Targeting ferroptosis for treating kidney disease
AbstractFerroptosis is a type of regulated cell death hallmarked by iron-mediated excessive lipid oxidation. Over the past decade since the coining of the term ferroptosis, advances in research have led to the identification of intracellular processes that regulate ferroptosis such as GSH-GPX4 pathway and FSP1-coenzyme Q10/vitamin K pathway. From a disease perspective, the involvement of ferroptosis in pathological conditions including kidney disease has attracted attention. In terms of renal pathophysiology, ferroptosis has been widely investigated for its involvement in ischemia –reperfusion injury, nephrotoxin-induced...
Source: Clinical and Experimental Nephrology - April 22, 2024 Category: Urology & Nephrology Source Type: research
Early postnatal high-dose fat-soluble enteral vitamin A supplementation for moderate or severe bronchopulmonary dysplasia or death in extremely low birthweight infants (NeoVitaA): a multicentre, randomised, parallel-group, double-blind, placebo-controlled, investigator-initiated phase 3 trial
Lancet Respir Med. 2024 Apr 18:S2213-2600(24)00073-0. doi: 10.1016/S2213-2600(24)00073-0. Online ahead of print.ABSTRACTBACKGROUND: Vitamin A plays a key role in lung development, but there is no consensus regarding the optimal vitamin A dose and administration route in extremely low birthweight (ELBW) infants. We aimed to assess whether early postnatal additional high-dose fat-soluble enteral vitamin A supplementation versus placebo would lower the rate of moderate or severe bronchopulmonary dysplasia or death in ELBW infants receiving recommended basic enteral vitamin A supplementation.METHODS: This prospective, multicen...
Source: Respiratory Care - April 21, 2024 Category: Respiratory Medicine Authors: Sascha Meyer Johannes Bay Axel R Franz Harald Erhardt Lars Klein Jutta Petzinger Christoph Binder Susanne Kirschenhofer Anja Stein Britta H üning Axel Heep Eva Cloppenburg Julia Muyimbwa Torsten Ott Julia Sandk ötter Norbert Teig Susanne Wiegand Michael Source Type: research
Vitamin A and bronchopulmonary dysplasia: the next steps
Lancet Respir Med. 2024 Apr 18:S2213-2600(24)00108-5. doi: 10.1016/S2213-2600(24)00108-5. Online ahead of print.NO ABSTRACTPMID:38643781 | DOI:10.1016/S2213-2600(24)00108-5 (Source: Respiratory Care)
Source: Respiratory Care - April 21, 2024 Category: Respiratory Medicine Authors: Abhijeet Rakshasbhuvankar J Jane Pillow Source Type: research
Performance of direct oral anticoagulant (DOAC) testing by hemostasis laboratories: The Australasian/Asia-Pacific experience
CONCLUSION: We hope our findings, reflecting on mostly consistent reporting of DOAC levels and interpretation provides reassurance for clinicians requesting these measurements, and helps support their implementation in regions where there is a paucity of test availability.PMID:38644463 | DOI:10.1111/ijlh.14288 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - April 21, 2024 Category: Hematology Authors: Emmanuel J Favaloro Sandya Arunachalam Elysse Dean Source Type: research
Acute coronary syndrome in patients treated by vitamin K antagonists or non-vitamin K antagonist oral anticoagulants: Proposed management algorithm for the first 48hours
Arch Cardiovasc Dis. 2024 Apr 12:S1875-2136(24)00058-5. doi: 10.1016/j.acvd.2024.02.012. Online ahead of print.ABSTRACTAround 10% of patients with acute coronary syndrome are treated by vitamin K antagonists or non-vitamin K antagonist oral anticoagulants for various indications. The initial management of these patients is highly complex, and new guidelines specify that, only during percutaneous coronary intervention, a bolus of unfractionated heparin is recommended in one of the following circumstances: (1) if the patient is receiving a non-vitamin K antagonist oral anticoagulant; or (2) if the international normalized ra...
Source: Archives of Cardiovascular Diseases - April 21, 2024 Category: Cardiology Authors: Alexandre Salaun Emmanuel de Maistre Marl ène Daller Chan Sombrun Fr édéric Chagué Florence Bichat Luc Rochette Nicolas Danchin Laurent Fauchier Marianne Zeller Yves Cottin Source Type: research
Exploring Micronutrient Dynamics in COVID-19 Severity and Mortality: Unraveling the Roles of Vitamin D, Calcium, Phosphorus, Magnesium and ALP
This study explores the impact of Vitamin D, calcium, phosphorus, magnesium, and alkaline phosphatase (ALP) on COVID-19 severity and mortality. The study involves 200 participants (100 COVID-19 patients, 100 controls), we meticulously analyzed micronutrient dynamics. Calcium, phosphorus, magnesium and ALP was measured spectrophotometrically. Vitamin D was measured using Chemiluminescent method. The study reveals that diminished levels of calcium, phosphorus, magnesium, and with elevated ALP, are significantly associated with COVID-19 cases. Whereas the Vitamin D levels in severe group was increased when compared to mild ca...
Source: Indian Journal of Clinical Biochemistry - April 21, 2024 Category: Biochemistry Source Type: research
Targeted metabolomics profiling in pregnancy associated with vitamin D deficiency
Vitamin D deficiency is common in pregnancy, however, its effects has not been fully elucidated. Here, we conducted targeted metabolomics profiling to study the relationship. (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - April 20, 2024 Category: OBGYN Authors: Xiaogang Li, Zhuoling An, Aimin Yao, Rui Li, Suhan Zhang, Songlin Yu, Liangkun Ma and Yanping Liu Tags: Research Source Type: research
Association between avocado consumption and diabetes in Mexican adults: Results from the 2012, 2016, and 2018 Mexican National Health and Nutrition Surveys
Avocado contains numerous vitamins, minerals, and phytochemicals, which can contribute to reducing the risk of metabolic syndrome and diabetes. However, limited studies have examined the association between avocados and diabetes risk. (Source: Journal of the American Dietetic Association)
Source: Journal of the American Dietetic Association - April 20, 2024 Category: Nutrition Authors: Feon W. Cheng, Sonia Rodr íguez-Ramírez, Teresa Shamah-Levy, Sandra Pérez-Tepayo, Nikki A. Ford Source Type: research
Response to “Characteristics of the prothrombotic milieu in mitral stenosis patients managed with direct oral anticoagulants”
We read Dr. Jolobe's valuable comments regarding our study. We believe that any recommendation on the utility of direct oral anticoagulants (DOACs) in mitral stenosis (MS) patients with atrial fibrillation (AF) should only be based on the recently published INVICTUS trial [1] providing reliable evidence on the superiority of vitamin K antagonists (VKAs) compared to DOACs. However, the excellent time-in-therapeutic-range in the VKA group in INVICTUS [1] is in contrast with the current real-world experience in countries with a high prevalence of rheumatic heart disease [2], which opens a debate on the transferability of INVI...
Source: International Journal of Cardiology - April 20, 2024 Category: Cardiology Authors: Parham Sadeghipour, Mohammadhossein Mozafarybazargany, Melody Farrashi, Raffaele De Caterina Source Type: research
The yield of routine laboratory examination in osteoporosis evaluation in primary care
ConclusionsWe identified a low prevalence of laboratory abnormalities in a primary care population of older women and the majority of these findings had no medical consequences. (Source: Osteoporosis International)
Source: Osteoporosis International - April 19, 2024 Category: Orthopaedics Source Type: research
New anticoagulants in 2024: Development of factor XI and XIa inhibitors
Ann Biol Clin (Paris). 2024 Apr 19;82(1):9-23. doi: 10.1684/abc.2024.1865.ABSTRACTThrombosis remains one of the leading causes of death in the world. The history of anticoagulation has evolved considerably from non-specific drugs (i.e., heparins and vitamin K antagonists, VKA) to agents that directly target specific coagulation factors (i.e., argatroban, fondaparinux and direct oral anticoagulants, DOAC). Since the last decade, DOAC are widely used in clinical practice because of their ease to use, their favorable pharmacological profile and the fact that they do not require monitoring. However, despite having a better saf...
Source: Annales de Biologie Clinique - April 19, 2024 Category: Biochemistry Authors: N ûn K Bentounes Sophie Melicine Anne-C éline Martin David M Smadja Nicolas Gendron Source Type: research
VDR is a potential prognostic biomarker and positively correlated with immune infiltration: a comprehensive pan-cancer analysis with experimental verification
In conclusion, VDR is a potential prognostic biomarker and positively correlated with immune infiltration as well as stromal or immune components in TME in multiple human cancers.PMID:38639057 | DOI:10.1042/BSR20231845 (Source: Bioscience Reports)
Source: Bioscience Reports - April 19, 2024 Category: Biomedical Science Authors: Xuedi Xia Feng Xu Dexing Dai An Xiong Ruoman Sun Yali Ling Lei Qiu Rui Wang Ya Ding Miaoying Lin Haibo Li Zhongjian Xie Source Type: research
Exploration of Vitamin B6-Based Redox-Active Pyridinium Salts towards the Application in Aqueous Organic Flow Batteries
Chemistry. 2024 Apr 19:e202400828. doi: 10.1002/chem.202400828. Online ahead of print.ABSTRACTPyridoxal hydrochloride, a vitamin B6 vitamer, was synthetically converted to a series of diverse redox-active benzoyl pyridinium salts. Cyclic voltammetry studies demonstrated redox reversibility under basic conditions, and two of the most promising salts were subjected to laboratory-scale redox flow battery tests involving galvanostatic cycling at 10 mM in 0.1 M NaOH. In these tests, the battery was charged completely, corresponding to the transfer of two electrons to the electrolyte, but no discharge was observed. Both CV analy...
Source: Chemistry - April 19, 2024 Category: Chemistry Authors: Anton A Nechaev Gabriel Gonzalez Prachi Verma Vsevolod A Peshkov Anton Bannykh Arsalan Hashemi Jenna Hannonen Andrea Hamza Imre Papai Kari Laasonen Pekka Peljo Petri M Pihko Source Type: research
Impact of carbimazole combined with vitamin E on testicular injury induced by experimental hyperthyroidism in adult albino rats: oxidative/inflammatory/apoptotic pathways
This study aimed to evaluate the impact of combining carbimazole (CBZ) with vitamin E (VE) on testicular injury induced by experimental hyperthyroidism in adult albino rats, focusing on oxidative, inflammatory, and apoptotic pathways. In this experimental study, 64 adult male albino Wistar rats were divided into eight groups: Group I (control-untreated), Group II (CBZ-control), Group III (VE-control), Group IV (CBZ + VE-control), Group V (levothyroxine-induced testicular injury), Group VI (levothyroxine + CBZ-treated), Group VII (levothyroxine + VE-treated), and Group VIII (levothyroxine + CBZ + VE-treated). The study was ...
Source: Asian Journal of Andrology - April 19, 2024 Category: Urology & Nephrology Authors: Ramadan S Hussein Moustafa M Eyada Rashad M Mostafa Samah M Elaidy Shereen H Elsayed Hany M Saad Source Type: research
A Novel Ornithine Aminotransferase Splice Site Mutation Causes Vitamin B6-Responsive Gyrate Atrophy
CONCLUSION: Our knowledge about the diagnosis and treatment of GACR can be improved by identifying novel mutations in the OAT gene and accurate follow-up of the patients to determine how they respond to treatment.PMID:38638626 | PMC:PMC11022026 | DOI:10.18502/jovr.v19i1.15446 (Source: Journal of Ophthalmic and Vision Research)
Source: Journal of Ophthalmic and Vision Research - April 19, 2024 Category: Opthalmology Authors: Samira Molaei Ramshe Safoura Zardadi Elham Alehabib Ramin Nourinia Javad Jamshidi Mohsen Soosanabadi Hossein Darvish Source Type: research
