Cancers, Vol. 16, Pages 1453: Emerging and Clinically Accepted Biomarkers for Hepatocellular Carcinoma
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R. Matthew Walsh
Charles Miller
Koji Hashimoto
Andrea Schlegel
David Choon Hyuck Kwon
Federico Aucejo
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death and the sixth most diagnosed malignancy worldwide. Serum alpha-fetoprotein (AFP) is the traditional, ubiquitous biomarker for HCC. However, there has been an increasing call for the use of multiple biomarkers to optimize care for these patients. AFP, AFP-L3, and prothrombin induced by vitamin K absence II (DCP) have described clinical utility for HCC, but unfortunately, they also have well established and significant limitat...
Source: Cancers - April 10, 2024 Category: Cancer & Oncology Authors: Sami Fares Chase J. Wehrle Hanna Hong Keyue Sun Chunbao Jiao Mingyi Zhang Abby Gross Erlind Allkushi Melis Uysal Suneel Kamath Wen Wee Ma Jamak Modaresi Esfeh Maureen Whitsett Linganna Mazhar Khalil Alejandro Pita Jaekeun Kim R. Matthew Walsh Charles Mill Tags: Review Source Type: research
Analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammatory biomarkers in chronic kidney disease: impact of parathyroidectomy
CONCLUSION: N/L and P/L ratios are not reliable biomarkers of inflammation in SHPT patients undergoing PTX. Uremia, which induces a state of chronic inflammation in dialysis patients, and the use of immunosuppression in kidney transplant recipients are some of the confounding factors that prevent the use of this tool in clinical practice.PMID:38591824 | DOI:10.1590/2175-8239-JBN-2023-0175en (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Andre Kakinoki Teng Eduardo Jorge Duque Shirley Ferraz Crispilho Wagner Domingues Vanda Jorgetti Luciene M Dos Reis Rosilene M Elias Rosa Maria Affonso Moys és Source Type: research
Revisiting the association between vitamin D deficiency and active tuberculosis: A prospective case-control study in Taiwan
CONCLUSIONS: VDD is an independent risk factor for incident active TB. Future randomized trials examining the effect of vitamin D supplementation on TB incidence should focus on people with a low BMI or other risk factors to maximize the statistical power.PMID:38594108 | DOI:10.1016/j.jmii.2024.03.005 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - April 9, 2024 Category: Microbiology Authors: Meng-Shiuan Hsu Tzu-Chien Chung Ping-Huai Wang Shih-Lung Cheng Yen-Wen Wu Jung-Cheng Hsu Bing-Hsiean Tzeng Heng-Hsu Lin Chung-Ming Tu Fang-Yeh Chu Chi-Tai Fang Source Type: research
Analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammatory biomarkers in chronic kidney disease: impact of parathyroidectomy
CONCLUSION: N/L and P/L ratios are not reliable biomarkers of inflammation in SHPT patients undergoing PTX. Uremia, which induces a state of chronic inflammation in dialysis patients, and the use of immunosuppression in kidney transplant recipients are some of the confounding factors that prevent the use of this tool in clinical practice.PMID:38591824 | DOI:10.1590/2175-8239-JBN-2023-0175en (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Andre Kakinoki Teng Eduardo Jorge Duque Shirley Ferraz Crispilho Wagner Domingues Vanda Jorgetti Luciene M Dos Reis Rosilene M Elias Rosa Maria Affonso Moys és Source Type: research
Management of Inoculation with < em > Bradyrhizobium japonicum < /em > and Application of Vitamins for Hydroponic Soybean Cultivation
Int J Microbiol. 2024 Mar 31;2024:4463693. doi: 10.1155/2024/4463693. eCollection 2024.ABSTRACTThe exchange of technologies used in field cultivation for hydroponic systems can potentially increase plant development and grain production, requiring studies to verify the best management forms, such as growth-promoting bacteria and biostimulant compounds. With this in mind, the study aimed to evaluate the effect of the application of thiamine and niacin, alone and combined, to soybean plants in the absence and presence of inoculation with B. japonicum on the agronomic and physiological characteristics of the crop grown in an ...
Source: International Journal of Microbiology - April 9, 2024 Category: Microbiology Authors: Alexandre H de F Lima Josiane S Salles Eduardo P Vendruscolo C ássio de C Seron Rog ério S de Freitas Sebasti ão F de Lima Gabriela R Sant'Ana Edilson Costa Source Type: research
Analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammatory biomarkers in chronic kidney disease: impact of parathyroidectomy
CONCLUSION: N/L and P/L ratios are not reliable biomarkers of inflammation in SHPT patients undergoing PTX. Uremia, which induces a state of chronic inflammation in dialysis patients, and the use of immunosuppression in kidney transplant recipients are some of the confounding factors that prevent the use of this tool in clinical practice.PMID:38591824 | DOI:10.1590/2175-8239-JBN-2023-0175en (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Andre Kakinoki Teng Eduardo Jorge Duque Shirley Ferraz Crispilho Wagner Domingues Vanda Jorgetti Luciene M Dos Reis Rosilene M Elias Rosa Maria Affonso Moys és Source Type: research
Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation
Eur J Immunol. 2024 Apr 9:e2250342. doi: 10.1002/eji.202250342. Online ahead of print.ABSTRACTNatural killer (NK) cells are innate cytotoxic lymphocytes that contribute to immune responses against stressed, transformed, or infected cells. NK cell effector functions are regulated by microenvironmental factors, including cytokines, metabolites, and nutrients. Vitamin A is an essential micronutrient that plays an indispensable role in embryogenesis and development, but was also reported to regulate immune responses. However, the role of vitamin A in regulating NK cell functions remains poorly understood. Here, we show that th...
Source: European Journal of Immunology - April 9, 2024 Category: Allergy & Immunology Authors: Mingeum Jeong Francesco Cortopassi Jia-Xiang See Carolina De La Torre Adelheid Cerwenka Ana Stojanovic Source Type: research
Revisiting the association between vitamin D deficiency and active tuberculosis: A prospective case-control study in Taiwan
CONCLUSIONS: VDD is an independent risk factor for incident active TB. Future randomized trials examining the effect of vitamin D supplementation on TB incidence should focus on people with a low BMI or other risk factors to maximize the statistical power.PMID:38594108 | DOI:10.1016/j.jmii.2024.03.005 (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - April 9, 2024 Category: Microbiology Authors: Meng-Shiuan Hsu Tzu-Chien Chung Ping-Huai Wang Shih-Lung Cheng Yen-Wen Wu Jung-Cheng Hsu Bing-Hsiean Tzeng Heng-Hsu Lin Chung-Ming Tu Fang-Yeh Chu Chi-Tai Fang Source Type: research
Analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammatory biomarkers in chronic kidney disease: impact of parathyroidectomy
CONCLUSION: N/L and P/L ratios are not reliable biomarkers of inflammation in SHPT patients undergoing PTX. Uremia, which induces a state of chronic inflammation in dialysis patients, and the use of immunosuppression in kidney transplant recipients are some of the confounding factors that prevent the use of this tool in clinical practice.PMID:38591824 | DOI:10.1590/2175-8239-JBN-2023-0175en (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Andre Kakinoki Teng Eduardo Jorge Duque Shirley Ferraz Crispilho Wagner Domingues Vanda Jorgetti Luciene M Dos Reis Rosilene M Elias Rosa Maria Affonso Moys és Source Type: research
Management of Inoculation with < em > Bradyrhizobium japonicum < /em > and Application of Vitamins for Hydroponic Soybean Cultivation
Int J Microbiol. 2024 Mar 31;2024:4463693. doi: 10.1155/2024/4463693. eCollection 2024.ABSTRACTThe exchange of technologies used in field cultivation for hydroponic systems can potentially increase plant development and grain production, requiring studies to verify the best management forms, such as growth-promoting bacteria and biostimulant compounds. With this in mind, the study aimed to evaluate the effect of the application of thiamine and niacin, alone and combined, to soybean plants in the absence and presence of inoculation with B. japonicum on the agronomic and physiological characteristics of the crop grown in an ...
Source: International Journal of Microbiology - April 9, 2024 Category: Microbiology Authors: Alexandre H de F Lima Josiane S Salles Eduardo P Vendruscolo C ássio de C Seron Rog ério S de Freitas Sebasti ão F de Lima Gabriela R Sant'Ana Edilson Costa Source Type: research
Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation
Eur J Immunol. 2024 Apr 9:e2250342. doi: 10.1002/eji.202250342. Online ahead of print.ABSTRACTNatural killer (NK) cells are innate cytotoxic lymphocytes that contribute to immune responses against stressed, transformed, or infected cells. NK cell effector functions are regulated by microenvironmental factors, including cytokines, metabolites, and nutrients. Vitamin A is an essential micronutrient that plays an indispensable role in embryogenesis and development, but was also reported to regulate immune responses. However, the role of vitamin A in regulating NK cell functions remains poorly understood. Here, we show that th...
Source: European Journal of Immunology - April 9, 2024 Category: Allergy & Immunology Authors: Mingeum Jeong Francesco Cortopassi Jia-Xiang See Carolina De La Torre Adelheid Cerwenka Ana Stojanovic Source Type: research
Probiotics Pediococcus acidilactici GR-1 promotes the functional strains and remodels gut microbiota to reduce the Cr(VI) toxicity in a dual-chamber simulated intestinal system
Chemosphere. 2024 Apr 7:141927. doi: 10.1016/j.chemosphere.2024.141927. Online ahead of print.ABSTRACTNumerous animal studies have demonstrated the toxicity of hexavalent chromium [Cr(VI)] and the bioremediative effects of probiotics on the composition and functions of gut microbiota. Since the precise mechanisms of Cr(VI) detoxification and its interactions with human gut microbiota were unknown, a novel dual-chamber simulated intestinal (DCSI) system was developed to maintain both the stability of the simulated system and the composition of the gut microbiota. Probiotic GR-1 was found to regulate intestinal gut microbiot...
Source: Chemosphere - April 9, 2024 Category: Chemistry Authors: Xing Wang Zemin Wang Shaochen Su Ying Wu Jingjing Fan Xiaoxiao Hou Kunyue Zhang El-Sayed Salama Saurabh Kulshrestha Zhenmin Ling Pu Liu Xiangkai Li Source Type: research
Probiotics Pediococcus acidilactici GR-1 promotes the functional strains and remodels gut microbiota to reduce the Cr(VI) toxicity in a dual-chamber simulated intestinal system
Chemosphere. 2024 Apr 7:141927. doi: 10.1016/j.chemosphere.2024.141927. Online ahead of print.ABSTRACTNumerous animal studies have demonstrated the toxicity of hexavalent chromium [Cr(VI)] and the bioremediative effects of probiotics on the composition and functions of gut microbiota. Since the precise mechanisms of Cr(VI) detoxification and its interactions with human gut microbiota were unknown, a novel dual-chamber simulated intestinal (DCSI) system was developed to maintain both the stability of the simulated system and the composition of the gut microbiota. Probiotic GR-1 was found to regulate intestinal gut microbiot...
Source: Chemosphere - April 9, 2024 Category: Chemistry Authors: Xing Wang Zemin Wang Shaochen Su Ying Wu Jingjing Fan Xiaoxiao Hou Kunyue Zhang El-Sayed Salama Saurabh Kulshrestha Zhenmin Ling Pu Liu Xiangkai Li Source Type: research
