Diverse Functions of Vitamin D in Health and Disease
Publication date: Available online 4 April 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Afrozul Haq, Seyed E. Hasnain, Mohammed S. Razzaque (Source: The Journal of Steroid Biochemistry and Molecular Biology)
Source: The Journal of Steroid Biochemistry and Molecular Biology - April 5, 2020 Category: Biochemistry Source Type: research

Myocardial calcifications: thinking beyond the heart.
Myocardial calcifications are often discovered incidentally and result from dystrophic or metastatic deposition of calcium1. Dystrophic calcification represents the sequalae of local tissue damage with necrosis, most commonly from myocardial ischemia. Unlike the prior, metastatic calcification is the result of abnormal calcium homeostasis; including renal failure, hyperparathyroidism, and vitamin D deficiency. Myocardial calcifications are not entirely a benign finding, since they can lead to heart failure, arrhythmias and sudden cardiac death2. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 5, 2020 Category: General Medicine Authors: Kenneth Hoang, Katia Bravo-Jaimes, Daniel Ocazionez Tags: Clinical Communication to the Editor Source Type: research

Vitamin D serum levels in patients with migraine: A meta-analysis.
Authors: Liampas I, Siokas V, Brotis A, Dardiotis E Abstract BACKGROUND/PURPOSE: Dietary habits and nutrients have been associated with migraine. The present study comprises a meta-analysis of observational studies evaluating serum levels of 25-hydroxyvitamin D (25(OH)D) in patients with migraine and healthy controls. METHODS: MEDLINE and Cochrane databases were comprehensively searched. References from retrieved observational studies, reviews and meta-analyses were manually screened. Quality assessment was performed based on the Newcastle-Ottawa Scale. 25(OH)D concentrations were assessed by estimates of mean ...
Source: Revue Neurologique - April 4, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

An overview of statin-induced myopathy and perspectives for the future.
Authors: Nikolic D, Banach M, Chianetta R, Luzzu LM, Pantea Stoian A, Diaconu CC, Citarrella R, Montalto G, Rizzo M Abstract Introduction: Statins remain the most commonly prescribed lipid-lowering drug class for the treatment of atherosclerotic cardiovascular disease. Their well-recognized side effects are known as statin-associated muscle symptom (SAMS). Some advances in this field have been made in recent years, but the understanding of the mechanisms has lagged. Investigating the specific role of the anti-HMGCR autoantibody, pharmacokinetic genetic variants, characterization of the known phenotypes of statin to...
Source: Expert Opinion on Drug Safety - April 4, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Bilateral calcaneal insufficiency fractures due to chronic carbamazepine use for trigeminal neuralgia: A case report
We report here a 41-year-old lady suffering from bilateral heel pain without trauma history. Her complaining did not respond to analgesics and stretching exercises of plantar fascia. In her past medical history she reported ongoing carbamazepine (CBZ) use over 8 years for trigeminal neuralgia. She had had low bone mineral density; defined as osteopenia. Both calcaneus MRI revealed bilateral stress fractures of calcaneum. She had been advised immobilization for 6 weeks, vitamin D and calcium supplements. CBZ has been stopped by neurology specialist and she had undergone microvascular decompression surgery for intractable pa...
Source: Nigerian Journal of Clinical Practice - April 4, 2020 Category: Rural Health Authors: O Kaya C Hurel G Gumussuyu O Kose Source Type: research

The impact of statins on physical activity and exercise capacity: an overview of the evidence, mechanisms, and recommendations
ConclusionThe available evidence indicates that the benefits of engaging in physical activity while on statin medication largely outweigh the risks. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - April 4, 2020 Category: Physiology Source Type: research

Vitamin D levels correlate with Metabolic Syndrome Criteria in Algerian Patients: The Ex-vivo Immuomodulatory Effect of α, 25 Dihydroxyvitamin D3.
CONCLUSION: Our report indicated the relationship between MetS factors and Vitamin D deficiency. The ex-vivo findings emphasize its impact on maintaining regulated immune balance. PMID: 32238143 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 3, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Intralesional Injection of Vitamin D in Verruca Vulgaris Increases Cathelicidin (LL37) Expression; Therapeutic and Immunohistochemical Study.
Conclusions: Intralesional injection of vitamin D is effective and safe treatment for verruca vulgaris and causes increase in LL37 expression. PMID: 32237947 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Thiamine pyrophosphate diminishes nitric oxide synthesis in endothelial cells.
Authors: Alcázar-Leyva S, Zapata E, Bernal-Alcántara D, Gorocica P, Alvarado-Vásquez N Abstract Although thiamine pyrophosphate (TPP) is considered a protective agent for endothelial cells, it is still unknown if this is associated with nitric oxide (NO) synthesis. Our aim was to evaluate the synthesis of NO in endothelial cells incubated with TPP and high glucose concentrations. Endothelial cells from the umbilical cord vein from newborns (n = 20), were incubated with 5, 15 or 30 mmol/L glucose, in absence or presence of 0.625 mg/ml of TPP. Our results showed a significant...
Source: International Journal for Vitamin and Nutrition Research - April 3, 2020 Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research

Vitamin D and liver cancer risk: A meta-analysis of prospective studies.
CONCLUSIONS: The present study provides substantial evidence that a higher concentration of circulating vitamin D would have conferred protection against liver cancer. PMID: 32229457 [PubMed - in process] (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - April 3, 2020 Category: Nutrition Authors: Guo XF, Zhao T, Han JM, Li S, Li D Tags: Asia Pac J Clin Nutr Source Type: research

Nutraceuticals and blood pressure control: a European Society of Hypertension position document
High-normal blood pressure (BP) is associated with an increased risk of cardiovascular disease, however the cost–benefit ratio of the use of antihypertensive treatment in these patients is not yet clear. Some dietary components and natural products seems to be able to significantly lower BP without significant side effects. The aim of this position document is to highlight which of these products have the most clinically significant antihypertensive action and wheter they could be suggested to patients with high-normal BP. Among foods, beetroot juice has the most covincing evidence of antihypertensive effect. Antioxi...
Source: Journal of Hypertension - April 3, 2020 Category: Cardiology Tags: REVIEWS AND META-ANALYSES Source Type: research

Trends in anticoagulant prescribing: a review of local policies in English primary care
Oral anticoagulants are prescribed for stroke prophylaxis in patients with atrial fibrillation, which is the most common heart arrhythmia worldwide. The vitamin K antagonist (VKA) warfarin is a long-establishe... (Source: BMC Health Services Research)
Source: BMC Health Services Research - April 3, 2020 Category: General Medicine Authors: Katherine H. Ho, Maria van Hove and Gillian Leng Tags: Research article Source Type: research

The association among enterobacterial flora, dietary factors, and prognosis in patients with ulcerative colitis.
Authors: Sugiyama T, Sasaki M, Nakagawa S, Inoue S, Adachi K, Yoshimine T, Yamaguchi Y, Tamura Y, Izawa S, Hijikata Y, Ebi M, Mizuno M, Yamamoto S, Funaki Y, Ogasawara N, Goto C, Kasugai K Abstract The role of enterobacterial flora in the onset and progression of inflammatory bowel diseases is a topic of considerable interest. Here, we assessed the association among enterobacterial flora, dietary factors, and ulcerative colitis (UC) progression. Forty-six patients with UC who were diagnosed as being in remission were enrolled. We collected each patient's stool sample one or two days before diagnostic colonoscopy. A...
Source: Journal of Clinical Biochemistry and Nutrition - April 3, 2020 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

Inhibition of lipid peroxidation during the reproductive period extends the lifespan of Caenorhabditis elegans.
Authors: Sakamoto T, Maebayashi K, Tsunoda Y, Imai H Abstract Glutathione peroxidase 4 (GPx4) is a unique antioxidant enzyme that directly reduces the phospholipid hydroperoxides (PLOOH) generated in biomembranes using glutathione as the reductant. We have previously reported that the Caenorhabditis elegans gpx-quad mutant, which lacks all homologous genes of GPx4 has a reduced lifespan compared with the wild-type. However, the mechanisms underlying the lifespan reduction remain unclear. By monitoring the change in PLOOH production with age, we found that PLOOH was elevated in the gpx-quad mutants compared with the...
Source: Journal of Clinical Biochemistry and Nutrition - April 3, 2020 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

Long-Term Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density: a 4-Year Longitudinal Study
AbstractIntroductionBone mineral density (BMD) declines in the initial years after bariatric surgery, but long-term skeletal effects are unclear and comparisons between sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) are rare.Design and MethodsAn observational longitudinal study of obese patients undergoing SG or RYGB was performed. Whole-body (WB) BMD, along with BMD of the total hip (TH), femoral neck (FN), and lumbar spine (LS), was measured by dual-energy X-ray absorptiometry (DXA) before surgery and yearly thereafter for 4  years. Calciotropic hormones were also measured.ResultsForty-seven patients un...
Source: Obesity Surgery - April 3, 2020 Category: Surgery Source Type: research

EVALI and the Pulmonary Toxicity of Electronic Cigarettes: A Review
AbstractElectronic cigarettes are a novel and emerging product increasingly used by the general public. However, despite their popularity, they remain poorly studied and with likely serious health risks. EVALI, or “electronic cigarette or vaping product use–associated lung injury,” is a recently described entity at the forefront of current investigations. Though EVALI has been linked to vitamin E acetate, a constituent of THC vaping products, electronic cigarettes likely pose a host of other pulmonary t oxicities. The presentation, diagnostic work-up, treatment, and pathophysiology of EVALI are herein des...
Source: Journal of General Internal Medicine - April 3, 2020 Category: Internal Medicine Source Type: research

IJERPH, Vol. 17, Pages 2464: Oncological-Therapy Related Oral Mucositis as an Interdisciplinary Problem —Literature Review
IJERPH, Vol. 17, Pages 2464: Oncological-Therapy Related Oral Mucositis as an Interdisciplinary Problem—Literature Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072464 Authors: Kusiak AlicjaJereczek-Fossa Cichońska Alterio Oral mucositis is a toxic side effect of non-surgical cancer treatments: chemotherapy and radiotherapy, which strongly impair quality of life and can not only cause strong pain, but also lead to problems with basic physiological needs as eating and swallowing. Development of oral mucositis is associated with type, dosage, and schedu...
Source: International Journal of Environmental Research and Public Health - April 3, 2020 Category: Environmental Health Authors: Kusiak AlicjaJereczek-Fossa Cicho ńska Alterio Tags: Review Source Type: research

Review Balkans' Asteraceae species as a source of biologically active compounds for pharmaceutical and food industry.
ć ZP Abstract Herbal drugs are a useful source of different bioactive compounds. Asteraceae species, as the most widespread vascular plants can be used both as food and as medicine due to the great diversity of recorded chemical components - different phenolic compounds, terpenes, carotenoids, vitamins, alkaloids, etc. The Balkan Peninsula is characterized by great diversity of plants from Asteraceae family, including presence of rare and endemic species. In this review, results of the survey of chemical composition and biological activity, mainly focusing on antioxidant, antimicrobial and anticancer effects of s...
Source: Chemistry and Biodiversity - April 3, 2020 Category: Biochemistry Authors: Kostić AŽ, Janaćković P, Kolašinac SM, Dajić-Stevanović ZP Tags: Chem Biodivers Source Type: research

Vitamin D supplementation reduces the occurrence of colorectal polyps in high-latitude locations
Publication date: Available online 1 April 2020Source: Preventive MedicineAuthor(s): R. Liam Sutherland, Jennifer Ormsbee, Joy Pader, Nauzer Forbes, Susanna Town, Robert J. Hilsden, Darren R. Brenner (Source: Preventive Medicine)
Source: Preventive Medicine - April 2, 2020 Category: International Medicine & Public Health Source Type: research

Association between adherence to the Mediterranean Diet and circulating Vitamin D levels.
This study argues that a closer adherence to Med-Diet is independently associated with an increase of 25(OH)D suggesting that higher vitamin D levels may contribute to the protective effect of the Med-Diet on osteoporosis. PMID: 32223463 [PubMed - as supplied by publisher] (Source: International Journal of Food Sciences and Nutrition)
Source: International Journal of Food Sciences and Nutrition - April 2, 2020 Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research

An Update on the Reversal of Non-Vitamin K Antagonist Oral Anticoagulants.
Authors: Mujer MTP, Rai MP, Atti V, Dimaandal IL, Chan AS, Shrotriya S, Gundabolu K, Dhakal P Abstract Non-vitamin K antagonist oral anticoagulants (NOACs) include thrombin inhibitor dabigatran and coagulation factor Xa inhibitors rivaroxaban, apixaban, edoxaban, and betrixaban. NOACs have several benefits over warfarin, including faster time to the achieve effect, rapid onset of action, fewer documented food and drug interactions, lack of need for routine INR monitoring, and improved patient satisfaction. Local hemostatic measures, supportive care, and withholding the next NOAC dose are usually sufficient to achie...
Source: Advances in Hematology - April 2, 2020 Category: Hematology Tags: Adv Hematol Source Type: research

Serum levels of matrix metalloproteinase-2, -9, and vitamin D in patients with multiple sclerosis with or without herpesvirus-6 seropositivity
Publication date: Available online 31 March 2020Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Razieh Amini, Sajad karampoor, Hamid Zahednasab, Hossein Keyvani, Masoud Gheiasian, Farid Azizi Jalilian (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - April 2, 2020 Category: Infectious Diseases Source Type: research

Association of Vitamin D With Periodontal Disease: A Narrative Review
Conclusions: There is conflicting evidence regarding the effects of 25(OH)D on periodontal disease severity, progression and tooth loss, with some studies reporting beneficial effects of higher 25(OH)D serum concentrations on periodontal health and tooth retention, whereas others could not find such an association. Limited evidence also supports a positive association between 1,25(OH)2D3 and periodontal health as well as a trend towards better periodontal health with vitamin D supplementation. Finally, various vitamin D polymorphisms were associated with chronic and aggressive periodontitis, with different outcomes reporte...
Source: Oral health and Preventive dentistry - April 2, 2020 Category: Dentistry Source Type: research

Vitamin C and Its Role in Periodontal Diseases – The Past and the Present: A Narrative Review
Van der Velden, UbelePage 115 - 124In humans, ascorbic acid, better known as vitamin C, is a true vitamin because humans lack the ability to synthesise it. Vitamin C exhibits a number of enzymatic and non-enzymatic effects but all are accounted for by the ability of vitamin C to donate electrons and therefore acts as a reducing agent. It has a wide range of functions. For example, it acts as co-factor for a number of enzymes including those involved in collagen hydroxylation, prevents oxidative damage to DNA and intracellular proteins, and in plasma it increases endothelium-dependent vasodilatation, and reduces extracellul...
Source: Oral health and Preventive dentistry - April 2, 2020 Category: Dentistry Source Type: research

α1-Microglobulin Binds Illuminated Flavins and Has a Protective Effect Against Sublethal Riboflavin-Induced Damage in Retinal Epithelial Cells
Riboflavin (vitamin B2) is an important constituent of the prosthetic groups flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), which are utilized as electron-carriers in energy metabolism. Excitation by UV-light leads to the generation of riboflavin radicals and reactive oxygen species (ROS), which can oxidize a wide range of biomolecules. The human protein α1-microglobulin (A1M) is a reductase and a radical scavenger, which can protect cells and matrix against oxidative damage. Here, we provide evidence of a molecular interaction between illuminated riboflavin and A1M, similar to the radical scaveng...
Source: Frontiers in Physiology - April 2, 2020 Category: Physiology Source Type: research

The metabolic changes in the hippocampus of an atherosclerotic rat model and the regulation of aerobic training
AbstractAtherosclerosis has been associated with the progression of cognitive impairment and the effect of metabolic changes in the brain on cognitive function may be pronounced. The aim is to reveal the metabolic changes during atherosclerosis and clarify the possible role of exercise in regulating hippocampal metabolism. Hence, A rat model of atherosclerosis was established by high-fat diet feeding in combination with vitamin D3 intraperitoneal injection, then 4  weeks of aerobic exercise was conducted. Metabolomics based on GC-MS was applied to detect small molecules metabolites and western blot was used to detect ...
Source: Metabolic Brain Disease - April 2, 2020 Category: Neurology Source Type: research

Correction to: Prevalence of vitamin D deficiency and its predictors in the Portuguese population: a nationwide population-based study
The original version of this article, published on 02 March 2020, unfortunately contained an error on “Fig. 3 Prevalence of Vitamin D Levels by NUTSII.” (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - April 2, 2020 Category: Orthopaedics Source Type: research

Single Versus Double-Anastomosis Duodenal Switch: Single-Site Comparative Cohort Study in 440 Consecutive Patients
AbstractPurposeTo study weight loss, comorbidity remission, complications, and nutritional deficits after duodenal switch (DS) and single-anastomosis DS with sleeve gastrectomy (SADI-S).Material and MethodsRetrospective review of patients submitted to DS or SADI-S for morbid obesity in a single university hospital.ResultsFour hundred forty patients underwent DS (n = 259) or SADI-S (n = 181). Mean preoperative body mass index (BMI) was 50.8 ± 6.4Kg/m2. Mean follow-up was 56.1  ± 37.2 months for DS and 27.2 ± 18.9 months for ...
Source: Obesity Surgery - April 2, 2020 Category: Surgery Source Type: research

Secondary hyperparathyroidism and thoracic vertebral fractures in heart failure middle-aged patients: a 3-year prospective study
This study aimed at assessing whether secondary hyperparathyroidism (SHPT) may influence the risk of VFs in middle-aged patients with HF.Methods84 patients (44 males, median age 48.5  years, range 43–65) with HF were prospectively evaluated at the baseline and after 36-month follow-up for bone mineral density (BMD) and VFs by quantitative morphometry on chest X-rays. Serum PTH, calcium, 25-hydroxyvitamin D and 24-h-urinary calcium were evaluated at the baseline and every 6– 12 months during the study period.ResultsAt baseline, SHPT, hypovitaminosis D and VFs were found in 43 patients (51.2%), 73 patie...
Source: Journal of Endocrinological Investigation - April 2, 2020 Category: Endocrinology Source Type: research

Dietary antioxidants, non-enzymatic antioxidant capacity and the risk of osteoarthritis in the Swedish National March Cohort
ConclusionOur findings do not provide evidence for dietary antioxidants to protect from the development of OA, and a higher dietary vitamin E intake might even increase the risk. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - April 2, 2020 Category: Nutrition Source Type: research

Endothelial injury, F-actin and vitamin-D binding protein after hematopoietic stem cell transplant and association with clinical outcomes.
Abstract Endothelial injury after hematopoietic stem cell transplant is an important initiating factor for early transplant toxicities of thrombotic microangiopathy and acute graft versus host disease. We hypothesized that release of the angiopathic molecule filamentous actin from hematopoietic cells lysed during conditioning prior to stem cell transplant would be associated with clinical outcomes. We detected filamentous actin in the blood of 52% of stem cell transplant recipients in the first 14 days after transplant, and children with detectable filamentous actin had significantly elevated risk of thrombotic mi...
Source: Haematologica - April 2, 2020 Category: Hematology Authors: Luebbering N, Abdullah S, Lounder D, Lane A, Dole N, Rubinstein J, Hewison M, Gloude N, Jodele S, Perentesis KMR, Lake K, Litts B, Duell A, Dandoy CE, Davies SM Tags: Haematologica Source Type: research

Maternal use of folic acid and multivitamin supplements and infant risk of birth defects in Norway 1999-2013.
llset SE, Øyen N Abstract The association between folic acid supplementation and birth defects other than neural tube defects remains unclear. We used a log-binomial regression model to investigate if periconceptional folic acid and/or multivitamin use was associated with birth defects in Norway with prospectively collected data from the Medical Birth Registry of Norway (MBRN) during 1999-2013. We used the EUROCAT classification system to define 11 organ-specific major birth defect groups (nervous system, eye, ear-face-neck, cardiovascular system, respiratory system, oral clefts, digestive system, abdominal...
Source: The British Journal of Nutrition - April 2, 2020 Category: Nutrition Authors: Gildestad T, Bjørge T, Haaland ØA, Klungsøyr K, Vollset SE, Øyen N Tags: Br J Nutr Source Type: research

Reconsidering Garth Robinson: fluid flow and the glomerular filtration barrier
Purpose of review The goal of this review is to present recent models of the filtration barrier that may suggest mechanism-based treatments for proteinuric renal disease. The vast majority of renal failure occurs in diseases of glomerular proteinuria. The physiology of the filtration barrier remains incompletely understood, preventing invention of mechanism-based therapies. Research is currently dominated by molecular biology approaches to the kidney instead of engineering-based filtration and transport models. Recent findings Reexamination of two older paradigms (basement membrane and slit diaphragm) and critical ana...
Source: Current Opinion in Nephrology and Hypertension - April 1, 2020 Category: Urology & Nephrology Tags: RENAL IMMUNOLOGY AND PATHOLOGY: Edited by Agnes B. Fogo Source Type: research

Where next with for vitamin D and tuberculosis?
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 1, 2020 Category: Respiratory Medicine Authors: Dedicoat, M. Tags: EDITORIALS Source Type: research

Vitamin D status and latent tuberculosis infection: conversion in nursing homes, Spain
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 1, 2020 Category: Respiratory Medicine Authors: Arnedo-Pena, A. Juan-Cerd án, J. V. Romeu-Garcia, M. Sorribes-Segura, S. Tirado-Balaguer, M. Gil-Fortu ño, M. Garcia-Ferrer, D. Sabater-Vidal, S. Iborra-Millet, J. Vizcaino-Batll és, A. Meseguer-Ferrer, N. Vivas-Fornas, I. Moreno-Mu ñoz, R. Bellido-Bl Tags: ORIGINAL ARTICLES Source Type: research

Food allergy prevention: current evidence
Purpose of review The aim of the article is to critically appraise the most relevant studies in the rapidly advancing field of food allergy prevention. Recent findings Epidemiologic studies identified atopic dermatitis as a strong risk factor for food allergy, with mounting evidence for impaired skin barrier and cutaneous inflammation in the pathogenesis. Additional risk factors include a family history of atopy, the timing of allergenic food introduction into the infant's diet, dietary diversity, vitamin D, and environmental factors, such as dog ownership. Early introduction of allergenic foods (such as peanut) into ...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - April 1, 2020 Category: Nutrition Tags: PAEDIATRICS: Edited by Berthold Koletzko and Raanan Shamir Source Type: research

Is serum vitamin B12 decrease a necessity for the diagnosis of subacute combined degeneration?: A meta-analysis
Conclusion: Decreased level of serum vitamin B12 may not be a necessity for the diagnosis of SCD. Approximately one third of the SCD patients have normal or elevated serum vitamin B12 level. No differences were found in clinical severity between patients with normal or elevated serum vitamin B12 level and those with low level of serum vitamin B12 on admission. (Source: Medicine)
Source: Medicine - April 1, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

GSE138376 Expression data from HepG2 cells transfected with the Vitamin D Receptor (VDR) and activated by Vitamin D (calcitriol)
Contributor : Ramiro JoverSeries Type : Expression profiling by arrayOrganism : Homo sapiensIn the present study, we aimed to define the role of VDR in the overall lipid metabolism by transcriptomic and metabolomic analyses of human hepatocytes upon VDR activation by vitamin D (VitD)In this dataset we include the expression data obtained from HepG2 cells transfected with an insertless adenoviral vector or with an adenovirus encoding human VDR. Cells expressing VDR were treated with VitD or vehicle. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 1, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Bone Metabolism Impairment in Heart Transplant: Results From a Prospective Cohort Study
Background. Data on the prevention of fractures after heart transplant (HTx) are controversial in the literature. Understanding the effects of HTx on bone may guide appropriate treatments in this high-risk population. Methods. Seventy adult HTx patients were followed for 12 months. Clinical and laboratory parameters, bone mineral density, microarchitecture, and vertebral fractures were assessed at baseline (after intensive care unit discharge) and at 6 and 12 months. Patients received recommendations regarding calcium intake and vitamin D supplementation after HTx. Results. At baseline, 27% of patients had osteopor...
Source: Transplantation - April 1, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Towards new nanoporous biomaterials: self-assembly of sulfopillar[5]arenes with vitamin D3 into supramolecular polymers
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00411A, PaperDmitriy Shurpik, Yulia Aleksandrova, Pavel Zelenikhin, Evgenia Subakaeva, Peter Cragg, Ivan Stoikov Novel water-soluble, deca-substituted pillar[5]arenes containing thiosulfate and thiacarboxylate fragments were synthesized and characterized. UV-vis, 2D 1H-1H NOESY and DOSY NMR spectroscopy revealed the ability of pillar[5]arenes containing thiasulfate fragments to... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic and Biomolecular Chemistry)
Source: RSC - Organic and Biomolecular Chemistry - April 1, 2020 Category: Molecular Biology Authors: Dmitriy Shurpik Source Type: research

Status and influential factors of vitamin D among children aged 0 to 6 years in a Chinese population
This study aimed to survey vitamin D concentrations... (Source: BMC Public Health)
Source: BMC Public Health - April 1, 2020 Category: Consumer Health News Authors: Heng Zhang, Zhijuan Li, Yarong Wei, Jinyan Fu, Yaling Feng, Daozhen Chen and Dexiang Xu Tags: Research article Source Type: research

Vitamin B12 is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation
Bacterial meningitis (BM) causes apoptotic damage to the hippocampus and homocysteine (Hcy) accumulation to neurotoxic levels in the cerebrospinal fluid of children. The Hcy pathway controls bioavailability of... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 1, 2020 Category: Neurology Authors: Karina Barbosa de Queiroz, Vanessa Cavalcante-Silva, Fl ávia Lombardi Lopes, Gifone Aguiar Rocha, Vânia D’Almeida and Roney Santos Coimbra Tags: Research Source Type: research

Apixaban in Chronic Mechanical Circulatory Support in Patients Non-Compliant to Vitamin-K Based Anticoagulation
Non-Compliance has been defined as an independent late risk factor for patients with chronic Mechanic Circulatory Support. Times in therapeutic range (TTR) above 70% in Vitamin K based anticoagulation (VKA) are only achieved with INR self-management and additional telephone surveillance requiring tremendous logistics and compliance.We investigated an alternative anticoagulation regime with Apixaban and Multiplate controlled platelet inhibition therapy in this sensitive cohort. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: S. Schulte-Eistrup, N. Mayer-Wingert, T. Schmidt, H. Warnecke Tags: (95) Source Type: research

Effect of vitamin D supplementation on TSH levels in euthyroid subjects with autoimmune thyroiditis
AbstractPurposeThe impact of vitamin D supplementation on thyroid function is not clear and the relationship between hypovitaminosis D and autoimmune thyroiditis (ATD) incidence and evolution is still a matter of debate. The aim of this study was to retrospectively evaluate the impact of vitamin D supplementation on thyroid function in subjects with and without ATD.MethodsOne hundred and ninety-eight euthyroid subjects, with diagnosis of “hypovitaminosis D” (
Source: Endocrine - April 1, 2020 Category: Endocrinology Source Type: research

Vitamin C in Human Health and Disease: Effects, Mechanisms of Action, and New Guidance on Intake
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - April 1, 2020 Category: Nuclear Medicine Authors: Edmund Kim, E. Tags: Book Reviews Source Type: research

Reply to Letter to Editor: Yes, vitamin D can be a magic bullet.
(Source: Clinical Nutrition)
Source: Clinical Nutrition - April 1, 2020 Category: Nutrition Authors: P.L.M. Reijven, P.B. Soeters Tags: Letter to the Editor Source Type: research

Constitutive melanin density is associated with prevalent and short-term, but not long-term, incident fracture risk in older Caucasian adults
ConclusionsConstitutive melanin density was associated with prevalent and short-term, but not long-term, incident fracture risk in older Caucasian adults. This suggests melanin density either acts as a surrogate marker for an unmeasured fracture risk factor or the relationship between melanin density and fracture changes with time. (Source: Osteoporosis International)
Source: Osteoporosis International - April 1, 2020 Category: Orthopaedics Source Type: research

[Research Articles] Control of brain tumor growth by reactivating myeloid cells with niacin
Glioblastomas are generally incurable partly because monocytes, macrophages, and microglia in afflicted patients do not function in an antitumor capacity. Medications that reactivate these macrophages/microglia, as well as circulating monocytes that become macrophages, could thus be useful to treat glioblastoma. We have discovered that niacin (vitamin B3) is a potential stimulator of these inefficient myeloid cells. Niacin-exposed monocytes attenuated the growth of brain tumor–initiating cells (BTICs) derived from glioblastoma patients by producing anti-proliferative interferon-α14. Niacin treatment of mice bea...
Source: Science Translational Medicine - April 1, 2020 Category: Biomedical Science Authors: Sarkar, S., Yang, R., Mirzaei, R., Rawji, K., Poon, C., Mishra, M. K., Zemp, F. J., Bose, P., Kelly, J., Dunn, J. F., Yong, V. W. Tags: Research Articles Source Type: research

Vitamin D attenuates endothelial dysfunction in streptozotocin induced diabetic rats by reducing oxidative stress
. (Source: Archives of Physiology and Biochemistry)
Source: Archives of Physiology and Biochemistry - April 1, 2020 Category: Physiology Authors: Mona A. Said Source Type: research

"Efficacy and safety of Liangxue Jiedu decoction for the treatment of progressive psoriasis vulgaris: a multicenter, randomized, controlled study".
"Efficacy and safety of Liangxue Jiedu decoction for the treatment of progressive psoriasis vulgaris: a multicenter, randomized, controlled study". J Tradit Chin Med. 2020 Apr;40(2):296-304 Authors: Sun L, Zhou D, Wang P, Li T, Xu X, Yang X, Tian J, Zhao J, He Y, Liu F, Tong C, Chu X, Dai L, Zhu W Abstract OBJECTIVE: To determine the clinical efficacy and safety of Liangxue Jiedu decoction (LJD) for the treatment of progressive psoriasis vulgaris and to provide the basis for the development of a standardized treatment protocol for psoriasis vulgaris. METHODS: In this multicenter, random...
Source: Journal of Traditional Chinese Medicine - April 1, 2020 Category: Complementary Medicine Authors: Sun L, Zhou D, Wang P, Li T, Xu X, Yang X, Tian J, Zhao J, He Y, Liu F, Tong C, Chu X, Dai L, Zhu W Tags: J Tradit Chin Med Source Type: research