Rheumatology Source Type: research
Systematic Review of the roles of Inositol and Vitamin D in improving fertility among patients with Polycystic Ovary Syndrome
Clin Exp Reprod Med. 2024 Apr 11. doi: 10.5653/cerm.2023.06485. Online ahead of print.ABSTRACTPolycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder among reproductive-age women. As a leading cause of anovulatory infertility, it complicates fertility treatments, including in vitro fertilization. The widely accepted 2003 Rotterdam diagnostic criteria for PCOS include sub-phenotypes based on variations in androgen excess, ovulatory dysfunction, and polycystic ovarian morphology. In this systematic review, we examined the impacts of inositol and vitamin D on fertility in PCOS. Adhering to the Preferred ...
Source: Clinical and Experimental Reproductive Medicine - April 10, 2024 Category: Reproduction Medicine Authors: Gitika Katyal Gursharan Kaur Hafsa Ashraf Adiprasad Bodapati Ayesha Hanif Donatus Kaine Okafor Safeera Khan Source Type: research
