Higher prevalence of thyroid-specific autoantibodies (TPOAb and TgAb) is related to a higher prevalence of fractures in females: results from NHANES 2007 –2010
ConclusionHigher prevalence of thyroid-specific autoantibodies may lead to decreased BMD. In females, higher prevalence of TgAb and TPOAb significantly associated with fractures and TPOAb especially relating to the fractures of hip and spine. Males patients with vitamin D deficiency or insufficiency associated a higher possibility of fractures. (Source: Osteoporosis International)
Source: Osteoporosis International - April 12, 2024 Category: Orthopaedics Source Type: research
Role of one-carbon nutrient intake and diabetes during pregnancy in children ’s growth and neurodevelopment: a 2-year follow-up study of a prospective cohort
This study aimed to determine how maternal 1C nutrient intake was associated with DNA methylation and further, development of children, as well as whether maternal GDM status modified the association in a prospective cohort. (Source: Clinical Nutrition)
Source: Clinical Nutrition - April 12, 2024 Category: Nutrition Authors: Isma ’il Kadam, Mudar Dalloul, Jeanette Hausser, Doron Vaday, Ella Gilboa, Liang Wang, Joan Hittelman, Lori Hoepner, Lawrence Fordjour, Pavani Chitamanni, Anjana Saxena, Xinyin Jiang Source Type: research
Enzalutamide: Understanding and Managing Drug Interactions to Improve Patient Safety and Drug Efficacy
AbstractEnzalutamide is an oral androgen receptor signaling inhibitor utilized in the treatment of men with prostate cancer. It is a moderate inducer of the cytochrome P450 (CYP) enzymes CYP2C9 and CYP2C19, and a strong inducer of CYP3A4. It was also shown to be a mild inhibitor of the efflux transporter P-glycoprotein in patients with prostate cancer. Enzalutamide is primarily metabolized by CYP3A4 and CYP2C8. The risk of enzalutamide drug interactions arises primarily when it is coadministered with other drugs that interact with these CYPs, including CYP3A4. In this review, we begin by providing an overview of enzalutami...
Source: Drug Safety - April 12, 2024 Category: Drugs & Pharmacology Source Type: research
Serum trough concentration threshold and risk factors of cefoperazone-induced coagulopathy in critically ill patients: A retrospective case-control study
ConclusionCefoperazone-induced coagulopathy usually occurs on the 6th day of cefoperazone use in critically ill patients. The risk will increase in patients with an APACHE II score > 25, hepatic impairment, and cefoperazone Cmin ≥ 87.765 mg/l. Vitamin K1 is effective in preventing this adverse reaction. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Source Type: research
Vitamin D status in children
J Pediatr (Rio J). 2024 Apr 8:S0021-7557(24)00037-8. doi: 10.1016/j.jped.2024.04.001. Online ahead of print.NO ABSTRACTPMID:38604241 | DOI:10.1016/j.jped.2024.04.001 (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - April 11, 2024 Category: Pediatrics Authors: Roger Bouillon Leen Antonio Nick Narinx Source Type: research
Modulatory interactions of T-2 and deoxynivalenol mycotoxins on murine femoral development and osteological integrity
In this study, we conducted a systematic assessment of the effectsof Deoxynivalenol (DON) and T-2 mycotoxins on the developmental processes and structural integrity of murine femurs, considering both the isolated and synergistic effects of these toxins. To this end, we divided 72 male mice into nine groups, each subjected to varying dosages of T-2, DON, or their combinations. Over a four-week experimental period, meticulous monitoring was undertaken regarding the mice's body weight, biochemical markers of bone formation and resorption, and the activity of relevant cells. To comprehensively evaluate alterations in bone stru...
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: Cong Yao Shuichu Hao Chun Zhang Li Liu Yumeng Jia Peilin Meng Cuiyan Wu Xiong Guo Source Type: research
Sucrose esters of aryldihydronaphthalene-type lignans, and antitumor activity of extracts of < em > Moltkiopsis ciliata < /em > (Forssk.) aerial parts
Nat Prod Res. 2024 Apr 11:1-11. doi: 10.1080/14786419.2024.2341307. Online ahead of print.ABSTRACTOne new compound (3f-[(7'R,8'R)-4,4'-dihydroxy-5-methoxy-2,7'-cycloligna-7-en-9-methoxycarbonyl, 9'-carbonyl-O-] -β- D-fructofuranosyl- (2→1)-α- D-glucopyranoside) (Moltkiopsin A) (2) was isolated and identified from the extract of aerial parts of the wild Egyptian plant Moltkiopsis ciliata (Frossk.), family Boraginaceae, for the first time, along with two aryldihydronaphthalene lignans 3f→9':6f→9-[(7'R,8'R)-4,4'- dihydroxy-3,3',5-trimethoxy-2,7'-cycloligna-7-en-9,9'-dicarbonyl]-6g-acetyl-α-D-gluco pyranosyl-(1→2) -...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Amal Mahmoud Youssef Moustafa Mohamed Abdel-Moneim Mohamed E Mostafa Mamdouh Abdel-Mogib Marwa Rabee Abdel-Hak Source Type: research
Vitamin D status in children
J Pediatr (Rio J). 2024 Apr 8:S0021-7557(24)00037-8. doi: 10.1016/j.jped.2024.04.001. Online ahead of print.NO ABSTRACTPMID:38604241 | DOI:10.1016/j.jped.2024.04.001 (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - April 11, 2024 Category: Pediatrics Authors: Roger Bouillon Leen Antonio Nick Narinx Source Type: research
Modulatory interactions of T-2 and deoxynivalenol mycotoxins on murine femoral development and osteological integrity
In this study, we conducted a systematic assessment of the effectsof Deoxynivalenol (DON) and T-2 mycotoxins on the developmental processes and structural integrity of murine femurs, considering both the isolated and synergistic effects of these toxins. To this end, we divided 72 male mice into nine groups, each subjected to varying dosages of T-2, DON, or their combinations. Over a four-week experimental period, meticulous monitoring was undertaken regarding the mice's body weight, biochemical markers of bone formation and resorption, and the activity of relevant cells. To comprehensively evaluate alterations in bone stru...
Source: Food and Chemical Toxicology - April 11, 2024 Category: Food Science Authors: Cong Yao Shuichu Hao Chun Zhang Li Liu Yumeng Jia Peilin Meng Cuiyan Wu Xiong Guo Source Type: research
Sucrose esters of aryldihydronaphthalene-type lignans, and antitumor activity of extracts of < em > Moltkiopsis ciliata < /em > (Forssk.) aerial parts
Nat Prod Res. 2024 Apr 11:1-11. doi: 10.1080/14786419.2024.2341307. Online ahead of print.ABSTRACTOne new compound (3f-[(7'R,8'R)-4,4'-dihydroxy-5-methoxy-2,7'-cycloligna-7-en-9-methoxycarbonyl, 9'-carbonyl-O-] -β- D-fructofuranosyl- (2→1)-α- D-glucopyranoside) (Moltkiopsin A) (2) was isolated and identified from the extract of aerial parts of the wild Egyptian plant Moltkiopsis ciliata (Frossk.), family Boraginaceae, for the first time, along with two aryldihydronaphthalene lignans 3f→9':6f→9-[(7'R,8'R)-4,4'- dihydroxy-3,3',5-trimethoxy-2,7'-cycloligna-7-en-9,9'-dicarbonyl]-6g-acetyl-α-D-gluco pyranosyl-(1→2) -...
Source: Natural Product Research - April 11, 2024 Category: Biochemistry Authors: Amal Mahmoud Youssef Moustafa Mohamed Abdel-Moneim Mohamed E Mostafa Mamdouh Abdel-Mogib Marwa Rabee Abdel-Hak Source Type: research
Antioxidants accelerate tendon-to-bone healing after rotator cuff repair surgery
This study aimed to investigate the effects of reduction of oxidative stress induced by antioxidants such as N-acetylcysteine (NAC) and vitamin C (VC) on rotator cuff repair in a rotator cuff repair model in rats. Infraspinatus tendon was ruptured in 48 rats and repaired 1 week later. Rats were divided into 3 groups: NAC group, VC group, or control group, and were administered NAC, VC, or distilled water respectively. The specimens were collected at 3, 6, and 12 weeks after repair. Histological evaluation was performed using hematoxylin/eosin and toluidine blue staining, and oxidative stress was evaluated using dihydroethi...
Source: Journal of Shoulder and Elbow Surgery - April 11, 2024 Category: Orthopaedics Authors: Hirohisa Uehara, Yoshiaki Itoigawa, Daichi Morikawa, Akihisa Koga, Hironori Tsurukami, Muneaki Ishijima Source Type: research
Vitamin D as an intervention for improving quadriceps muscle strength in patients after anterior cruciate ligament reconstruction: study protocol for a randomized double-blinded, placebo-controlled clinical trial
The goal of anterior cruciate ligament reconstruction (ACLR) is to restore the preinjury level of knee function to return to play (RTP). However, even after completing the rehabilitation programme, some patien... (Source: Trials)
Source: Trials - April 11, 2024 Category: General Medicine Authors: Michael Tim-yun Ong, Xiaomin Lu, Ben Chi-yin Choi, Siu-Wai Wan, Qianwen Wang, Gene Chi-wai Man, Pauline Po-yee Lui, Daniel Tik-Pui Fong, Daniel Kam-wah Mok and Patrick Shu-hang Yung Tags: Study protocol Source Type: research
Lower Risk of Low Bone Mineral Density in High Vitamin E Level in Older People: A Cross-Sectional Study
In this study, we investigated the relationship between serum Vitamin E levels and LBMD in the elderly. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - April 11, 2024 Category: Nutrition Authors: Ying-Long Peng, Zi-Yan Wang, Xuan-Jia Wang, Yu-Tong Ji, Yaqing Wen, Yanpei Mai Source Type: research
Ambient ultraviolet-B radiation, supplements and other factors interact to impact vitamin D status differently depending on ethnicity: a cross-sectional study
Many determinants of vitamin D status have been well-described, yet supplementation guidelines largely follow a one-size-for-all model and deficiency remains common. We hypothesised that accounting accurately for ultraviolet-B (UVB) radiation and considering interactions could advance understanding of vitamin D status. (Source: Clinical Nutrition)
Source: Clinical Nutrition - April 11, 2024 Category: Nutrition Authors: Margaret M. Brennan, Jos van Geffen, Michiel van Weele, Lina Zgaga, Rasha Shraim Source Type: research
