Factor XI: structure, function and therapeutic inhibition
AbstractArterial and venous thromboembolism is a major medical concern that requires therapeutic anticoagulation in various medical fields to prevent its drastic consequences. Despite significant advances in anticoagulant therapy, thrombosis remains a leading cause of morbidity and mortality worldwide. Traditional anticoagulants like heparin and vitamin K antagonists (VKAs) have shown efficacy in preventing and treating thrombosis but come with an inherent risk of bleeding due to their non-specific inhibition of multiple coagulation factors. Subsequent direct oral anticoagulants (DOACs), targeting specific factors such as ...
Source: Journal of Thrombosis and Thrombolysis - April 16, 2024 Category: Hematology Source Type: research
PIVKA-II combined with alpha-fetoprotein for the diagnostic value of hepatic tumors in children: a multicenter, prospective observational study
ConclusionsThe serum level of PIVKA-II was significantly higher in children with hepatic tumors, especially those with malignant tumors. The combination of PIVKA-II with AFP further increased the diagnostic performance.Trial registrationClinical Trials, NCT03645655. Registered 20 August 2018,https://www.clinicaltrials.gov/ct2/show/NCT03645655. (Source: Hepatology International)
Source: Hepatology International - April 16, 2024 Category: Infectious Diseases Source Type: research
Impact of supplementation with iron-folic acid (IFA) and vitamin D3 compared with IFA alone on haemoglobin levels in elderly people with mild-to-moderate anaemia: protocol for the double-blind, randomised, placebo-controlled Iron and vitamin D trial in Elderly Anemia (IDEA)
This study is a community-based, double-blind, placebo-controlled, randomised trial. The study will be done in the Kalyani municipality area. Individuals aged ≥60 years with mild-to-moderate anaemia and normal vitamin D3 levels will be randomised into the intervention (IFA and vitamin D3 supplementation) group or the control group (IFA and olive oil as placebo). All medications will be self-administered. Follow-up will be done on a weekly basis for 12 weeks. The calculated sample size is 150 in each arm. Block randomisation will be done. The primary outcome is change in haemoglobin levels from baseline to 12 weeks. Seco...
Source: BMJ Open - April 16, 2024 Category: General Medicine Authors: Ahamed, F., Jaiswal, A., Sahoo, S., Ghosh, T., Kaur, A., Rehman, T., Goswami, K. Tags: Open access, Geriatric medicine Source Type: research
Experimental and new investigational drugs for the treatment of uterine fibroids
Expert Opin Investig Drugs. 2024 Apr 17:1-12. doi: 10.1080/13543784.2024.2343786. Online ahead of print.ABSTRACTINTRODUCTION: Uterine fibroids, the most prevalent benign tumors among reproductive-age women, pose treatment challenges that range from surgical interventions to medical therapies for symptom control. Progestins and estroprogestins effectively manage uterine bleeding by suppressing dysfunctional endometrium over fibroids. While GnRH agonists represent a crucial milestone in symptom treatment, their prolonged use results in menopausal-like symptoms and irreversible bone mineral density loss. Advancements in under...
Source: Expert Opinion on Investigational Drugs - April 15, 2024 Category: Drugs & Pharmacology Authors: Giulio Evangelisti Simone Ferrero Umberto Perrone Claudio Gustavino Eugenio Volpi Alberto Izzotti Fabio Barra Source Type: research
Influence of Silicon Supplementation on Growth, Immunity, Antioxidant, Hormonal Profile and Bone Health Biomarkers in Pre-ruminant Crossbred Calves
Biol Trace Elem Res. 2024 Apr 15. doi: 10.1007/s12011-024-04178-5. Online ahead of print.ABSTRACTSilicon (Si), a newer trace element, is believed to be important for healthy bone formation and to decrease bone resorption, improving the quality of bone by manipulating several hormones and enzymes. Therefore, the current investigation was conducted to determine the impact of Si supplementation on growth, immunity, antioxidant, hormonal profile and biomarkers of bone health in pre-ruminant crossbred calves. Twenty-four crossbred calves (5-7 days) were selected on the basis of their body weight (BW 31.65 ± 0.46 kg) and divide...
Source: Biological Trace Element Research - April 15, 2024 Category: Biology Authors: Lamella Ojha Raman Malik Veena Mani Abhishek Kumar Singh Manpreet Singh Source Type: research
Empowering γδ T-cell functionality with vitamin C
Eur J Immunol. 2024 Apr 15:e2451028. doi: 10.1002/eji.202451028. Online ahead of print.ABSTRACTVitamin C (ascorbic acid) is a potent antioxidant and a cofactor for various enzymes including histone demethylases and methylcytosine dioxygenases. Vitamin C also exerts direct cytotoxicity toward selected tumor cells including colorectal carcinoma. Moreover, vitamin C has been shown to impact immune cell differentiation at various levels including maturation and/or functionality of T cells and their progenitors, dendritic cells, B cells, and NK cells. γδ T cells have recently attracted great interest as effector cells for cel...
Source: European Journal of Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Dieter Kabelitz Lea Cierna Claudia Juraske Michal Zarobkiewicz Wolfgang W Schamel Christian Peters Source Type: research
The Role of Vitamin D Binding Protein and Vitamin D Level in Mortality of Sepsis Patients
CONCLUSIONS: Diminished levels of vitamin D binding protein and vitamin D contribute to an increased risk of mortality in septic patients.PMID:38618268 | PMC:PMC11015934 | DOI:10.61186/rbmb.12.3.366 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 15, 2024 Category: Molecular Biology Authors: Liliriawati Ananta Kahar Yusrawati Yusrawati Jamsari Jamsari Tinni Maskoen Kornelis Aribowo Wiwi Monika Sari Source Type: research
Influence of Silicon Supplementation on Growth, Immunity, Antioxidant, Hormonal Profile and Bone Health Biomarkers in Pre-ruminant Crossbred Calves
Biol Trace Elem Res. 2024 Apr 15. doi: 10.1007/s12011-024-04178-5. Online ahead of print.ABSTRACTSilicon (Si), a newer trace element, is believed to be important for healthy bone formation and to decrease bone resorption, improving the quality of bone by manipulating several hormones and enzymes. Therefore, the current investigation was conducted to determine the impact of Si supplementation on growth, immunity, antioxidant, hormonal profile and biomarkers of bone health in pre-ruminant crossbred calves. Twenty-four crossbred calves (5-7 days) were selected on the basis of their body weight (BW 31.65 ± 0.46 kg) and divide...
Source: Biological Trace Element Research - April 15, 2024 Category: Biology Authors: Lamella Ojha Raman Malik Veena Mani Abhishek Kumar Singh Manpreet Singh Source Type: research
Experimental and new investigational drugs for the treatment of uterine fibroids
Expert Opin Investig Drugs. 2024 Apr 17:1-12. doi: 10.1080/13543784.2024.2343786. Online ahead of print.ABSTRACTINTRODUCTION: Uterine fibroids, the most prevalent benign tumors among reproductive-age women, pose treatment challenges that range from surgical interventions to medical therapies for symptom control. Progestins and estroprogestins effectively manage uterine bleeding by suppressing dysfunctional endometrium over fibroids. While GnRH agonists represent a crucial milestone in symptom treatment, their prolonged use results in menopausal-like symptoms and irreversible bone mineral density loss. Advancements in under...
Source: Expert Opinion on Investigational Drugs - April 15, 2024 Category: Drugs & Pharmacology Authors: Giulio Evangelisti Simone Ferrero Umberto Perrone Claudio Gustavino Eugenio Volpi Alberto Izzotti Fabio Barra Source Type: research
Delving the vitamin D receptor variation and expression profiles in the context of type 2 diabetes among families
CONCLUSION: A linkage was found among the FDRs with probands. Variation in the gene VDR at loci rs731236 and rs2228570 was associated with familial T2D. However further research is required to explore more genetic factors that could influence T2D risks in families.PMID:38622480 | DOI:10.1007/s11033-024-09387-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Asia Parveen Andleeb Batool Abdul Wajid Maryam Mukhtar Khajid Ullah Khan Aqsa Zahid Anjum Jabeen Kashif Iqbal Sahibzada Source Type: research
Empowering γδ T-cell functionality with vitamin C
Eur J Immunol. 2024 Apr 15:e2451028. doi: 10.1002/eji.202451028. Online ahead of print.ABSTRACTVitamin C (ascorbic acid) is a potent antioxidant and a cofactor for various enzymes including histone demethylases and methylcytosine dioxygenases. Vitamin C also exerts direct cytotoxicity toward selected tumor cells including colorectal carcinoma. Moreover, vitamin C has been shown to impact immune cell differentiation at various levels including maturation and/or functionality of T cells and their progenitors, dendritic cells, B cells, and NK cells. γδ T cells have recently attracted great interest as effector cells for cel...
Source: European Journal of Immunology - April 15, 2024 Category: Allergy & Immunology Authors: Dieter Kabelitz Lea Cierna Claudia Juraske Michal Zarobkiewicz Wolfgang W Schamel Christian Peters Source Type: research
Influence of Silicon Supplementation on Growth, Immunity, Antioxidant, Hormonal Profile and Bone Health Biomarkers in Pre-ruminant Crossbred Calves
Biol Trace Elem Res. 2024 Apr 15. doi: 10.1007/s12011-024-04178-5. Online ahead of print.ABSTRACTSilicon (Si), a newer trace element, is believed to be important for healthy bone formation and to decrease bone resorption, improving the quality of bone by manipulating several hormones and enzymes. Therefore, the current investigation was conducted to determine the impact of Si supplementation on growth, immunity, antioxidant, hormonal profile and biomarkers of bone health in pre-ruminant crossbred calves. Twenty-four crossbred calves (5-7 days) were selected on the basis of their body weight (BW 31.65 ± 0.46 kg) and divide...
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Lamella Ojha Raman Malik Veena Mani Abhishek Kumar Singh Manpreet Singh Source Type: research
Delving the vitamin D receptor variation and expression profiles in the context of type 2 diabetes among families
CONCLUSION: A linkage was found among the FDRs with probands. Variation in the gene VDR at loci rs731236 and rs2228570 was associated with familial T2D. However further research is required to explore more genetic factors that could influence T2D risks in families.PMID:38622480 | DOI:10.1007/s11033-024-09387-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 15, 2024 Category: Molecular Biology Authors: Asia Parveen Andleeb Batool Abdul Wajid Maryam Mukhtar Khajid Ullah Khan Aqsa Zahid Anjum Jabeen Kashif Iqbal Sahibzada Source Type: research
Experimental and new investigational drugs for the treatment of uterine fibroids
Expert Opin Investig Drugs. 2024 Apr 15. doi: 10.1080/13543784.2024.2343786. Online ahead of print.ABSTRACTINTRODUCTION: Uterine fibroids, the most prevalent benign tumors among reproductive-age women, pose treatment challenges that range from surgical interventions to medical therapies for symptom control. Progestins and estroprogestins effectively manage uterine bleeding by suppressing dysfunctional endometrium over fibroids. While GnRH agonists represent a crucial milestone in symptom treatment, their prolonged use results in menopausal-like symptoms and irreversible bone mineral density loss. Advancements in understand...
Source: Expert Opinion on Investigational Drugs - April 15, 2024 Category: Drugs & Pharmacology Authors: Giulio Evangelisti Simone Ferrero Umberto Perrone Claudio Gustavino Eugenio Volpi Alberto Izzotti Fabio Barra Source Type: research
