Vitamin E succinate with multiple functions: A versatile agent in nanomedicine-based cancer therapy and its delivery strategies
Publication date: Available online 4 March 2021Source: International Journal of PharmaceuticsAuthor(s): Lina Liang, Liyan Qiu (Source: International Journal of Pharmaceutics)
Source: International Journal of Pharmaceutics - March 5, 2021 Category: Drugs & Pharmacology Source Type: research

DSM prevails in vitamin patent case against China's Anhui Tiger
Dutch firm wins enforcement of its intellectual property for stereoselective synthesis of biotin (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - March 5, 2021 Category: Chemistry Source Type: research

Association between vitamin D deficiency and exercise capacity in patients with CKD, a cross-sectional analysis
Publication date: Available online 3 March 2021Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Emma L. Watson, Thomas J. Wilkinson, Tom F. O’Sullivan, Luke A. Baker, Douglas W. Gould, Soteris Xenophontos, Matt Graham-Brown, Rupert Major, Carl Jenkinson, Martin Hewison, Andrew Philp, Alice C. Smith (Source: The Journal of Steroid Biochemistry and Molecular Biology)
Source: The Journal of Steroid Biochemistry and Molecular Biology - March 4, 2021 Category: Biochemistry Source Type: research

Influences of dietary vitamin D3 on growth, antioxidant capacity, immunity and molting of Chinese mitten crab (Eriocheir sinensis) larvae
Publication date: Available online 3 March 2021Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Shubin Liu, Xiaodan Wang, Xianyong Bu, Cong Zhang, Fang Qiao, Chuanjie Qin, Erchao Li, Jian G. Qin, Liqiao Chen (Source: The Journal of Steroid Biochemistry and Molecular Biology)
Source: The Journal of Steroid Biochemistry and Molecular Biology - March 4, 2021 Category: Biochemistry Source Type: research

Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density in Zucker Diabetic Fatty Rats: A Short-Term Comparative Study
Conclusions: Despite its excellent ability to provide short-term glycemic control, the RYGB procedure could led to more severe impairment of bone health compared to the SG procedure. Bone health should be procured after bariatric surgery, especially with the RYGB procedure. Early detection of BMD and BTM may help to avoid deterioration of bone.Obes Facts (Source: Obesity Facts)
Source: Obesity Facts - March 4, 2021 Category: Eating Disorders & Weight Management Source Type: research

Association between serum 25-hydroxy vitamin D level and metabolic associated fatty liver disease (MAFLD)- ‍a ‍population-based study
Conclusion, lower serum 25(OH)D level is associated with higher prevalence of MAFLD in general population. No relationship was found between serum 25(OH)D level and the severity of hepatic steatosis or fibrosis in MAFLD.PMID:33658438 | DOI:10.1507/endocrj.EJ20-0758 (Source: Endocrine Journal)
Source: Endocrine Journal - March 4, 2021 Category: Endocrinology Authors: Bo Wan Yuan Gao Yushan Zheng Ruanqin Chen Source Type: research

The Confounding Story of Vitamin D
Skinmed. 2021 Feb 1;19(1):49-50. eCollection 2021.NO ABSTRACTPMID:33658113 (Source: Skinmed)
Source: Skinmed - March 4, 2021 Category: Dermatology Authors: Howard Epstein Source Type: research

36-month follow-up of a pure sensory mononeuritis multiplex and IgG1 deficiency improved after treatment with sitagliptin and Vitamin D3
Eur Rev Med Pharmacol Sci. 2021 Feb;25(4):1768-1769. doi: 10.26355/eurrev_202102_25064.NO ABSTRACTPMID:33660837 | DOI:10.26355/eurrev_202102_25064 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 4, 2021 Category: Drugs & Pharmacology Authors: M Maia Pinheiro F M Maia Pinheiro L L P Amaral Resende S N Diniz A Fabbri M Infante Source Type: research

The interplay between vitamin D and COVID-19: protective or bystander?
We describe in this article that individuals at high risk of vitamin D deficiency should consider taking vitamin D supplements to keep optimal concentrations. Moreover, we discuss different possible mechanisms by which vitamin D can efficiently reduce the risk of infections through modulation of innate and adaptive immunity against various types of infections. It is advisable to perform further studies addressing the observed influence of vitamin D levels to reduce the risk of COVID-19 infection and mortality.PMID:33660833 | DOI:10.26355/eurrev_202102_25119 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 4, 2021 Category: Drugs & Pharmacology Authors: H F Hetta K Muhammad E A El-Masry A E Taha E A Ahmed C Phares H A Kader Y Waheed A M Zahran R Yahia A Kh Meshaal G El-Saber Batiha Source Type: research

The relationship between vitamin D levels and cognitive impairment in patients with multiple sclerosis
The objective of this study is to investigate the relationship between vitamin D levels and cognitive function in patients with MS as assessed by the Cambridge Neuropsychological Test Automated Battery (CANTAB).PATIENTS AND METHODS: This was a cross-sectional, case-control study; the subjects were 39 Saudi patients diagnosed with MS. For all participants, demographic information, including age, sex, and educational level, was collected. Participants were also evaluated using the disease steps scale and the PHQ-9 scale. Their vitamin D levels were assessed, and the participants completed a computerized cognitive assessment ...
Source: European Review for Medical and Pharmacological Sciences - March 4, 2021 Category: Drugs & Pharmacology Authors: F Alhussain M Alomar A Alenazi M Aldraihem L Alshiha S Bashir Source Type: research

Foetal 25-hydroxyvitamin D moderates the association of prenatal air pollution exposure with foetal glucolipid metabolism disorder and systemic inflammatory responses
Environ Int. 2021 Mar 1;151:106460. doi: 10.1016/j.envint.2021.106460. Online ahead of print.ABSTRACTBACKGROUND: Previous studies have indicated that systemic inflammation may play an important role in the association between air pollution exposure and glucolipid metabolism disorders, and vitamin D supplementation was beneficial in improving systemic inflammation and glucolipid metabolism. However, the role of foetal 25-hydroxyvitamin D (25(OH)D) and high-sensitivity C-reactive protein (hs-CRP) in the association between prenatal air pollution exposure and foetal glucolipid metabolism disorders is still not clear.OBJECTIVE...
Source: Environment International - March 4, 2021 Category: Environmental Health Authors: Yang Liu Lei Li Jun Xie Xuechun Jiao Honglin Hu Ying Zhang Ruixue Tao Fangbiao Tao Peng Zhu Source Type: research

Xylene delays the development of Leydig cells in pubertal rats by inducing reactive oxidative species
In conclusion, xylene exposure may disrupt the development of pubertal Leydig cells by increasing reactive oxygen species production and reducing the expression of GSK-3β, ERK1/2, AKT1, and SIRT1.PMID:33662507 | DOI:10.1016/j.tox.2021.152740 (Source: Toxicology)
Source: Toxicology - March 4, 2021 Category: Toxicology Authors: Qiqi Zhu Songyi Zhou Zina Wen Huitao Li Bingwu Huang Yier Chen Xiaoheng Li Han Lin Yiyan Wang Ren-Shan Ge Source Type: research

GSE158215 Very low protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice
Contributors : Y Wu ; B Li ; L Li ; S E Mitchell ; C L Green ; G D'Agostino ; G Wang ; L Wang ; M Li ; J Li ; C Niu ; Z Jin ; A Wang ; A Douglas ; Y Zheng ; J R SpeakmanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusPurpose: To investigate graded levels of low protien dites effects on hypothalamic gene expression pattern, RNA-seq was performed on hypothalamus of mice treated with different levels of low protein and normal protein under both 60% fat and 20% fat conditions. Methods: There were 8 diets in total, the fat content of first 4 diets were fixed at 60% fat level by energy and ...
Source: GEO: Gene Expression Omnibus - March 4, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Effects of soaking seeds in exogenous vitamins on active oxygen metabolism and seedling growth under low-temperature stress
Publication date: Available online 2 March 2021Source: Saudi Journal of Biological SciencesAuthor(s): Yu Xin Chi, Li Yang, Chang Jiang Zhao, Ihsan Muhammad, Xun Bo Zhou (Source: Saudi Journal of Biological Sciences)
Source: Saudi Journal of Biological Sciences - March 4, 2021 Category: Biology Source Type: research

Management of warfarin-associated intracerebral hemorrhage before and after implementation of an order set and prospective pharmacist order verification
AbstractManagement of warfarin-associated intracerebral hemorrhage (ICH) necessitates rapid reversal of anticoagulation. Guideline-based management of warfarin-associated ICH includes timely administration of prothrombin complex concentrate (PCC) and intravenous (IV) vitamin K. In 2017, our hospital implemented an order set for warfarin reversal to facilitate computerized provider order entry (CPOE), and the pharmacy department began prospective verification and dispensing of all PCC orders for anticoagulant reversal. We sought to compare the proportion of patients who received timely, guideline-based therapy for warfarin-...
Source: Journal of Thrombosis and Thrombolysis - March 4, 2021 Category: Hematology Source Type: research

Bone resorption and dietary calcium in pregnancy —a window to future maternal bone health
AbstractBackgroundPregnancy is characterized by increased bone turnover and reversible loss of bone mineral density (BMD) to meet fetal calcium demands. The long-term effect of bone turnover and maternal diet in pregnancy on maternal bone is not well established.ObjectiveWe aimed to determine if an association exists between [1] bone resorption, [2] dietary calcium, and [3] serum 25-hydroxyvitamin D in pregnancy with maternal BMD 5-year postpartum.DesignThis is a prospective, longitudinal study of 107 women recruited to the ROLO low glycemic index dietary intervention trial in pregnancy and followed-up at 13, 28, and 34 &n...
Source: Osteoporosis International - March 4, 2021 Category: Orthopaedics Source Type: research

Associations between maternal vitamin D status during three trimesters and cord blood 25(OH)D concentrations in newborns: a prospective Shanghai birth cohort study
AbstractPurposePrenatal vitamin D (VitD) deficiency influences children ’s health in later life. We aimed to test the associations between maternal VitD status in each of the three trimesters of pregnancy and cord blood 25(OH)D concentrations in newborns.MethodsParticipants were pregnant women recruited from the Shanghai Birth Cohort (SBC) (n = 1100). Of all the participants, 946 completed the collection of venous blood at early (
Source: European Journal of Nutrition - March 4, 2021 Category: Nutrition Source Type: research

Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women: a randomized controlled trial
European Journal of Clinical Nutrition, Published online: 04 March 2021; doi:10.1038/s41430-021-00884-8Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women: a randomized controlled trial (Source: European Journal of Clinical Nutrition)
Source: European Journal of Clinical Nutrition - March 4, 2021 Category: Nutrition Authors: Sofie Hertz R ønn Torben Harsl øf Steen B ønløkke Pedersen Bente Lomholt Langdahl Source Type: research

Elevated β-Carotene Production Using Codon-Adapted CarRA & B and Metabolic Balance in Engineered Yarrowia lipolytica
This study focused on improving β-carotene production by constructing codon-adapted genes and minimizing intermediate accumulation. The codon-adapted CarRA and CarB genes from the industrial strain of Blakeslea trispora were integrated into the genome of the Yarrowia lipolytica to construct YL-C0, the baseline strain for producing β-carotene. Thereafter, the β-carotene biosynthetic pathway’s metabolic balance was accurately regulated to reduce the intermediates’ accumulation. Notably, the β-carotene content increased by 21 times to reach 12.5 dry cell weight (DCW) mg/g when minimizing HMG-Co...
Source: Frontiers in Microbiology - March 4, 2021 Category: Microbiology Source Type: research

Vitamin D 3 Supplementation Alleviates Left Ventricular Dysfunction in a Mouse Model of Diet-Induced Type 2 Diabetes: Potential Involvement of Cardiac Lipotoxicity Modulation
ConclusionThis work brought to light the beneficial effects of cholecalciferol supplementation, in secondary prevention, on cardiac remodeling and function in a mouse model of diet-induced type 2 diabetes. Those cardioprotective effects may be, at least in part, attributed to the modulation of myocardial levels of lipotoxic species by vitamin D. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - March 4, 2021 Category: Cardiology Source Type: research

Monitoring of cardiac biomarkers and vitamin D concentration in response to calcium infusion in Darehshori horses
AbstractCalcium is an essential mineral and plays a direct role on cardiac muscle activities when given intravenously. The aim of the present study was to determine the effects of calcium infusion on serum cardiac biomarkers and vitamin D concentration in Darehshori horses. Calcium infusion was made once a week, and blood samples were taken before and 1 h after to determine serum cardiac troponin I, creatine kinase myocardial band (CK-MB), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), calcium, and vitamin D changes up to four consecutive weeks. Increases in blood calcium along with suppression of serum vitamin D...
Source: Comparative Clinical Pathology - March 4, 2021 Category: Pathology Source Type: research

International citizen project to assess early stage adherence to public health measures for COVID-19 in South Africa
ConclusionDespite high reported adherence, face mask use and symptomatic individuals not self-isolating, were areas for improvement. However, these factors cannot solely account for SA ’s increasing COVID-19 cases. Larger general population studies are needed to identify other adherence predictors for a strengthened SA COVID-19 response. While the government must continue to educate the entire population on preventative measures, provide personal protective equipment and stress the importance of adherence, there also needs to be implementation of prioritised prevention strategies for men and single individuals to add...
Source: PLoS One - March 4, 2021 Category: Biomedical Science Authors: Mohammed Majam Source Type: research

Low maternal vitamin A intake increases the incidence of teratogen induced congenital diaphragmatic hernia in mice
CONCLUSION: Low dietary vitamin A intake and marginal vitamin A status lead to an increased incidence of teratogen-induced CDH in mice, highlighting the importance of adequate dietary vitamin A intake and CDH risk.IMPACT: This study describes and validates a mouse model of altered maternal and fetal vitamin A status. This study links existing epidemiological data with a mouse model of teratogen-induced congenital diaphragmatic hernia, highlighting the importance of low maternal vitamin A intake as a risk factor for the development of congenital diaphragmatic hernia. This study supports the Retinoid Hypothesis, which posits...
Source: Pediatric Research - March 3, 2021 Category: Pediatrics Authors: Ayanna W Rocke Tianna G Clarke Timothy R A Dalmer Sydney A McCluskey Juan F Garcia Rivas Robin D Clugston Source Type: research

Vitamin D Supplementation: A Treatment With Possible Benefits in Asthma
Arch Bronconeumol. 2021 Jan 28:S0300-2896(21)00027-2. doi: 10.1016/j.arbres.2021.01.006. Online ahead of print.NO ABSTRACTPMID:33653580 | DOI:10.1016/j.arbres.2021.01.006 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - March 3, 2021 Category: Respiratory Medicine Authors: Rub én Andújar-Espinosa Lourdes Salinero-Gonz ález Source Type: research

ATP binding cassette importers in eukaryotic organisms
Biol Rev Camb Philos Soc. 2021 Mar 2. doi: 10.1111/brv.12702. Online ahead of print.ABSTRACTATP-binding cassette (ABC) transporters are ubiquitous across all realms of life. Dogma suggests that bacterial ABC transporters include both importers and exporters, whilst eukaryotic members of this family are solely exporters, implying that ABC import function was lost during evolution. This view is being challenged, for example energy-coupling factor (ECF)-type ABC importers appear to fulfil important roles in both algae and plants where they form the ABCI sub-family. Herein we discuss whether bacterial Type I and Type II ABC im...
Source: Biological Reviews of the Cambridge Philosophical Society - March 3, 2021 Category: Biology Authors: Cheri C Choi Robert C Ford Source Type: research

MicroRNA-122 promotes apoptosis of keratinocytes in oral lichen planus through suppressing VDR expression
J Cell Mol Med. 2021 Mar 3. doi: 10.1111/jcmm.16418. Online ahead of print.ABSTRACTMicroRNA-122 (miR-122) is known to be up-regulated by inflammation to exert a variety of biological functions in hepatocellular carcinoma (HCC)-derived human cell lines. Vitamin D receptor (VDR) is reported to regulate excessive oral keratinocytes apoptosis which compromises oral epithelial barrier in oral lichen planus (OLP). Although many studies have suggested that miR-122 is capable of regulating cell apoptosis, its effects on the development of OLP and VDR expression are still unclear. Herein, we demonstrate that miR-122 expression is i...
Source: J Cell Mol Med - March 3, 2021 Category: Molecular Biology Authors: Xuejun Ge Hanting Xie Lu Wang Ran Li Fang Zhang Jing Xu Bin Zhao Jie Du Source Type: research

All-Trans Retinoic Acid Potentiates Antitumor Efficacy of Cisplatin by Increasing Differentiation of Cancer Stem-Like Cells in Cervical Cancer
The objective of this study was to investigate the antitumor effect of ATRA with or without cisplatin and elucidate its potential mechanisms in cervical cancer cells.METHODS: Cell viability was determined by CCK-8 assay. Cell cycle and cell apoptosis were analyzed by flow cytometry. Caspase-3, cleaved caspase-3 and cell cycle-related proteins were detected by western blotting. Scratch wound-healing assay was performed to evaluate cell migration ability. The expression of CD44, a biomarker of cervical cancer stem-like cells, was determined by flow cytometry and western blotting. In addition, the activity of the Wnt signalin...
Source: Annals of Clinical and Laboratory Science - March 3, 2021 Category: Laboratory Medicine Authors: Wen-Jie Fan Hao Ding Xiang-Xun Chen Lin Yang Source Type: research

Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
CONCLUSIONS: Current studies on vitamin D used for purposes other than bone health promotion cannot be taken as support to justify its use in a disease as recent as COVID-19. Studies of greater robustness, with higher levels of clinical evidence, need to be conducted. Rational use of this vitamin needs to be ensured, thereby minimizing the impacts on the patient and the public healthcare system.PMID:33656132 | DOI:10.1590/1516-3180.2020.0532.02112020 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - March 3, 2021 Category: General Medicine Authors: Stephanye Carolyne Christino Chagas Francisca Sueli Monte Moreira Irla Carla Fran ça Barbosa Osvaldo de Sousa Leal J únior Leila Bastos Leal Davi Pereira de Santana Source Type: research

Low maternal vitamin A intake increases the incidence of teratogen induced congenital diaphragmatic hernia in mice
CONCLUSION: Low dietary vitamin A intake and marginal vitamin A status lead to an increased incidence of teratogen-induced CDH in mice, highlighting the importance of adequate dietary vitamin A intake and CDH risk.IMPACT: This study describes and validates a mouse model of altered maternal and fetal vitamin A status. This study links existing epidemiological data with a mouse model of teratogen-induced congenital diaphragmatic hernia, highlighting the importance of low maternal vitamin A intake as a risk factor for the development of congenital diaphragmatic hernia. This study supports the Retinoid Hypothesis, which posits...
Source: Pediatric Research - March 3, 2021 Category: Pediatrics Authors: Ayanna W Rocke Tianna G Clarke Timothy R A Dalmer Sydney A McCluskey Juan F Garcia Rivas Robin D Clugston Source Type: research

Vitamin D Supplementation: A Treatment With Possible Benefits in Asthma
Arch Bronconeumol. 2021 Jan 28:S0300-2896(21)00027-2. doi: 10.1016/j.arbres.2021.01.006. Online ahead of print.NO ABSTRACTPMID:33653580 | DOI:10.1016/j.arbres.2021.01.006 (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - March 3, 2021 Category: Respiratory Medicine Authors: Rub én Andújar-Espinosa Lourdes Salinero-Gonz ález Source Type: research

ATP binding cassette importers in eukaryotic organisms
Biol Rev Camb Philos Soc. 2021 Mar 2. doi: 10.1111/brv.12702. Online ahead of print.ABSTRACTATP-binding cassette (ABC) transporters are ubiquitous across all realms of life. Dogma suggests that bacterial ABC transporters include both importers and exporters, whilst eukaryotic members of this family are solely exporters, implying that ABC import function was lost during evolution. This view is being challenged, for example energy-coupling factor (ECF)-type ABC importers appear to fulfil important roles in both algae and plants where they form the ABCI sub-family. Herein we discuss whether bacterial Type I and Type II ABC im...
Source: Biological Reviews of the Cambridge Philosophical Society - March 3, 2021 Category: Biology Authors: Cheri C Choi Robert C Ford Source Type: research

MicroRNA-122 promotes apoptosis of keratinocytes in oral lichen planus through suppressing VDR expression
J Cell Mol Med. 2021 Mar 3. doi: 10.1111/jcmm.16418. Online ahead of print.ABSTRACTMicroRNA-122 (miR-122) is known to be up-regulated by inflammation to exert a variety of biological functions in hepatocellular carcinoma (HCC)-derived human cell lines. Vitamin D receptor (VDR) is reported to regulate excessive oral keratinocytes apoptosis which compromises oral epithelial barrier in oral lichen planus (OLP). Although many studies have suggested that miR-122 is capable of regulating cell apoptosis, its effects on the development of OLP and VDR expression are still unclear. Herein, we demonstrate that miR-122 expression is i...
Source: J Cell Mol Med - March 3, 2021 Category: Molecular Biology Authors: Xuejun Ge Hanting Xie Lu Wang Ran Li Fang Zhang Jing Xu Bin Zhao Jie Du Source Type: research

Feasibility of supramolecular nanosized solvent based microsyringe-assisted liquid-phase microextraction for preconcentration and separation of Vitamin B12 from infant formula, food supplement, and dairy products: Spectrophotometric analysis and chemometric optimization
Publication date: June 2021Source: Microchemical Journal, Volume 165Author(s): Nail Altunay, Adil Elik, Didem Aydın (Source: Microchemical Journal)
Source: Microchemical Journal - March 3, 2021 Category: Chemistry Source Type: research

Prevention of food allergy: can we stop the rise of IgE mediated food allergies?
Purpose of review Food allergy has become more prevalent in recent decades. Without a curative treatment for food allergy, prevention is key. Can we intervene and halt the food allergy epidemic? Recent findings There are three main hypotheses to explain the rise in food allergy: the dual-allergen exposure hypothesis, the hygiene hypothesis and the vitamin D hypothesis. In a recent systematic review of randomized controlled trials, only introduction of allergenic foods, namely egg and peanut, in the diet at the time of weaning and avoidance of temporary supplementation with cow's milk formula in the first few day...
Source: Current Opinion in Allergy and Clinical Immunology - March 3, 2021 Category: Allergy & Immunology Tags: GENETICS AND EPIDEMIOLOGY: Edited by Isabella Annesi-Maesano and Antonella Cianferoni Source Type: research

The genetic background and vitamin D supplementation can affect irisin levels in Prader –Willi syndrome
ConclusionWe demonstrated the possible role of genetic background and vitamin-D supplementation on irisin serum levels in PWS patients. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 3, 2021 Category: Endocrinology Source Type: research

The effect of vitamin C on procalcitonin biomarker in community ‐acquired pneumonia
Community acquired pneumonia (CAP) is a prevalent low respiratory infection. Diagnosis is based on clinical symptoms, radiologic evidence and culture. Biomarkers such as IL6, CRP and procalcitonin are helpful ... (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - March 3, 2021 Category: Allergy & Immunology Authors: Mahsa Nikzad, Hamid Reza Banafshe, Mansooreh Momen-Heravi, Hamed Haddad Kashani and Maryam Shiehmorteza Tags: Research Source Type: research

Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients
Several immune mechanisms activate in COVID-19 pathogenesis. Usually, coronavirus infection is characterized by dysregulated host immune responses, interleukine-6 increase, hyper-activation of cytotoxic CD8 T ... (Source: Respiratory Research)
Source: Respiratory Research - March 3, 2021 Category: Respiratory Medicine Authors: Alberto Ricci, Alessandra Pagliuca, Michela D ’Ascanio, Marta Innammorato, Claudia De Vitis, Rita Mancini, Simonetta Giovagnoli, Francesco Facchiano, Bruno Sposato, Paolo Anibaldi, Adriano Marcolongo, Chiara De Dominicis, Andrea Laghi, Emanuele Muscogiu Tags: Research Source Type: research

Vitamin B12 Deficiency and West Syndrome: An Uncommon but Preventable Cause of Neurological Disorder. Report on Three Cases, One of Them with Late Onset during Vitamin B12 Treatment
Neuropediatrics DOI: 10.1055/s-0041-1725013Vitamin B12 is a water-soluble vitamin that plays a fundamental role as an essential cofactor for two enzymes responsible for the production of succinyl-CoA and methionine. Vitamin B12 deficiency can occur in infants and may be related to the breastfeeding mother's adherence to a vegan diet or somatic diseases in the mother. It should be differentiated from inborn errors of vitamin B12 metabolism. Herein, we report the cases of three infants with West syndrome; all three were breastfed by mothers who followed a strict vegan diet. In one of the three infants, West syndrome develope...
Source: Neuropediatrics - March 3, 2021 Category: Neurology Authors: Pavone, Piero Sullo, Federica Falsaperla, Raffaele Greco, Filippo Crespo, Agustina Calvo, Agustin Caraballo, Roberto Tags: Short Communication Source Type: research

Evaluation of Vitamin D Storage in Patients with Chronic Kidney Disease: Detection of Serum Vitamin D Metabolites Using High Performance Liquid Chromatography-tandem Mass Spectrometry
Publication date: Available online 1 March 2021Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Yuan-meng Li, Qian Feng, Wen-qiang Jiang, Bi-tao Wu, Jia-fu Feng (Source: The Journal of Steroid Biochemistry and Molecular Biology)
Source: The Journal of Steroid Biochemistry and Molecular Biology - March 2, 2021 Category: Biochemistry Source Type: research

The Parkinson & rsquo;s Disease Death Rate: Carbidopa and Vitamin B6 [Retraction]
(Source: International Journal of COPD)
Source: International Journal of COPD - March 2, 2021 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research

Vitamin C in severe preeclampsia: a promising therapeutic option against peripartum pulmonary oedema?
Publication date: February 2021Source: Anaesthesia Critical Care & Pain Medicine, Volume 40, Issue 1Author(s): Marie-Pierre Bonnet, Nouhad Ayoub, Agnès Le Gouez, Frédéric J. Mercier (Source: Anaesthesia, Critical Care and Pain Medicine)
Source: Anaesthesia, Critical Care and Pain Medicine - March 2, 2021 Category: Anesthesiology Source Type: research

Targeting multiple enzymes in vitamin K metabolism for anticoagulation
J Thromb Haemost. 2021 Mar;19(3):633-636. doi: 10.1111/jth.15212.NO ABSTRACTPMID:33650246 | DOI:10.1111/jth.15212 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 2, 2021 Category: Hematology Authors: Weikai Li Source Type: research

Helicobacter pylori: When to look for an infection and treat it in adults?
Rev Med Interne. 2021 Feb 26:S0248-8663(20)30792-X. doi: 10.1016/j.revmed.2020.11.012. Online ahead of print.ABSTRACTHelicobacter pylori infection is acquired during childhood mainly within the family. It causes active chronic gastritis associated with the development of many digestive and extra digestive diseases. Its expression results from interactions between the bacteria, the host and environmental factors modulating the evolution of gastritis and acid secretion. The French recommendations for research and treatment for curative or preventive purposes were updated in 2017. These are indications with a high level of ev...
Source: Revue de Medecine Interne - March 2, 2021 Category: Internal Medicine Authors: J-D de Korwin Source Type: research

SpoT-mediated NapA upregulation promotes oxidative stress-induced < em > Helicobacter pylori < /em > biofilm formation and confers multidrug resistance
This study hypothesized that ROS can promote H. pylori biofilm formation and treatment with low concentrations of hydrogen peroxide (H2O2) promoted this process in vitro The comparative transcriptome analysis of planktonic and biofilm-forming cells revealed that the expression of SpoT, a (p)ppGpp (guanosine 3'-diphosphate 5'-triphosphate and guanosine 3',5'-bispyrophosphate) synthetase/hydrolase, is upregulated in H2O2-induced biofilms and that knockout of spoT inhibited H. pylori biofilm formation. Additionally, this study examined the key target molecules involved in SpoT regulation using weighted gene co-expression netw...
Source: Antimicrobial Agents and Chemotherapy - March 2, 2021 Category: Microbiology Authors: Yican Zhao Yuying Cai Zhenghong Chen Huanjie Li Zhengzheng Xu Wenjuan Li Jihui Jia Yundong Sun Source Type: research

Targeting multiple enzymes in vitamin K metabolism for anticoagulation
J Thromb Haemost. 2021 Mar;19(3):633-636. doi: 10.1111/jth.15212.NO ABSTRACTPMID:33650246 | DOI:10.1111/jth.15212 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 2, 2021 Category: Hematology Authors: Weikai Li Source Type: research

Helicobacter pylori: When to look for an infection and treat it in adults?
Rev Med Interne. 2021 Feb 26:S0248-8663(20)30792-X. doi: 10.1016/j.revmed.2020.11.012. Online ahead of print.ABSTRACTHelicobacter pylori infection is acquired during childhood mainly within the family. It causes active chronic gastritis associated with the development of many digestive and extra digestive diseases. Its expression results from interactions between the bacteria, the host and environmental factors modulating the evolution of gastritis and acid secretion. The French recommendations for research and treatment for curative or preventive purposes were updated in 2017. These are indications with a high level of ev...
Source: Revue de Medecine Interne - March 2, 2021 Category: Internal Medicine Authors: J-D de Korwin Source Type: research

SpoT-mediated NapA upregulation promotes oxidative stress-induced < em > Helicobacter pylori < /em > biofilm formation and confers multidrug resistance
This study hypothesized that ROS can promote H. pylori biofilm formation and treatment with low concentrations of hydrogen peroxide (H2O2) promoted this process in vitro The comparative transcriptome analysis of planktonic and biofilm-forming cells revealed that the expression of SpoT, a (p)ppGpp (guanosine 3'-diphosphate 5'-triphosphate and guanosine 3',5'-bispyrophosphate) synthetase/hydrolase, is upregulated in H2O2-induced biofilms and that knockout of spoT inhibited H. pylori biofilm formation. Additionally, this study examined the key target molecules involved in SpoT regulation using weighted gene co-expression netw...
Source: Antimicrobial Agents and Chemotherapy - March 2, 2021 Category: Microbiology Authors: Yican Zhao Yuying Cai Zhenghong Chen Huanjie Li Zhengzheng Xu Wenjuan Li Jihui Jia Yundong Sun Source Type: research

Postoperative Hypokalz ämie – die häufigste Komplikation der endokrinen Chirurgie der Halsregion: Akutes Management
Laryngorhinootologie DOI: 10.1055/a-1381-8286 Hintergrund In Deutschland sind jährlich ca. 8000 Patienten nach Eingriffen an Schilddrüse, Nebenschilddrüse und Larynx von einem behandlungsbedürftigen postoperativen Hypoparathyreoidismus betroffen. Die Patienten leiden im Akutstadium der Hypokalzämie an Parästhesien und nicht selten auch über viele Jahre hinweg unter der Angst vor einem erneuten körperlichen Kontrollverlust bei schweren postoperativen Tetanien. Fragestellung/Ziel Ziel dieser Arbeit ist es, für die Wichtigkeit des Managements des postoperativen Hypo...
Source: Laryngo- Rhino- Otologie - March 2, 2021 Category: ENT & OMF Authors: Lammert, Anne Nowak, Kai Weber, Roland Rotter, Nicole Sch ölch, Sebastian Kr ämer, Bernhard K. Lammert, Alexander Tags: Übersicht Source Type: research

Inappropriate low dosing of direct oral anticoagulants in older patients with non-valvular atrial fibrillation: Impact on plasma drug levels
Direct oral anticoagulants (DOACs) are increasingly prescribed in older patients with non-valvular atrial fibrillation (NVAF). They provide higher convenience than vitamin K antagonists (VKA), with an improved efficacy and a reduced risk of intracranial bleeding [1]. Dose reduction criteria are clearly established for each DOAC, depending on renal function, weight, age or concomitant medications. However, many observational studies have reported that DOACs were frequently prescribed at an off-label dose, especially in older patients [2]. (Source: Thrombosis Research)
Source: Thrombosis Research - March 2, 2021 Category: Hematology Authors: Anne-Lore Comans, Anne-Laure Sennesael, Beno ît Bihin, Maxime Regnier, François Mullier, Marie de Saint-Hubert Tags: Letter to the Editor Source Type: research

Robotic Proximal Gastrectomy with Double-Tract Reconstruction for Gastroesophageal Junction Cancer
AbstractThe current standard surgical procedure for proximal gastric and gastroesophageal junction (P/GEJ) cancers with limited esophageal involvement is total gastrectomy (TG). TG is associated with impaired appetite and weight loss due to decreased levels of ghrelin (a “hunger hormone” secreted by the stomach) and with anemia due to intrinsic factor loss and vitamin B12 malabsorption. Theoretically, proximal gastrectomy (PG) with an anti-reflux technique such as double-tract reconstruction (DTR) can improve quality of life (QoL) by preserving gastric function.1 A recent Japanese prospective GEJ adenocarcinoma...
Source: Journal of Gastrointestinal Surgery - March 2, 2021 Category: Surgery Source Type: research