Fe < sup > 3+ < /sup > -induced coordination cross-linking gallic acid-carboxymethyl cellulose self-healing hydrogel
Int J Biol Macromol. 2024 Apr 15:131626. doi: 10.1016/j.ijbiomac.2024.131626. Online ahead of print.ABSTRACTSelf-healing hydrogel is a promising soft material for applications in wound dressings, drug delivery, tissue engineering, biomimetic electronic skin, and wearable electronic devices. However, it is a challenge to fabricate the self-healing hydrogels without external stimuli. Inspired by mussel, the metal-catechol complexes were introduced into the hydrogel systems to prepare the mussel-inspired hydrogels by regulating the gelation kinetics of Fe3+ crosslinkers with gallic acid (GA) in this research. The amine-functi...
Source: International Journal of Biological Macromolecules - April 17, 2024 Category: Biochemistry Authors: Yongyan Yang Ying Ma Meiliang Wu Xueping Wang Yuan Zhao Shuangling Zhong Yan Gao Xuejun Cui Source Type: research
A prospective analysis of the efficacy of phase II autologous skin grafting on deep second ‑degree burns on the dorsum of the hand
Exp Ther Med. 2024 Mar 27;27(5):238. doi: 10.3892/etm.2024.12526. eCollection 2024 May.ABSTRACTThe aim of the present study was to investigate the possibility of reducing the damage to the donor site while preserving the functional recovery of the dorsum of the hand following burn injury. An attempt was made to analyze the effect of a phased surgery approach on inflammatory indicators. A two-phase treatment was administered on a total of 64 patients with deep second-degree burns on the dorsum of the hand who were admitted to Guangzhou Red Cross Hospital between January 2020 and March 2023. During phase I treatment, the wou...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Jing'en Sun Siman Su Songsong Jiao Gang Li Zhi Zhang Weihua Lin Shuyao Zhang Source Type: research
Reconstruction of soft tissue defects of the Achilles region: a simple algorithm through a lateral approach
ConclusionsPeroneal artery perforators are safe for the elevation of a perforator-based flap. In case of no suitable perforator, it is possible to harvest a db-PB flap through the same surgical incision. EPAP flap can be used as rescue-procedure after harvesting a propeller PAP flap. For small-to-moderate defects, a lateral approach provides a reconstructive armamentarium that ranges from the propeller perforator flaps, to those extended up to peroneal artery to the distally-based peroneus brevis muscle.Level of EvidenceLevel IV, Therapeutic Study (Source: European Journal of Plastic Surgery)
Source: European Journal of Plastic Surgery - April 17, 2024 Category: Cosmetic Surgery Source Type: research
Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10103-z. Online ahead of print.ABSTRACTThe skin's protective functions are compromised over time by both endogenous and exogenous aging. Senescence is well-documented in skin phenotypes, such as wrinkling and sagging, a consequence of the senescence-associated secretory phenotype (SASP) that involves the accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling. Although therapeutic approaches for eliminating senescent cells from the skin are available, their efficacy remains unclear. Accordingly, we aimed to examine the effects of dasatinib in...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Kento Takaya Kazuo Kishi Source Type: research
Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10103-z. Online ahead of print.ABSTRACTThe skin's protective functions are compromised over time by both endogenous and exogenous aging. Senescence is well-documented in skin phenotypes, such as wrinkling and sagging, a consequence of the senescence-associated secretory phenotype (SASP) that involves the accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling. Although therapeutic approaches for eliminating senescent cells from the skin are available, their efficacy remains unclear. Accordingly, we aimed to examine the effects of dasatinib in...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Kento Takaya Kazuo Kishi Source Type: research
Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10103-z. Online ahead of print.ABSTRACTThe skin's protective functions are compromised over time by both endogenous and exogenous aging. Senescence is well-documented in skin phenotypes, such as wrinkling and sagging, a consequence of the senescence-associated secretory phenotype (SASP) that involves the accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling. Although therapeutic approaches for eliminating senescent cells from the skin are available, their efficacy remains unclear. Accordingly, we aimed to examine the effects of dasatinib in...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Kento Takaya Kazuo Kishi Source Type: research
Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10103-z. Online ahead of print.ABSTRACTThe skin's protective functions are compromised over time by both endogenous and exogenous aging. Senescence is well-documented in skin phenotypes, such as wrinkling and sagging, a consequence of the senescence-associated secretory phenotype (SASP) that involves the accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling. Although therapeutic approaches for eliminating senescent cells from the skin are available, their efficacy remains unclear. Accordingly, we aimed to examine the effects of dasatinib in...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Kento Takaya Kazuo Kishi Source Type: research
Combined dasatinib and quercetin treatment contributes to skin rejuvenation through selective elimination of senescent cells in vitro and in vivo
Biogerontology. 2024 Apr 15. doi: 10.1007/s10522-024-10103-z. Online ahead of print.ABSTRACTThe skin's protective functions are compromised over time by both endogenous and exogenous aging. Senescence is well-documented in skin phenotypes, such as wrinkling and sagging, a consequence of the senescence-associated secretory phenotype (SASP) that involves the accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling. Although therapeutic approaches for eliminating senescent cells from the skin are available, their efficacy remains unclear. Accordingly, we aimed to examine the effects of dasatinib in...
Source: Biogerontology - April 15, 2024 Category: Geriatrics Authors: Kento Takaya Kazuo Kishi Source Type: research
Single-stage reconstruction of very-wide nasal defects with full-thickness skin grafts: Retrospective analysis of patient reported outcomes
Dear JPRAS Editor, JPRAS Audience, and Colleagues: (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - April 13, 2024 Category: Cosmetic Surgery Authors: Francisco J. Villegas-Alzate, Ana G. Cabezas-Charry, V íctor A. Cardona, Juan F. Ayala, José D. Villegas Source Type: research
GSE263557 Distinctive Transcriptional and Microbial Signature in Cutaneous Acute Graft-vs-Host-Disease
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSkin acute graft-vs-host disease (aGVHD) is often the first manifestation of GVHD, yet very few preclinical and clinical studies have focused on this target organ, leaving a critical information gap in the pathophysiology of GVHD. We hypothesized that analysis of host gene expression and microbiome profiling could yield novel insights into the molecular and immunologic mechanisms underlying skin GVHD. Our objectives were to determine the differential host gene expression and microbiome profile of human skin aGVHD samples compared to norm...
Source: GEO: Gene Expression Omnibus - April 12, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Cancers, Vol. 16, Pages 1469: Delay in Cutaneous Squamous Cell Carcinoma Diagnosis Due to Interrupted Services Is Associated with Worse Prognoses and Modified Surgical Approaches
Conclusions: Diagnostic delays of cutaneous SCCs associated with reduced patient access to clinical and diagnostic services are associated with a 4.7-times increased risk of more severe invasion, a three-times increased risk of positive surgical margins, and a significant impact on surgical management, compared to the pre-pandemic period. Comparable patient cohort characteristics and time to surgery remained unchanged. (Source: Cancers)
Source: Cancers - April 11, 2024 Category: Cancer & Oncology Authors: Filippo Taccioli Claudio Gio Francesco Blessent Alessia Paganelli Francesca Fagioli Johanna Mary Chester Shaniko Kaleci Matteo Costantini Barbara Ferrari Chiara Fiorentini Giorgio De Santis Cristina Magnoni Tags: Article Source Type: research
Bioengineered MSC(Cxcr2) transdifferentiated keratinocyte-like cell-derived organoid potentiates skin regeneration through ERK1/2 and STAT3 signaling in diabetic wound
Cell Mol Life Sci. 2024 Apr 10;81(1):172. doi: 10.1007/s00018-023-05057-3.ABSTRACTSkin regeneration is severely compromised in diabetic foot ulcers. Allogeneic mesenchymal stem cell (MSC) transplantation is limited due to the poor engraftment, mitogenic, and differentiation potential in the harsh wound microenvironment. Thus, to improve the efficacy of cell therapy, the chemokine receptor Cxcr2 was overexpressed in MSCs (MSCCxcr2). CXCL2/CXCR2 axis induction led to the enhanced proliferation of MSCs through the activation of STAT3 and ERK1/2 signaling. Transcriptional upregulation of FGFR2IIIb (KGF Receptor) promoter by th...
Source: Cell Research - April 10, 2024 Category: Cytology Authors: Subholakshmi Choudhury Neha R Dhoke Shilpa Chawla Amitava Das Source Type: research
Bioengineered MSC < sup > Cxcr2 < /sup > transdifferentiated keratinocyte-like cell-derived organoid potentiates skin regeneration through ERK1/2 and STAT3 signaling in diabetic wound
Cell Mol Life Sci. 2024 Apr 10;81(1):172. doi: 10.1007/s00018-023-05057-3.ABSTRACTSkin regeneration is severely compromised in diabetic foot ulcers. Allogeneic mesenchymal stem cell (MSC) transplantation is limited due to the poor engraftment, mitogenic, and differentiation potential in the harsh wound microenvironment. Thus, to improve the efficacy of cell therapy, the chemokine receptor Cxcr2 was overexpressed in MSCs (MSCCxcr2). CXCL2/CXCR2 axis induction led to the enhanced proliferation of MSCs through the activation of STAT3 and ERK1/2 signaling. Transcriptional upregulation of FGFR2IIIb (KGF Receptor) promoter by th...
Source: Cellular and Molecular Life Sciences : CMLS - April 10, 2024 Category: Cytology Authors: Subholakshmi Choudhury Neha R Dhoke Shilpa Chawla Amitava Das Source Type: research
Bioengineered MSC < sup > Cxcr2 < /sup > transdifferentiated keratinocyte-like cell-derived organoid potentiates skin regeneration through ERK1/2 and STAT3 signaling in diabetic wound
Cell Mol Life Sci. 2024 Apr 10;81(1):172. doi: 10.1007/s00018-023-05057-3.ABSTRACTSkin regeneration is severely compromised in diabetic foot ulcers. Allogeneic mesenchymal stem cell (MSC) transplantation is limited due to the poor engraftment, mitogenic, and differentiation potential in the harsh wound microenvironment. Thus, to improve the efficacy of cell therapy, the chemokine receptor Cxcr2 was overexpressed in MSCs (MSCCxcr2). CXCL2/CXCR2 axis induction led to the enhanced proliferation of MSCs through the activation of STAT3 and ERK1/2 signaling. Transcriptional upregulation of FGFR2IIIb (KGF Receptor) promoter by th...
Source: Cellular and Molecular Life Sciences : CMLS - April 10, 2024 Category: Cytology Authors: Subholakshmi Choudhury Neha R Dhoke Shilpa Chawla Amitava Das Source Type: research
Skin Grafting for Dermatologists: Past, Present, and Future
ConclusionSkin grafting is a complex procedure that requires careful planning and postoperative care. Success depends on factors like the type of graft, wound management, and overall health of the patient. Skin grafting has evolved with advancements in surgery, anesthesia, and wound care and remains a crucial technique for restoring function and appearance. (Source: Current Dermatology Reports)
Source: Current Dermatology Reports - April 9, 2024 Category: Dermatology Source Type: research
