Mechanisms of Cardiovascular Calcification and Experimental Models: Impact of Vitamin K Antagonists
J Clin Med. 2024 Feb 29;13(5):1405. doi: 10.3390/jcm13051405.ABSTRACTCardiovascular calcification is a multifactorial and complex process involving an array of molecular mechanisms eventually leading to calcium deposition within the arterial walls. This process increases arterial stiffness, decreases elasticity, influences shear stress events and is related to an increased risk of morbidity and mortality associated with cardiovascular disease. In numerous in vivo and in vitro models, warfarin therapy has been shown to cause vascular calcification in the arterial wall. However, the exact mechanisms of calcification formatio...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Chiara Siracusa Annarita Carino Nicole Carabetta Marzia Manica Jolanda Sabatino Eleonora Cianflone Isabella Leo Antonio Strangio Daniele Torella Salvatore De Rosa Source Type: research
Coadministration of doxorubicin with vitamin D3, Lactobacillus acidophilus, and Lactobacillus casei in the 4T1 mouse model of breast cancer: anticancer and enteroprotective effects
Med Oncol. 2024 Apr 9;41(5):111. doi: 10.1007/s12032-024-02346-0.ABSTRACTThe use of doxorubicin (Dox) in the treatment of breast cancer negatively affects the intestines and other tissues. Many studies have proven that probiotics and vitamin D3 have antitumor and intestinal tissue-protecting properties. To achieve effectiveness and minimize side effects, the current study aims to administer Dox together with probiotics (Lactobacillus acidophilus and Lactobacillus casei) and vitamin D3. Forty-two female BALB/c inbred mice were divided into six groups: Group 1 (Control), Group 2 (Dox), Group 3 (Dox and probiotics), Group 4 (...
Source: Cancer Control - April 9, 2024 Category: Cancer & Oncology Authors: Mohammad Ali Mirzadeh Majid Eslami Ali Ghanbari Sam Zarbakhsh Sedighe Yosefi Abbas Pakdel Source Type: research
Acquired methemoglobinemia due to nitrobenzene poisoning: An unusual acquaintance
Key Clinical MessageNitrobenzene poisoning is a rare yet life-threatening contention. The ensuing acute methemoglobinemia has a high fatality rate, hence early prompt intervention is required. Methylene blue (intravenous or oral) and ascorbic acid are the cornerstones of management. They must be administered to suspected patients without tardiness.AbstractAn aromatic organic chemical used in paints and the printing industry is nitrobenzene. Its poisoning causes potentially fatal methemoglobinemia. One aspect of its management involves reducing the iron moiety from its ferric to ferrous form by administering intravenous met...
Source: Clinical Case Reports - April 9, 2024 Category: General Medicine Authors: Sunil Bhatta,
Pusp Raj Awasthi Tags: CASE REPORT Source Type: research
Safety of cinacalcet in children and adolescents with chronic kidney disease-mineral bone disorder: systematic review and proportional meta-analysis of case series
Conclusions and implications of key findingsIf used in the pediatric population, the calcimimetic cinacalcet should be carefully monitored for serum calcium levels and attention to possible adverse events, especially in children under 50 months.Systematic review registration number (PROSPERO register)CRD42019132809. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - April 9, 2024 Category: Urology & Nephrology Source Type: research
Epidemiological analysis to identify predictors of X-linked hypophosphatemia (XLH) diagnosis in an Italian pediatric population: the EPIX project
ConclusionFindings showed that data-driven machine learning models may play a prominent role for the prediction of the diagnosis of rare diseases such as XLH. (Source: Endocrine)
Source: Endocrine - April 9, 2024 Category: Endocrinology Source Type: research
